-
1
-
-
35148838537
-
Drug-target network
-
(doi: 10. 1038/nbt1338)
-
Yildirim MA, Goh KI, Cusick ME, Barabasi AL, Vidal M. 2007 Drug-target network. Nat. Biotechnol. 25, 1119-1126. (doi: 10. 1038/nbt1338).
-
(2007)
Nat. Biotechnol
, vol.25
, pp. 1119-1126
-
-
Yildirim, M.A.1
Goh, K.I.2
Cusick, M.E.3
Barabasi, A.L.4
Vidal, M.5
-
2
-
-
0022348605
-
Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3 Åresolution
-
(doi: 10. 1038/318618a0)
-
Deisenhofer J, Epp O, Miki K, Huber R, Michel H. 1985 Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3 Åresolution. Nature 318, 618-624. (doi: 10. 1038/318618a0).
-
(1985)
Nature
, vol.318
, pp. 618-624
-
-
Deisenhofer, J.1
Epp, O.2
Miki, K.3
Huber, R.4
Michel, H.5
-
3
-
-
84872587737
-
Breaking the barriers in membrane protein crystallography
-
(doi: 10. 1016/j. biocel. 2012. 12. 018)
-
Kang HJ, Lee C, Drew D. 2013 Breaking the barriers in membrane protein crystallography. Int. J. Biochem. Cell. Biol. 45, 636-644. (doi: 10. 1016/j. biocel. 2012. 12. 018).
-
(2013)
Int. J. Biochem. Cell. Biol
, vol.45
, pp. 636-644
-
-
Kang, H.J.1
Lee, C.2
Drew, D.3
-
4
-
-
84872221774
-
Structurefunction of the G protein-coupled receptor superfamily
-
(doi: 10. 1146/annurev-pharmtox-032112-135923)
-
Katritch V, Cherezov V, Stevens RC. 2013 Structurefunction of the G protein-coupled receptor superfamily. Annu. Rev. Pharmacol. Toxicol. 53, 531-556. (doi: 10. 1146/annurev-pharmtox-032112-135923).
-
(2013)
Annu. Rev. Pharmacol. Toxicol
, vol.53
, pp. 531-556
-
-
Katritch, V.1
Cherezov, V.2
Stevens, R.C.3
-
5
-
-
84862601592
-
Structural genomics plucks high-hanging membrane proteins
-
(doi: 10. 1016/j. sbi. 2012. 05. 002)
-
Kloppmann E, Punta M, Rost B. 2012 Structural genomics plucks high-hanging membrane proteins. Curr. Opin. Struct. Biol. 22, 326-332. (doi: 10. 1016/j. sbi. 2012. 05. 002).
-
(2012)
Curr. Opin. Struct. Biol
, vol.22
, pp. 326-332
-
-
Kloppmann, E.1
Punta, M.2
Rost, B.3
-
6
-
-
33947172767
-
Detergents for the stabilization and crystallization of membrane proteins
-
(doi: 10. 1016/j. ymeth. 2007. 01. 007)
-
Prive GG. 2007 Detergents for the stabilization and crystallization of membrane proteins. Methods 41, 388-397. (doi: 10. 1016/j. ymeth. 2007. 01. 007).
-
(2007)
Methods
, vol.41
, pp. 388-397
-
-
Prive, G.G.1
-
7
-
-
80052089906
-
Lipidic cubic phase technologies for membrane protein structural studies
-
(doi: 10. 1016/j. sbi. 2011. 06. 007)
-
Cherezov V. 2011 Lipidic cubic phase technologies for membrane protein structural studies. Curr. Opin. Struct. Biol. 21, 559-566. (doi: 10. 1016/j. sbi. 2011. 06. 007).
-
(2011)
Curr. Opin. Struct. Biol
, vol.21
, pp. 559-566
-
-
Cherezov, V.1
-
8
-
-
66049128793
-
Crystallizing membrane proteins for structure determination: Use of lipidic mesophases
-
(doi: 10. 1146/annurev. biophys. 050708. 133655)
-
Caffrey M. 2009 Crystallizing membrane proteins for structure determination: use of lipidic mesophases. Annu. Rev. Biophys. 38, 29-51. (doi: 10. 1146/annurev. biophys. 050708. 133655).
-
(2009)
Annu. Rev. Biophys
, vol.38
, pp. 29-51
-
-
Caffrey, M.1
-
9
-
-
84855991060
-
Crystallizing membrane proteins using lipidic bicelles
-
(doi: 10. 1016/j. ymeth. 2011. 09. 020)
-
Ujwal R, Bowie JU. 2011 Crystallizing membrane proteins using lipidic bicelles. Methods 55, 337-341. (doi: 10. 1016/j. ymeth. 2011. 09. 020).
-
(2011)
Methods
, vol.55
, pp. 337-341
-
-
Ujwal, R.1
Bowie, J.U.2
-
10
-
-
4344579363
-
A pedestrian guide to membrane protein crystallization
-
(doi: 10. 1016/j. ymeth. 2004. 03. 025)
-
Wiener MC. 2004 A pedestrian guide to membrane protein crystallization. Methods 34, 364-372. (doi: 10. 1016/j. ymeth. 2004. 03. 025).
