Peptide and small molecules rescue the functional activity and agonist potency of dysfunctional human melanocortin-4 receptor polymorphisms

Biochemistry

Volumn 46, Issue 28, 2007, Pages 8273-8287

  Xiang, Zhimin ^a   Pogozheva, Irina D ^c   Sorenson, Nicholas B ^a   Wilczynski, Andrzej M ^a   Holder, Jerry Ryan ^a,d   Litherland, Sally A ^b   Millard, William J ^a   Mosberg, Henry I ^c   Haskell Luevano, Carrie ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENERGY HOMEOSTASIS; MOLECULAR MECHANISM; PHENOTYPE; RECEPTOR MODIFICATIONS; SMALL MOLECULES;

LIGANDS; PEPTIDES; POLYMORPHISM;

BIOCHEMISTRY;

MELANOCORTIN; MELANOCORTIN 4 RECEPTOR;

ANIMAL CELL; ARTICLE; DRUG POTENCY; GENETIC POLYMORPHISM; HETEROZYGOSITY; HOMEOSTASIS; HOMOZYGOSITY; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MECHANICS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; WEIGHT CONTROL;

ALPHA-MSH; AMINO ACID SEQUENCE; CELL LINE; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDES; POLYMORPHISM, GENETIC; RECEPTOR, MELANOCORTIN, TYPE 4; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 34447535425     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7007382     Document Type: Article

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