메뉴 건너뛰기




Volumn 32, Issue 1, 2013, Pages 42-48

Aberrant DNA methylation in cervical carcinogenesis

Author keywords

Cervical cancer; Cervical intraepithelial neoplasm; DNA methylation; Human papillomavirus; Tumor suppressor genes

Indexed keywords

BETA CATENIN; BIOLOGICAL MARKER; CISPLATIN; HYDRALAZINE; PROTEIN P53; TOPOTECAN; TUMOR MARKER; VALPROIC ACID; WNT PROTEIN;

EID: 84872185909     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.012.10033     Document Type: Review
Times cited : (69)

References (61)
  • 1
    • 77955273537 scopus 로고    scopus 로고
    • GLOBOCAN 2008 v1.2, Cancer incidence and mortality worldwide: IARC CancerBase No. 10 [Internet]
    • Available from
    • Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008 v1.2, Cancer incidence and mortality worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France: International agency for research on cancer; 2010. Available from: http://globocan.iarc.fr,accessedon16/02/2012.
    • (2010) Lyon, France: International Agency For Research On Cancer
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 2
    • 0032772179 scopus 로고    scopus 로고
    • The molecular genetics of cervical carcinoma
    • Lazo PA. The molecular genetics of cervical carcinoma. Br J Cancer, 1999,80:2008-2018.
    • (1999) Br J Cancer , vol.80 , pp. 2008-2018
    • Lazo, P.A.1
  • 3
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet, 2002,3:415-428.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 4
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med, 2003,349: 2042-2054.
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 5
    • 63449123166 scopus 로고    scopus 로고
    • Epigenetic alterations in cervical carcinogenesis
    • Szalmas A, Konya J. Epigenetic alterations in cervical carcinogenesis. Semin Cancer Biol, 2009,19:144-152.
    • (2009) Semin Cancer Biol , vol.19 , pp. 144-152
    • Szalmas, A.1    Konya, J.2
  • 6
    • 27744492604 scopus 로고    scopus 로고
    • Epigenetics of cervical cancer. An overview and therapeutic perspectives
    • Duenas-Gonzalez A, Lizano M, Candelaria M, et al. Epigenetics of cervical cancer. An overview and therapeutic perspectives. Mol Cancer, 2005,4:38.
    • (2005) Mol Cancer , vol.4 , pp. 38
    • Duenas-Gonzalez, A.1    Lizano, M.2    Candelaria, M.3
  • 7
    • 0037243946 scopus 로고    scopus 로고
    • Human papillomavirus and cervical cancer
    • Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev, 2003,16:1-17.
    • (2003) Clin Microbiol Rev , vol.16 , pp. 1-17
    • Burd, E.M.1
  • 8
    • 77954955259 scopus 로고    scopus 로고
    • Human papillomavirus oncoproteins: Pathways to transformation
    • Moody CA, Laimins LA. Human papillomavirus oncoproteins: pathways to transformation. Nat Rev Cancer, 2010,10:550-560.
    • (2010) Nat Rev Cancer , vol.10 , pp. 550-560
    • Moody, C.A.1    Laimins, L.A.2
  • 9
    • 71849101810 scopus 로고    scopus 로고
    • Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia
    • Ding DC, Chiang MH, Lai HC, et al. Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia. Eur J Obstet Gynecol Reprod Biol, 2009,147:215-220.
    • (2009) Eur J Obstet Gynecol Reprod Biol , vol.147 , pp. 215-220
    • Ding, D.C.1    Chiang, M.H.2    Lai, H.C.3
  • 10
    • 69249097032 scopus 로고    scopus 로고
    • Methylation status of the long control region of HPV 16 in clinical cervical specimens
    • Hong D, Ye F, Lu W, et al. Methylation status of the long control region of HPV 16 in clinical cervical specimens. Mol Med Report, 2008,1:555-560.