-
(2004)
Methods
, vol.34
, pp. 364-372
-
-
Wiener, M.C.1
-
11
-
-
0029992660
-
Lipidic cubic phases: A novel concept for the crystallization of membrane proteins
-
(doi: 10. 1073/pnas. 93. 25. 14532)
-
Landau EM, Rosenbusch JP. 1996 Lipidic cubic phases: a novel concept for the crystallization of membrane proteins. Proc. Natl Acad. Sci. USA 93, 14 532-14 535. (doi: 10. 1073/pnas. 93. 25. 14532).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 14532-14535
-
-
Landau, E.M.1
Rosenbusch, J.P.2
-
12
-
-
0030864048
-
X-ray structure of bacteriorhodopsin at 2. 5 angstroms from microcrystals grown in lipidic cubic phases
-
(doi: 10. 1126/science. 277. 5332. 1676)
-
Pebay-Peyroula E, Rummel G, Rosenbusch JP, Landau EM. 1997 X-ray structure of bacteriorhodopsin at 2. 5 angstroms from microcrystals grown in lipidic cubic phases. Science 277, 1676-1681. (doi: 10. 1126/science. 277. 5332. 1676).
-
(1997)
Science
, vol.277
, pp. 1676-1681
-
-
Pebay-Peyroula, E.1
Rummel, G.2
Rosenbusch, J.P.3
Landau, E.M.4
-
13
-
-
0032422462
-
A simple mechanical mixer for small viscous lipidcontaining samples
-
(doi: 10. 1016/S0009-3084(98)00060-7)
-
Cheng A, Hummel B, Qiu H, Caffrey M. 1998 A simple mechanical mixer for small viscous lipidcontaining samples. Chem. Phys. Lipids 95, 11-21. (doi: 10. 1016/S0009-3084(98)00060-7).
-
(1998)
Chem. Phys. Lipids
, vol.95
, pp. 11-21
-
-
Cheng, A.1
Hummel, B.2
Qiu, H.3
Caffrey, M.4
-
14
-
-
9944252602
-
A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases
-
(doi: 10. 1107/S0907444904019109)
-
Cherezov V, Peddi A, Muthusubramaniam L, Zheng YF, Caffrey M. 2004 A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases. Acta Crystallogr. D Biol. Crystallogr. 60, 1795-1807. (doi: 10. 1107/S0907444904019109).
-
(2004)
Acta Crystallogr. D Biol. Crystallogr
, vol.60
, pp. 1795-1807
-
-
Cherezov, V.1
Peddi, A.2
Muthusubramaniam, L.3
Zheng, Y.F.4
Caffrey, M.5
-
15
-
-
0242367561
-
Nano-volume plates with excellent optical properties for fast, inexpensive crystallization screening of membrane proteins
-
(doi: 10. 1107/S002188980301906x)
-
Cherezov V, Caffrey M. 2003 Nano-volume plates with excellent optical properties for fast, inexpensive crystallization screening of membrane proteins. J. Appl. Crystallogr. 36, 1372-1377. (doi: 10. 1107/S002188980301906x).
-
(2003)
J. Appl. Crystallogr
, vol.36
, pp. 1372-1377
-
-
Cherezov, V.1
Caffrey, M.2
-
16
-
-
5144234232
-
Rational design of lipid for membrane protein crystallization
-
(doi: 10. 1016/j. jsb. 2004. 06. 008)
-
Misquitta Y, Cherezov V, Havas F, Patterson S, Mohan JM, Wells AJ, Hart DJ, Caffrey M. 2004 Rational design of lipid for membrane protein crystallization. J. Struct. Biol. 148, 169-175. (doi: 10. 1016/j. jsb. 2004. 06. 008).
-
(2004)
J. Struct. Biol
, vol.148
, pp. 169-175
-
-
Misquitta, Y.1
Cherezov, V.2
Havas, F.3
Patterson, S.4
Mohan, J.M.5
Wells, A.J.6
Hart, D.J.7
Caffrey, M.8
-
17
-
-
84879867305
-
Host lipid and temperature as important screening variables for crystallizing integral membrane proteins in lipidic mesophases. Trials with diacylglycerol kinase
-
(doi: 10. 1021/cg400254v)
-
Li D, Shah ST, Caffrey M. 2013 Host lipid and temperature as important screening variables for crystallizing integral membrane proteins in lipidic mesophases. Trials with diacylglycerol kinase. Cryst. Growth Des. 13, 2846-2857. (doi: 10. 1021/cg400254v).
-
(2013)
Cryst. Growth Des
, vol.13
, pp. 2846-2857
-
-
Li, D.1
Shah, S.T.2
Caffrey, M.3
-
18
-
-
79953901342
-
Development of an automated high throughput LCP-FRAP assay to guide membrane protein crystallization in lipid mesophases
-
(doi: 10. 1021/cg101385e)
-
Xu F, Liu W, Hanson MA, Stevens RC, Cherezov V. 2011 Development of an automated high throughput LCP-FRAP assay to guide membrane protein crystallization in lipid mesophases. Cryst. Growth Des. 11, 1193-1201. (doi: 10. 1021/cg101385e).
