Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Jung, Christine J ^a   Iyengar, Sushma ^b   Blahnik, Kimberly R ^b   Ajuha, Tijess P ^a   Jiang, Joy X ^a   Farnham, Peggy J ^b   Zern, Mark ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; MICRORNA; MICRORNA 122; RNA POLYMERASE II; UNCLASSIFIED DRUG; MESSENGER RNA; MIRN122 MICRORNA, HUMAN;

ARTICLE; CANCER CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; DNA METHYLATION; EMBRYONIC STEM CELL; GENE EXPRESSION PROFILING; GENE SEQUENCE; GENETIC REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LIVER CELL CARCINOMA; MODULATION; NUCLEOTIDE SEQUENCE; ONCOGENE; PKM2 GENE; RNA TRANSLATION; TRANSCRIPTION INITIATION; 3' UNTRANSLATED REGION; ANIMAL; CELL DIVISION; CHROMATIN IMMUNOPRECIPITATION; CYTOLOGY; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HUMAN GENOME; LIVER TUMOR; METABOLISM; MOLECULAR GENETICS; MOUSE; PATHOLOGY; PROMOTER REGION; PROTEIN BINDING; PROTEIN SYNTHESIS; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; DNA METHYLATION; EMBRYONIC STEM CELLS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MICE; MICRORNAS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; RNA POLYMERASE II; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA;

EID: 82155182009     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027740     Document Type: Article

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