Specific control of cell-material interactions: Targeting cell receptors using ligand-functionalized polymer substrates

Progress in Polymer Science

Volumn 39, Issue 7, 2014, Pages 1312-1347

  Rodda, Andrew E ^a,b,c   Meagher, Laurence ^b,c   Nisbet, David R ^d   Forsythe, John S ^a,c  

^a MONASH UNIVERSITY   (Australia)

^b CSIRO   (Australia)

^c School of Earth and Environmental Sciences   (Australia)

^d AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Attachment; Bio orthogonal; Bioconjugation; Conformation; Immobilization; Orientation

Indexed keywords

CELL MEMBRANES; CONFORMATIONS; CRYSTAL ORIENTATION; CYTOLOGY; LIGANDS; RADIOACTIVE WASTE VITRIFICATION;

ATTACHMENT; BIO-CONJUGATION; BIO-ORTHOGONAL; CELL-MATERIAL INTERACTION; FUNDAMENTAL STUDIES; PEPTIDOMIMETICS; POLYMER SUBSTRATE; RECEPTOR SIGNALING;

CELL SIGNALING;

EID: 84902106888     PISSN: 00796700     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.progpolymsci.2013.11.006     Document Type: Review

References (379)

1. Y. Ito Growth factors and protein-modified surfaces and interfaces P. Ducheyne, K. Healy, D. Hutmacher, D.W. Grainger, C.J. Kirkpatrick, Comprehensive biomaterials vol. 4 2011 Elsevier Sci Amsterdam 247 279
2. A.E. Carson, and T.H. Barker Emerging concepts in engineering extracellular matrix variants for directing cell phenotype Regener Med 4 2009 593 600
3. J. Humphries, A. Byron, and M. Humphries Integrin ligands at a glance J Cell Sci 119 2006 3901 3903
4. W. Friedman Growth factors S.T. Brady, G.J. Siegel, R.W. Albers, D.L. Price, Basic neurochem 8th ed. 2012 Elsevier Ltd. Amsterdam 546 557
5. K. Masters Covalent growth factor immobilization strategies for tissue repair and regeneration Macromol Biosci 11 2011 1149 1163
6. Y. Ito Covalently immobilized biosignal molecule materials for tissue engineering Soft Matter 4 2008 46 56
7. U. Hersel, C. Dahmen, and H. Kessler RGD modified polymers: biomaterials for stimulated cell adhesion and beyond Biomaterials 24 2003 4385 4415
8. L. Perlin, S. MacNeil, and S. Rimmer Production and performance of biomaterials containing RGD peptides Soft Matter 4 2008 2331 2349
9. J. Zhu Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering Biomaterials 31 2010 4639 4656
10. R. Green, N. Lovell, and L. Poole-Warren Cell attachment functionality of bioactive conducting polymers for neural interfaces Biomaterials 30 2009 3637 3644
11. L.Y. Santiago, R.W. Nowak, J. Peter Rubin, and K.G. Marra Peptide-surface modification of poly(caprolactone) with laminin-derived sequences for adipose-derived stem cell applications Biomaterials 27 2006 2962 2969
12. Y. Yamada, F. Katagiri, K. Hozumi, Y. Kikkawa, and M. Nomizu Cell behavior on protein matrices containing laminin α1 peptide AG73 Biomaterials 32 2011 4327 4335
13. S. Kubinová, D. Horák, N. Kozubenko, V. Vanecek, V. Proks, J. Price, G. Cocks, and E. Syková The use of superporous Ac-CGGASIKVAVS-OH-modified PHEMA scaffolds to promote cell adhesion and the differentiation of human fetal neural precursors Biomaterials 31 2010 5966 5975
14. G. Silva, C. Czeisler, K. Niece, E. Beniash, D. Harrington, J. Kessler, and S. Stupp Selective differentiation of neural progenitor cells by high-epitope density nanofibers Science 303 2004 1352 1355
15. S. Skaper The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors CNS Neurol Disord Drug Targets 7 2008 46 62
16. J.Y. Lee, J.E. Choo, Y.S. Choi, J.S. Suh, S.J. Lee, C.P. Chung, and Y.J. Park Osteoblastic differentiation of human bone marrow stromal cells in self-assembled BMP-2 receptor-binding peptide-amphiphiles Biomaterials 30 2009 3532 3541
17. H. Chen, L. Yuan, W. Song, Z. Wu, and D. Li Biocompatible polymer materials: role of protein-surface interactions Prog Polym Sci 33 2008 1059 1087
18. L. Jongpaiboonkit, W. King, and W. Murphy Screening for 3D environments that support human mesenchymal stem cell viability using hydrogel arrays Tissue Eng Part A 15 2009 343 353
19. T.H. Barker The role of ECM proteins and protein fragments in guiding cell behavior in regenerative medicine Biomaterials 32 2011 4211 4214
20. J.H. Collier, and T. Segura Evolving the use of peptides as components of biomaterials Biomaterials 32 2011 4198 4204
21. R. Hynes The extracellular matrix: not just pretty fibrils Science 326 2009 1216 1219
22. T. Petrie, J. Capadona, C. Reyes, and A. García Integrin specificity and enhanced cellular activities associated with surfaces presenting a recombinant fibronectin fragment compared to RGD supports Biomaterials 27 2006 5459 5470
23. M. Martino, M. Mochizuki, D. Rothenfluh, S. Rempel, J. Hubbell, and T. Barker Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability Biomaterials 30 2009 1089 1097
24. D. Heckmann, and H. Kessler Design and chemical synthesis of integrin ligands Methods Enzymol 426 2007 463 503
25. G. Harbers, and K. Healy The effect of ligand type and density on osteoblast adhesion, proliferation, and matrix mineralization J Biomed Mater Res Part A 75 2005 855 869
26. K. Saha, E.F. Irwin, J. Kozhukh, D.V. Schaffer, and K.E. Healy Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior J Biomed Mater Res Part A 81 2007 240 249
27. S. Khew, X. Zhu, and Y. Tong An integrin-specific collagen-mimetic peptide approach for optimizing Hep3B liver cell adhesion, proliferation, and cellular functions Tissue Eng 13 2007 2451 2463
28. E. Koivunen, B. Wang, and E. Ruoslahti Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-Directed Integrins Nat Biotechnol 13 1995 265 270
29. S. Hsiong, T. Boontheekul, N. Huebsch, and D. Mooney Cyclic arginine-glycine-aspartate peptides enhance three-dimensional stem cell osteogenic differentiation Tissue Eng Part A 15 2009 263 272
30. R. Haubner, R. Gratias, B. Diefenbach, S.L. Goodman, A. Jonczyk, and H. Kessler Structural and functional aspects of RGD-containing cyclic pentapeptides as highly potent and selective integrin αVβ3 antagonists J Am Chem Soc 118 1996 7461 7472
31. N. Assa-Munt, X. Jia, P. Laakkonen, and E. Ruoslahti Solution structures and integrin binding activities of an RGD peptide with two isomers Biochemistry 40 2001 2373 2378
32. S. Biltresse, M. Attolini, and J. Marchand-Brynaert Cell adhesive PET membranes by surface grafting of RGD peptidomimetics Biomaterials 26 2005 4576 4587
33. J.R. Klim, A.J. Fowler, A.H. Courtney, P.J. Wrighton, R.T.C. Sheridan, M.L. Wong, and L.L. Kiessling Small-molecule-modified surfaces engage cells through the αvβ3 integrin ACS Chem Biol 7 2012 518 525
34. V. Rerat, G. Dive, Cordi Aa, G.C. Tucker, R. Bareille, J. Amédée, L. Bordenave, and J. Marchand-Brynaert alphavbeta3 Integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers J Med Chem 52 2009 7029 7043
35. C. Dahmen, J. Auernheimer, A. Meyer, A. Enderle, S. Goodman, and H. Kessler Improving implant materials by coating with nonpeptidic, highly specific integrin ligands Angew Chem Int Ed 43 2004 6649 6652
36. F. Rechenmacher, S. Neubauer, J. Polleux, C. Mas-Moruno, M. De Simone, E. Cavalcanti-Adam, J. Spatz, R. Fässler, and H. Kessler Functionalizing αvβ3- or α5β1-selective integrin antagonists for surface coating: a method to discriminate integrin subtypes in vitro Angew Chem Int Ed 52 2013 1572 1575
37. T. Nakaji-Hirabayashi, K. Kato, and H. Iwata Essential role of structural integrity and firm attachment of surface-anchored epidermal growth factor in adherent culture of neural stem cells Biomaterials 29 2008 4403 4408
38. C. Boucher, B. Liberelle, M. Jolicoeur, Y. Durocher, and G. De Crescenzo Epidermal growth factor tethered through coiled-coil interactions induces cell surface receptor phosphorylation Bioconjugate Chem 20 2009 1569 1577
39. B. Keselowsky, D. Collard, and A. García Surface chemistry modulates focal adhesion composition and signaling through changes in integrin binding Biomaterials 25 2004 5947 5954