-
(2011)
Cryst. Growth Des
, vol.11
, pp. 1193-1201
-
-
Xu, F.1
Liu, W.2
Hanson, M.A.3
Stevens, R.C.4
Cherezov, V.5
-
19
-
-
77951645706
-
LCP-Tm: An assay to measure and understand stability of membrane proteins in a membrane environment
-
(doi: 10. 1016/j. bpj. 2009. 12. 4296)
-
Liu W, Hanson MA, Stevens RC, Cherezov V. 2010 LCP-Tm: an assay to measure and understand stability of membrane proteins in a membrane environment. Biophys. J. 98, 1539-1548. (doi: 10. 1016/j. bpj. 2009. 12. 4296).
-
(2010)
Biophys. J
, vol.98
, pp. 1539-1548
-
-
Liu, W.1
Hanson, M.A.2
Stevens, R.C.3
Cherezov, V.4
-
20
-
-
75649119689
-
Nonlinear optical imaging of integral membrane protein crystals in lipidic mesophases
-
(doi: 10. 1021/ac902139w)
-
Kissick DJ, Gualtieri EJ, Simpson GJ, Cherezov V. 2010 Nonlinear optical imaging of integral membrane protein crystals in lipidic mesophases. Anal. Chem. 82, 491-497. (doi: 10. 1021/ac902139w).
-
(2010)
Anal. Chem
, vol.82
, pp. 491-497
-
-
Kissick, D.J.1
Gualtieri, E.J.2
Simpson, G.J.3
Cherezov, V.4
-
21
-
-
67649392795
-
Crystallizing membrane proteins using lipidic mesophases
-
(doi: 10. 1038/nprot. 2009. 31)
-
Caffrey M, Cherezov V. 2009 Crystallizing membrane proteins using lipidic mesophases. Nat. Protoc. 4, 706-731. (doi: 10. 1038/nprot. 2009. 31).
-
(2009)
Nat. Protoc
, vol.4
, pp. 706-731
-
-
Caffrey, M.1
Cherezov, V.2
-
22
-
-
78049502261
-
Recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets
-
(doi: 10. 1007/978-1-60761-762-4_8)
-
Cherezov V, Abola E, Stevens RC. 2010 Recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets. Methods Mol. Biol. 654, 141-168. (doi: 10. 1007/978-1-60761-762-4_8).
-
(2010)
Methods Mol. Biol
, vol.654
, pp. 141-168
-
-
Cherezov, V.1
Abola, E.2
Stevens, R.C.3
-
23
-
-
80055115291
-
Crystallization of membrane proteins in lipidic mesophases
-
(doi: 10. 3791/2501)
-
Liu W, Cherezov V. 2011 Crystallization of membrane proteins in lipidic mesophases. J. Vis. Exp. 49, e2501. (doi: 10. 3791/2501).
-
(2011)
J. Vis. Exp
, vol.49
-
-
Liu, W.1
Cherezov, V.2
-
24
-
-
80055110454
-
Crystallizing membrane proteins for structure determination using lipidic mesophases
-
(doi: 10. 3791/1712)
-
Caffrey M, Porter C. 2010 Crystallizing membrane proteins for structure determination using lipidic mesophases. J. Vis. Exp. 45, e1712. (doi: 10. 3791/1712).
-
(2010)
J. Vis. Exp
, vol.45
-
-
Caffrey, M.1
Porter, C.2
-
25
-
-
84865146809
-
Harvesting and cryo-cooling crystals of membrane proteins grown in lipidic mesophases for structure determination by macromolecular crystallography
-
(doi: 10. 3791/4001)
-
Li D, Boland C, Aragao D, Walsh K, Caffrey M. 2012 Harvesting and cryo-cooling crystals of membrane proteins grown in lipidic mesophases for structure determination by macromolecular crystallography. J. Vis. Exp. 67, e4001. (doi: 10. 3791/4001).
-
(2012)
J. Vis. Exp
, vol.67
-
-
Li, D.1
Boland, C.2
Aragao, D.3
Walsh, K.4
Caffrey, M.5
-
26
-
-
70349594570
-
Effects of impurities on membraneprotein crystallization in different systems
-
(doi: 10. 1107/S0907444909029163)
-
Kors CA, Wallace E, Davies DR, Li L, Laible PD, Nollert P. 2009 Effects of impurities on membraneprotein crystallization in different systems. Acta Crystallogr. D Biol. Crystallogr. 65, 1062-1073. (doi: 10. 1107/S0907444909029163).
-
(2009)
Acta Crystallogr. D Biol. Crystallogr
, vol.65
, pp. 1062-1073
-
-
Kors, C.A.1
Wallace, E.2
Davies, D.R.3
Li, L.4
Laible, P.D.5
Nollert, P.6
-
27
-
-
84863012221
-
Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger
-
(doi: 10. 1126/science. 1215759)
-
Liao J, Li H, Zeng W, Sauer DB, Belmares R, Jiang Y. 2012 Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger. Science 335, 686-690. (doi: 10. 1126/science. 1215759).
-
(2012)
Science
, vol.335
, pp. 686-690
-
-
Liao, J.1
Li, H.2
Zeng, W.3
Sauer, D.B.4
Belmares, R.5
Jiang, Y.6
-
28
-
-
0001504254
-
Macromolecular cryocrystallography
-
(doi: 10. 1107/S0021889897002677)
-
Garman E, Schneider T. 1997 Macromolecular cryocrystallography. J. Appl. Crystallogr. 30, 211-237. (doi: 10. 1107/S0021889897002677).
