Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates β-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment

Journal of Neuroscience

Volumn 30, Issue 21, 2010, Pages 7326-7334

  McAllister, Carrie ^a   Long, Jiangang ^a   Bowers, Adrienne ^a   Walker, Aaron ^a   Cao, Philip ^a   Honda, Shin Ichiro ^b   Harada, Nobuhiro ^b   Staufenbiel, Matthias ^c   Shen, Yong ^a   Li, Rena ^a  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

^b FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AROMATASE; BETA SECRETASE 1; ESTROGEN; MEMBRANE METALLOENDOPEPTIDASE; MESSENGER RNA; TESTOSTERONE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN FUNCTION; BRAIN PROTECTION; COGNITION; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE TARGETING; MALE; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE; UPREGULATION;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AROMATASE; ASPARTIC ACID ENDOPEPTIDASES; BRAIN; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTROGENS; EXPLORATORY BEHAVIOR; HUMANS; INSULYSIN; MALE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NEPRILYSIN; PHOSPHOPYRUVATE HYDRATASE; RADIOIMMUNOASSAY; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; TESTOSTERONE;

EID: 77953060341     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1180-10.2010     Document Type: Article

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