    • (2008) Mol Med Report , vol.1 , pp. 555-560
    • Hong, D.1    Ye, F.2    Lu, W.3
  • 11
    • 74549136674 scopus 로고    scopus 로고
    • Recombination of human papillomavirus-16 and host DNA in exfoliated cervical cells: A pilot study of L1 gene methylation and chromosomal integration as biomarkers of carcinogenic progression
    • Kalantari M, Chase DM, Tewari KS, et al. Recombination of human papillomavirus-16 and host DNA in exfoliated cervical cells: a pilot study of L1 gene methylation and chromosomal integration as biomarkers of carcinogenic progression. J Med Virol, 2010,82:311-320.
    • (2010) J Med Virol , vol.82 , pp. 311-320
    • Kalantari, M.1    Chase, D.M.2    Tewari, K.S.3
  • 12
    • 33646501446 scopus 로고    scopus 로고
    • Methylation of the human papillomavirus-18 L1 gene: A biomarker of neoplastic progression?
    • Turan T, Kalantari M, Calleja-Macias IE, et al. Methylation of the human papillomavirus-18 L1 gene: a biomarker of neoplastic progression? Virology, 2006,349:175-183.
    • (2006) Virology , vol.349 , pp. 175-183
    • Turan, T.1    Kalantari, M.2    Calleja-Macias, I.E.3
  • 13
    • 34147098854 scopus 로고    scopus 로고
    • High-th roughput detection of human papillomavirus-18 L1 gene methylation, a candidate biomarker for the progression of cervical neoplasia
    • Turan T, Kalantari M, Cuschieri K, et al. High-th roughput detection of human papillomavirus-18 L1 gene methylation, a candidate biomarker for the progression of cervical neoplasia. Virology, 2007,361:185-193.
    • (2007) Virology , vol.361 , pp. 185-193
    • Turan, T.1    Kalantari, M.2    Cuschieri, K.3
  • 14
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB. The epigenomics of cancer. Cell, 2007,128:683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 15
    • 0035870248 scopus 로고    scopus 로고
    • A gene hypermethylation profile of human cancer
    • Esteller M, Corn PG, Baylin SB, et al. A gene hypermethylation profile of human cancer. Cancer Res, 2001,61:3225-3229.
    • (2001) Cancer Res , vol.61 , pp. 3225-3229
    • Esteller, M.1    Corn, P.G.2    Baylin, S.B.3
  • 16
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med, 2008,358: 1148-1159.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 17
    • 48449090298 scopus 로고    scopus 로고
    • Epigenetic biomarkers for human cancer: The time is now
    • Mulero-Navarro S, Esteller M. Epigenetic biomarkers for human cancer: the time is now. Crit Rev Oncol Hematol, 2008,68:1-11.
    • (2008) Crit Rev Oncol Hematol , vol.68 , pp. 1-11
    • Mulero-Navarro, S.1    Esteller, M.2
  • 18
    • 77950595010 scopus 로고    scopus 로고
    • Utility of DNA methylation markers for diagnosing cancer
    • Qureshi SA, Bashir MU, Yaqinuddin A. Utility of DNA methylation markers for diagnosing cancer. Int J Surg, 2010,8: 194-198.
    • (2010) Int J Surg , vol.8 , pp. 194-198
    • Qureshi, S.A.1    Bashir, M.U.2    Yaqinuddin, A.3
  • 19
    • 58249144847 scopus 로고    scopus 로고
    • Utility of methylation markers in cervical cancer early detection: Appraisal of the state-of-the-science
    • Wentzensen N, Sherman ME, Schiffman M, et al. Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science. Gynecol Oncol, 2009,112: 293-299.
    • (2009) Gynecol Oncol , vol.112 , pp. 293-299
    • Wentzensen, N.1    Sherman, M.E.2    Schiffman, M.3
  • 20
    • 0034772724 scopus 로고    scopus 로고
    • Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix
    • Dong SM, Kim HS, Rha SH, et al. Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin Cancer Res, 2001,7:1982-1986.
