CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer

Cancer Science

Volumn 102, Issue 12, 2011, Pages 2126-2131

  Kitano, Kentaro ^a   Watanabe, Kousuke ^a   Emoto, Noriko ^a   Kage, Hidenori ^a   Hamano, Emi ^a   Nagase, Takahide ^a   Sano, Atsushi ^a   Murakawa, Tomohiro ^a   Nakajima, Jun ^a   Goto, Akiteru ^a   Fukayama, Masashi ^a   Yatomi, Yutaka ^a   Ohishi, Nobuya ^a   Takai, Daiya ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BISULFITE; MICRORNA;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; GENE LOCUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; METHYLATION; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; TUMOR GROWTH; TUMOR VOLUME;

AGED; CARCINOMA, NON-SMALL-CELL LUNG; CPG ISLANDS; DISEASE PROGRESSION; DNA METHYLATION; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MALE; MICRORNAS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL;

EID: 81855166206     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.02101.x     Document Type: Article

References (31)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60: 277-300.
2. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120: 15-20.
3. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857-66.
4. Takamizawa J, Konishi H, Yanagisawa K et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 2004; 64: 3753-6.
5. Saito M, Schetter AJ, Mollerup S et al. The association of microRNA expression with prognosis and progression in early-stage, non-small cell lung adenocarcinoma: a retrospective analysis of three cohorts. Clin Cancer Res 2011; 17: 1875-82.
6. Kunej T, Godnic I, Ferdin J, Horvat S, Dovc P, Calin GA. Epigenetic regulation of microRNAs in cancer: an integrated review of literature. Mutat Res 2011. doi:.
7. Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J. Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res 2008; 68: 2094-105.
8. Saito Y, Jones PA. Epigenetic activation of tumor suppressor microRNAs in human cancer cells. Cell Cycle 2006; 5: 2220-2.
9. Watanabe K, Emoto N, Hamano E et al. Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer. Int J Cancer 2011. doi:.
10. Lujambio A, Ropero S, Ballestar E et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 2007; 67: 1424-9.
11. Lujambio A, Calin GA, Villanueva A et al. A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci USA 2008; 105: 13556-61.
12. Sobin LH, Wittekind C, eds. TNM Classification of Malignant Tumours (Uicc International Union Against Cancer), 6th edn. New York, NY: Wiley-Liss, 2002.
13. Sambrook J, Russell DW, eds. Molecular Cloning: A Laboratory Manual, 3rd edn. New York, NY: Cold Spring Harbor Laboratory Press, 2001.
14. Sano A, Kage H, Sugimoto K et al. A second-generation profiling system for quantitative methylation analysis of multiple gene promoters: application to lung cancer. Oncogene 2007; 26: 6518-25.
15. Xiong Z, Laird PW. COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res 1997; 25: 2532-4.
16. Watanabe K, Emoto N, Sunohara M et al. Treatment of PCR products with exonuclease I and heat-labile alkaline phosphatase improves the visibility of combined bisulfite restriction analysis. Biochem Biophys Res Commun 2010; 399: 422-4.
17. Dudziec E, Miah S, Choudhry HM et al. Hypermethylation of CpG islands and shores around specific microRNAs and mirtrons is associated with the phenotype and presence of bladder cancer. Clin Cancer Res 2011; 17: 1287-96.
18. Rakyan VK, Down TA, Thorne NP et al. An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res 2008; 18: 1518-29.
19. Bandres E, Agirre X, Bitarte N et al. Epigenetic regulation of microRNA expression in colorectal cancer. Int J Cancer 2009; 125: 2737-43.
20. Agirre X, Vilas-Zornoza A, Jimenez-Velasco A et al. Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia. Cancer Res 2009; 69: 4443-53.
21. Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I, Inazawa J. miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis 2010; 31: 766-76.
22. Brock MV, Hooker CM, Ota-Machida E et al. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med 2008; 358: 1118-28.
23. Tian L, Suzuki M, Nakajima T et al. Clinical significance of aberrant methylation of prostaglandin E receptor 2 (PTGER2) in nonsmall cell lung cancer: association with prognosis, PTGER2 expression, and epidermal growth factor receptor mutation. Cancer 2008; 113: 1396-403.
24. Kim DS, Kim MJ, Lee JY et al. Epigenetic inactivation of Homeobox A5 gene in nonsmall cell lung cancer and its relationship with clinicopathological features. Mol Carcinog 2009; 48: 1109-15.
25. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 1999; 96: 8681-6.
26. Teodoridis JM, Hardie C, Brown R. CpG island methylator phenotype (CIMP) in cancer: causes and implications. Cancer Lett 2008; 268: 177-86.
27. Liu Z, Zhao J, Chen XF et al. CpG island methylator phenotype involving tumor suppressor genes located on chromosome 3p in non-small cell lung cancer. Lung Cancer 2008; 62: 15-22.
28. Zhang Y, Wang R, Song H et al. Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer. Cancer Lett 2011; 303: 21-8.
29. Kusakabe M, Kutomi T, Watanabe K et al. Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches. Int J Cancer 2010; 126: 1895-902.
30. Baylin S, Bestor TH. Altered methylation patterns in cancer cell genomes: cause or consequence? Cancer Cell 2002; 1: 299-305.
31. Kimura M. Recent development of the neutral theory viewed from the Wrightian tradition of theoretical population genetics. Proc Natl Acad Sci USA 1991; 88: 5969-73.