Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist

Biochemistry

Volumn 49, Issue 22, 2010, Pages 4583-4600

  Xiang, Zhimin ^a   Proneth, Bettina ^a   Dirain, Marvin L ^a   Litherland, Sally A ^b   Haskell Luevano, Carrie ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b KENNEDY SPACE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGONIST ACTIVITY; AGOUTI-RELATED PROTEINS; CELL SURFACE EXPRESSION; CENTRAL NERVOUS SYSTEMS; COMPUTATIONAL DEVELOPMENT; ENERGY HOMEOSTASIS; FEEDING BEHAVIOR; G-PROTEIN COUPLED RECEPTORS; GENETIC FACTORS; HUMAN OBESITY; HUMAN PATIENTS; IN-VITRO; KNOCKOUT MICE; MOLECULAR LINKS; PHARMACOLOGICAL CHARACTERIZATION; SINGLE NUCLEOTIDE POLYMORPHISMS; SYNTHETIC LIGANDS; TETRAPEPTIDE; TYPE-2 DIABETES;

BLOOD PRESSURE; CELL MEMBRANES; FLOW CYTOMETRY; MEDICAL PROBLEMS; NUCLEOTIDES; NUTRITION; POLYMORPHISM; PROTEINS;

LIGANDS;

CORTICOTROPIN; MELANOCORTIN 4 RECEPTOR; PROOPIOMELANOCORTIN;

AMINO ACID SEQUENCE; ARTICLE; CELL SURFACE; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTER; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

AGOUTI-RELATED PROTEIN; ALPHA-MSH; AMINO ACID SEQUENCE; BETA-MSH; BINDING, COMPETITIVE; CELL LINE; GAMMA-MSH; GENE EXPRESSION REGULATION; HUMANS; LIGANDS; MALE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OBESITY; POLYMORPHISM, GENETIC; PRO-OPIOMELANOCORTIN; PROTEIN BINDING; RECEPTOR, MELANOCORTIN, TYPE 4;

AGOUTI;

EID: 77953111939     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100068u     Document Type: Article

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