    • (2001) Clin Cancer Res , vol.7 , pp. 1982-1986
    • Dong, S.M.1    Kim, H.S.2    Rha, S.H.3
  • 21
    • 34248386122 scopus 로고    scopus 로고
    • Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma
    • Kang S, Kim HS, Seo SS, et al. Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma. Gynecol Oncol, 2007,105:662-666.
    • (2007) Gynecol Oncol , vol.105 , pp. 662-666
    • Kang, S.1    Kim, H.S.2    Seo, S.S.3
  • 22
    • 33645676043 scopus 로고    scopus 로고
    • Comparison of DNA hypermethylation patterns in different types of uterine cancer: Cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma
    • Kang S, Kim JW, Kang GH, et al. Comparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma. Int J Cancer, 2006,118: 2168-2171.
    • (2006) Int J Cancer , vol.118 , pp. 2168-2171
    • Kang, S.1    Kim, J.W.2    Kang, G.H.3
  • 23
    • 54249083919 scopus 로고    scopus 로고
    • P16 methylation does not affect protein expression in cervical carcinogenesis
    • Nehls K, Vinokurova S, Schmidt D, et al. P16 methylation does not affect protein expression in cervical carcinogenesis. Eur J Cancer, 2008,44:2496-2505.
    • (2008) Eur J Cancer , vol.44 , pp. 2496-2505
    • Nehls, K.1    Vinokurova, S.2    Schmidt, D.3
  • 24
    • 80051635146 scopus 로고    scopus 로고
    • P16 methylation is an early event in cervical carcinogenesis
    • Huang LW, Pan HS, Lin YH, et al. P16 methylation is an early event in cervical carcinogenesis. Int J Gynecol Cancer, 2011,21:452-456.
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 452-456
    • Huang, L.W.1    Pan, H.S.2    Lin, Y.H.3
  • 25
    • 79955477199 scopus 로고    scopus 로고
    • Smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: A longitudinal study
    • Ma YT, Collins SI, Young LS, et al. Smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study. Br J Cancer, 2011,104:1500-1504.
    • (2011) Br J Cancer , vol.104 , pp. 1500-1504
    • Ma, Y.T.1    Collins, S.I.2    Young, L.S.3
  • 26
    • 38549099046 scopus 로고    scopus 로고
    • Aberrant promoter methylation can be useful as a marker of recurrent disease in patients with cervical intraepithelial neoplasia grade III
    • Terra AP, Murta EF, Maluf PJ, et al. Aberrant promoter methylation can be useful as a marker of recurrent disease in patients with cervical intraepithelial neoplasia grade III. Tumori, 2007,93:572-579.
    • (2007) Tumori , vol.93 , pp. 572-579
    • Terra, A.P.1    Murta, E.F.2    Maluf, P.J.3
  • 27
    • 0344196961 scopus 로고    scopus 로고
    • Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins
    • Yang R, Muller C, Huynh V, et al. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol Cell Biol, 1999,19:2400-2407.
    • (1999) Mol Cell Biol , vol.19 , pp. 2400-2407
    • Yang, R.1    Muller, C.2    Huynh, V.3
  • 28
    • 33645777513 scopus 로고    scopus 로고
    • Cyclin A1 promoter hypermethylation in human papillomavirusassociated cervical cancer
    • Kitkumthorn N, Yanatatsanajit P, Kiatpongsan S, et al. Cyclin A1 promoter hypermethylation in human papillomavirusassociated cervical cancer. BMC Cancer, 2006,6:55.
    • (2006) BMC Cancer , vol.6 , pp. 55
    • Kitkumthorn, N.1    Yanatatsanajit, P.2    Kiatpongsan, S.3
  • 29
    • 77749273438 scopus 로고    scopus 로고
    • Gene promoter methylation patterns throughout the process of cervical carcinogenesis
    • Yang N, Nijhuis ER, Volders HH, et al. Gene promoter methylation patterns throughout the process of cervical carcinogenesis. Cell Oncol, 2010,32:131-143.
