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Volumn 31, Issue 6, 2014, Pages 2467-2476

Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review)

Author keywords

Cervical cancer; Human papilloma virus; Methylation; miRNAs

Indexed keywords

DNA METHYLTRANSFERASE 1; MICRORNA; MICRORNA 1246; MICRORNA 126; MICRORNA 143; MICRORNA 145; MICRORNA 155; MICRORNA 182; MICRORNA 183; MICRORNA 195; MICRORNA 196A; MICRORNA 203; MICRORNA 20A; MICRORNA 21; MICRORNA 210; MICRORNA 218; MICRORNA 221; MICRORNA 2392; MICRORNA 27A; MICRORNA 3147; MICRORNA 3162-5P; MICRORNA 34A; MICRORNA 368; MICRORNA 4484; MICRORNA 497; PROTEIN E6; PROTEIN E7; PROTEIN P53; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS DNA;

EID: 84902122783     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3142     Document Type: Review
Times cited : (73)

References (95)
  • 1
    • 49749107841 scopus 로고    scopus 로고
    • Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth
    • Wang X, Tang S, Le SY, et al: Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One 3: e2557, 2008.
    • (2008) PLoS One , vol.3
    • Wang, X.1    Tang, S.2    Le, S.Y.3
  • 2
    • 77953853387 scopus 로고    scopus 로고
    • Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer
    • Wilting SM, van Boerdonk RA, Henken FE, et al: Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer. Mol Cancer 9: 167, 2010.
    • (2010) Mol Cancer , vol.9 , pp. 167
    • Wilting, S.M.1    Van Boerdonk, R.A.2    Henken, F.E.3
  • 3
    • 84872185909 scopus 로고    scopus 로고
    • Aberrant DNA methylation in cervical carcinogenesis
    • Yang HJ: Aberrant DNA methylation in cervical carcinogenesis. Chin J Cancer 32: 42-48, 2013.
    • (2013) Chin J Cancer , vol.32 , pp. 42-48
    • Yang, H.J.1
  • 4
    • 79957801393 scopus 로고    scopus 로고
    • Oncogenic potential of human papillomavirus (HPV) and its relation with cervical cancer
    • Faridi R, Zahra A, Khan K and Idrees M: Oncogenic potential of human papillomavirus (HPV) and its relation with cervical cancer. Virol J 8: 269, 2011.
    • (2011) Virol J , vol.8 , pp. 269
    • Faridi, R.1    Zahra, A.2    Khan, K.3    Idrees, M.4
  • 5
    • 34447134869 scopus 로고    scopus 로고
    • Patterns of known and novel small RNAs in human cervical cancer
    • DOI 10.1158/0008-5472.CAN-06-0561
    • Lui WO, Pourmand N, Patterson BK and Fire A: Patterns of known and novel small RNAs in human cervical cancer. Cancer Res 67: 6031-6043, 2007. (Pubitemid 47037482)
    • (2007) Cancer Research , vol.67 , Issue.13 , pp. 6031-6043
    • Lui, W.-O.1    Pourmand, N.2    Patterson, B.K.3    Fire, A.4
  • 6
    • 56449129788 scopus 로고    scopus 로고
    • Human papillomavirus and molecular considerations for cancer risk
    • Whiteside MA, Siegel EM and Unger ER: Human papillomavirus and molecular considerations for cancer risk. Cancer 113 (Supp 10): 2981-2994, 2008.
    • (2008) Cancer , vol.113 , Issue.SUPPL. 10 , pp. 2981-2994
    • Whiteside, M.A.1    Siegel, E.M.2    Unger, E.R.3
  • 7
    • 84886953875 scopus 로고    scopus 로고
    • Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix
    • Saavedra KP, Brebi PM and Roa JC: Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix. Clin Epigenetics 4: 13, 2012.
    • (2012) Clin Epigenetics , vol.4 , pp. 13
    • Saavedra, K.P.1    Brebi, P.M.2    Roa, J.C.3
  • 8
    • 84873939792 scopus 로고    scopus 로고
    • Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma
    • Lechner M, Fenton T, West J, et al: Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma. Genome Med 5: 15, 2013.
    • (2013) Genome Med , vol.5 , pp. 15
    • Lechner, M.1    Fenton, T.2    West, J.3
  • 9
    • 84874110812 scopus 로고    scopus 로고
    • Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions
    • Chaiwongkot A, Vinokurova S, Pientong C, et al: Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions. Int J Cancer 132: 2087-2094, 2013.