-
(1997)
J. Appl. Crystallogr
, vol.30
, pp. 211-237
-
-
Garman, E.1
Schneider, T.2
-
29
-
-
0009528256
-
Studies of insulin crystals at low temperatures: Effects on mosaic character and radiation sensitivity
-
(doi: 10. 1073/pnas. 56. 6. 1746)
-
Low BW, Chen CC, Berger JE, Singman L, Pletcher JF. 1966 Studies of insulin crystals at low temperatures: effects on mosaic character and radiation sensitivity. Proc. Natl Acad. Sci. USA 56, 1746-1750. (doi: 10. 1073/pnas. 56. 6. 1746).
-
(1966)
Proc. Natl Acad. Sci. USA
, vol.56
, pp. 1746-1750
-
-
Low, B.W.1
Chen, C.C.2
Berger, J.E.3
Singman, L.4
Pletcher, J.F.5
-
30
-
-
0014279606
-
Preliminary studies on the denaturation of cross-linked lysozyme crystals
-
(doi: 10. 1016/S0006-3495(68)86507-5)
-
Haas DJ. 1968 Preliminary studies on the denaturation of cross-linked lysozyme crystals. Biophys. J. 8, 549-555. (doi: 10. 1016/S0006-3495(68)86507-5).
-
(1968)
Biophys. J
, vol.8
, pp. 549-555
-
-
Haas, D.J.1
-
31
-
-
0014948595
-
Crystallographic studies on lactate dehydrogenase at 275 degrees C
-
(doi: 10. 1107/S0567740870003485)
-
Haas DJ, Rossmann MG. 1970 Crystallographic studies on lactate dehydrogenase at 275 degrees C. Acta Crystallogr. B 26, 998-1004. (doi: 10. 1107/S0567740870003485).
-
(1970)
Acta Crystallogr. B
, vol.26
, pp. 998-1004
-
-
Haas, D.J.1
Rossmann, M.G.2
-
32
-
-
0016853253
-
Protein crystallography at sub-zero temperatures: Cryo-protective mother liquors for protein crystals
-
(doi: 10. 1016/0022-2836(75)90167-9)
-
Petsko GA. 1975 Protein crystallography at sub-zero temperatures: cryo-protective mother liquors for protein crystals. J. Mol. Biol. 96, 381-392. (doi: 10. 1016/0022-2836(75)90167-9).
-
(1975)
J. Mol. Biol
, vol.96
, pp. 381-392
-
-
Petsko, G.A.1
-
33
-
-
84867740408
-
Microcrystallography comes of age
-
(doi: 10. 1016/j. sbi. 2012. 09. 001)
-
Smith JL, Fischetti RF, Yamamoto M. 2012 Microcrystallography comes of age. Curr. Opin. Struct. Biol. 22, 602-612. (doi: 10. 1016/j. sbi. 2012. 09. 001).
-
(2012)
Curr. Opin. Struct. Biol
, vol.22
, pp. 602-612
-
-
Smith, J.L.1
Fischetti, R.F.2
Yamamoto, M.3
-
34
-
-
41949138317
-
A 7mum mini-beam improves diffraction data from small or imperfect crystals of macromolecules
-
(doi: 10. 1107/S0907444908001741)
-
Sanishvili R, Nagarajan V, Yoder D, Becker M, Xu S, Corcoran S, Akey DL, Smith JL, Fischetti RF. 2008 A 7mum mini-beam improves diffraction data from small or imperfect crystals of macromolecules. Acta Crystallogr. D Biol. Crystallogr. 64, 425-435. (doi: 10. 1107/S0907444908001741).
-
(2008)
Acta. Crystallogr. D Biol. Crystallogr
, vol.64
, pp. 425-435
-
-
Sanishvili, R.1
Nagarajan, V.2
Yoder, D.3
Becker, M.4
Xu, S.5
Corcoran, S.6
Akey, D.L.7
Smith, J.L.8
Fischetti, R.F.9
-
35
-
-
33847403674
-
The molecular organization of cypovirus polyhedra
-
(doi: 10. 1038/nature05628)
-
Coulibaly F, Chiu E, Ikeda K, Gutmann S, Haebel PW, Schulze-Briese C, Mori H, Metcalf P. 2007 The molecular organization of cypovirus polyhedra. Nature 446, 97-101. (doi: 10. 1038/nature05628).
-
(2007)
Nature
, vol.446
, pp. 97-101
-
-
Coulibaly, F.1
Chiu, E.2
Ikeda, K.3
Gutmann, S.4
Haebel, P.W.5
Schulze-Briese, C.6
Mori, H.7
Metcalf, P.8
-
36
-
-
20444440728
-
Structure of the cross-beta spine of amyloid-like fibrils
-
(doi: 10. 1038/nature03680)
-
Nelson R, Sawaya MR, Balbirnie M, Madsen AO, Riekel C, Grothe R, Eisenberg D. 2005 Structure of the cross-beta spine of amyloid-like fibrils. Nature 435, 773-778. (doi: 10. 1038/nature03680).
-
(2005)
Nature
, vol.435
, pp. 773-778
-
-
Nelson, R.1
Sawaya, M.R.2
Balbirnie, M.3
Madsen, A.O.4
Riekel, C.5
Grothe, R.6
Eisenberg, D.7
-
37
-
-
36448995359
-
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
-
(doi: 10. 1126/science. 1150577)
-
Cherezov V et al. 2007 High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318, 1258-1265. (doi: 10. 1126/science. 1150577).
