Epigenetic silencing of MIR203 in multiple myeloma

British Journal of Haematology

Volumn 154, Issue 5, 2011, Pages 569-578

  Wong, Kwan Yeung ^a   Liang, Raymond ^a   So, Chi Chiu ^a   Jin, Dong Yan ^a   Costello, Joseph F ^b   Chim, Chor Sang ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hypermethylation; MicroRNA; MIR203; Myeloma; Tumour suppressor

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ACTIVATING TRANSCRIPTION FACTOR 2; LUCIFERASE; MESSENGER RNA; MICRORNA; MICRORNA 203; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER RELAPSE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DEMETHYLATION; DOWN REGULATION; ENZYME ACTIVITY; GENE INACTIVATION; GENE SILENCING; HOMOZYGOSITY; HUMAN; HUMAN CELL; INHIBITION KINETICS; MAJOR CLINICAL STUDY; METHYLATION; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; WILD TYPE;

BONE MARROW; CASE-CONTROL STUDIES; CELL PROLIFERATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA METHYLATION; EPIGENESIS, GENETIC; GENE SILENCING; HUMANS; MICRORNAS; MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE; MULTIPLE MYELOMA; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 80051598906     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08782.x     Document Type: Article

References (34)

1. Bando, T., Kato, Y., Ihara, Y., Yamagishi, F., Tsukada, K. & Isobe, M. (1999) Loss of heterozygosity of 14q32 in colorectal carcinoma. Cancer Genetics and Cytogenetics, 111, 161-165.
2. Bueno, M.J., Perez de Castro, I., Gomez de Cedron, M., Santos, J., Calin, G.A., Cigudosa, J.C., Croce, C.M., Fernandez-Piqueras, J. & Malumbres, M. (2008) Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell, 13, 496-506.
3. Calin, G.A. & Croce, C.M. (2006) MicroRNA signatures in human cancers. Nature Reviews Cancer, 6, 857-866.
4. Chen, C.Z. (2005) MicroRNAs as oncogenes and tumor suppressors. New England Journal of Medicine, 353, 1768-1771.
5. Cheng, J.C., Kinjo, K., Judelson, D.R., Chang, J., Wu, W.S., Schmid, I., Shankar, D.B., Kasahara, N., Stripecke, R., Bhatia, R., Landaw, E.M. & Sakamoto, K.M. (2008) CREB is a critical regulator of normal hematopoiesis and leukemogenesis. Blood, 111, 1182-1192.
6. Chesi, M., Nardini, E., Brents, L.A., Schrock, E., Ried, T., Kuehl, W.M. & Bergsagel, P.L. (1997) Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nature Genetics, 16, 260-264.
7. Chim, C.S., Liang, R., Tam, C.Y.Y. & Kwong, Y.L. (2001) Methylation of p15 and p16 Genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance. Journal of Clinical Oncology, 19, 2033-2040.
8. Chim, C.S., Liang, R. & Kwong, Y.L. (2002) Hypermethylation of gene promoters in hematological neoplasia. Hematological Oncology, 20, 167-176.
9. Chim, C.S., Fung, T.K., Cheung, W.C., Liang, R. & Kwong, Y.L. (2004) SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway. Blood, 103, 4630-4635.
10. Chim, C.S., Chan, W.W.L., Pang, A. & Kwong, Y.L. (2006a) Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor. Leukemia, 20, 907-909.
11. Chim, C.S., Liang, R., Leung, M.H., Yip, S.F. & Kwong, Y.L. (2006b) Aberrant gene promoter methylation marking disease progression in multiple myeloma. Leukemia, 20, 1190-1192.
12. Chim, C.S., Kwong, Y.L. & Liang, R. (2008) Gene hypermethylation in multiple myeloma: lessons from a cancer pathway approach. Clinical Lymphoma and Myeloma, 8, 331-339.
13. Chim, C.S., Wong, K.Y., Qi, Y., Loong, F., Lam, W.L., Wong, L.G., Jin, D.Y., Costello, J.F. & Liang, R. (2010) Epigenetic inactivation of the miR-34a in hematological malignancies. Carcinogenesis, 31, 745-750.
14. Esquela-Kerscher, A. & Slack, F.J. (2006) Oncomirs - microRNAs with a role in cancer. Nature Reviews Cancer, 6, 259-269.
15. Furuta, M., Kozaki, K.I., Tanaka, S., Arii, S., Imoto, I. & Inazawa, J. (2010) miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis, 31, 766-776.