    • (2013) Int J Cancer , vol.132 , pp. 2087-2094
    • Chaiwongkot, A.1    Vinokurova, S.2    Pientong, C.3
  • 11
    • 42249105032 scopus 로고    scopus 로고
    • Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells
    • DOI 10.1038/sj.onc.1210919, PII 1210919
    • Martinez I, Gardiner AS, Board KF, Monzon FA, Edwards RP and Khan SA: Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene 27: 2575-2582, 2008. (Pubitemid 351550884)
    • (2008) Oncogene , vol.27 , Issue.18 , pp. 2575-2582
    • Martinez, I.1    Gardiner, A.S.2    Board, K.F.3    Monzon, F.A.4    Edwards, R.P.5    Khan, S.A.6
  • 12
    • 80655127810 scopus 로고    scopus 로고
    • Regulation of cellular miRNA expression by human papillomaviruses
    • Zheng ZM and Wang X: Regulation of cellular miRNA expression by human papillomaviruses. Biochim Biophys Acta 1809: 668-677, 2011.
    • (2011) Biochim Biophys Acta , vol.1809 , pp. 668-677
    • Zheng, Z.M.1    Wang, X.2
  • 13
    • 84866287777 scopus 로고    scopus 로고
    • Aberrant microRNA expression in human cervical carcinomas
    • Rao Q, Shen Q, Zhou H, Peng Y, Li J and Lin Z: Aberrant microRNA expression in human cervical carcinomas. Med Oncol 29: 1242-1248, 2012.
    • (2012) Med Oncol , vol.29 , pp. 1242-1248
    • Rao, Q.1    Shen, Q.2    Zhou, H.3    Peng, Y.4    Li, J.5    Lin, Z.6
  • 14
    • 78449310086 scopus 로고    scopus 로고
    • High-risk human papillomavirus reduces the expression of microRNA-218 in women with cervical intraepithelial neoplasia
    • Li Y, Liu J, Yuan C, Cui B, Zou X and Qiao Y: High-risk human papillomavirus reduces the expression of microRNA-218 in women with cervical intraepithelial neoplasia. J Int Med Res 38: 1730-1736, 2010.
    • (2010) J Int Med Res , vol.38 , pp. 1730-1736
    • Li, Y.1    Liu, J.2    Yuan, C.3    Cui, B.4    Zou, X.5    Qiao, Y.6
  • 15
    • 78650171702 scopus 로고    scopus 로고
    • Differential expression of cellular microRNAs in HPV-11 transfected cells. An analysis by three different array platforms and qRT-PCR
    • Dreher A, Rossing M, Kaczkowski B, Nielsen FC and Norrild B: Differential expression of cellular microRNAs in HPV-11 transfected cells. An analysis by three different array platforms and qRT-PCR. Biochem Biophys Res Commun 403: 357-362, 2010.
    • (2010) Biochem Biophys Res Commun , vol.403 , pp. 357-362
    • Dreher, A.1    Rossing, M.2    Kaczkowski, B.3    Nielsen, F.C.4    Norrild, B.5
  • 17
    • 77957002485 scopus 로고    scopus 로고
    • Burden of human papillomavirus infection and related comorbidities in men: Implications for research, disease prevention and health promotion among Hispanic men
    • Colón-López V, Ortiz AP and Palefsky J: Burden of human papillomavirus infection and related comorbidities in men: implications for research, disease prevention and health promotion among Hispanic men. P R Health Sci J 29: 232-240, 2010.
    • (2010) P R Health Sci J , vol.29 , pp. 232-240
    • Colón-López, V.1    Ortiz, A.P.2    Palefsky, J.3
  • 18
    • 77949427495 scopus 로고    scopus 로고
    • Beyond cervical cancer: Burden of other HPV-related cancers among men and women
    • Chaturvedi AK: Beyond cervical cancer: burden of other HPV-related cancers among men and women. J Adolesc Health 46: S20-S26, 2010.
    • (2010) J Adolesc Health , vol.46
    • Chaturvedi, A.K.1
  • 19
    • 84860007985 scopus 로고    scopus 로고
    • DNA methylation changes in cervical cancers
    • Lu Q, Ma D and Zhao S: DNA methylation changes in cervical cancers. Methods Mol Biol 863: 155-176, 2012.
    • (2012) Methods Mol Biol , vol.863 , pp. 155-176
    • Lu, Q.1    Ma, D.2    Zhao, S.3
  • 20
    • 78651403558 scopus 로고    scopus 로고
    • Quantitative analysis of the relationship between microRNA-124a, -34b and -203 gene methylation and cervical oncogenesis
    • Botezatu A, Goia-Rusanu CD, Iancu IV, et al: Quantitative analysis of the relationship between microRNA-124a, -34b and -203 gene methylation and cervical oncogenesis. Mol Med Rep 4: 121-128, 2011.
    • (2011) Mol Med Rep , vol.4 , pp. 121-128
    • Botezatu, A.1    Goia-Rusanu, C.D.2    Iancu, I.V.3
  • 21
    • 84880418304 scopus 로고    scopus 로고
    • Immune responses against human papillomavirus (HPV) infection and evasion of host defense in cervical cancer
    • Sasagawa T, Takagi H and Makinoda S: Immune responses against human papillomavirus (HPV) infection and evasion of host defense in cervical cancer. J Infect Chemother 18: 807-815, 2012.