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
-
38
-
-
69949132434
-
Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam
-
(doi: 10. 1098/rsif. 2009. 0142. focus)
-
Cherezov V et al. 2009 Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam. J. R. Soc. Interface 6(Suppl. 5), S587-S597. (doi: 10. 1098/rsif. 2009. 0142. focus).
-
(2009)
J.R. Soc. Interface
, vol.6
, Issue.SUPPL. 5
-
-
Cherezov, V.1
-
39
-
-
80052178606
-
Automated sample-scanning methods for radiation damage mitigation and diffraction-based centering of macromolecular crystals
-
(doi: 10. 1107/S0909049511029918)
-
Hilgart MC, Sanishvili R, Ogata CM, Becker M, Venugopalan N, Stepanov S, Makarov O, Smith JL, Fischetti RF. 2011 Automated sample-scanning methods for radiation damage mitigation and diffraction-based centering of macromolecular crystals. J. Synchrotron Radiat. 18, 717-722. (doi: 10. 1107/S0909049511029918).
-
(2011)
J. Synchrotron Radiat
, vol.18
, pp. 717-722
-
-
Hilgart, M.C.1
Sanishvili, R.2
Ogata, C.M.3
Becker, M.4
Venugopalan, N.5
Stepanov, S.6
Makarov, O.7
Smith, J.L.8
Fischetti, R.F.9
-
40
-
-
84879154648
-
Integrated nonlinear optical imaging microscope for on-axis crystal detection and centering at a synchrotron beamline
-
(doi: 10. 1107/S0909049513007942)
-
Madden JT et al. 2013 Integrated nonlinear optical imaging microscope for on-axis crystal detection and centering at a synchrotron beamline. J. Synchrotron Radiat. 20, 531-540. (doi: 10. 1107/S0909049513007942).
-
(2013)
J. Synchrotron Radiat
, vol.20
, pp. 531-540
-
-
Madden, J.T.1
-
41
-
-
84866315674
-
X-ray lasers for structural and dynamic biology
-
(doi: 10. 1088/0034-4885/75/10/102601)
-
Spence JC, Weierstall U, Chapman HN. 2012 X-ray lasers for structural and dynamic biology. Rep. Prog. Phys. 75, 102601. (doi: 10. 1088/0034-4885/75/10/102601).
-
(2012)
Rep. Prog. Phys
, vol.75
, pp. 102601
-
-
Spence, J.C.1
Weierstall, U.2
Chapman, H.N.3
-
42
-
-
0034680144
-
Potential for biomolecular imaging with femtosecond X-ray pulses
-
(doi: 10. 1038/35021099)
-
Neutze R, Wouts R, van der Spoel D, Weckert E, Hajdu J. 2000 Potential for biomolecular imaging with femtosecond X-ray pulses. Nature 406, 752-757. (doi: 10. 1038/35021099).
-
(2000)
Nature
, vol.406
, pp. 752-757
-
-
Neutze, R.1
Wouts, R.2
van der Spoel, D.3
Weckert, E.4
Hajdu, J.5
-
43
-
-
79551658540
-
Femtosecond X-ray protein nanocrystallography
-
(doi: 10. 1038/nature09750)
-
Chapman HN et al. 2011 Femtosecond X-ray protein nanocrystallography. Nature 470, 73-77. (doi: 10. 1038/nature09750).
-
(2011)
Nature
, vol.470
, pp. 73-77
-
-
Chapman, H.N.1
-
44
-
-
79951928807
-
Structure-factor analysis of femtosecond microdiffraction patterns from protein nanocrystals
-
(doi: 10. 1107/S0108767310050981)
-
Kirian RA et al. 2011 Structure-factor analysis of femtosecond microdiffraction patterns from protein nanocrystals. Acta Crystallogr. A 67, 131-140. (doi: 10. 1107/S0108767310050981).
-
(2011)
Acta Crystallogr. A
, vol.67
, pp. 131-140
-
-
Kirian, R.A.1
-
45
-
-
84862777982
-
Lipidic phase membrane protein serial femtosecond crystallography
-
(doi: 10. 1038/nmeth. 1867)
-
Johansson LC et al. 2012 Lipidic phase membrane protein serial femtosecond crystallography. Nat. Methods 9, 263-265. (doi: 10. 1038/nmeth. 1867).
-
(2012)
Nat. Methods
, vol.9
, pp. 263-265
-
-
Johansson, L.C.1
-
46
-
-
84864004802
-
High-resolution protein structure determination by serial femtosecond crystallography
-
(doi: 10. 1126/science. 1217737)
-
Boutet S et al. 2012 High-resolution protein structure determination by serial femtosecond crystallography. Science 337, 362-364. (doi: 10. 1126/science. 1217737).
-
(2012)
Science
, vol.337
, pp. 362-364
-
-
Boutet, S.1
-
47
-
-
84872148917
-
Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser
-
(doi: 10. 1126/science. 1229663)
-
Redecke L et al. 2013 Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser. Science 339, 227-230. (doi: 10. 1126/science. 1229663).
-
(2013)
Science
, vol.339
, pp. 227-230
-
-
Redecke, L.1
-
48
-
-
84861602614
-
Injector for scattering measurements on fully solvated biospecies
-
(doi: 10. 1063/1. 3693040)
-
Weierstall U, Spence JC, Doak RB. 2012 Injector for scattering measurements on fully solvated biospecies. Rev. Sci. Instrum. 83, 035108. (doi: 10. 1063/1. 3693040).