40. B. Keselowsky, D. Collard, and A. García Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation Proc Natl Acad Sci U S A 102 2005 5953 5957
41. N. Kohen, L. Little, and K. Healy Characterization of Matrigel interfaces during defined human embryonic stem cell culture Biointerphases 4 2009 69 79
42. C. Salinas, and K. Anseth The influence of the RGD peptide motif and its contextual presentation in PEG gels on human mesenchymal stem cell viability J Tissue Eng Regen Med 2 2008 296 304
43. J. Goddard, and J.H. Hotchkiss Polymer surface modification for the attachment of bioactive compounds Prog Polym Sci 32 2007 698 725
44. J. Beer, K. Springer, and B. Coller Immobilized Arg-Gly-Asp (RGD) peptides of varying lengths as structural probes of the platelet glycoprotein IIb/IIIa receptor Blood 79 1992 117 128
45. D. Pallarola, A. Bochen, H. Boehm, F. Rechenmacher, T.R. Sobahi, J.P. Spatz, and H. Kessler Interface immobilization chemistry of cRGD-based peptides regulates integrin mediated cell adhesion Adv Funct Mater 2013 10.1002/adfm.201302411
46. V.H. Fan, K. Tamama, A. Au, R. Littrell, L.B. Richardson, J.W. Wright, A. Wells, and L.G. Griffith Tethered epidermal growth factor provides a survival advantage to mesenchymal stem cells Stem Cells 25 2007 1241 1251
47. B.K. Mann, R.H. Schmedlen, and J.L. West Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells Biomaterials 22 2001 439 444
48. M.K. Horne, D.R. Nisbet, J.S. Forsythe, and C. Parish Three dimensional nanofibrous scaffolds incorporating immobilized BDNF promote proliferation and differentiation of cortical neural stem cells Stem Cells Dev 19 2009 843 852
49. T.Y. Wang, J.S. Forsythe, D.R. Nisbet, and C.L. Parish Promoting engraftment of transplanted neural stem cells/progenitors using biofunctionalised electrospun scaffolds Biomaterials 33 2012 9188 9197
50. Y.Z. Zhang, D.B. Moheban, B.R. Conway, A. Bhattacharyya, and R.A. Segal Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation J Neurosci 20 2000 5671 5678
51. B.L. MacInnis, and R.B. Campenot Retrograde support of neuronal survival without retrograde transport of nerve growth factor Science 295 2002 1536 1539
52. S. Anderson, T. Chen, M. Iruela-Arispe, and T. Segura The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF Biomaterials 30 2009 4618 4628
53. S. Anderson, B. Shergill, Z. Barry, E. Manousiouthakis, T. Chen, E. Botvinick, M. Platt, M. Iruela-Arispe, and T. Segura VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF Integr Biol 3 2011 887 896
54. J. Zheng, W.H. Shen, T.J. Lu, Y. Zhou, Q. Chen, Z. Wang, T. Xiang, Y.C. Zhu, C. Zhang, S. Duan, and Z.Q. Xiong Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth J Biol Chem 283 2008 13280 13288
55. E.V. Amirgoulova, J. Groll, C.D. Heyes, T. Ameringer, C. Röcker, M. Möller, and G.U. Nienhaus Biofunctionalized polymer surfaces exhibiting minimal interaction towards immobilized proteins ChemPhysChem 5 2004 552 555
56. J. Groll, E.V. Amirgoulova, T. Ameringer, C.D. Heyes, C. Röcker, G.U. Nienhaus, and M. Möller Biofunctionalized, ultrathin coatings of cross-linked star-shaped poly(ethylene oxide) allow reversible folding of immobilized proteins J Am Chem Soc 126 2004 4234 4239
57. Q. Liu, A. Singh, R. Lalani, and L. Liu Ultralow fouling polyacrylamide on gold surfaces via surface-initiated atom transfer radical polymerization Biomacromolecules 13 2012 1086 1092
58. D.S. Wavhal, and E.R. Fisher Membrane surface modification by plasma-induced polymerization of acrylamide for improved surface properties and reduced protein fouling Langmuir 19 2003 79 85
59. G. Gunkel, M. Weinhart, T. Becherer, R. Haag, and W. Huck Effect of polymer brush architecture on antibiofouling properties Biomacromolecules 12 2011 4169 4172
60. C. Rodriguez-Emmenegger, E. Brynda, T. Riedel, M. Houska, V. Subr, A. Alles, E. Hasan, J. Gautrot, and W. Huck Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces Macromol Rapid Commun 32 2011 952 957
61. C. Zhao, L. Li, and J. Zheng Achieving highly effective nonfouling performance for surface-grafted poly(HPMA) via atom-transfer radical polymerization Langmuir 26 2010 17375 17382
62. A. Telford, M. James, L. Meagher, and C. Neto Thermally cross-linked PNVP films as antifouling coatings for biomedical applications ACS Appl Mater Interfaces 2 2010 2399 2408
63. S. Jiang, and Z. Cao Ultralow-fouling, functionalizable, and hydrolyzable zwitterionic materials and their derivatives for biological applications Adv Mater 22 2010 920 932
64. L. Zhang, Z. Cao, T. Bai, L. Carr, J.R. Ella-Menye, C. Irvin, B. Ratner, and S. Jiang Zwitterionic hydrogels implanted in mice resist the foreign-body reaction Nat Biotechnol 31 2013 553 556
65. J.E. Krause, N.D. Brault, Y. Li, H. Xue, Y. Zhou, and S. Jiang Photoiniferter-mediated polymerization of zwitterionic carboxybetaine monomers for low-fouling and functionalizable surface coatings Macromolecules 44 2011 9213 9220
66. S. Massia, M. Holecko, and G. Ehteshami In vitro assessment of bioactive coatings for neural implant applications J Biomed Mater Res Part A 68 2004 177 186
67. M. Doran, J. Frith, A. Prowse, J. Fitzpatrick, E. Wolvetang, T. Munro, P. Gray, and J. Cooper-White Defined high protein content surfaces for stem cell culture Biomaterials 31 2010 5137 5142
68. A. Khademhosseini, K. Suh, J. Yang, G. Eng, J. Yeh, S. Levenberg, and R. Langer Layer-by-layer deposition of hyaluronic acid and poly-l-lysine for patterned cell co-cultures Biomaterials 25 2004 3583 3592
69. S. Stabenfeldt, G. Munglani, A. García, and M. LaPlaca Biomimetic microenvironment modulates neural stem cell survival, migration, and differentiation Tissue Eng Part A 16 2010 3747 3758
70. S. Meyers, and M. Grinstaff Biocompatible and bioactive surface modifications for prolonged in vivo efficacy Chem Rev 112 2012 1615 1632
71. C.A. DeForest, and K.S. Anseth Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions Nat Chem 3 2011 925 931
72. A. Hucknall, S. Rangarajan, and A. Chilkoti In pursuit of zero: polymer brushes that resist the adsorption of proteins Adv Mater 21 2009 2441 2446
73. M. Strulson, D. Johnson, and J. Maurer Increased stability of glycol-terminated self-assembled monolayers for long-term patterned cell culture Langmuir 28 2012 4318 4324
74. F.J. Xu, K.G. Neoh, and E.T. Kang Bioactive surfaces and biomaterials via atom transfer radical polymerization Prog Polym Sci 34 2009 719 761
75. R. Barbey, L. Lavanant, D. Paripovic, N. Schüwer, C. Sugnaux, S. Tugulu, and H.A. Klok Polymer brushes via surface-initiated controlled radical polymerization: synthesis, characterization, properties, and applications Chem Rev 109 2009 5437 5527
76. D.J. Siegwart, J.K. Oh, and K. Matyjaszewski ATRP in the design of functional materials for biomedical applications Prog Polym Sci 37 2012 18 37
77. H. Ma, M. Wells, T.P. Beebe, and A. Chilkoti Surface-initiated atom transfer radical polymerization of oligo(ethylene glycol) methyl methacrylate from a mixed self-assembled monolayer on gold Adv Funct Mater 16 2006 640 648
78. J. Kuang, and P. Messersmith Universal surface-initiated polymerization of antifouling zwitterionic brushes using a mussel-mimetic peptide initiator Langmuir 28 2012 7258 7266
79. S. Edmondson, and S.P. Armes Synthesis of surface-initiated polymer brushes using macro-initiators Polym Int 58 2009 307 316
80. L.T. Strover, J. Malmström, O. Laita, J. Reynisson, N. Aydemir, M.K. Nieuwoudt, D.E. Williams, P.R. Dunbar, M.A. Brimble, and J. Travas-Sejdic A new precursor for conducting polymer-based brush interfaces with electroactivity in aqueous solution Polymer 54 2013 1305 1317
81. B. Coad, Y. Lu, V. Glattauer, and L. Meagher Substrate-independent method for growing and modulating the density of polymer brushes from surfaces by ATRP ACS Appl Mater Interfaces 4 2012 2811 2823
82. Tsang K, Hou X, Coad B, Forsythe JS, Meagher L, Thissen H, Ameringer T, Evans R, Pasic P. Polymer coatings. Int Pat Wo/2010/020008; 2010.