    • (2012) J Infect Chemother , vol.18 , pp. 807-815
    • Sasagawa, T.1    Takagi, H.2    Makinoda, S.3
  • 22
    • 55349125360 scopus 로고    scopus 로고
    • Silenciamiento de genes mediante RNA interferencia: Consid eraciones sobre el mecanismo y diseño de los sistemas efectores
    • Correa de Adjounian MF, Adjounian H and Adjounian SH: Silenciamiento de genes mediante RNA interferencia: consid eraciones sobre el mecanismo y diseño de los sistemas efectores. AVFT 27: 22-25, 2008.
    • (2008) AVFT , vol.27 , pp. 22-25
    • Correa De Adjounian, M.F.1    Adjounian, H.2    Adjounian, S.H.3
  • 24
    • 76349113184 scopus 로고    scopus 로고
    • Epigenetic biomarker development
    • Bock C: Epigenetic biomarker development. Epigenomics 1: 99-110, 2009.
    • (2009) Epigenomics , vol.1 , pp. 99-110
    • Bock, C.1
  • 25
    • 38749137007 scopus 로고    scopus 로고
    • MicroRNA epigenetic alterations in human cancer: One step forward in diagnosis and treatment
    • DOI 10.1002/ijc.23325
    • Yang N, Coukos G and Zhang L: MicroRNA epigenetic alterations in human cancer: one step forward in diagnosis and treatment. Int J Cancer 122: 963-968, 2008. (Pubitemid 351213992)
    • (2008) International Journal of Cancer , vol.122 , Issue.5 , pp. 963-968
    • Yang, N.1    Coukos, G.2    Zhang, L.3
  • 26
    • 72849147757 scopus 로고    scopus 로고
    • Epigenetics, miRNAs, and human cancer: A new chapter in human gene regulation
    • Valeri N, Vannini I, Fanini F, Calore F, Adair B and Fabbri M: Epigenetics, miRNAs, and human cancer: a new chapter in human gene regulation. Mamm Genome 20: 573-580, 2009.
    • (2009) Mamm Genome , vol.20 , pp. 573-580
    • Valeri, N.1    Vannini, I.2    Fanini, F.3    Calore, F.4    Adair, B.5    Fabbri, M.6
  • 27
    • 77954661906 scopus 로고    scopus 로고
    • DNA hypomethylation in cancer cells
    • Ehrlich M: DNA hypomethylation in cancer cells. Epigenomics 1: 239-259, 2009.
    • (2009) Epigenomics , vol.1 , pp. 239-259
    • Ehrlich, M.1
  • 29
    • 78149478781 scopus 로고    scopus 로고
    • Aberrant epigenetic landscape in cancer: How cellular identity goes awry
    • Berdasco M and Esteller M: Aberrant epigenetic landscape in cancer: how cellular identity goes awry. Dev Cell 19: 698-711, 2010.
    • (2010) Dev Cell , vol.19 , pp. 698-711
    • Berdasco, M.1    Esteller, M.2
  • 30
    • 84860408968 scopus 로고    scopus 로고
    • DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer
    • Lopez-Serra P and Esteller M: DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer. Oncogene 31: 1609-1622, 2012.
    • (2012) Oncogene , vol.31 , pp. 1609-1622
    • Lopez-Serra, P.1    Esteller, M.2
  • 31
    • 33749598345 scopus 로고    scopus 로고
    • Epigenetic activation of tumor suppressor microRNAs in human cancer cells
    • Saito Y and Jones PA: Epigenetic activation of tumor suppressor microRNAs in human cancer cells. Cell Cycle 5: 2220-2222, 2006. (Pubitemid 44546557)
    • (2006) Cell Cycle , vol.5 , Issue.19 , pp. 2220-2222
    • Saito, Y.1    Jones, P.A.2
  • 32
    • 38349191617 scopus 로고    scopus 로고
    • CpG island hypermethylation of tumor suppressor microRNAs in human cancer
    • Lujambio A and Esteller M: CpG island hypermethylation of tumor suppressor microRNAs in human cancer. Cell Cycle 6: 1455-1459, 2007.
    • (2007) Cell Cycle , vol.6 , pp. 1455-1459
    • Lujambio, A.1    Esteller, M.2
  • 33
    • 49249121155 scopus 로고    scopus 로고
    • Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer
    • Toyota M, Suzuki H, Sasaki Y, et al: Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res 68: 4123-4132, 2008.
    • (2008) Cancer Res , vol.68 , pp. 4123-4132
    • Toyota, M.1    Suzuki, H.2    Sasaki, Y.3
  • 34
    • 71549121035 scopus 로고    scopus 로고
    • Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer
    • Huang YW, Liu JC, Deatherage DE, et al: Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer. Cancer Res 69: 9038-9046, 2009.
