Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs)

Journal of Medicinal Chemistry

Volumn 57, Issue 11, 2014, Pages 4615-4628

  Haslach, Erica M ^a   Huang, Huisuo ^a,b   Dirain, Marvin ^a   Debevec, Ginamarie ^c   Geer, Phaedra ^c   Santos, Radleigh G ^c   Giulianotti, Marc A ^c   Pinilla, Clemencia ^c   Appel, Jon R ^c   Doering, Skye R ^b   Walters, Michael A ^b,d   Houghten, Richard A ^c   Haskell Luevano, Carrie ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; INTERMEDIN; LIGAND; MELANOCORTIN 4 RECEPTOR; TETRAPEPTIDE;

ARTICLE; COMBINATORIAL LIBRARY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; PHARMACOPHORE; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DATABASES, CHEMICAL; HEK293 CELLS; HUMANS; LIGANDS; MICE; MODELS, MOLECULAR; OLIGOPEPTIDES; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, MELANOCORTIN, TYPE 4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902491258     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500064t     Document Type: Article

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