    • (2010) Cell Oncol , vol.32 , pp. 131-143
    • Yang, N.1    Nijhuis, E.R.2    Volders, H.H.3
  • 30
    • 77949274045 scopus 로고    scopus 로고
    • Role of 5'-C pG island hypermethylation of the FHIT gene in cervical carcinoma
    • Ki KD, Lee SK, Tong SY, et al. Role of 5'-C pG island hypermethylation of the FHIT gene in cervical carcinoma. J Gynecol Oncol, 2008,19:117-122.
    • (2008) J Gynecol Oncol , vol.19 , pp. 117-122
    • Ki, K.D.1    Lee, S.K.2    Tong, S.Y.3
  • 31
    • 33749183587 scopus 로고    scopus 로고
    • Regulation of DNA methylation on the expression of the FHIT gene contributes to cervical carcinoma cell tumorigenesis
    • Wu Y, Meng L, Wang H, et al. Regulation of DNA methylation on the expression of the FHIT gene contributes to cervical carcinoma cell tumorigenesis. Oncol Rep, 2006,16:625-629.
    • (2006) Oncol Rep , vol.16 , pp. 625-629
    • Wu, Y.1    Meng, L.2    Wang, H.3
  • 32
    • 49449087807 scopus 로고    scopus 로고
    • Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC
    • Overmeer RM, Henken FE, Snijders P J, et al. Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC. J Pathol, 2008,215:388-397.
    • (2008) J Pathol , vol.215 , pp. 388-397
    • Overmeer, R.M.1    Henken, F.E.2    Snijders, P.J.3
  • 33
    • 80052269041 scopus 로고    scopus 로고
    • Combined CADM1 and MAL promoter methylation analysis to detect (pre-) malignant cervical lesions in high-risk HPV-positive women
    • Overmeer RM, Louwers JA, Meijer CJ, et al. Combined CADM1 and MAL promoter methylation analysis to detect (pre-) malignant cervical lesions in high-risk HPV-positive women. Int J Cancer, 2011,129:2218-2225.
    • (2011) Int J Cancer , vol.129 , pp. 2218-2225
    • Overmeer, R.M.1    Louwers, J.A.2    Meijer, C.J.3
  • 34
    • 0037363349 scopus 로고    scopus 로고
    • E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours
    • Chen CL, Liu SS, Ip SM, et al. E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours. Eur J Cancer, 2003,39:517-523.
    • (2003) Eur J Cancer , vol.39 , pp. 517-523
    • Chen, C.L.1    Liu, S.S.2    Ip, S.M.3
  • 35
    • 36348989016 scopus 로고    scopus 로고
    • Evaluation of candidate methylation markers to detect cervical neoplasia
    • Shivapurkar N, Sherman ME, Stastny V, et al. Evaluation of candidate methylation markers to detect cervical neoplasia. Gynecol Oncol, 2007,107:549-553.
    • (2007) Gynecol Oncol , vol.107 , pp. 549-553
    • Shivapurkar, N.1    Sherman, M.E.2    Stastny, V.3
  • 36
    • 73649118820 scopus 로고    scopus 로고
    • Death-associated protein kinase (DAPK) and signal transduction: Regulation in cancer
    • Michie AM, Mccaig AM, Nakagawa R, et al. Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer. FEBS J, 2010,277:74-80.
    • (2010) FEBS J , vol.277 , pp. 74-80
    • Michie, A.M.1    McCaig, A.M.2    Nakagawa, R.3
  • 37
    • 70749090028 scopus 로고    scopus 로고
    • Assessment of DNA methylation for the detection of cervical neoplasia in liquidbased cytology specimens
    • Kim JH, Choi YD, Lee JS, et al. Assessment of DNA methylation for the detection of cervical neoplasia in liquidbased cytology specimens. Gynecol Oncol, 2010,116:99-104.