    • (2009) Cancer Res , vol.69 , pp. 9038-9046
    • Huang, Y.W.1    Liu, J.C.2    Deatherage, D.E.3
  • 35
    • 84865191715 scopus 로고    scopus 로고
    • Oncogenic human papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women
    • Leonard SM, Wei W, Collins SI, et al: Oncogenic human papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women. Carcinogenesis 33: 1286-1293, 2012.
    • (2012) Carcinogenesis , vol.33 , pp. 1286-1293
    • Leonard, S.M.1    Wei, W.2    Collins, S.I.3
  • 36
    • 79956117582 scopus 로고    scopus 로고
    • Global DNA methylation in precancerous and cancerous lesions of the uterine cervix
    • Missaoui N, Hmissa S, Dante R and Frappart L: Global DNA methylation in precancerous and cancerous lesions of the uterine cervix. Asian Pac J Cancer Prev 11: 1741-1744, 2010.
    • (2010) Asian Pac J Cancer Prev , vol.11 , pp. 1741-1744
    • Missaoui, N.1    Hmissa, S.2    Dante, R.3    Frappart, L.4
  • 39
    • 78649396546 scopus 로고    scopus 로고
    • HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53
    • Au Yeung CL, Tsang WP, Tsang TY, Co NN, Yau PL and Kwok TT: HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53. Oncol Rep 24: 1599-1604, 2010.
    • (2010) Oncol Rep , vol.24 , pp. 1599-1604
    • Au Yeung, C.L.1    Tsang, W.P.2    Tsang, T.Y.3    Co, N.N.4    Yau, P.L.5    Kwok, T.T.6
  • 40
    • 18144419362 scopus 로고    scopus 로고
    • Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway
    • DOI 10.1158/0008-5472.CAN-04-2158
    • McCabe MT, Davis JN and Day ML: Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway. Cancer Res 65: 3624-3632, 2005. (Pubitemid 40616339)
    • (2005) Cancer Research , vol.65 , Issue.9 , pp. 3624-3632
    • McCabe, M.T.1    Davis, J.N.2    Day, M.L.3
  • 41
    • 62849122233 scopus 로고    scopus 로고
    • Genome-wide hypomethylation in head and neck cancer is more pronounced in HPV-negative tumors and is associated with genomic instability
    • Richards KL, Zhang B, Baggerly KA, et al: Genome-wide hypomethylation in head and neck cancer is more pronounced in HPV-negative tumors and is associated with genomic instability. PLoS One 4: e4941, 2009.
    • (2009) PLoS One , vol.4
    • Richards, K.L.1    Zhang, B.2    Baggerly, K.A.3
  • 42
    • 77955015091 scopus 로고    scopus 로고
    • Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer
    • Lin RK, Wu CY, Chang JW, et al: Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer. Cancer Res 70: 5807-5817, 2010.
    • (2010) Cancer Res , vol.70 , pp. 5807-5817
    • Lin, R.K.1    Wu, C.Y.2    Chang, J.W.3
  • 43
    • 84902142826 scopus 로고    scopus 로고
    • Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization
    • Jul 19, (Epub ahead of print)
    • Jin-Tao W, Ling D, Shi-Wen J, et al: Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization. Curr Pharm Des: Jul 19, 2013 (Epub ahead of print).
    • (2013) Curr Pharm des
    • Jin-Tao, W.1    Ling, D.2    Shi-Wen, J.3
  • 44
    • 77951156890 scopus 로고    scopus 로고
    • Prognostic significance of HPV physical status and integration sites in cervical cancer
    • Nambaru L, Meenakumari B, Swaminathan R and Rajkumar T: Prognostic significance of HPV physical status and integration sites in cervical cancer. Asian Pac J Cancer Prev 10: 355-360, 2009.
    • (2009) Asian Pac J Cancer Prev , vol.10 , pp. 355-360
    • Nambaru, L.1    Meenakumari, B.2    Swaminathan, R.3    Rajkumar, T.4
  • 45
    • 34147098854 scopus 로고    scopus 로고
    • High-throughput detection of human papillomavirus-18 L1 gene methylation, a candidate biomarker for the progression of cervical neoplasia
    • DOI 10.1016/j.virol.2006.11.010, PII S0042682206008397
    • Turan T, Kalantari M, Cuschieri K, Cubie HA, Skomedal H and Bernard HU: High-throughput detection of human papil lomavirus-18 L1 gene methylation, a candidate biomarker for the progression of cervical neoplasia. Virology 361: 185-193, 2007. (Pubitemid 46553810)
    • (2007) Virology , vol.361 , Issue.1 , pp. 185-193
    • Turan, T.1    Kalantari, M.2    Cuschieri, K.3    Cubie, H.A.4    Skomedal, H.5    Bernard, H.-U.6
  • 46
    • 79960040020 scopus 로고    scopus 로고
    • MicroRNA in cancer: The involvement of aberrant microRNA biogenesis regulatory pathways
    • Davis-Dusenbery BN and Hata A: MicroRNA in cancer: the involvement of aberrant microRNA biogenesis regulatory pathways. Genes Cancer 1: 1100-1114, 2010.
