Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor

Endocrinology

Volumn 150, Issue 1, 2009, Pages 114-125

  Tan, Karen ^a   Pogozheva, Irina D ^b   Yeo, Giles S H ^a   Hadaschik, Dirk ^a   Keogh, Julia M ^a   Haskell Leuvano, Carrie ^c   O'Rahilly, Stephen ^a   Mosberg, Henry I ^b   Farooqi, I Sadaf ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; IODINE 125; MELANOCORTIN 4 RECEPTOR; MEMBRANE PROTEIN; RADIOLIGAND;

ARTICLE; CELL MIGRATION; CELL SURFACE; CONFORMATION; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; LIGAND BINDING; MISSENSE MUTATION; MUTANT; MUTATION; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; WILD TYPE;

AGE OF ONSET; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CYCLIC AMP; GENE EXPRESSION REGULATION; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; MUTATION, MISSENSE; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN CONFORMATION; RECEPTOR, MELANOCORTIN, TYPE 4; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 58149471232     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0721     Document Type: Article

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