83. A. Wörz, B. Berchtold, K. Moosmann, O. Prucker, and J. Rühe Protein-resistant polymer surfaces J Mater Chem 22 2012 19547 19561
84. R. Latour Thermodynamic perspectives on the molecular mechanisms providing protein adsorption resistance that include protein-surface interactions J Biomed Mater Res Part A 78 2006 843 854
85. B. Muir, A. Tarasova, T. Gengenbach, D. Menzies, L. Meagher, F. Rovere, A. Fairbrother, K. McLean, and P. Hartley Characterization of low-fouling ethylene glycol containing plasma polymer films Langmuir 24 2008 3828 3835
86. S. Tugulu, and H.A. Klok Stability and nonfouling properties of poly(poly(ethylene glycol) methacrylate) brushes under cell culture conditions Biomacromolecules 9 2008 906 912
87. D.A. Herold, K. Keil, and D.E. Bruns Oxidation of polyethylene glycols by alcohol dehydrogenase Biochem Pharmacol 38 1989 73 76
88. A. Roosjen, J. de Vries, H. van der Mei, W. Norde, and H. Busscher Stability and effectiveness against bacterial adhesion of poly(ethylene oxide) coatings in biological fluids J Biomed Mater Res Part A 73 2005 347 354
89. J. Ladd, Z. Zhang, S. Chen, J. Hower, and S. Jiang Zwitterionic polymers exhibiting high resistance to nonspecific protein adsorption from human serum and plasma Biomacromolecules 9 2008 1357 1361
90. S. Chen, L. Li, C. Zhao, and J. Zheng Surface hydration: principles and applications toward low-fouling/nonfouling biomaterials Polymer 51 2010 5283 5293
91. Q. Yu, Y. Zhang, H. Wang, J. Brash, and H. Chen Anti-fouling bioactive surfaces Acta Biomater 7 2011 1550 1557
92. A. Halperin, and M. Kröger Ternary protein adsorption onto brushes: strong versus weak Langmuir 25 2009 11621 11634
93. M. Nakajima, T. Ishimuro, K. Kato, I.K. Ko, I. Hirata, Y. Arima, and H. Iwata Combinatorial protein display for the cell-based screening of biomaterials that direct neural stem cell differentiation Biomaterials 28 2007 1048 1060
94. Y. Soen, A. Mori, T. Palmer, and P. Brown Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments Mol Syst Biol 2 2006 37/1-14
95. J. Raynor, J. Capadona, D. Collard, T. Petrie, and A. García Polymer brushes and self-assembled monolayers: versatile platforms to control cell adhesion to biomaterials (review) Biointerphases 4 2009 FA3 FA16
96. T. Hayashi, and M. Hara Nonfouling self-assembled monolayers: mechanisms underlying protein and cell resistance Curr Phys Chem 1 2011 90 98
97. E. Ostuni, R.G. Chapman, M.N. Liang, G. Meluleni, G. Pier, D.E. Ingber, and G.M. Whitesides Self-assembled monolayers that resist the adsorption of proteins and the adhesion of bacterial and mammalian cells Langmuir 17 2001 6336 6343
98. L. Li, S. Chen, J. Zheng, B. Ratner, and S. Jiang Protein adsorption on oligo(ethylene glycol)-terminated alkanethiolate self-assembled monolayers: the molecular basis for nonfouling behavior J Phys Chem B 109 2005 2934 2941
99. P. Vermette, T. Gengenbach, U. Divisekera, P.A. Kambouris, H.J. Griesser, and L. Meagher Immobilization and surface characterization of NeutrAvidin biotin-binding protein on different hydrogel interlayers J Colloid Interface Sci 259 2003 13 26
100. N. Ayres Polymer brushes: applications in biomaterials and nanotechnology Polym Chem 1 2010 769 777
101. L. Little, K. Dane, P. Daugherty, K. Healy, and D. Schaffer Exploiting bacterial peptide display technology to engineer biomaterials for neural stem cell culture Biomaterials 32 2011 1484 1494
102. K. Saha, A.J. Keung, E.F. Irwin, Y. Li, L.E. Little, D.V. Schaffer, and K.E. Healy Substrate modulus directs neural stem cell behavior Biophys J 95 2008 4426 4438
103. M. Berg, S. Yang, P. Hammond, and M. Rubner Controlling mammalian cell interactions on patterned polyelectrolyte multilayer surfaces Langmuir 20 2004 1362 1368
104. T. Ameringer, P. Fransen, P. Bean, G. Johnson, S. Pereira, R.A. Evans, H. Thissen, and L. Meagher Polymer coatings that display specific biological signals while preventing nonspecific interactions J Biomed Mater Res Part A 100 2012 370 379
105. A. Ruiz, L. Buzanska, D. Gilliland, H. Rauscher, L. Sirghi, T. Sobanski, M. Zychowicz, L. Ceriotti, F. Bretagnol, S. Coecke, P. Colpo, and F. Rossi Micro-stamped surfaces for the patterned growth of neural stem cells Biomaterials 29 2008 4766 4774
106. B. Ananthanarayanan, L. Little, D. Schaffer, K. Healy, and M. Tirrell Neural stem cell adhesion and proliferation on phospholipid bilayers functionalized with RGD peptides Biomaterials 31 2010 8706 8715
107. D. Thid, K. Holm, P. Eriksson, J. Ekeroth, B. Kasemo, and J. Gold Supported phospholipid bilayers as a platform for neural progenitor cell culture J Biomed Mater Res Part A 84 2008 940 953
108. A.R. Cameron, J.E. Frith, and J.J. Cooper-White The influence of substrate creep on mesenchymal stem cell behaviour and phenotype Biomaterials 32 2011 5979 5993
109. B. Trappmann, J.E. Gautrot, J.T. Connelly, D.G.T. Strange, Y. Li, M.L. Oyen, M.A. Cohen Stuart, H. Boehm, B. Li, V. Vogel, J.P. Spatz, F.M. Watt, and W.T.S. Huck Extracellular-matrix tethering regulates stem-cell fate Nat Mater 11 2012 642 649
110. C.M. Lo, H.B. Wang, M. Dembo, and Y.L. Wang Cell movement is guided by the rigidity of the substrate Biophys J 79 2000 144 152
111. R. Pelham, and Y. Wang Cell locomotion and focal adhesions are regulated by substrate flexibility Proc Natl Acad Sci U S A 94 1997 13661 13665
112. A.J. Engler, S. Sen, H.L. Sweeney, and D.E. Discher Matrix elasticity directs stem cell lineage specification Cell 126 2006 677 689
113. N.D. Leipzig, and M.S. Shoichet The effect of substrate stiffness on adult neural stem cell behavior Biomaterials 30 2009 6867 6878
114. B. Geiger, J. Spatz, and A. Bershadsky Environmental sensing through focal adhesions Nat Rev Mol Cell Biol 10 2009 21 33
115. D. Discher, P. Janmey, and Y.L. Wang Tissue cells feel and respond to the stiffness of their substrate Science 310 2005 1139 1143
116. A. Keung, K. Healy, S. Kumar, and D. Schaffer Biophysics and dynamics of natural and engineered stem cell microenvironments Wiley Interdiscip Rev Syst Biol Med 2 2010 49 64
117. B. Trappmann, and C.S. Chen How cells sense extracellular matrix stiffness: a material's perspective Curr Opin Biotechnol 24 2013 948 953
118. N. Huebsch, P.R. Arany, A.S. Mao, D. Shvartsman, O.A. Ali, S.A. Bencherif, J. Rivera-Feliciano, and D.J. Mooney Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate Nat Mater 9 2010 518 526
119. A. Keung, E. de Juan-Pardo, D. Schaffer, and S. Kumar Rho GTPases mediate the mechanosensitive lineage commitment of neural stem cells Stem Cells 29 2011 1886 1897
120. C. Grashoff, B.D. Hoffman, M.D. Brenner, R. Zhou, M. Parsons, M.T. Yang, M.A. McLean, S.G. Sligar, C.B. Chen, T. Ha, and M.A. Schwartz Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics Nature 466 2010 263 266
121. D. Discher, D. Mooney, and P. Zandstra Growth factors, matrices, and forces combine and control stem cells Science 324 2009 1673 1677
122. A. Keung, S. Kumar, and D. Schaffer Presentation counts: microenvironmental regulation of stem cells by biophysical and material cues Ann Rev Cell Dev Biol 26 2010 533 556
123. R. Marklein, and J. Burdick Controlling stem cell fate with material design Adv Mater 22 2010 175 189
124. W. Algar, D. Prasuhn, M. Stewart, T. Jennings, J. Blanco-Canosa, P. Dawson, and I. Medintz The controlled display of biomolecules on nanoparticles: a challenge suited to bioorthogonal chemistry Bioconjugate Chem 22 2011 825 858
125. F. Rusmini, Z. Zhong, and J. Feijen Protein immobilization strategies for protein biochips Biomacromolecules 8 2007 1775 1789
126. C.S. Hughes, L.M. Postovit, G.A. Lajoie, and Matrigel: A complex protein mixture required for optimal growth of cell culture Proteomics 10 2010 1886 1890
127. C. Hughes, L. Radan, D. Betts, L. Postovit, and G. Lajoie Proteomic analysis of extracellular matrices used in stem cell culture Proteomics 11 2011 3983 3991
128. F. Yang, S.W. Cho, S. Son, S. Hudson, S. Bogatyrev, L. Keung, D. Kohane, R. Langer, and D. Anderson Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D Biomacromolecules 11 2010 1909 1914
129. J. Lee, H.S. Yu, G.S. Lee, A. Ji, J. Hyun, and H.W. Kim Collagen gel three-dimensional matrices combined with adhesive proteins stimulate neuronal differentiation of mesenchymal stem cells J R Soc Interface 8 2011 998 1010
130. J. Matson, R. Zha, and S. Stupp Peptide self-assembly for crafting functional biological materials Curr Opin Solid State Mater Sci 15 2011 225 235
131. D. Nisbet, and R. Williams Self-assembled peptides: characterisation and in vivo response Biointerphases 7 2012 2/1-14
132. M. Guler, L. Hsu, S. Soukasene, D. Harrington, J. Hulvat, and S. Stupp Presentation of RGDS epitopes on self-assembled nanofibers of branched peptide amphiphiles Biomacromolecules 7 2006 1855 1863
133. H. Storrie, M. Guler, S. Abu-Amara, T. Volberg, M. Rao, B. Geiger, and S. Stupp Supramolecular crafting of cell adhesion Biomaterials 28 2007 4608 4618