    • (2010) Genes Cancer , vol.1 , pp. 1100-1114
    • Davis-Dusenbery, B.N.1    Hata, A.2
  • 47
    • 33845242919 scopus 로고    scopus 로고
    • MicroRNAs: Regulators of gene expression and cell differentiation
    • Shivdasani RA: MicroRNAs: regulators of gene expression and cell differentiation. Blood 108: 3646-3653, 2006.
    • (2006) Blood , vol.108 , pp. 3646-3653
    • Shivdasani, R.A.1
  • 48
    • 36649025655 scopus 로고    scopus 로고
    • OncomiRs: The discovery and progress of microRNAs in cancers
    • Cho WC: OncomiRs: the discovery and progress of microRNAs in cancers. Mol Cancer 6: 60, 2007.
    • (2007) Mol Cancer , vol.6 , pp. 60
    • Cho, W.C.1
  • 49
    • 79960711108 scopus 로고    scopus 로고
    • Altered methylation at microRNA-associated CpG islands in hereditary and sporadic carcinomas: A methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)-based approach
    • Pavicic W, Perkiö E, Kaur S, et al: Altered methylation at microRNA-associated CpG islands in hereditary and sporadic carcinomas: a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)-based approach. Mol Med 17: 726-735, 2011.
    • (2011) Mol Med , vol.17 , pp. 726-735
    • Pavicic, W.1    Perkiö, E.2    Kaur, S.3
  • 50
    • 79959984920 scopus 로고    scopus 로고
    • Identification of miR-23a as a novel microRNA normalizer for relative quantification in human uterine cervical tissues
    • Shen Y, Li Y, Ye F, et al: Identification of miR-23a as a novel microRNA normalizer for relative quantification in human uterine cervical tissues. Exp Mol Med 43: 358-366, 2011.
    • (2011) Exp Mol Med , vol.43 , pp. 358-366
    • Shen, Y.1    Li, Y.2    Ye, F.3
  • 51
    • 79959783574 scopus 로고    scopus 로고
    • Human papillomavirus 16 E5 modulates the expression of host microRNAs
    • Greco D, Kivi N, Qian K, et al: Human papillomavirus 16 E5 modulates the expression of host microRNAs. PLoS One 6: e21646, 2011.
    • (2011) PLoS One , vol.6
    • Greco, D.1    Kivi, N.2    Qian, K.3
  • 52
    • 79955921676 scopus 로고    scopus 로고
    • DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs
    • So AY, Jung JW, Lee S, Kim HS and Kang KS: DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs. PLoS One 6: e19503, 2011.
    • (2011) PLoS One , vol.6
    • So, A.Y.1    Jung, J.W.2    Lee, S.3    Kim, H.S.4    Kang, K.S.5
  • 53
    • 84863446610 scopus 로고    scopus 로고
    • CpG island hypermethylation-associated silencing of small nucleolar RNAs in human cancer
    • Ferreira HJ, Heyn H, Moutinho C, et al: CpG island hypermethylation- associated silencing of small nucleolar RNAs in human cancer. RNA Biol 9: 881-890, 2012.
    • (2012) RNA Biol , vol.9 , pp. 881-890
    • Ferreira, H.J.1    Heyn, H.2    Moutinho, C.3
  • 54
    • 70649086975 scopus 로고    scopus 로고
    • Control of microRNA biogenesis by TGFβ signaling pathway - A novel role of Smads in the nucleus
    • Hata A and Davis BN: Control of microRNA biogenesis by TGFβ signaling pathway - a novel role of Smads in the nucleus. Cytokine Growth Factor Rev 20: 517-521, 2009.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 517-521
    • Hata, A.1    Davis, B.N.2
  • 55
    • 52449093137 scopus 로고    scopus 로고
    • MicroRNA: Basic mechanisms and tran scriptional regulatory networks for cell fate determination
    • Fazi F and Nervi C: MicroRNA: basic mechanisms and tran scriptional regulatory networks for cell fate determination. Cardiovasc Res 79: 553-561, 2008.
    • (2008) Cardiovasc Res , vol.79 , pp. 553-561
    • Fazi, F.1    Nervi, C.2
  • 56
    • 77955597990 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription-1 (STAT1) regulates microRNA transcription in interferon γ-stimulated HeLa cells
    • Wang G, Wang Y, Teng M, Zhang D, Li L and Liu Y: Signal transducers and activators of transcription-1 (STAT1) regulates microRNA transcription in interferon γ-stimulated HeLa cells. PLoS One 5: e11794, 2010.
    • (2010) PLoS One , vol.5
    • Wang, G.1    Wang, Y.2    Teng, M.3    Zhang, D.4    Li, L.5    Liu, Y.6
  • 57
    • 70350731129 scopus 로고    scopus 로고
    • Epigenetic regulation of microRNA expression in colorectal cancer
    • Bandres E, Agirre X, Bitarte N, et al: Epigenetic regulation of microRNA expression in colorectal cancer. Int J Cancer 125: 2737-2743, 2009.
