Quantitative analysis of the relationship between microRNA-124a, -34b and -203 gene methylation and cervical oncogenesis

Molecular Medicine Reports

Volumn 4, Issue 1, 2011, Pages 121-128

  Botezatu, Anca ^a   Goia Rusanu, Cristina Daniela ^a   Iancu, Iulia Virginia ^a   Huica, Irina ^a   Plesa, Adriana ^a   Socolov, Demetra ^b   Ungureanu, Carmen ^b   Anton, Gabriela ^a  

^a STEFAN S NICOLAU INSTITUTE OF VIROLOGY   (Romania)

^b GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Cervical cancer; DNA methylation; Human papillomavirus; miRNAs

Indexed keywords

MICRORNA; MICRORNA 124A; MICRORNA 203; MICRORNA 34B; UNCLASSIFIED DRUG; VIRUS DNA;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; CPG ISLAND; EPIGENETICS; FEMALE; GENETIC ANALYSIS; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; RNA METHYLATION; UTERINE CERVIX CANCER; WART VIRUS;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CPG ISLANDS; DNA METHYLATION; DNA, VIRAL; FEMALE; HELA CELLS; HUMANS; MICRORNAS; MIDDLE AGED; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; UTERINE CERVICAL NEOPLASMS; YOUNG ADULT;

HUMAN PAPILLOMAVIRUS; PAPILLOMAVIRIDAE;

EID: 78651403558     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2010.394     Document Type: Article

References (25)

1. US Cancer Statistics Working Group: United States Cancer Statistics: 1999-2004 Incidence and mortality web-based report. US Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute, 2007, Atlanta, www.cdc.gov/uscs. Accessed April 7, 2010.
2. Todorova I, Baban A, Alexandrova-Karamanova A and Bradley J: Inequalities in cervical cancer screening in Eastern Europe: perspectives from Bulgaria and Romania. Int J Public Health 54: 222-232, 2009.
3. Zur Hausen H: Viruses in human cancers. Science 254: 1167-1173, 1991.
4. Li HP, Leu YW and Chang YS: Epigenetic changes in virus-associated human cancers. Cell Res 15: 262-271, 2005. (Pubitemid 41642882)
5. Lee JO, Kwun HJ, Jung JK, Choi KH, Min DS and Jang KL: Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. Oncogene 24: 6617-6625, 2005.
6. Esteller M: Epigenetics provides a new generation of oncogenes and tumour-suppressor genes. Br J Cancer 94: 179-183, 2006.
7. Guil S and Esteller M: DNA methylomes, histone codes and miRNAs: tying it all together. Int J Biochem Cell Biol 41: 87-95, 2009.
8. Faraoni I, Antonetti FR, Cardonea J and Bonmassar E: miR-155 gene: A typical multifunctional microRNA. Biochim Biophys Acta 1792: 497-505, 2009.
9. Jiang S, Zhang HW, Lu MH, He XH, Li Y, Gu H, Liu MF and Wang ED: MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Cancer Res 70: 3119-3127, 2010.
10. Pierson J, Hostager B, Fan R and Vibhakar R: Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma. J Neurooncol 90: 1-7, 2008.
11. Agirre X, Vilas-Zornoza A, Jiménez-Velasco A, et al: Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia. Cancer Res 69: 4443-4453, 2009.
12. Kozaki K, Imoto I, Mogi S, Omura K and Inazawa J: Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res 68: 2094-2105, 2008. (Pubitemid 351521781)
13. Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K and Shinomura Y: Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res 68: 4123-4132, 2008.
14. Comey DC, Flesken-Nitkin A, Godwin AK, Wang W and Nikitin AY: MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res 67: 8433-8438, 2007. (Pubitemid 47437414)
15. Lujambio A, Calin GA, Villanueva A, Ropero S, Sánchez- Céspedes M and Blanco D: A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci USA 105: 13556-13561, 2008.
16. Iorio MV, Visone R, Di Leva G, Donati V, Petrocca F and Casalini P: MicroRNA signatures in human ovarian cancer. Cancer Res 67: 8699-707, 2007. (Pubitemid 47437445)
17. Wilting SM, van Boerdonk RA, Henken FE, Meijer CJ, Diosdado B, Meijer GA, Le Sage C, Agami R, Snijders PJ and Steenbergen RD: Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer. Mol Cancer 9: 167, 2010.
18. Fackler MJ, McVeigh M, Mehrotra J, Blum MA, Lange J, Lapides A, Garrett E, Argani P and Sukumar S: Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer. Cancer Res 64: 4442-4452, 2004. (Pubitemid 38856915)
19. Weber B, Stresemann C, Brueckner B and Lyko F: Methylation of human microRNA genes in normal and neoplastic cells. Cell Cycle 6: 1001-1005, 2007. (Pubitemid 46708569)
20. Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA and Jones PA: Specific activation of microRNA-127 with down-regulation of the protooncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9: 435-443, 2006. (Pubitemid 43832188)
21. Lujambio A, Ropero S, Ballestar E et al: Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 67: 1424-1429, 2007. (Pubitemid 46383366)
22. Hackanson B, Bennett KL, Brena RM, Jiang J, Claus R, Chen SS, Blagitko-Dorfs N, Maharry K, Whitman SP, Schmittgen TD, Lübbert M, Marcucci G, Bloomfield CD and Plass C: Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia. Cancer Res 68: 3142-3151, 2008.
23. Yang Z, Chen S, Luan X, Li Y, Liu M, Li X, Liu T and Tang H: MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of HeLa cells. IUBMB Life 61: 1075-1082, 2009.
24. Baohua L, Ying H, Feng Y, Yang L, Weiguo L and Xing X: Reduced miR-34a Expression in normal cervical tissues and cervical lesions with high-risk human papillomavirus infection. Int J Gynecol Cancer 20: 597-604, 2010.
25. Melar-New M and Laimins LA: Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins. J Virol 84: 5212-5221, 2010.