134. M. Zhou, A. Smith, A. Das, N. Hodson, R. Collins, R. Ulijn, and J. Gough Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells Biomaterials 30 2009 2523 2530
135. A.L. Rodriguez, C.L. Parish, D.R. Nisbet, and R.J. Williams Tuning the amino acid sequence of minimalist peptides to present biological signals via charge neutralised self assembly Soft Matter 9 2013 3915 3919
136. F. Gelain, D. Bottai, A. Vescovi, and S. Zhang Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures PLoS ONE 1 e119 2006 1 11
137. C. Cunha, S. Panseri, O. Villa, D. Silva, and F. Gelain 3D culture of adult mouse neural stem cells within functionalized self-assembling peptide scaffolds Int J Nanomed 6 2011 943 955
138. K. Lampe, and S. Heilshorn Building stem cell niches from the molecule up through engineered peptide materials Neurosci Lett 519 2012 138 146
139. R. DiMarco, and S. Heilshorn Multifunctional materials through modular protein engineering Adv Mater 24 2012 3923 3940
140. C.W.P. Foo, J. Lee, W. Mulyasasmita, A. Parisi-Amon, and S. Heilshorn Two-component protein-engineered physical hydrogels for cell encapsulation Proc Natl Acad Sci U S A 106 2009 22067 22072
141. C. Flaim, S. Chien, and S. Bhatia An extracellular matrix microarray for probing cellular differentiation Nat Methods 2 2005 119 125
142. K.E. Michael, V.N. Vernekar, B.G. Keselowsky, J.C. Meredith, R.A. Latour, and A.J. García Adsorption-induced conformational changes in fibronectin due to interactions with well-defined surface chemistries Langmuir 19 2003 8033 8040
143. R. Gunawan, J. King, B. Lee, P. Messersmith, and W. Miller Surface presentation of bioactive ligands in a nonadhesive background using DOPA-tethered biotinylated poly(ethylene glycol) Langmuir 23 2007 10635 10643
144. H. Lee, J. Rho, and P. Messersmith Facile conjugation of biomolecules onto surfaces via mussel adhesive protein inspired coatings Adv Mater 21 2009 431 434
145. S. Saxer, C. Portmann, S. Tosatti, K. Gademann, S. Zürcher, and M. Textor Surface assembly of catechol-functionalized poly(l-lysine)-graft- poly(ethylene glycol) copolymer on titanium exploiting combined electrostatically driven self-organization and biomimetic strong adhesion Macromolecules 43 2010 1050 1060
146. Y. Mei, K. Saha, S. Bogatyrev, J. Yang, A. Hook, Z. Kalcioglu, S.W. Cho, M. Mitalipova, N. Pyzocha, F. Rojas, K. Van Vliet, M. Davies, M. Alexander, R. Langer, R. Jaenisch, and D. Anderson Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells Nat Mater 9 2010 768 778
147. K. Saha, Y. Mei, C. Reisterer, N. Pyzocha, J. Yang, J. Muffat, M. Davies, M. Alexander, R. Langer, D. Anderson, and R. Jaenisch Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions Proc Natl Acad Sci U S A 108 2011 18714 18719
148. G. Hudalla, and W. Murphy Biomaterials that regulate growth factor activity via bioinspired interactions Adv Funct Mater 21 2011 1754 1768
149. N.X. Wang, and H.A. von Recum Affinity-based drug delivery Macromol Biosci 11 2011 321 332
150. C. McGann, and K. Kiick Heparin-functionalized materials in tissue engineering applications S.K. Bhatia, Engineering biomaterials for regenerative medicine 2012 Springer New York 225 250
151. U. Freudenberg, A. Hermann, P. Welzel, K. Stirl, S. Schwarz, M. Grimmer, A. Zieris, W. Panyanuwat, S. Zschoche, D. Meinhold, A. Storch, and C. Werner A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases Biomaterials 30 2009 5049 5060
152. S.E. Sakiyama-Elbert Drug delivery via heparin conjugates P. Ducheyne, K. Healy, D. Hutmacher, D.W. Grainger, C.J. Kirkpatrick, Comprehensive biomaterials vol. 4 2011 Elsevier Sci Amsterdam 333 338
153. D. Benoit, A. Durney, and K. Anseth The effect of heparin-functionalized PEG hydrogels on three-dimensional human mesenchymal stem cell osteogenic differentiation Biomaterials 28 2007 66 77
154. T. Nie, A. Baldwin, N. Yamaguchi, and K. Kiick Production of heparin-functionalized hydrogels for the development of responsive and controlled growth factor delivery systems J Controlled Release 122 2007 287 296
155. G. Hudalla, N. Kouris, J. Koepsel, B. Ogle, and W. Murphy Harnessing endogenous growth factor activity modulates stem cell behavior Integr Biol 3 2011 832 842
156. G. Hudalla, J. Koepsel, and W. Murphy Surfaces that sequester serum-borne heparin amplify growth factor activity Adv Mater 23 2011 5415 5418
157. G. Hudalla, and W. Murphy Immobilization of peptides with distinct biological activities onto stem cell culture substrates using orthogonal chemistries Langmuir 26 2010 6449 6456
158. J. Klim, L. Li, P. Wrighton, M. Piekarczyk, and L. Kiessling A defined glycosaminoglycan-binding substratum for human pluripotent stem cells Nat Methods 7 2010 989 994
159. S. Willerth, A. Rader, and S. Sakiyama-Elbert The effect of controlled growth factor delivery on embryonic stem cell differentiation inside fibrin scaffolds Stem Cell Res 1 2008 205 218
160. S. Sakiyama-Elbert, and J. Hubbell Development of fibrin derivatives for controlled release of heparin-binding growth factors J Controlled Release 65 2000 389 402
161. K. Rajangam, H. Behanna, M. Hui, X. Han, J. Hulvat, J. Lomasney, and S. Stupp Heparin binding nanostructures to promote growth of blood vessels Nano Lett 6 2006 2086 2090
162. L. Chow, L.J. Wang, D. Kaufman, and S. Stupp Self-assembling nanostructures to deliver angiogenic factors to pancreatic islets Biomaterials 31 2010 6154 6161
163. A. Kanematsu, A. Marui, S. Yamamoto, M. Ozeki, Y. Hirano, M. Yamamoto, O. Ogawa, M. Komeda, and Y. Tabata Type I collagen can function as a reservoir of basic fibroblast growth factor J Controlled Release 99 2004 281 292
164. A. Goerges, and M. Nugent pH regulates vascular endothelial growth factor binding to fibronectin: a mechanism for control of extracellular matrix storage and release J Biol Chem 279 2004 2307 2315
165. C.C. Lin, and K. Anseth Controlling affinity binding with peptide-functionalized poly(ethylene glycol) hydrogels Adv Funct Mater 19 2009 2325 2331
166. J. McCall, C.C. Lin, and K. Anseth Affinity peptides protect transforming growth factor beta during encapsulation in poly(ethylene glycol) hydrogels Biomacromolecules 12 2011 1051 1057
167. R.N. Shah, N.A. Shah, M.M. Del Rosario Lim, C. Hsieh, G. Nuber, and S.I. Stupp Supramolecular design of self-assembling nanofibers for cartilage regeneration Proc Natl Acad Sci U S A 107 2010 3293 3298
168. S. Kim, and K. Kiick Heparin-mimetic sulfated peptides with modulated affinities for heparin-binding peptides and growth factors Peptides 28 2007 2125 2136
169. H. Maynard, and J. Hubbell Discovery of a sulfated tetrapeptide that binds to vascular endothelial growth factor Acta Biomater 1 2005 451 459
170. K. Christman, V. Vázquez-Dorbatt, E. Schopf, C. Kolodziej, R. Li, R. Broyer, Y. Chen, and H. Maynard Nanoscale growth factor patterns by immobilization on a heparin-mimicking polymer J Am Chem Soc 130 2008 16585 16591
171. C. Kolodziej, S. Kim, R. Broyer, S. Saxer, C. Decker, and H. Maynard Combination of integrin-binding peptide and growth factor promotes cell adhesion on electron-beam-fabricated patterns J Am Chem Soc 134 2012 247 255
172. T. Chen, A. Luque, S. Lee, S. Anderson, T. Segura, and M. Iruela-Arispe Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells J Cell Biol 188 2010 595 609
173. A.J. de Graaf, M. Kooijman, W.E. Hennink, and E. Mastrobattista Nonnatural amino acids for site-specific protein conjugation Bioconjugate Chem 20 2009 1281 1295
174. G.T. Hermanson Bioconjugate techniques 2nd ed. 2008 Elsevier Amsterdam 1323
175. Y. Aizawa, N. Leipzig, T. Zahir, and M. Shoichet The effect of immobilized platelet derived growth factor AA on neural stem/progenitor cell differentiation on cell-adhesive hydrogels Biomaterials 29 2008 4676 4683
176. N. Leipzig, C. Xu, T. Zahir, and M. Shoichet Functional immobilization of
177. M.J. Roberts, M.D. Bentley, and J.M. Harris Chemistry for peptide and protein PEGylation Adv Drug Deliv Rev 54 2002 459 476
178. P. Sejwal, S.K. Narasimhan, D. Prashar, D. Bandyopadhyay, and Y.Y. Luk Selective immobilization of peptides exclusively via N-terminus cysteines by water-driven reactions on surfaces J Org Chem 74 2009 6843 6846
179. I. Carrico Chemoselective modification of proteins: hitting the target Chem Soc Rev 37 2008 1423 1431
180. M. Gauthier, and H.A. Klok Peptide/protein-polymer conjugates: synthetic strategies and design concepts Chem Commun 2008 2591 2611
181. E. Phelps, N. Enemchukwu, V. Fiore, J. Sy, N. Murthy, T. Sulchek, T. Barker, and A. García Maleimide cross-linked bioactive PEG hydrogel exhibits improved reaction kinetics and cross-linking for cell encapsulation and in situ delivery Adv Mater 24 2012 64 70
182. J. Ichinose, M. Morimatsu, T. Yanagida, and Y. Sako Covalent immobilization of epidermal growth factor molecules for single-molecule imaging analysis of intracellular signaling Biomaterials 27 2006 3343 3350
