Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors

Biochemistry

Volumn 44, Issue 9, 2005, Pages 3418-3431

  Chai, Biao Xin ^a,c   Pogozheva, Irina D ^b   Lai, Yu Mei ^a   Li, Ji Yao ^a   Neubig, Richard R ^a   Mosberg, Henry I ^b   Gantz, Ira ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c MSRB I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BIOLOGICAL MEMBRANES; COMPLEXATION; HYDROGEN BONDS; MOLECULAR DYNAMICS; MUTAGENESIS; SIGNAL PROCESSING;

AGOUTI SIGNALING PROTEIN (ASIP); AGOUTI-RELATED PROTEIN (AGRP); BINDING AFFINITY; MOLECULAR INTERACTIONS; SITE-DIRECTED MUTATIONS;

PROTEINS;

AGOUTI RELATED PROTEIN; ARGININE; DITHIOTHREITOL; IODINE 125; MELANOCORTIN; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 4 RECEPTOR; PHENYLALANINE; RHODOPSIN; TRIPEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISULFIDE BOND; DRUG MECHANISM; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR BINDING; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATTLE; CELL LINE; DISULFIDES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEINS; RECEPTOR, MELANOCORTIN, TYPE 1; RECEPTOR, MELANOCORTIN, TYPE 4; RHODOPSIN; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 14644403649     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0478704     Document Type: Article

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