16. Greipp, P.R., Miguel, J.S., Durie, B.G.M., Crowley, J.J., Barlogie, B., Blade, J., Boccadoro, M., Child, J.A., Avet-Loiseau, H., Kyle, R.A., Lahuerta, J.J., Ludwig, H., Morgan, G., Powles, R., Shimizu, K., Shustik, C., Sonneveld, P., Tosi, P., Turesson, I. & Westin, J. (2005) International staging system for multiple myeloma. Journal of Clinical Oncology, 23, 3412-3420.
17. Herman, J.G. & Baylin, S.B. (2003) Gene silencing in cancer in association with promoter hypermethylation. New England Journal of Medicine, 349, 2042-2054.
18. Hoshi, M., Otagiri, N., Shiwaku, H.O., Asakawa, S., Shimizu, N., Kaneko, Y., Ohi, R., Hayashi, Y. & Horii, A. (2000) Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss. British Journal of Cancer, 82, 1801-1807.
19. International Myeloma Working Group (2003) Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. British Journal of Haematology, 121, 749-757.
20. Kawakami, T., Chano, T., Minami, K., Okabe, H., Okada, Y. & Okamoto, K. (2006) Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma. Human Molecular Genetics, 15, 821-830.
21. Kuehl, W.M. & Bergsagel, P.L. (2002) Multiple myeloma: evolving genetic events and host interactions. Nature Reviews Cancer, 2, 175-187.
22. Lewis, B.P., Shih, I.h., Jones-Rhoades, M.W., Bartel, D.P. & Burge, C.B. (2003) Prediction of mammalian MicroRNA targets. Cell, 115, 787-798.
23. Livak, K.J. & Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-[Delta][Delta]CT Method. Methods, 25, 402-408.
24. Lujambio, A. & Esteller, M. (2007) CpG island hypermethylation of tumor suppressor microRNAs in human cancer. Cell Cycle, 6, 1455-1459.
25. Lujambio, A., Ropero, S., Ballestar, E., Fraga, M.F., Cerrato, C., Setien, F., Casado, S., Suarez-Gauthier, A., Sanchez-Cespedes, M., Gitt, A., Spiteri, I., Das, P.P., Caldas, C., Miska, E. & Esteller, M. (2007) Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Research, 67, 1424-1429.
26. Nowakowski, G.S., Witzig, T.E., Dingli, D., Tracz, M.J., Gertz, M.A., Lacy, M.Q., Lust, J.A., Dispenzieri, A., Greipp, P.R., Kyle, R.A. & Rajkumar, S.V. (2005) Circulating plasma cells detected by flow cytometry as a predictor of survival in 302 patients with newly diagnosed multiple myeloma. Blood, 106, 2276-2279.
27. Pichiorri, F., Suh, S.-S., Rocci, A., De Luca, L., Taccioli, C., Santhanam, R., Zhou, W., Benson, Jr, D.M., Hofmainster, C., Alder, H., Garofalo, M., Di Leva, G., Volinia, S., Lin, H.-J., Perrotti, D., Kuehl, M., Aqeilan, R.I., Palumbo, A. & Croce, C.M. (2010) Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell, 18, 367-381.
28. Pigazzi, M., Ricotti, E., Germano, G., Faggian, D., Arico, M. & Basso, G. (2007) cAMP response element binding protein (CREB) overexpression CREB has been described as critical for leukemia progression. Haematologica, 92, 1435-1437.
29. Pigazzi, M., Manara, E., Baron, E. & Basso, G. (2009) miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. Cancer Research, 69, 2471-2478.
30. Rajewsky, N. (2006) microRNA target predictions in animals. Nature Genetics, 38, S8-S13.
31. Saito, Y., Liang, G., Egger, G., Friedman, J.M., Chuang, J.C., Coetzee, G.A. & Jones, P.A. (2006) Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell, 9, 435-443.
32. Shankar, D.B., Cheng, J.C., Kinjo, K., Federman, N., Moore, T.B., Gill, A., Rao, N.P., Landaw, E.M. & Sakamoto, K.M. (2005) The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. Cancer Cell, 7, 351-362.
33. Thorstensen, L., Qvist, H., Nesland, J.M., Giercksky, K.E. & Lothe, R.A. (2001) Identification of two potential suppressor gene regions on chromosome arm 14q that are commonly lost in advanced colorectal carcinomas. Scandinavian Journal of Gastroenterology, 36, 1327-1331.
34. Wong, K.Y., So, C.C., Loong, F., Chung, L.P., Lam, W.W.L., Liang, R., Li, G.K.H., Jin, D.-Y. & Chim, C.S. (2011) Epigenetic inactivation of the miR-124-1 in haematological malignancies. PLoS ONE, 6, e19027.