    • (2009) Int J Cancer , vol.125 , pp. 2737-2743
    • Bandres, E.1    Agirre, X.2    Bitarte, N.3
  • 58
    • 77951964981 scopus 로고    scopus 로고
    • Posttranscriptional regulation of microRNA biogenesis in animals
    • Siomi H and Siomi MC: Posttranscriptional regulation of microRNA biogenesis in animals. Mol Cell 38: 323-332, 2010.
    • (2010) Mol Cell , vol.38 , pp. 323-332
    • Siomi, H.1    Siomi, M.C.2
  • 60
    • 84880399358 scopus 로고    scopus 로고
    • Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma
    • Chen J, Yao D, Li Y, et al: Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma. Int J Mol Med 32: 557-567, 2013.
    • (2013) Int J Mol Med , vol.32 , pp. 557-567
    • Chen, J.1    Yao, D.2    Li, Y.3
  • 62
    • 84871945452 scopus 로고    scopus 로고
    • Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis
    • Wilting SM, Snijders PJ, Verlaat W, et al: Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis. Oncogene 32: 106-116, 2013.
    • (2013) Oncogene , vol.32 , pp. 106-116
    • Wilting, S.M.1    Snijders, P.J.2    Verlaat, W.3
  • 63
    • 84863344858 scopus 로고    scopus 로고
    • Downregulation of six microRNAs is associated with advanced stage, lymph node metastasis and poor prognosis in small cell carcinoma of the cervix
    • Huang L, Lin JX, Yu YH, Zhang MY, Wang HY and Zheng M: Downregulation of six microRNAs is associated with advanced stage, lymph node metastasis and poor prognosis in small cell carcinoma of the cervix. PLoS One 7: e33762, 2012.
    • (2012) PLoS One , vol.7
    • Huang, L.1    Lin, J.X.2    Yu, Y.H.3    Zhang, M.Y.4    Wang, H.Y.5    Zheng, M.6
  • 64
    • 84864568344 scopus 로고    scopus 로고
    • Dysregulated microRNAs in the pathogenesis and progression of cervical neoplasm
    • Cheung TH, Man KN, Yu MY, et al: Dysregulated microRNAs in the pathogenesis and progression of cervical neoplasm. Cell Cycle 11: 2876-2884, 2012.
    • (2012) Cell Cycle , vol.11 , pp. 2876-2884
    • Cheung, T.H.1    Man, K.N.2    Yu, M.Y.3
  • 65
    • 84870734858 scopus 로고    scopus 로고
    • Profiling of microRNA-mRNA reveals roles of microRNAs in cervical cancer
    • Ma D, Zhang YY, Guo YL, Li ZJ and Geng L: Profiling of microRNA-mRNA reveals roles of microRNAs in cervical cancer. Chin Med J 125: 4270-4276, 2012.
    • (2012) Chin Med J , vol.125 , pp. 4270-4276
    • Ma, D.1    Zhang, Y.Y.2    Guo, Y.L.3    Li, Z.J.4    Geng, L.5
  • 67
    • 76749142479 scopus 로고    scopus 로고
    • A microRNA expression signature for cervical cancer prognosis
    • Hu X, Schwarz JK, Lewis JS Jr, et al: A microRNA expression signature for cervical cancer prognosis. Cancer Res 70: 1441-1448, 2010.
    • (2010) Cancer Res , vol.70 , pp. 1441-1448
    • Hu, X.1    Schwarz, J.K.2    Lewis Jr., J.S.3
  • 68
    • 52049097315 scopus 로고    scopus 로고
    • Altered microRNA expression in cervical carcinomas
    • Lee JW, Choi CH, Choi JJ, et al: Altered microRNA expression in cervical carcinomas. Clin Cancer Res 14: 2535-2542, 2008.
    • (2008) Clin Cancer Res , vol.14 , pp. 2535-2542
    • Lee, J.W.1    Choi, C.H.2    Choi, J.J.3
  • 69
    • 84878376565 scopus 로고    scopus 로고
    • Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in cervical cancer
    • Yao T, Rao Q, Liu L, et al: Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in cervical cancer. Virol J 10: 175, 2013.
    • (2013) Virol J , vol.10 , pp. 175
    • Yao, T.1    Rao, Q.2    Liu, L.3
  • 70
    • 84874360475 scopus 로고    scopus 로고
    • Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis
    • Wilting SM, Verlaat W, Jaspers A, et al: Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis. Epigenetics 8: 220-228, 2013.
    • (2013) Epigenetics , vol.8 , pp. 220-228
    • Wilting, S.M.1    Verlaat, W.2    Jaspers, A.3
  • 71
    • 79957603048 scopus 로고    scopus 로고
    • Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer
    • Kalimutho M, Di Cecilia S, Del Vecchio Blanco G, et al : Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer. Br J Cancer 104: 1770-1778, 2011.