    • (2010) Gynecol Oncol , vol.116 , pp. 99-104
    • Kim, J.H.1    Choi, Y.D.2    Lee, J.S.3
  • 38
    • 77749273438 scopus 로고    scopus 로고
    • Gene promoter methylation patterns throughout the process of cervical carcinogenesis
    • Yang N, Nijhuis ER, Volders HH, et al. Gene promoter methylation patterns throughout the process of cervical carcinogenesis. Cell Oncol, 2010,32:131-143.
    • (2010) Cell Oncol , vol.32 , pp. 131-143
    • Yang, N.1    Nijhuis, E.R.2    Volders, H.H.3
  • 39
    • 1942508904 scopus 로고    scopus 로고
    • Detection of hypermethylated genes in tumor and plasma of cervical cancer patients
    • Yang HJ, Liu VW, Wang Y, et al. Detection of hypermethylated genes in tumor and plasma of cervical cancer patients. Gynecol Oncol, 2004,93:435-440.
    • (2004) Gynecol Oncol , vol.93 , pp. 435-440
    • Yang, H.J.1    Liu, V.W.2    Wang, Y.3
  • 40
    • 33748639077 scopus 로고    scopus 로고
    • Differential DNA methylation profiles in gynecological cancers and correlation with clinicopathological data
    • Yang HJ, Liu VW, Wang Y, et al. Differential DNA methylation profiles in gynecological cancers and correlation with clinicopathological data. BMC Cancer, 2006,6:212.
    • (2006) BMC Cancer , vol.6 , pp. 212
    • Yang, H.J.1    Liu, V.W.2    Wang, Y.3
  • 41
    • 3543067045 scopus 로고    scopus 로고
    • Detecting cervical cancer by quantitative promoter hypermethylation assay on cervical scrapings: A feasibility study
    • Reesink-Peters N, Wisman GB, Jeronimo C, et al. Detecting cervical cancer by quantitative promoter hypermethylation assay on cervical scrapings: a feasibility study. Mol Cancer Res, 2004,2:289-295.
    • (2004) Mol Cancer Res , vol.2 , pp. 289-295
    • Reesink-Peters, N.1    Wisman, G.B.2    Jeronimo, C.3
  • 42
    • 0036828569 scopus 로고    scopus 로고
    • Retinoid, retinoic acid receptor beta and breast cancer
    • Yang Q, Sakurai T, Kakudo K. Retinoid, retinoic acid receptor beta and breast cancer. Breast Cancer Res Treat, 2002,76: 167-173.
    • (2002) Breast Cancer Res Treat , vol.76 , pp. 167-173
    • Yang, Q.1    Sakurai, T.2    Kakudo, K.3
  • 43
    • 78449297484 scopus 로고    scopus 로고
    • Reversal of hypermethylation and reactivation of the RARbeta2 gene by natural compounds in cervical cancer cell lines
    • Jha AK, Nikbakht M, Parashar G, et al. Reversal of hypermethylation and reactivation of the RARbeta2 gene by natural compounds in cervical cancer cell lines. Folia Biol (Praha), 2010,56:195-200.
    • (2010) Folia Biol (Praha) , vol.56 , pp. 195-200
    • Jha, A.K.1    Nikbakht, M.2    Parashar, G.3
  • 45
    • 33847358769 scopus 로고    scopus 로고
    • The role of RASSF1A methylation in cancer
    • Hesson LB, Cooper WN, Latif F. The role of RASSF1A methylation in cancer. Dis Markers, 2007,23:73-87.
    • (2007) Dis Markers , vol.23 , pp. 73-87
    • Hesson, L.B.1    Cooper, W.N.2    Latif, F.3
  • 46
    • 0043026893 scopus 로고    scopus 로고
    • The RASSF1A tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix
    • Cohen Y, Singer G, Lavie O, et al. The RASSF1A tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix. Clin Cancer Res, 2003,9:2981-2984.
