Testosterone effect on brain metabolism in elderly patients with Alzheimer's disease: Comparing two cases at different disease stages

Aging Clinical and Experimental Research

Volumn 25, Issue 3, 2013, Pages 343-347

  Tan, R S ^a,b,c,d  

^a MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d OPAL Medical Clinic   (United States)

Author keywords

Alzheimer's disease; Cerebral glucose metabolism; Dementia; Hypogonadism; PET scan; Testosterone

Indexed keywords

TESTOSTERONE; GLUCOSE;

AGED; ALZHEIMER DISEASE; ANDROGEN THERAPY; ARTICLE; BRAIN METABOLISM; BRAIN REGION; BRAIN STEM; CASE REPORT; COMPARATIVE STUDY; DRUG EFFICACY; ELECTROENCEPHALOGRAM; GERIATRIC CARE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; INSULA; LIMBIC SYSTEM; PARIETAL LOBE; POSITRON EMISSION TOMOGRAPHY; TEMPORAL LOBE; AGING; BRAIN; DISEASE COURSE; HORMONE SUBSTITUTION; HYPOGONADISM; MALE; METABOLISM; SCINTISCANNING; TREATMENT OUTCOME; VERY ELDERLY;

AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; BRAIN; DISEASE PROGRESSION; GLUCOSE; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOGONADISM; MALE; POSITRON-EMISSION TOMOGRAPHY; TESTOSTERONE; TREATMENT OUTCOME;

EID: 84886654048     PISSN: 15940667     EISSN: 17208319     Source Type: Journal    
DOI: 10.1007/s40520-013-0049-2     Document Type: Article

References (19)

1. Buchsbaum MS, Henkin RI (1980) Perceptual abnormalities in patients with chromatin negative gonadal dysgenesis and hypogonadotropic hypogonadism. Int J Neurosci 11:201-209
2. Cappa SF, Guariglia C, Papagno C et al (1988) Patterns of lateralization and performance levels for verbal and spatial tasks in congenital androgen deficiency. Behav Brain Res 31:177-183
3. Holland J, Bandelow S, Hogervorst E (2011) Testosterone levels and cognition in elderly men: a review. Maturitas 69:322-337
4. Janowsky JS, Chavez B, Orwoll E (2000) Sex steroids modify working memory. J Cogn Neurosci. 12:407-414
5. Janowsky JS, Oviatt SK, Orwoll ES (1994) Testosterone influences spatial cognition in older men. Behav Neurosci 108:325-332
6. LeBlanc ES, Wang PY, Janowsky JS et al (2010) Association between sex steroids and cognition in elderly men. Clin Endocrinol (Oxf) 72:393-403
7. Cherrier MM, Matsumoto AM, Amory JK et al (2005) Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment. Neurology 64:2063-2068
8. Tan RS, Pu SJ (2003) A pilot study on the effects of testosterone in hypogonadal aging male patients with Alzheimer's disease. Aging Male 6:13-17
9. Rosen WG, Mohs RC, Davis KL (1984) A new rating scale for Alzheimer's disease. Am J Psychiatry 141:1356-1364
10. Lu PH, Masterman DA, Mulnard R et al (2006) Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men. Arch Neurol 63:177-185
11. Zitzmann M, Weckesser M, Schober O et al (2001) Changes in cerebral glucose metabolism and visuospatial capability in hypogonadal males under testosterone substitution therapy. Exp Clin Endocrinol Diabetes 109:302-304
12. Azad N, Pitale S, Barnes WE, Friedman N (2003) Testosterone treatment enhances regional brain perfusion in hypogonadal men. J Clin Endocrinol Metab 88:3064-3068
13. Simerly RB, Chang C, Muramatsu M et al (1990) Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J Comp Neurol 294:76-95
14. Carpenter MB, Sutin J (1983) Human Neuroanatomy. Williams and Wilkins Co, Baltimore
15. Jack CR Jr (2012) Alzheimer disease: new concepts on its neurobiology and the clinical role imaging will play. Radiology 263(2):344-361
16. Small GW, Siddarth P, Kepe V et al (2012) Prediction of cognitive decline by positron emission tomography of brain amyloid and tau. Arch Neurol 69(2):215-222
17. Amariglio RE, Becker JA, Carmasin J et al (2012) Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia 50(12):2880-2886
18. Rinne JO, Brooks DJ, Rossor MN et al (2010) 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol 9(4):363-372
19. Egefjord L, Gejl M, Møller A et al (2012) Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer′s disease - protocol for a controlled, randomized double-blinded trial. Dan Med J 59(10):A4519