    • (2011) Br J Cancer , vol.104 , pp. 1770-1778
    • Kalimutho, M.1    Di Cecilia, S.2    Del Vecchio Blanco, G.3
  • 72
    • 79954455860 scopus 로고    scopus 로고
    • Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas
    • Vogt M, Munding J, Grüner M, et al: Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas. Virchows Arch 458: 313-322, 2011.
    • (2011) Virchows Arch , vol.458 , pp. 313-322
    • Vogt, M.1    Munding, J.2    Grüner, M.3
  • 73
    • 84882686726 scopus 로고    scopus 로고
    • Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer
    • Zhang Y, Wang X, Xu B, et al: Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer. Oncol Rep 30: 1976-1984, 2013.
    • (2013) Oncol Rep , vol.30 , pp. 1976-1984
    • Zhang, Y.1    Wang, X.2    Xu, B.3
  • 74
    • 84867985496 scopus 로고    scopus 로고
    • MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer
    • Zhu A, Xia J, Zuo J, et al : MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer. Med Oncol 29: 2701-2709, 2012.
    • (2012) Med Oncol , vol.29 , pp. 2701-2709
    • Zhu, A.1    Xia, J.2    Zuo, J.3
  • 75
    • 80051785482 scopus 로고    scopus 로고
    • Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer
    • Tsai KW, Wu CW, Hu LY, et al: Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer. Int J Cancer 129: 2600-2610, 2011.
    • (2011) Int J Cancer , vol.129 , pp. 2600-2610
    • Tsai, K.W.1    Wu, C.W.2    Hu, L.Y.3
  • 76
    • 80053450990 scopus 로고    scopus 로고
    • Aberrant hypermethylation of miR-9 genes in gastric cancer
    • Tsai KW, Liao YL, Wu CW, et al: Aberrant hypermethylation of miR-9 genes in gastric cancer. Epigenetics 6: 1189-1197, 2011.
    • (2011) Epigenetics , vol.6 , pp. 1189-1197
    • Tsai, K.W.1    Liao, Y.L.2    Wu, C.W.3
  • 77
    • 79958753869 scopus 로고    scopus 로고
    • Epigenetic regulation of microRNA-10b and targeting of oncogenic MAPRE1 in gastric cancer
    • Kim K, Lee HC, Park JL, et al: Epigenetic regulation of microRNA-10b and targeting of oncogenic MAPRE1 in gastric cancer. Epigenetics 6: 740-751, 2011.
    • (2011) Epigenetics , vol.6 , pp. 740-751
    • Kim, K.1    Lee, H.C.2    Park, J.L.3
  • 78
    • 84880167281 scopus 로고    scopus 로고
    • The tumor suppressor roles of miR-433 and miR-127 in gastric cancer
    • Guo LH, Li H, Wang F, Yu J and He JS: The tumor suppressor roles of miR-433 and miR-127 in gastric cancer. Int J Mol Sci 14: 14171-14184, 2013.
    • (2013) Int J Mol Sci , vol.14 , pp. 14171-14184
    • Guo, L.H.1    Li, H.2    Wang, F.3    Yu, J.4    He, J.S.5
  • 79
    • 84875381358 scopus 로고    scopus 로고
    • MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer
    • Deng H, Guo Y, Song H, et al: MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer. Gene 518: 351-359, 2013.
    • (2013) Gene , vol.518 , pp. 351-359
    • Deng, H.1    Guo, Y.2    Song, H.3
  • 80
    • 84880335447 scopus 로고    scopus 로고
    • The promoter of miR-663 is hypermethylated in Chinese pediatric acute myeloid leukemia (AML)
    • Yan-Fang T, Jian N, Jun L, et al: The promoter of miR-663 is hypermethylated in Chinese pediatric acute myeloid leukemia (AML). BMC Med Genet 14: 74, 2013.
    • (2013) BMC Med Genet , vol.14 , pp. 74
    • Yan-Fang, T.1    Jian, N.2    Jun, L.3
  • 81
    • 84881549300 scopus 로고    scopus 로고
    • Analyses in human urothelial cells identify methylation of miR-152, miR-200b and miR-10a genes as candidate bladder cancer biomarkers
    • Köhler CU, Bryk O, Meier S, et al: Analyses in human urothelial cells identify methylation of miR-152, miR-200b and miR-10a genes as candidate bladder cancer biomarkers. Biochem Biophys Res Commun 438: 48-53, 2013.
    • (2013) Biochem Biophys Res Commun , vol.438 , pp. 48-53
    • Köhler, C.U.1    Bryk, O.2    Meier, S.3
  • 82
    • 48549091046 scopus 로고    scopus 로고
    • Methylation mediated silencing of microRNA-1 gene and its role in hepatocellular carcinogenesis
    • Datta J, Kutay H, Nasser MW, et al: Methylation mediated silencing of microRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res 68: 5049-5058, 2008.