    • (2003) Clin Cancer Res , vol.9 , pp. 2981-2984
    • Cohen, Y.1    Singer, G.2    Lavie, O.3
  • 47
    • 0344754091 scopus 로고    scopus 로고
    • Inactivation of RAS association domain family 1A gene in cervical carcinomas and the role of human papillomavirus infection
    • Kuzmin I, Liu L, Dammann R, et al. Inactivation of RAS association domain family 1A gene in cervical carcinomas and the role of human papillomavirus infection. Cancer Res, 2003,63:1888-1893.
    • (2003) Cancer Res , vol.63 , pp. 1888-1893
    • Kuzmin, I.1    Liu, L.2    Dammann, R.3
  • 48
    • 35648988947 scopus 로고    scopus 로고
    • Adenomatous polyposis coli (APC): A multi-fu nctional tumor suppressor gene
    • Aoki K, Taketo MM. Adenomatous polyposis coli (APC): a multi-fu nctional tumor suppressor gene. J Cell Sci, 2007,120: 3327-3335.
    • (2007) J Cell Sci , vol.120 , pp. 3327-3335
    • Aoki, K.1    Taketo, M.M.2
  • 49
    • 0034772724 scopus 로고    scopus 로고
    • Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix
    • Dong SM, Kim HS, Rha SH, et al. Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin Cancer Res, 2001,7:1982-1986.
    • (2001) Clin Cancer Res , vol.7 , pp. 1982-1986
    • Dong, S.M.1    Kim, H.S.2    Rha, S.H.3
  • 50
    • 58849128287 scopus 로고    scopus 로고
    • Hydralazine inhibits human cervical cancer cell growth in vitro in association with APC demethylation and re-expression
    • Song Y, Zhang C. Hydralazine inhibits human cervical cancer cell growth in vitro in association with APC demethylation and re-expression. Cancer Chemother Pharmacol, 2009,63:605-613.
    • (2009) Cancer Chemother Pharmacol , vol.63 , pp. 605-613
    • Song, Y.1    Zhang, C.2
  • 51
    • 2542433039 scopus 로고    scopus 로고
    • P73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy
    • Liu SS, Leung RC, Chan KY, et al. P73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy. Clin Cancer Res, 2004,10:3309-3316.
    • (2004) Clin Cancer Res , vol.10 , pp. 3309-3316
    • Liu, S.S.1    Leung, R.C.2    Chan, K.Y.3
  • 52
    • 71949083197 scopus 로고    scopus 로고
    • Role of MGMT in tumor development, progression, diagnosis, treatment and prognosis
    • Sharma S, Salehi F, Scheithauer BW, et al. Role of MGMT in tumor development, progression, diagnosis, treatment and prognosis. Anticancer Res, 2009,29:3759-3768.
    • (2009) Anticancer Res , vol.29 , pp. 3759-3768
    • Sharma, S.1    Salehi, F.2    Scheithauer, B.W.3
  • 53
    • 58249144847 scopus 로고    scopus 로고
    • Utility of methylation markers in cervical cancer early detection: Appraisal of the state-of-the-science
    • Wentzensen N, Sherman ME, Schiffman M, et al. Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science. Gynecol Oncol, 2009,112: 293-299.
    • (2009) Gynecol Oncol , vol.112 , pp. 293-299
    • Wentzensen, N.1    Sherman, M.E.2    Schiffman, M.3
  • 54
    • 70749090028 scopus 로고    scopus 로고
    • Assessment of DNA methylation for the detection of cervical neoplasia in liquidbased cytology specimens
    • Kim JH, Choi YD, Lee JS, et al. Assessment of DNA methylation for the detection of cervical neoplasia in liquidbased cytology specimens. Gynecol Oncol, 2010,116:99-104.