183. R. Lösel, D. Grafahrend, M. Möller, and D. Klee Bioresorbable electrospun fibers for immobilization of thiol-containing compounds Macromol Biosci 10 2010 1177 1183
184. B.D. Fairbanks, M.P. Schwartz, A.E. Halevi, C.R. Nuttelman, C.N. Bowman, and K.S. Anseth A versatile synthetic extracellular matrix mimic via thiol-norbornene photopolymerization Adv Mater 21 2009 5005 5010
185. K. Gujraty, R. Ashton, S. Bethi, S. Kate, C. Faulkner, G. Jennings, and R. Kane Thiol-mediated anchoring of ligands to self-assembled monolayers for studies of biospecific interactions Langmuir 22 2006 10157 10162
186. M.H. Stenzel Bioconjugation using thiols: old chemistry rediscovered to connect polymers with nature's building blocks ACS Macro Lett 2 2013 14 18
187. C. Hoyle, A. Lowe, and C. Bowman Thiol-click chemistry: a multifaceted toolbox for small molecule and polymer synthesis Chem Soc Rev 39 2010 1355 1387
188. H. Ban, J. Gavrilyuk, and C. Barbas Tyrosine bioconjugation through aqueous ene-type reactions: a click-like reaction for tyrosine J Am Chem Soc 132 2010 1523 1525
189. A. Vashi, J. Ramshaw, V. Glattauer, C. Elvin, R. Lyons, and J. Werkmeister Controlled surface modification of tissue culture polystyrene for selective cell binding using resilin-inspired polypeptides Biofabrication 5 2013 035005/1-9
190. R. Barbucci, A. Magnani, A. Chiumiento, D. Pasqui, I. Cangioli, and S. Lamponi Fibroblast cell behavior on bound and adsorbed fibronectin onto hyaluronan and sulfated hyaluronan substrates Biomacromolecules 6 2005 638 645
191. J. Ho, E. Chung, S. Wall, D. Schaffer, and K. Healy Immobilized sonic hedgehog N-terminal signaling domain enhances differentiation of bone marrow-derived mesenchymal stem cells J Biomed Mater Res Part A 83 2007 1200 1208
192. M. Backer, V. Patel, B. Jehning, K. Claffey, and J. Backer Surface immobilization of active vascular endothelial growth factor via a cysteine-containing tag Biomaterials 27 2006 5452 5458
193. A.H. Zisch, M.P. Lutolf, M. Ehrbar, G.P. Raeber, S.C. Rizzi, N. Davies, H. Schmökel, D. Bezuidenhuit, V. Djonov, P. Zilla, and J.A. Hubbell Cell-demanded release of VEGF from synthetic, biointeractive cell-ingrowth matrices for vascularized tissue growth FASEB J 17 2003 2260 2262
194. E. Sletten, and C. Bertozzi Bioorthogonal chemistry: fishing for selectivity in a sea of functionality Angew Chem Int Ed 48 2009 6974 6998
195. J. Johnson, Y. Lu, J. Van Deventer, and D. Tirrell Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications Curr Opin Chem Biol 14 2010 774 780
196. D. Rabuka Chemoenzymatic methods for site-specific protein modification Curr Opin Chem Biol 14 2010 790 796
197. I. Carrico, B. Carlson, and C. Bertozzi Introducing genetically encoded aldehydes into proteins Nat Chem Biol 3 2007 321 322
198. J. Gilmore, R. Scheck, A. Esser-Kahn, N. Joshi, and M. Francis N-terminal protein modification through a biomimetic transamination reaction Angew Chem Int Ed 45 2006 5307 5311
199. B.P. Duckworth, J. Xu, T.A. Taton, A. Guo, and M.D. Distefano Site-specific, covalent attachment of proteins to a solid surface Bioconjugate Chem 17 2006 967 974
200. X.L. Sun, C. Stabler, C. Cazalis, and E. Chaikof Carbohydrate and protein immobilization onto solid surfaces by sequential Diels-Alder and azide-alkyne cycloadditions Bioconjugate Chem 17 2006 52 57
201. N.D. Leipzig, R.G. Wylie, H. Kim, and M.S. Shoichet Differentiation of neural stem cells in three-dimensional growth factor-immobilized chitosan hydrogel scaffolds Biomaterials 32 2011 57 64
202. I. Carrico, S. Maskarinec, S. Heilshorn, M. Mock, J. Liu, P. Nowatzki, C. Franck, G. Ravichandran, and D. Tirrell Lithographic patterning of photoreactive cell-adhesive proteins J Am Chem Soc 129 2007 4874 4875
203. K. Ogiwara, M. Nagaoka, C.S. Cho, and T. Akaike Effect of photo-immobilization of epidermal growth factor on the cellular behaviors Biochem Biophys Res Commun 345 2006 255 259
204. K. Zhang, M. Diehl, and D. Tirrell Artificial polypeptide scaffold for protein immobilization J Am Chem Soc 127 2005 10136 10137
205. A. de Araújo, J. Palomo, J. Cramer, M. Köhn, H. Schröder, R. Wacker, C. Niemeyer, K. Alexandrov, and H. Waldmann Diels-Alder ligation and surface immobilization of proteins Angew Chem Int Ed 45 2005 296 301
206. M.R. Doran, B.D. Markway, T.I. Croll, S. Sara, T.P. Munro, and J.J. Cooper-White Controlled presentation of recombinant proteins via a zinc-binding peptide-linker in two and three dimensional formats Biomaterials 30 2009 6614 6620
207. T. Nakaji-Hirabayashi, K. Kato, and H. Iwata Improvement of neural stem cell survival in collagen hydrogels by incorporating laminin-derived cell adhesive polypeptides Bioconjugate Chem 23 2012 212 221
208. M. Hiraoka, K. Kato, T. Nakaji-Hirabayashi, and H. Iwata Enhanced survival of neural cells embedded in hydrogels composed of collagen and laminin-derived cell adhesive peptide Bioconjugate Chem 20 2009 976 983
209. S. Konagaya, K. Kato, T. Nakaji-Hirabayashi, and H. Iwata Design of culture substrates for large-scale expansion of neural stem cells Biomaterials 32 2011 992 1001
210. R. Wylie, and M. Shoichet Three-dimensional spatial patterning of proteins in hydrogels Biomacromolecules 12 2011 3789 3796
211. R.G. Wylie, S. Ahsan, Y. Aizawa, K.L. Maxwell, C.M. Morshead, and M.S. Shoichet Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels Nat Mater 10 2011 799 806
212. C. Nimmo, and M. Shoichet Regenerative biomaterials that "click": simple, aqueous-based protocols for hydrogel synthesis, surface immobilization, and 3D patterning Bioconjugate Chem 22 2011 2199 2209
213. H. Nandivada, X. Jiang, and J. Lahann Click chemistry: versatility and control in the hands of materials scientists Adv Mater 19 2007 2197 2208
214. H. Kolb, M. Finn, and K. Sharpless Click chemistry: diverse chemical function from a few good reactions Angew Chem Int Ed 40 2001 2004 2021
215. N. Gallant, K. Lavery, E. Amis, and M. Becker Universal gradient substrates for "Click" biofunctionalization Adv Mater 19 2007 965 969
216. J.F. Lutz, H.G. Börner, and K. Weichenhan Combining ATRP and "Click" chemistry: a promising platform toward functional biocompatible polymers and polymer bioconjugates Macromolecules 39 2006 6376 6383
217. T. Ameringer, F. Ercole, K.M. Tsang, B.R. Coad, X. Hou, A. Rodda, D.R. Nisbet, H. Thissen, R.A. Evans, L. Meagher, and J.S. Forsythe Surface grafting of electrospun fibers using ATRP and RAFT for the control of biointerfacial interactions Biointerphases 2013 8/1-11
218. R.A. Evans The rise of azide-alkyne 1, 3-dipolar 'Click' cycloaddition and its application to polymer science and surface modification Aust J Chem 60 2007 384 395
219. C. DeForest, B. Polizzotti, and K. Anseth Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments Nat Mater 8 2009 659 664
220. M.A. Tasdelen Diels-Alder "click" reactions: recent applications in polymer and material science Polym Chem 2 2011 2133 2145
221. Shoichet MS, Yuan Y, Shi M, Wosnick J. Method of biomolecule immobilization on polymers using click-type chemistry. US Pat Appl 2009/0297609 A1; 2009.
222. M.N. Yousaf, and M. Mrksich Diels-Alder reaction for the selective immobilization of protein to electroactive self-assembled monolayers J Am Chem Soc 121 1999 4286 4287
223. W. Dillmore, M. Yousaf, and M. Mrksich A photochemical method for patterning the immobilization of ligands and cells to self-assembled monolayers Langmuir 20 2004 7223 7231
224. M. Yousaf, B. Houseman, and M. Mrksich Using electroactive substrates to pattern the attachment of two different cell populations Proc Natl Acad Sci U S A 98 2001 5992 5996
225. E. Chan, and M. Yousaf Immobilization of ligands with precise control of density to electroactive surfaces J Am Chem Soc 128 2006 15542 15546
226. E. Chan, and M. Yousaf Site-selective immobilization of ligands with control of density on electroactive microelectrode arrays ChemPhysChem 8 2007 1469 1472
227. E. Chan, and M. Yousaf A photo-electroactive surface strategy for immobilizing ligands in patterns and gradients for studies of cell polarization Mol Biosyst 4 2008 746 753
228. D. Hoover, E. Chan, and M. Yousaf Asymmetric peptide nanoarray surfaces for studies of single cell polarization J Am Chem Soc 130 2008 3280 3281
229. D.K. Hoover, Lee Ej, E.W.L. Chan, and M.N. Yousaf Electroactive nanoarrays for biospecific ligand mediated studies of cell adhesion Chembiochem 8 2007 1920 1923
230. T. Pauloehrl, G. Delaittre, M. Bruns, M. Meißler, H. Börner, M. Bastmeyer, and C. Barner-Kowollik (Bio)molecular surface patterning by phototriggered oxime ligation Angew Chem Int Ed 51 2012 9181 9184
231. D. Rabuka, J. Rush, G. deHart, P. Wu, and C. Bertozzi Site-specific chemical protein conjugation using genetically encoded aldehyde tags Nat Protoc 7 2012 1052 1067
232. K.L. Christman, R.M. Broyer, Z.P. Tolstyka, and H.D. Maynard Site-specific protein immobilization through N-terminal oxime linkages J Mater Chem 17 2007 2021 2027