    • (2008) Cancer Res , vol.68 , pp. 5049-5058
    • Datta, J.1    Kutay, H.2    Nasser, M.W.3
  • 83
    • 82155182009 scopus 로고    scopus 로고
    • Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation
    • Jung CJ, Iyengar S, Blahnik KR, et al: Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation. PLoS One 6: e27740, 2011.
    • (2011) PLoS One , vol.6
    • Jung, C.J.1    Iyengar, S.2    Blahnik, K.R.3
  • 84
    • 80053435478 scopus 로고    scopus 로고
    • Hypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinoma
    • He Y, Cui Y, Wang W, et al: Hypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinoma. Neoplasia 13: 841-853, 2011.
    • (2011) Neoplasia , vol.13 , pp. 841-853
    • He, Y.1    Cui, Y.2    Wang, W.3
  • 85
    • 79956150179 scopus 로고    scopus 로고
    • miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer
    • Zhang Y, Yan LX, Wu QN, et al: miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer Res 71: 3552-3562, 2011.
    • (2011) Cancer Res , vol.71 , pp. 3552-3562
    • Zhang, Y.1    Yan, L.X.2    Wu, Q.N.3
  • 86
    • 84856283173 scopus 로고    scopus 로고
    • miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer
    • Augoff K, McCue B, Plow EF and Sossey-Alaoui K: miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer. Mol Cancer 11: 5, 2012.
    • (2012) Mol Cancer , vol.11 , pp. 5
    • Augoff, K.1    McCue, B.2    Plow, E.F.3    Sossey-Alaoui, K.4
  • 87
    • 84872453829 scopus 로고    scopus 로고
    • miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer
    • Vrba L, Muñoz-Rodríguez JL, Stampfer MR and Futscher BW: miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer. PLoS One 8: e54398, 2013.
    • (2013) PLoS One , vol.8
    • Vrba, L.1    Muñoz-Rodríguez, J.L.2    Stampfer, M.R.3    Futscher, B.W.4
  • 88
    • 77955590791 scopus 로고    scopus 로고
    • miR-193b is an epige netically regulated putative tumor suppressor in prostate cancer
    • Rauhala HE, Jalava SE, Isotalo J, et al: miR-193b is an epige netically regulated putative tumor suppressor in prostate cancer. Int J Cancer 127: 1363-1372, 2010.
    • (2010) Int J Cancer , vol.127 , pp. 1363-1372
    • Rauhala, H.E.1    Jalava, S.E.2    Isotalo, J.3
  • 89
    • 84879418913 scopus 로고    scopus 로고
    • Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer
    • Hulf T, Sibbritt T, Wiklund ED, et al: Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer. Oncogene 32: 2891-2899, 2013.
    • (2013) Oncogene , vol.32 , pp. 2891-2899
    • Hulf, T.1    Sibbritt, T.2    Wiklund, E.D.3
  • 90
    • 84872167310 scopus 로고    scopus 로고
    • DNA methylation silences miR-132 in prostate cancer
    • Formosa A, Lena AM, Markert EK, et al: DNA methylation silences miR-132 in prostate cancer. Oncogene 32: 127-134, 2013.
    • (2013) Oncogene , vol.32 , pp. 127-134
    • Formosa, A.1    Lena, A.M.2    Markert, E.K.3
  • 91
    • 84858239830 scopus 로고    scopus 로고
    • Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers
    • Heller G, Weinzierl M, Noll C, et al: Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers. Clin Cancer Res 18: 1619-1629, 2012.
    • (2012) Clin Cancer Res , vol.18 , pp. 1619-1629
    • Heller, G.1    Weinzierl, M.2    Noll, C.3
  • 92
    • 84858777556 scopus 로고    scopus 로고
    • Epigenetic regulation of miR-212 expression in lung cancer
    • Incoronato M, Urso L, Portela A, et al: Epigenetic regulation of miR-212 expression in lung cancer. PLoS One 6: e27722, 2011.
    • (2011) PLoS One , vol.6
    • Incoronato, M.1    Urso, L.2    Portela, A.3
  • 93
    • 81855166206 scopus 로고    scopus 로고
    • CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer
    • Kitano K, Watanabe K, Emoto N, et al: CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer. Cancer Sci 102: 2126-2131, 2011.
    • (2011) Cancer Sci , vol.102 , pp. 2126-2131
    • Kitano, K.1    Watanabe, K.2    Emoto, N.3
  • 94
    • 79952331586 scopus 로고    scopus 로고
    • DNA hypermethylation of microRNA-34b/c has prognostic value for stage I non-small cell lung cancer
    • Wang Z, Chen Z, Gao Y, et al: DNA hypermethylation of microRNA-34b/c has prognostic value for stage I non-small cell lung cancer. Cancer Biol Ther 11: 490-496, 2011.
    • (2011) Cancer Biol Ther , vol.11 , pp. 490-496
    • Wang, Z.1    Chen, Z.2    Gao, Y.3


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