    • (2010) Gynecol Oncol , vol.116 , pp. 99-104
    • Kim, J.H.1    Choi, Y.D.2    Lee, J.S.3
  • 55
    • 0035286225 scopus 로고    scopus 로고
    • The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    • Ali-Osman F, Srivenugopal K, Sawaya R. The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med, 2001,344:687-688.
    • (2001) N Engl J Med , vol.344 , pp. 687-688
    • Ali-Osman, F.1    Srivenugopal, K.2    Sawaya, R.3
  • 56
    • 37549062180 scopus 로고    scopus 로고
    • Liquid compared with conventional cervical cytology: A systematic review and meta-analysis
    • Arbyn M, Bergeron C, Klinkhamer P, et al. Liquid compared with conventional cervical cytology: a systematic review and meta-analysis. Obstet Gynecol, 2008,111:167-177.
    • (2008) Obstet Gynecol , vol.111 , pp. 167-177
    • Arbyn, M.1    Bergeron, C.2    Klinkhamer, P.3
  • 57
    • 78650691991 scopus 로고    scopus 로고
    • Testing for methylated PCDH10 or WT1 is superior to the HPV test in detecting severe neoplasms (CIN3 or greater) in the triage of ASC-U S smear results
    • Lin CJ, Lai HC, Wang KH, et al. Testing for methylated PCDH10 or WT1 is superior to the HPV test in detecting severe neoplasms (CIN3 or greater) in the triage of ASC-U S smear results. Am J Obstet Gynecol, 2011,204:21.e1-e7.
    • (2011) Am J Obstet Gynecol , vol.204 , Issue.21
    • Lin, C.J.1    Lai, H.C.2    Wang, K.H.3
  • 58
    • 84872838041 scopus 로고    scopus 로고
    • Triage of cervical cytological diagnoses of atypical squamous cells by DNA methylation of paired boxed gene 1 (PAX1)
    • doi: 10.1002/dc.21758. [Epub ahead of print]
    • Chao TK, Ke FY, Liao YP, et al. Triage of cervical cytological diagnoses of atypical squamous cells by DNA methylation of paired boxed gene 1 (PAX1). Diagn Cytopathol, 2011. doi: 10.1002/dc.21758. [Epub ahead of print]
    • (2011) Diagn Cytopathol
    • Chao, T.K.1    Ke, F.Y.2    Liao, Y.P.3
  • 59
    • 79251598419 scopus 로고    scopus 로고
    • Detection of cervical neoplasia by DNA methylation analysis in cervico-vaginal lavages, a feasibility study
    • Eijsink JJ, Yang N, Lendvai A, et al, Detection of cervical neoplasia by DNA methylation analysis in cervico-vaginal lavages, a feasibility study. Gynecol Oncol, 2011,120:280-283.
    • (2011) Gynecol Oncol , vol.120 , pp. 280-283
    • Eijsink, J.J.1    Yang, N.2    Lendvai, A.3
  • 60
    • 26844499872 scopus 로고    scopus 로고
    • A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes
    • Zambrano P, Segura-Pacheco B, Perez-C ardenas E, et al. A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes. BMC Cancer, 2005,5: 44.
    • (2005) BMC Cancer , vol.5 , pp. 44
    • Zambrano, P.1    Segura-Pacheco, B.2    Perez-C ardenas, E.3
  • 61
    • 84655175030 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized phase III trial of chemotherapy plus epigenetic therapy with hydralazine valproate for advanced cervical cancer
    • Coronel J, Cetina L, Pacheco I, et al. A double-blind, placebo-controlled, randomized phase III trial of chemotherapy plus epigenetic therapy with hydralazine valproate for advanced cervical cancer. Preliminary results. Med Oncol. 2011, 28 Suppl.1:S540-S546.
    • (2011) Preliminary Results. Med Oncol , vol.28 , Issue.1 SUPPL.
    • Coronel, J.1    Cetina, L.2    Pacheco, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.