-
(2012)
Rev. Sci. Instrum
, vol.83
, pp. 035108
-
-
Weierstall, U.1
Spence, J.C.2
Doak, R.B.3
-
49
-
-
53449087721
-
Gas dynamic virtual nozzle for generation of microscopic droplet streams
-
(doi: 10. 1088/0022-3727/41/19/195505)
-
DePonte DP, Weierstall U, Starodub D, Schmidt K, Spence JC, Doak RB. 2008 Gas dynamic virtual nozzle for generation of microscopic droplet streams. J. Phys. D 41, 195505. (doi: 10. 1088/0022-3727/41/19/195505).
-
(2008)
J. Phys. D
, vol.41
, pp. 195505
-
-
DePonte, D.P.1
Weierstall, U.2
Starodub, D.3
Schmidt, K.4
Spence, J.C.5
Doak, R.B.6
-
50
-
-
84867837841
-
Nanoflow electrospinning serial femtosecond crystallography
-
(doi: 10. 1107/S0907444912038152)
-
Sierra RG et al. 2012 Nanoflow electrospinning serial femtosecond crystallography. Acta Crystallogr. D Biol. Crystallogr. 68, 1584-1587. (doi: 10. 1107/S0907444912038152).
-
(2012)
Acta Crystallogr. D Biol. Crystallogr
, vol.68
, pp. 1584-1587
-
-
Sierra, R.G.1
-
51
-
-
84862545637
-
Room temperature femtosecond X-ray diffraction of photosystem II microcrystals
-
(doi: 10. 1073/pnas. 1204598109)
-
Kern J et al. 2012 Room temperature femtosecond X-ray diffraction of photosystem II microcrystals. Proc. Natl Acad. Sci. USA 109, 9721-9726. (doi: 10. 1073/pnas. 1204598109).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 9721-9726
-
-
Kern, J.1
-
52
-
-
84894037590
-
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
-
(doi: 10. 1038/ncomms4309)
-
Weierstall U et al. 2014 Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography. Nat. Commun. 5, 3309. (doi: 10. 1038/ncomms4309).
-
(2014)
Nat. Commun
, vol.5
, pp. 3309
-
-
Weierstall, U.1
-
53
-
-
84861961427
-
Structural basis for allosteric regulation of GPCRs by sodium ions
-
(doi: 10. 1126/science. 1219218)
-
Liu W et al. 2012 Structural basis for allosteric regulation of GPCRs by sodium ions. Science 337, 232-236. (doi: 10. 1126/science. 1219218).
-
(2012)
Science
, vol.337
, pp. 232-236
-
-
Liu, W.1
-
54
-
-
0033992338
-
The phase diagram of the monoolein/water system: Metastability and equilibrium aspects
-
(doi: 10. 1016/S0142-9612(99)00126-X)
-
Qiu H, Caffrey M. 2000 The phase diagram of the monoolein/water system: metastability and equilibrium aspects. Biomaterials 21, 223-234. (doi: 10. 1016/S0142-9612(99)00126-X).
-
(2000)
Biomaterials
, vol.21
, pp. 223-234
-
-
Qiu, H.1
Caffrey, M.2
-
55
-
-
84877631485
-
Structural features for functional selectivity at serotonin receptors
-
(doi: 10. 1126/science. 1232808)
-
Wacker D et al. 2013 Structural features for functional selectivity at serotonin receptors. Science 340, 615-619. (doi: 10. 1126/science. 1232808).
-
(2013)
Science
, vol.340
, pp. 615-619
-
-
Wacker, D.1
-
56
-
-
84890840505
-
Serial femtosecond crystallography of G protein-coupled receptors
-
(doi: 10. 1126/science. 1244142)
-
Liu W et al. 2013 Serial femtosecond crystallography of G protein-coupled receptors. Science 342, 1521-1524. (doi: 10. 1126/science. 1244142).
-
(2013)
Science
, vol.342
, pp. 1521-1524
-
-
Liu, W.1
-
57
-
-
80053626537
-
Accessing protein conformational ensembles using room-temperature X-ray crystallography
-
(doi: 10. 1073/pnas. 1111325108)
-
Fraser JS, van den Bedem H, Samelson AJ, Lang PT, Holton JM, Echols N, Alber T. 2011 Accessing protein conformational ensembles using room-temperature X-ray crystallography. Proc. Natl Acad. Sci. USA 108, 16 247-16 252. (doi: 10. 1073/pnas. 1111325108).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 16247-16252
-
-
Fraser, J.S.1
van den Bedem, H.2
Samelson, A.J.3
Lang, P.T.4
Holton, J.M.5
Echols, N.6
Alber, T.7
-
58
-
-
21644436120
-
Pros and cons of cryocrystallography: Should we also collect a roomtemperature data set?
-
(doi: 10. 1107/S0907444904027179)
-
Dunlop KV, Irvin RT, Hazes B. 2005 Pros and cons of cryocrystallography: should we also collect a roomtemperature data set? Acta Crystallogr. D Biol. Crystallogr. 61, 80-87. (doi: 10. 1107/S0907444904027179).
