Male sex hormones and systemic inflammation in alzheimer disease

Alzheimer Disease and Associated Disorders

Volumn 27, Issue 2, 2013, Pages 153-156

  Butchart, Joe ^a   Birch, Brian ^b   Bassily, Ramy ^a   Wolfe, Laura ^a   Holmes, Clive ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Alzheimer disease; luteinizing hormone; testosterone; TNF

Indexed keywords

LUTEINIZING HORMONE; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA;

AGED; ALZHEIMER DISEASE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DEMENTIA; DISEASE SEVERITY; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; TESTOSTERONE BLOOD LEVEL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CROSS-SECTIONAL STUDIES; HUMANS; IMMUNOASSAY; INFLAMMATION; LUTEINIZING HORMONE; MALE; NEUROIMMUNOMODULATION; TESTOSTERONE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84878844502     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/WAD.0b013e318258cd63     Document Type: Article

References (27)

1. Bowen RL, Isley JP, Atkinson RL. An association of elevated serum gonadotropin concentrations and Alzheimer disease? J Neuroendocrinol. 2000;12:351-354.
2. Hogervorst E, Combrinck M, Smith AD. Testosterone and gonadotropin levels in men with dementia. Neuro Endocrinol Lett. 2003;24:203-208.
3. Moffat SD, Zonderman AB, Metter EJ, et al. Free testosterone and risk for Alzheimer disease in older men. Neurology. 2004;62:188-193.
4. Hammond J, Le Q, Goodyer C, et al. Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons. J Neurochem. 2001;77:1319-1326.
5. Amantea D, Russo R, Bagetta G, et al. From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens. Pharmacol Res. 2005;52:119-132.
6. Hyde Z, Flicker L, Almeida OP, et al. Higher luteinizing hormone is associated with poor memory recall: the Health in Men Study. J Alzheimers Dis. 2010;19:943-951.
7. Webber KM, Perry G, Smith MA, et al. The contribution of luteinizing hormone to Alzheimer disease pathogenesis. Clin Med Res. 2007;5:177-183.
8. Tan ZS, Beiser AS, Vasan RS, et al. Inflammatory markers and the risk of Alzheimer disease-The Framingham study. Neurology. 2007;68:1902-1908.
9. Yaffe K, Lindquist K, Penninx BW, et al. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology. 2003;61:76-80.
10. Holmes C, Cunningham C, Zotova E, et al. Systemic inflammation and disease progression in Alzheimer disease. Neurology. 2009;73:768-774.
11. Kaplan SA, Johnson-Levonas AO, Lin JX, et al. Elevated high sensitivity C-reactive protein levels in aging men with low testosterone. Aging Male. 2010;13:108-112.
12. Kupelian V, Chiu GR, Araujo AB, et al. Association of sex hormones and C-reactive protein levels in men. Clin Endocrinol. 2010;72:527-533.
13. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDSADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-944.
14. Yeap BB, Almeida OP, Hyde Z, et al. In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men Study. Eur J Endocrinol. 2007;156:585-594.
15. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 1999;84:3666-3672.
16. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry. 1984;141:1356-1364.
17. Rosario ER, Chang L, Stanczyk FZ, et al. Age-related testosterone depletion and the development of Alzheimer disease. JAMA. 2004;292:1431-1432.
18. Short RA, Bowen RL, O'Brien PC, et al. Elevated gonadotropin levels in patients with Alzheimer disease. Mayo Clin Proc. 2001;76:906-909.
19. Kass AS, Lea TE, Torjesen PA, et al. The association of luteinizing hormone and follicle-stimulating hormone with cytokines and markers of disease activity in rheumatoid arthritis: a case-control study. Scand J Rheumatol. 2010;39:109-117.
20. Kaczmarek P, Pokoca L, Niemirowicz J, et al. Effect of luteinizing hormone-releasing hormone (LHRH) analogue treatment on a cytokine profile in prostate cancer patients. Pharmacol Rep. 2008;60:399-403.
21. Colton CA, Brown CA, Vitek MP. Sex steroids, APOE genotype and the innate immune system. Neurobiol Aging. 2005;26:363-372.
22. Bellido T, Jilka RL, Boyce BF, et al. Regulation of interleukin- 6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest. 1995;95:2886-2895.
23. Weiner CP, Lizasoain I, Baylis SA, et al. Induction of calciumdependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci USA. 1994;91:5212-5216.
24. Bornstein SR, Rutkowski H, Vrezas I. Cytokines and steroidogenesis. Mol Cell Endocrinol.. 2004;215:135-141.
25. Foster SC, Daniels C, Bourdette DN, et al. Dysregulation of the hypothalamic-pituitary-gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosis. J Neuroimmunol. 2003;140:78-87.
26. Vanderpoll T, Romijn JA, Endert E, et al. Effects of tumornecrosis- factor on the hypothalamic-pituitary-testicular axis in healthy men. Metab-Clin Exp. 1993;42:303-307.
27. Swardfager W, Lanctot K, Rothenburg L, et al. A metaanalysis of cytokines in Alzheimer's disease. Biol Psychiatry. 2010;68:930-941.