233. M. Dettin, N. Muncan, A. Bugatti, F. Grezzo, R. Danesin, and M. Rusnati Chemoselective surface immobilization of proteins through a cleavable peptide Bioconjugate Chem 22 2011 1753 1757
234. J.C. Hoffmann, and J.L. West Three-dimensional photolithographic patterning of multiple bioactive ligands in poly(ethylene glycol) hydrogels Soft Matter 6 2010 5056 5063
235. M. Azagarsamy, and K. Anseth Bioorthogonal click chemistry: an indispensable tool to create multifaceted cell culture scaffolds ACS Macro Lett 2 2013 5 9
236. H. Jeon, R. Schmidt, J. Barton, D. Hwang, L. Gamble, D. Castner, C. Grigoropoulos, and K. Healy Chemical patterning of ultrathin polymer films by direct-write multiphoton lithography J Am Chem Soc 133 2011 6138 6141
237. T. Shahal, B. Geiger, I. Dunlop, and J. Spatz Regulation of integrin adhesions by varying the density of substrate-bound epidermal growth factor Biointerphases 7 2012 23/1-11
238. N. Patel, R. Padera, G. Sanders, S. Cannizzaro, M. Davies, R. Langer, C. Roberts, S. Tendler, P. Williams, and K. Shakesheff Spatially controlled cell engineering on biodegradable polymer surfaces FASEB J 12 1998 1447 1454
239. K. Christman, E. Schopf, R. Broyer, R. Li, Y. Chen, and H. Maynard Positioning multiple proteins at the nanoscale with electron beam cross-linked functional polymers J Am Chem Soc 131 2009 521 527
240. R. Schmidt, and K. Healy Effect of avidin-like proteins and biotin modification on mesenchymal stem cell adhesion Biomaterials 34 2013 3758 3762
241. S. Konagaya, K. Kato, T. Nakaji-Hirabayashi, Y. Arima, and H. Iwata Array-based functional screening of growth factors toward optimizing neural stem cell microenvironments Biomaterials 32 2011 5015 5022
242. T. Nakaji-Hirabayashi, K. Kato, Y. Arima, and H. Iwata Oriented immobilization of epidermal growth factor onto culture substrates for the selective expansion of neural stem cells Biomaterials 28 2007 3517 3529
243. M. Dubey, K. Emoto, H. Takahashi, D. Castner, and D. Grainger Affinity-based protein surface pattern formation by ligand self-selection from mixed protein solutions Adv Funct Mater 19 2009 3046 3055
244. E. Egawa, K. Kato, M. Hiraoka, T. Nakaji-Hirabayashi, and H. Iwata Enhanced proliferation of neural stem cells in a collagen hydrogel incorporating engineered epidermal growth factor Biomaterials 32 2011 4737 4743
245. N. Nishi, O. Matsushita, K. Yuube, H. Miyanaka, A. Okabe, and F. Wada Collagen-binding growth factors: production and characterization of functional fusion proteins having a collagen-binding domain Proc Natl Acad Sci U S A 95 1998 7018 7023
246. S. Meyers, X. Khoo, X. Huang, E. Walsh, M. Grinstaff, and D. Kenan The development of peptide-based interfacial biomaterials for generating biological functionality on the surface of bioinert materials Biomaterials 30 2009 277 286
247. S.R. Meyers, D.J. Kenan, X. Khoo, and M.W. Grinstaff Bioactive stent surface coating that promotes endothelialization while preventing platelet adhesion Biomacromolecules 12 2011 533 539
248. X. Huang, S. Zauscher, B. Klitzman, G.A. Truskey, W.M. Reichert, D.J. Kenan, and M.W. Grinstaff Peptide interfacial biomaterials improve endothelial cell adhesion and spreading on synthetic polyglycolic acid materials Ann Biomed Eng 38 2010 1965 1976
249. A.B. Sanghvi, K.P.H. Miller, A.M. Belcher, and C.E. Schmidt Biomaterials functionalization using a novel peptide that selectively binds to a conducting polymer Nat Mater 4 2005 496 502
250. L. Forciniti, C. Schmidt, and M. Zaman Computational model provides insight into the distinct responses of neurons to chemical and topographical cues Ann Biomed Eng 37 2009 363 374
251. A. Rowlands, P. George, and J. Cooper-White Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation Am J Physiol Cell Physiol 295 2008 C1037 C1044
252. Y. Luo, and M. Shoichet A photolabile hydrogel for guided three-dimensional cell growth and migration Nat Mater 3 2004 249 253
253. F.J. Xu, H.Z. Li, J. Li, Y.H.E. Teo, C.X. Zhu, E.T. Kang, and K.G. Neoh Spatially well-defined binary brushes of poly(ethylene glycol)s for micropatterning of active proteins on anti-fouling surfaces Biosens Bioelectron 24 2008 773 780
254. L. Lavanant, B. Pullin, J. Hubbell, and H.A. Klok A facile strategy for the modification of polyethylene substrates with non-fouling, bioactive poly(poly(ethylene glycol) methacrylate) brushes Macromol Biosci 10 2010 101 108
255. S. Tugulu, P. Silacci, N. Stergiopulos, and H.A. Klok RGD-functionalized polymer brushes as substrates for the integrin specific adhesion of human umbilical vein endothelial cells Biomaterials 28 2007 2536 2546
256. 2 for immobilization of proteins and cells: SPR and QCM studies Biomacromolecules 8 2007 3922 3929
257. X. Ren, Y. Wu, Y. Cheng, H. Ma, and S. Wei Fibronectin and bone morphogenetic protein-2-decorated poly(OEGMA-r-HEMA) brushes promote osseointegration of titanium surfaces Langmuir 27 2011 12069 12073
258. K. Alberti, R. Davey, K. Onishi, S. George, K. Salchert, F. Seib, M. Bornhäuser, T. Pompe, A. Nagy, C. Werner, and P. Zandstra Functional immobilization of signaling proteins enables control of stem cell fate Nat Methods 5 2008 645 650
259. F. Xu, Z. Wang, and W. Yang Surface functionalization of polycaprolactone films via surface-initiated atom transfer radical polymerization for covalently coupling cell-adhesive biomolecules Biomaterials 31 2010 3139 3147
260. F. Xu, S. Zhong, L. Yung, Y. Tong, E. Kang, and K. Neoh Collagen-coupled poly(2-hydroxyethyl methacrylate)-Si(1 1 1) hybrid surfaces for cell immobilization Tissue Eng 11 2005 1736 1748
261. S. Alang Ahmad, A. Hucknall, A. Chilkoti, and G. Leggett Protein patterning by UV-induced photodegradation of poly(oligo(ethylene glycol) methacrylate) brushes Langmuir 26 2010 9937 9942
262. D. Grafahrend, K.H. Heffels, M. Beer, P. Gasteier, M. Möller, G. Boehm, P. Dalton, and J. Groll Degradable polyester scaffolds with controlled surface chemistry combining minimal protein adsorption with specific bioactivation Nat Mater 10 2011 67 73
263. C.A. DeForest, and K.S. Anseth Photoreversible patterning of biomolecules within click-based hydrogels Angew Chem 124 2012 1852 1855
264. M. Arnold, E. Cavalcanti-Adam, R. Glass, J. Blümmel, W. Eck, M. Kantlehner, H. Kessler, and J. Spatz Activation of integrin function by nanopatterned adhesive interfaces ChemPhysChem 5 2004 383 388
265. D. Aydin, I. Louban, N. Perschmann, J. Blümmel, T. Lohmüller, E. Cavalcanti-Adam, T. Haas, H. Walczak, H. Kessler, R. Fiammengo, and J. Spatz Polymeric substrates with tunable elasticity and nanoscopically controlled biomolecule presentation Langmuir 26 2010 15472 15480
266. E. Cavalcanti-Adam, T. Volberg, A. Micoulet, H. Kessler, B. Geiger, and J. Spatz Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands Biophys J 92 2007 2964 2974
267. J. Deeg, I. Louban, D. Aydin, C. Selhuber-Unkel, H. Kessler, and J. Spatz Impact of local versus global ligand density on cellular adhesion Nano Lett 11 2011 1469 1476
268. C. Selhuber-Unkel, T. Erdmann, M. López-García, H. Kessler, U. Schwarz, and J. Spatz Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors Biophys J 98 2010 543 551
269. M.V. Beer, C. Rech, P. Gasteier, B. Sauerzapfe, J. Salber, A. Ewald, M. Möller, L. Elling, and J. Groll The next step in biomimetic material design: poly-LacNAc-mediated reversible exposure of extra cellular matrix components Adv Healthc Mater 2 2012 306 311
270. S. Park, and M. Yousaf An interfacial oxime reaction to immobilize ligands and cells in patterns and gradients to photoactive surfaces Langmuir 24 2008 6201 6207
271. M. Hahn, L. Taite, J. Moon, M. Rowland, K. Ruffino, and J. West Photolithographic patterning of polyethylene glycol hydrogels Biomaterials 27 2006 2519 2524
272. J. Hoffmann, and J. West Three-dimensional photolithographic micropatterning: a novel tool to probe the complexities of cell migration Integr Biol 5 2013 817 827
273. S.H. Lee, J. Moon, and J. West Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration Biomaterials 29 2008 2962 2968
274. D.H. Kim, H. Lee, Y. Lee, J.M. Nam, and A. Levchenko Biomimetic nanopatterns as enabling tools for analysis and control of live cells Adv Mater 22 2010 4551 4566
275. M théry Micropatterning as a tool to decipher cell morphogenesis and functions J Cell Sci 123 2010 4201 4213
276. M. Arnold, V. Hirschfeld-Warneken, T. Lohmüller, P. Heil, J. Blümmel, E. Cavalcanti-Adam, M. López-García, P. Walther, H. Kessler, B. Geiger, and J. Spatz Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing Nano Lett 8 2008 2063 2069
277. K. Moore, M. MacSween, and M. Shoichet Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds Tissue Eng 12 2006 267 278
278. A. Telford, L. Meagher, V. Glattauer, T. Gengenbach, C. Easton, and C. Neto Micropatterning of polymer brushes: grafting from dewetting polymer films for biological applications Biomacromolecules 13 2012 2989 2996