-
(2005)
Acta Crystallogr. D Biol. Crystallogr
, vol.61
, pp. 80-87
-
-
Dunlop, K.V.1
Irvin, R.T.2
Hazes, B.3
-
59
-
-
84355163051
-
Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements
-
(doi: 10. 1038/nphoton. 2011. 297)
-
Barty A et al. 2012 Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements. Nat. Photonics 6, 35-40. (doi: 10. 1038/nphoton. 2011. 297).
-
(2012)
Nat. Photonics
, vol.6
, pp. 35-40
-
-
Barty, A.1
-
60
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
(doi: 10. 1101/gad. 938601)
-
Ingham PW, McMahon AP. 2001 Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15, 3059-3087. (doi: 10. 1101/gad. 938601).
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
61
-
-
0345059765
-
Hedgehog signalling in cancer formation and maintenance
-
(doi: 10. 1038/nrc1229)
-
Pasca di Magliano M, Hebrok M. 2003 Hedgehog signalling in cancer formation and maintenance. Nat. Rev. Cancer 3, 903-911. (doi: 10. 1038/nrc1229).
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 903-911
-
-
Pasca di Magliano, M.1
Hebrok, M.2
-
62
-
-
18644368453
-
Small-molecule modulators of Hedgehog signaling: Identification and characterization of Smoothened agonists and antagonists
-
(doi: 10. 1186/1475-4924-1-10)
-
Frank-Kamenetsky M et al. 2002 Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J. Biol. 1, 10. (doi: 10. 1186/1475-4924-1-10).
-
(2002)
J. Biol
, vol.1
, pp. 10
-
-
Frank-Kamenetsky, M.1
-
63
-
-
0037195074
-
Small molecule modulation of Smoothened activity
-
(doi: 10. 1073/pnas. 182542899)
-
Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. 2002 Small molecule modulation of Smoothened activity. Proc. Natl Acad. Sci. USA 99, 14 071-14076. (doi: 10. 1073/pnas. 182542899).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 14071-14076
-
-
Chen, J.K.1
Taipale, J.2
Young, K.E.3
Maiti, T.4
Beachy, P.A.5
-
64
-
-
67649983452
-
Hedgehog-Gli signaling pathway inhibitors as anticancer agents
-
(doi: 10. 1021/jm801420y)
-
Mahindroo N, Punchihewa C, Fujii N. 2009 Hedgehog-Gli signaling pathway inhibitors as anticancer agents. J. Med. Chem. 52, 3829-3845. (doi: 10. 1021/jm801420y).
-
(2009)
J. Med. Chem
, vol.52
, pp. 3829-3845
-
-
Mahindroo, N.1
Punchihewa, C.2
Fujii, N.3
-
65
-
-
84878112106
-
Structure of the human smoothened receptor bound to an antitumour agent
-
(doi: 10. 1038/nature12167)
-
Wang C et al. 2013 Structure of the human smoothened receptor bound to an antitumour agent. Nature 497, 338-343. (doi: 10. 1038/nature12167).
-
(2013)
Nature
, vol.497
, pp. 338-343
-
-
Wang, C.1
-
66
-
-
84859777150
-
CrystFEL: A software suite for snapshot serial crystallography
-
(doi: 10. 1107/S0021889812002312)
-
White A, Kirian RA, Martin AV, Aquila A, Nass K, Barty A, Chapman HN. 2012 CrystFEL: a software suite for snapshot serial crystallography. J. Appl. Crystallogr. 45, 335-341. (doi: 10. 1107/S0021889812002312).
-
(2012)
J. Appl. Crystallogr
, vol.45
, pp. 335-341
-
-
White, A.1
Kirian, R.A.2
Martin, A.V.3
Aquila, A.4
Nass, K.5
Barty, A.6
Chapman, H.N.7
-
67
-
-
70350496540
-
Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma
-
(doi: 10. 1126/science. 1179386)
-
Yauch RL et al. 2009 Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science 326, 572-574. (doi: 10. 1126/science. 1179386).
-
(2009)
Science
, vol.326
, pp. 572-574
-
-
Yauch, R.L.1
-
68
-
-
84893954062
-
Molecular control of delta-opioid receptor signalling
-
(doi: 10. 1038/nature12944)
-
Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC. 2014 Molecular control of delta-opioid receptor signalling. Nature 506, 191-196. (doi: 10. 1038/nature12944).
-
(2014)
Nature
, vol.506
, pp. 191-196
-
-
Fenalti, G.1
Giguere, P.M.2
Katritch, V.3
Huang, X.P.4
Thompson, A.A.5
Cherezov, V.6
Roth, B.L.7
Stevens, R.C.8
-
69
-
-
0036591874
-
Structural biology in drug design: Selective protein kinase inhibitors
-
(doi: 10. 1016/S1359-6446(02)02290-0)
-
Scapin G. 2002 Structural biology in drug design: selective protein kinase inhibitors. Drug Discov. Today 7, 601-611. (doi: 10. 1016/S1359-6446(02)02290-0).
-
(2002)
Drug Discov. Today
, vol.7
, pp. 601-611
-
-
Scapin, G.1
-
70
-
-
0027218692
-
Structure-based inhibitors of HIV-1 protease
-
(doi: 10. 1146/annurev. bi. 62. 070193. 002551)
-
Wlodawer A, Erickson JW. 1993 Structure-based inhibitors of HIV-1 protease. Annu. Rev. Biochem. 62, 543-585. (doi: 10. 1146/annurev. bi. 62. 070193. 002551).
