Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1379-1390

  Singh, Anamika ^a   Wilczynski, Andrzej ^a   Holder, Jerry R ^a   Witek, Rachel M ^a   Dirain, Marvin L ^a   Xiang, Zhimin ^a   Edison, Arthur S ^a   Haskell Luevano, Carrie ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; HISTIDINE; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 2 RECEPTOR; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 5 RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; MELANOCORTIN RECEPTOR ANTAGONIST; PEPTIDE DERIVATIVE; PHENYLALANINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; GENETIC TRANSFECTION; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTON NUCLEAR MAGNETIC RESONANCE; REGULATORY MECHANISM; SOLID PHASE SYNTHESIS;

AGOUTI-RELATED PROTEIN; AMINO ACID SEQUENCE; ANIMALS; HEK293 CELLS; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MELANOCORTINS; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PEPTIDOMIMETICS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, MELANOCORTIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 79952275654     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101425m     Document Type: Article

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