279. P. Zorlutuna, N. Annabi, G. Camci-Unal, M. Nikkhah, J. Cha, J. Nichol, A. Manbachi, H. Bae, S. Chen, and A. Khademhosseini Microfabricated biomaterials for engineering 3D tissues Adv Mater 24 2012 1782 1804
280. K.L. Christman, V.D. Enriquez-Rios, and H.D. Maynard Nanopatterning proteins and peptides Soft Matter 2 2006 928 939
281. T. Ekblad, and B. Liedberg Protein adsorption and surface patterning Curr Opin Colloid Interface Sci 15 2010 499 509
282. I. Wheeldon, A. Farhadi, A. Bick, E. Jabbari, and A. Khademhosseini Nanoscale tissue engineering: spatial control over cell-materials interactions Nanotechnology 2011 22/212001/1-16
283. D. Falconnet, G. Csucs, H. Grandin, and M. Textor Surface engineering approaches to micropattern surfaces for cell-based assays Biomaterials 27 2006 3044 3063
284. A.M. Ross, and J. Lahann Surface engineering the cellular microenvironment via patterning and gradients J Polym Sci Part B Polym Phys 51 2013 775 794
285. D. Qin, Y. Xia, and G. Whitesides Soft lithography for micro- and nanoscale patterning Nat Protoc 5 2010 491 502
286. R. Kane, S. Takayama, E. Ostuni, D. Ingber, and G. Whitesides Patterning proteins and cells using soft lithography Biomaterials 20 1999 2363 2376
287. S.A. Ruiz, and C.S. Chen Microcontact printing: a tool to pattern Soft Matter 3 2007 168 177
288. G. Csucs, T. Künzler, K. Feldman, F. Robin, and N.D. Spencer Microcontact printing of macromolecules with submicrometer resolution by means of polyolefin stamps Langmuir 19 2003 6104 6109
289. A.B. Faia-Torres, T. Goren, M. Textor, and M. Pla-Roca Patterned biointerfaces P. Ducheyne, K. Healy, D. Hutmacher, D.W. Grainger, C.J. Kirkpatrick, Comprehensive biomaterials vol. 4 2011 Elsevier Sci Amsterdam 181 201
290. C. Chen, M. Mrksich, S. Huang, G. Whitesides, and D. Ingber Geometric control of cell life and death Science 276 1997 1425 1428
291. D. Lehnert, B. Wehrle-Haller, C. David, U. Weiland, C. Ballestrem, B. Imhof, and M. Bastmeyer Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion J Cell Sci 117 2004 41 52
292. S. Coyer, E. Delamarche, and A. García Protein tethering into multiscale geometries by covalent subtractive printing Adv Mater 23 2011 1550 1553
293. S. Coyer, A. Singh, D. Dumbauld, D. Calderwood, S. Craig, E. Delamarche, and A. García Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension J Cell Sci 125 2012 5110 5123
294. K. Kilian, B. Bugarija, B. Lahn, and M. Mrksich Geometric cues for directing the differentiation of mesenchymal stem cells Proc Natl Acad Sci U S A 107 2010 4872 4877
295. N. Xia, C. Thodeti, T. Hunt, Q. Xu, M. Ho, G. Whitesides, R. Westervelt, and D. Ingber Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation FASEB J 22 2008 1649 1659
296. A. von Philipsborn, S. Lang, A. Bernard, J. Loeschinger, C. David, D. Lehnert, M. Bastmeyer, and F. Bonhoeffer Microcontact printing of axon guidance molecules for generation of graded patterns Nat Protoc 1 2006 1322 1328
297. A. Blawas, and W. Reichert Protein patterning Biomaterials 19 1998 595 609
298. M. Kim, J.C. Choi, H.R. Jung, J. Katz, M.G. Kim, and J. Doh Addressable micropatterning of multiple proteins and cells by microscope projection photolithography based on a protein friendly photoresist Langmuir 26 2010 12112 12118
299. J. Nakanishi, Y. Kikuchi, T. Takarada, H. Nakayama, K. Yamaguchi, and M. Maeda Spatiotemporal control of cell adhesion on a self-assembled monolayer having a photocleavable protecting group Anal Chim Acta 578 2006 100 104
300. B. Adzima, Y. Tao, C. Kloxin, C. DeForest, K. Anseth, and C. Bowman Spatial and temporal control of the alkyne-azide cycloaddition by photoinitiated Cu(II) reduction Nat Chem 3 2011 256 259
301. A. Doyle, F. Wang, K. Matsumoto, and K. Yamada One-dimensional topography underlies three-dimensional fibrillar cell migration J Cell Biol 184 2009 481 490
302. J. Bélisle, D. Kunik, and S. Costantino Rapid multicomponent optical protein patterning Lab Chip 9 2009 3580 3585
303. C.M. Kolodziej, and H.D. Maynard Electron-beam lithography for patterning biomolecules at the micron and nanometer scale Chem Mater 24 2012 774 780
304. D. Pesen, and D. Haviland Modulation of cell adhesion complexes by surface protein patterns ACS Appl Mater Interfaces 1 2009 543 548
305. P. Krsko, T. McCann, T.T. Thach, T. Laabs, H. Geller, and M. Libera Length-scale mediated adhesion and directed growth of neural cells by surface-patterned poly(ethylene glycol) hydrogels Biomaterials 30 2009 721 729
306. J. Rundqvist, B. Mendoza, J. Werbin, W. Heinz, C. Lemmon, L. Romer, D. Haviland, and J. Hoh High fidelity functional patterns of an extracellular matrix protein by electron beam-based inactivation J Am Chem Soc 129 2007 59 67
307. K. Salaita, Y. Wang, and C. Mirkin Applications of dip-pen nanolithography Nat Nanotechnol 2 2007 145 155
308. C.C. Wu, D. Reinhoudt, C. Otto, V. Subramaniam, and A. Velders Strategies for patterning biomolecules with dip-pen nanolithography Small 7 2011 989 1002
309. K.B. Lee, S.J. Park, C. Mirkin, J. Smith, and M. Mrksich Protein nanoarrays generated by dip-pen nanolithography Science 295 2002 1702 1705
310. D.L. Wilson, R. Martin, S. Hong, M. Cronin-Golomb, C.A. Mirkin, and D.L. Kaplan Surface organization and nanopatterning of collagen by dip-pen nanolithography Proc Natl Acad Sci U S A 98 2001 13660 13664
311. K. Wadu-Mesthrige, N. Amro, J. Garno, S. Xu, and G. Liu Fabrication of nanometer-sized protein patterns using atomic force microscopy and selective immobilization Biophys J 80 2001 1891 1899
312. S. Sekula, J. Fuchs, S. Weg-Remers, P. Nagel, S. Schuppler, J. Fragala, N theilacker, M. Franzreb, C. Wingren, P. Ellmark, C. Borrebaeck, C. Mirkin, H. Fuchs, and S. Lenhert Multiplexed lipid dip-pen nanolithography on subcellular scales for the templating of functional proteins and cell culture Small 4 2008 1785 1793
313. H. Agheli, J. Malmström, E. Larsson, M. Textor, and D. Sutherland Large area protein nanopatterning for biological applications Nano Lett 6 2006 1165 1171
314. J. Malmström, B. Christensen, H. Jakobsen, J. Lovmand, R. Foldbjerg, E. Sørensen, and D. Sutherland Large area protein patterning reveals nanoscale control of focal adhesion development Nano Lett 10 2010 686 694
315. J. Malmström, J. Lovmand, S. Kristensen, M. Sundh, M. Duch, and D. Sutherland Focal complex maturation and bridging on 200 nm vitronectin but not fibronectin patches reveal different mechanisms of focal adhesion formation Nano Lett 11 2011 2264 2271
316. J. Slater, and W. Frey Nanopatterning of fibronectin and the influence of integrin clustering on endothelial cell spreading and proliferation J Biomed Mater Res Part A 87 2008 176 195
317. H. Kong, S. Hsiong, and D. Mooney Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression Nano Lett 7 2007 161 166
318. K.Y. Lee, E. Alsberg, S. Hsiong, W. Comisar, J. Linderman, R. Ziff, and D. Mooney Nanoscale adhesion ligand organization regulates osteoblast proliferation and differentiation Nano Lett 4 2004 1501 1506
319. L. Koo, D. Irvine, A. Mayes, D. Lauffenburger, and L. Griffith Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus J Cell Sci 115 2002 1423 1433
320. G. Maheshwari, G. Brown, D. Lauffenburger, A. Wells, and L. Griffith Cell adhesion and motility depend on nanoscale RGD clustering J Cell Sci 113 2000 1677 1686
321. P. George, M. Doran, T. Croll, T. Munro, and J. Cooper-White Nanoscale presentation of cell adhesive molecules via block copolymer self-assembly Biomaterials 30 2009 4732 4737
322. J. Frith, R. Mills, and J. Cooper-White Lateral spacing of adhesion peptides influences human mesenchymal stem cell behaviour J Cell Sci 125 2012 317 327
323. C. Wei, and J. Dong Direct fabrication of high-resolution three-dimensional polymeric scaffolds using electrohydrodynamic hot jet plotting J Micromech Microeng 23 2013 025017
324. J. Lam, and T. Segura The modulation of MSC integrin expression by RGD presentation Biomaterials 34 2013 3938 3947
325. S.E. Ochsenhirt, E. Kokkoli, J.B. McCarthy, and M. Tirrell Effect of RGD secondary structure and the synergy site PHSRN on cell adhesion, spreading and specific integrin engagement Biomaterials 27 2006 3863 3874
326. D.S.W. Benoit, and K.S. Anseth The effect on osteoblast function of colocalized RGD and PHSRN epitopes on PEG surfaces Biomaterials 26 2005 5209 5220
327. M. Ebara, M. Yamato, T. Aoyagi, A. Kikuchi, K. Sakai, and T. Okano A novel approach to observing synergy effects of PHSRN on integrin-RGD binding using intelligent surfaces Adv Mater 20 2008 3034 3038
328. A. Mardilovich, J. Craig, M. McCammon, A. Garg, and E. Kokkoli Design of a novel fibronectin-mimetic peptide-amphiphile for functionalized biomaterials Langmuir 22 2006 3259 3264
329. M. Kisiel, M. Martino, M. Ventura, J. Hubbell, J. Hilborn, and D. Ossipov Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment Biomaterials 34 2013 704 712
330. I. Elloumi, R. Kobayashi, H. Funabashi, M. Mie, and E. Kobatake Construction of epidermal growth factor fusion protein with cell adhesive activity Biomaterials 27 2006 3451 3458