-
(1993)
Annu. Rev. Biochem
, vol.62
, pp. 543-585
-
-
Wlodawer, A.1
Erickson, J.W.2
-
71
-
-
84892364805
-
De novo protein crystal structure determination from X-ray free-electron laser data
-
(doi: 10. 1038/nature12773)
-
Barends TR et al. 2014 De novo protein crystal structure determination from X-ray free-electron laser data. Nature 505, 244-247. (doi: 10. 1038/nature12773).
-
(2014)
Nature
, vol.505
, pp. 244-247
-
-
Barends, T.R.1
-
72
-
-
81155123591
-
Multiwavelength anomalous diffraction at high X-ray intensity
-
(doi: 10. 1103/PhysRevLett. 107. 218102)
-
Son SK, Chapman HN, Santra R. 2011 Multiwavelength anomalous diffraction at high X-ray intensity. Phys. Rev. Lett. 107, 218 102-218 106. (doi: 10. 1103/PhysRevLett. 107. 218102).
-
(2011)
Phys. Rev. Lett
, vol.107
, pp. 218102-218106
-
-
Son, S.K.1
Chapman, H.N.2
Santra, R.3
-
73
-
-
84862777498
-
Crystal structure of the channelrhodopsin light-gated cation channel
-
(doi: 10. 1038/nature10870)
-
Kato HE et al. 2012 Crystal structure of the channelrhodopsin light-gated cation channel. Nature 482, 369-374. (doi: 10. 1038/nature10870).
-
(2012)
Nature
, vol.482
, pp. 369-374
-
-
Kato, H.E.1
-
74
-
-
84863527277
-
Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis
-
(doi: 10. 1016/j. str. 2012. 04. 011)
-
Fairman JW et al. 2012 Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis. Structure 20, 1233-1243. (doi: 10. 1016/j. str. 2012. 04. 011).
-
(2012)
Structure
, vol.20
, pp. 1233-1243
-
-
Fairman, J.W.1
-
75
-
-
84881193006
-
Structure of the human glucagon class B G-protein-coupled receptor
-
(doi: 10. 1038/nature12393)
-
Siu FY et al. 2013 Structure of the human glucagon class B G-protein-coupled receptor. Nature 499, 444-449. (doi: 10. 1038/nature12393).
-
(2013)
Nature
, vol.499
, pp. 444-449
-
-
Siu, F.Y.1
-
76
-
-
0031094307
-
Crystallization of a polar protein and small molecules from the aqueous compartment of lipidic cubic phases
-
(doi: 10. 1021/jp963347q)
-
Landau EM, Rummel G, Cowan-Jacob SW, Rosenbusch JP. 1997 Crystallization of a polar protein and small molecules from the aqueous compartment of lipidic cubic phases. J. Phys. Chem. B 101, 1935-1937. (doi: 10. 1021/jp963347q).
-
(1997)
J. Phys. Chem. B
, vol.101
, pp. 1935-1937
-
-
Landau, E.M.1
Rummel, G.2
Cowan-Jacob, S.W.3
Rosenbusch, J.P.4
-
77
-
-
84869193508
-
A fast, simple and robust protocol for growing crystals in the lipidic cubic phase
-
(doi: 10. 1107/S0021889812037880)
-
Aherne M, Lyons JA, Caffrey M. 2012 A fast, simple and robust protocol for growing crystals in the lipidic cubic phase. J. Appl. Crystallogr. 45, 1330-1333. (doi: 10. 1107/S0021889812037880).
-
(2012)
J. Appl. Crystallogr
, vol.45
, pp. 1330-1333
-
-
Aherne, M.1
Lyons, J.A.2
Caffrey, M.3
-
78
-
-
84876008644
-
Molecular imaging using X-ray free-electron lasers
-
(doi: 10. 1146/annurevphyschem-032511-143708)
-
Barty A, Küpper J, Chapman C. 2013 Molecular imaging using X-ray free-electron lasers. Annu. Rev. Phys. Chem. 64, 415-435. (doi: 10. 1146/annurevphyschem-032511-143708).
-
(2013)
Annu. Rev. Phys. Chem
, vol.64
, pp. 415-435
-
-
Barty, A.1
Küpper, J.2
Chapman, C.3
-
79
-
-
84863010963
-
Time-resolved protein nanocrystallography using an X-ray free-electron laser
-
(doi: 10. 1364/OE. 20. 002706)
-
Aquila A et al. 2012 Time-resolved protein nanocrystallography using an X-ray free-electron laser. Opt. Express. 20, 2706-2716. (doi: 10. 1364/OE. 20. 002706).
-
(2012)
Opt. Express
, vol.20
, pp. 2706-2716
-
-
Aquila, A.1
-
80
-
-
84876686612
-
Simultaneous femtosecond X-ray spectroscopy and diffraction of photosystem II at room temperature
-
(doi: 10. 1126/science. 1234273)
-
Kern J et al. 2013 Simultaneous femtosecond X-ray spectroscopy and diffraction of photosystem II at room temperature. Science 340, 491-495. (doi: 10. 1126/science. 1234273).
-
(2013)
Science
, vol.340
, pp. 491-495
-
-
Kern, J.1
|