331. M. Tibbitt, and K. Anseth Dynamic microenvironments: the fourth dimension Sci Transl Med 4 2012 160ps24/1-4
332. M. Lutolf, P. Gilbert, and H. Blau Designing materials to direct stem-cell fate Nature 462 2009 433 441
333. M. Kinney, and T. McDevitt Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis Trends Biotechnol 31 2013 78 84
334. K. Vulic, and M. Shoichet Tunable growth factor delivery from injectable hydrogels for tissue engineering J Am Chem Soc 134 2012 882 885
335. G. Ashley, J. Henise, R. Reid, and D. Santi Hydrogel drug delivery system with predictable and tunable drug release and degradation rates Proc Natl Acad Sci U S A 110 2013 2318 2323
336. A. Kloxin, A. Kasko, C. Salinas, and K. Anseth Photodegradable hydrogels for dynamic tuning of physical and chemical properties Science 324 2009 59 63
337. M. Wirkner, J. Alonso, V. Maus, M. Salierno, T. Lee, A. García, and A. del Campo Triggered cell release from materials using bioadhesive photocleavable linkers Adv Mater 23 2011 3907 3910
338. S. Petersen, J. Alonso, A. Specht, P. Duodu, M. Goeldner, and A. del Campo Phototriggering of cell adhesion by caged cyclic RGD peptides Angew Chem Int Ed 47 2008 3192 3195
339. M. Wirkner, S. Weis, V. San Miguel, M. Álvarez, R. Gropeanu, M. Salierno, A. Sartoris, R. Unger, C. Kirkpatrick, and A. del Campo Photoactivatable caged cyclic RGD peptide for triggering integrin binding and cell adhesion to surfaces ChemBioChem 12 2011 2623 2629
340. J. Auernheimer, C. Dahmen, U. Hersel, A. Bausch, and H. Kessler Photoswitched cell adhesion on surfaces with RGD peptides J Am Chem Soc 127 2005 16107 16110
341. A. Milbradt, M. Löweneck, S. Krupka, M. Reif, E.K. Sinner, L. Moroder, and C. Renner Photomodulation of conformational states. IV. Integrin-binding RGD-peptides with (4-aminomethyl)phenylazobenzoic acid as backbone constituent Biopolymers 77 2005 304 313
342. M. Schütt, S. Krupka, A. Milbradt, S. Deindl, E. Sinner, D. Oesterhelt, C. Renner, and L. Moroder Photocontrol of cell adhesion processes: model studies with cyclic azobenzene-RGD peptides Chem Biol 10 2003 487 490
343. S.J. Todd, D. Farrar, J.E. Gough, and R.V. Ulijn Enzyme-triggered cell attachment to hydrogel surfaces Soft Matter 3 2007 547 550
344. B. Liu, Y. Liu, J. Riesberg, and W. Shen Dynamic presentation of immobilized ligands regulated through biomolecular recognition J Am Chem Soc 132 2010 13630 13632
345. E. Chan, S. Park, and M. Yousaf An electroactive catalytic dynamic substrate that immobilizes and releases patterned ligands, proteins, and cells Angew Chem Int Ed 47 2008 6267 6271
346. M. Lutolf, and J. Hubbell Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering Nat Biotechnol 23 2005 47 55
347. A.H. Zisch, and M. Ehrbar Cell-demanded release of growth factors P. Ducheyne, K. Healy, D. Hutmacher, D.W. Grainger, C.J. Kirkpatrick, Comprehensive biomaterials vol. 4 2011 Elsevier Sci Amsterdam 463 473
348. C. Salinas, and K. Anseth The enhancement of chondrogenic differentiation of human mesenchymal stem cells by enzymatically regulated RGD functionalities Biomaterials 29 2008 2370 2377
349. M. Tsurkan, K. Chwalek, K. Levental, U. Freudenberg, and C. Werner Modular StarPEG-heparin gels with bifunctional peptide linkers Macromol Rapid Commun 31 2010 1529 1533
350. K. Lee, E. Silva, and D. Mooney Growth factor delivery-based tissue engineering: general approaches and a review of recent developments J R Soc Interface 8 2011 153 170
351. M. Ehrbar, V. Djonov, C. Schnell, S. Tschanz, G. Martiny-Baron, U. Schenk, J. Wood, P. Burri, J. Hubbell, and A. Zisch Cell-demanded liberation of VEGF121 from fibrin implants induces local and controlled blood vessel growth Circ Res 94 2004 1124 1132
352. S.E. Sakiyama-Elbert Development of growth factor fusion proteins for cell-triggered drug delivery FASEB J 15 2001 1300 1302
353. H. Schmoekel, F. Weber, J. Schense, K. Grätz, P. Schawalder, and J. Hubbell Bone repair with a form of BMP-2 engineered for incorporation into fibrin cell ingrowth matrices Biotechnol Bioeng 89 2005 253 262
354. I. Strehin, and J. Elisseeff Characterizing ECM production by cells encapsulated in hydrogels Methods Mol Biol 522 2009 349 362
355. J. Noble, and M. Bailey Quantitation of protein Methods Enzymol 463 2009 73 95
356. M. Dixon Quartz crystal microbalance with dissipation monitoring: enabling real-time characterization of biological materials and their interactions J Biomol Tech 19 2008 151 158
357. B. Coad, Y. Lu, and L. Meagher A substrate-independent method for surface grafting polymer layers by atom transfer radical polymerization: reduction of protein adsorption Acta Biomater 8 2012 608 618
358. N.O. Enemchukwu, and A. García Peptide- and protein-modified surfaces P. Ducheyne, K. Healy, D. Hutmacher, D.W. Grainger, C.J. Kirkpatrick, Comprehensive biomaterials vol. 4 2011 Elsevier Sci Amsterdam 145 159
359. L. Fägerstam, A. Frostell-Karlsson, R. Karlsson, B. Persson, and I. Rönnberg Biospecific interaction analysis using surface plasmon resonance detection applied to kinetic, binding site and concentration analysis J Chromatogr 597 1992 397 410
360. D. Nisbet, A. Rodda, D. Finkelstein, M. Horne, J. Forsythe, and W. Shen Surface and bulk characterisation of electrospun membranes: problems and improvements Colloids Surf B 71 2009 1 12
361. J. Lee, J.W. Lee, and C. Schmidt Neuroactive conducting scaffolds: nerve growth factor conjugation on active ester-functionalized polypyrrole J R Soc Interface 6 2009 801 810
362. P. Kingshott, G. Andersson, S. McArthur, and H. Griesser Surface modification and chemical surface analysis of biomaterials Curr Opin Chem Biol 15 2011 667 676
363. J. Baio, F. Cheng, D. Ratner, P. Stayton, and D. Castner Probing orientation of immobilized humanized anti-lysozyme variable fragment by time-of-flight secondary-ion mass spectrometry J Biomed Mater Res Part A 97 2011 1 7
364. N. Xia, C.J. May, S.L. McArthur, and D.G. Castner Time-of-flight secondary ion mass spectrometry analysis of conformational changes in adsorbed protein films Langmuir 18 2002 4090 4097
365. C. Barnes, J. Brison, R. Michel, B. Brown, D. Castner, S. Badylak, and B. Ratner The surface molecular functionality of decellularized extracellular matrices Biomaterials 32 2011 137 143
366. B. Brown, C. Barnes, R. Kasick, R. Michel, T. Gilbert, D. Beer-Stolz, D. Castner, B. Ratner, and S. Badylak Surface characterization of extracellular matrix scaffolds Biomaterials 31 2010 428 437
367. A. Sawyer, D. Weeks, S. Kelpke, M. McCracken, and S. Bellis The effect of the addition of a polyglutamate motif to RGD on peptide tethering to hydroxyapatite and the promotion of mesenchymal stem cell adhesion Biomaterials 26 2005 7046 7056
368. P.R. Chen, M.H. Chen, F.H. Lin, and W.Y. Su Release characteristics and bioactivity of gelatin-tricalcium phosphate membranes covalently immobilized with nerve growth factors Biomaterials 26 2005 6579 6587
369. S. Oh, T. Kim, and J. Lee Creating growth factor gradients in three dimensional porous matrix by centrifugation and surface immobilization Biomaterials 32 2011 8254 8260
370. M.M. Pakulska, K. Vulic, and M.S. Shoichet Affinity-based release of chondroitinase ABC from a modified methylcellulose hydrogel J Controlled Release 171 2013 11 16
371. J. Sharon, and D. Puleo Immobilization of glycoproteins, such as VEGF, on biodegradable substrates Acta Biomater 4 2008 1016 1023
372. R.Y. Tam, M.J. Cooke, and M.S. Shoichet A covalently modified hydrogel blend of hyaluronan-methyl cellulose with peptides and growth factors influences neural stem/progenitor cell fate J Mater Chem 22 2012 19402 19411
373. M.H. Ho, D.M. Wang, H.J. Hsieh, H.C. Liu, T.Y. Hsien, J.Y. Lai, and L.T. Hou Preparation and characterization of RGD-immobilized chitosan scaffolds Biomaterials 26 2005 3197 3206
374. T. Masuko, N. Iwasaki, S. Yamane, T. Funakoshi, T. Majima, A. Minami, N. Ohsuga, T. Ohta, and S.I. Nishimura Chitosan-RGDSGGC conjugate as a scaffold material for musculoskeletal tissue engineering Biomaterials 26 2005 5339 5347
375. S. Massia, and J. Hubbell An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3-mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation J Cell Biol 114 1991 1089 1100
376. B.K. Brandley, and R.L. Schnaar Tumor cell haptotaxis on covalently immobilized linear and exponential gradients of a cell adhesion peptide Dev Biol 135 1989 74 86
377. C. Chollet, C. Chanseau, B. Brouillaud, and M. Durrieu RGD peptides grafting onto poly(ethylene terephthalate) with well controlled densities Biomol Eng 24 2007 477 482
378. J. Clémence, J. Ranieri, P. Aebischer, and H. Sigrist Photoimmobilization of a bioactive laminin fragment and pattern-guided selective neuronal cell attachment Bioconjugate Chem 6 1995 411 417
379. T. Barber, G. Harbers, S. Park, M. Gilbert, and K. Healy Ligand density characterization of peptide-modified biomaterials Biomaterials 26 2005 6897 6905