Probing orientation of immobilized humanized anti-lysozyme variable fragment by time-of-flight secondary-ion mass spectrometry

Journal of Biomedical Materials Research - Part A

Volumn 97 A, Issue 1, 2011, Pages 1-7

  Baio, J E ^a   Cheng, Fang ^b   Ratner, Daniel M ^b   Stayton, Patrick S ^b   Castner, David G ^a,b  

^a University of Washington   (United States)

^b University of Washington   (United States)

Author keywords

Humanized anti lysozyme variable fragment; Protein orientation; Surface analysis; ToF SIMS

Indexed keywords

ENZYMES; ETHYLENE; ETHYLENE GLYCOL; IONS; SECONDARY EMISSION; SECONDARY ION MASS SPECTROMETRY; SPECTROMETRY; SURFACE ANALYSIS; SURFACE PLASMON RESONANCE; X RAY PHOTOELECTRON SPECTROSCOPY;

CYSTEINE RESIDUES; HEXAHISTIDINE TAG; HIS-TAG; IMMOBILIZED PROTEINS; INTENSITY DIFFERENCE; INTENSITY RATIO; LYSOZYME BINDING; MALEIMIDES; NITRILOTRIACETIC ACID; PHENYLALANINE RESIDUES; PROTEIN ORIENTATION; SECONDARY IONS; SURFACE COVERAGES; THIOL GROUPS; TIME OF FLIGHT SECONDARY ION MASS SPECTROMETRY; TOF SIMS; VARIABLE FRAGMENT; XPS;

AMINO ACIDS;

ANTIBODY; CYSTEINE; HEXAHISTIDINE; HUMANIZED ANTI LYSOZYME VARIABLE FRAGMENT; MACROGOL; MALEIMIDE OLIGOETHYLENE GLYCOL; NITRILOTRIACETIC ACID; POLYHISTIDINE TAG; UNCLASSIFIED DRUG; AMINO ACID; IMMOBILIZED PROTEIN; IMMUNOGLOBULIN VARIABLE REGION; LYSOZYME;

ARTICLE; BINDING AFFINITY; PROTEIN ANALYSIS; PROTEIN IMMOBILIZATION; SURFACE PLASMON RESONANCE; SURFACE PROPERTY; TIME OF FLIGHT MASS SPECTROMETRY; X RAY PHOTOELECTRON SPECTROSCOPY; CHEMISTRY; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MASS SPECTROMETRY; METABOLISM; PROCEDURES; PROTEIN TERTIARY STRUCTURE;

AMINO ACIDS; HUMANS; IMMOBILIZED PROTEINS; IMMUNOGLOBULIN VARIABLE REGION; MURAMIDASE; PHOTOELECTRON SPECTROSCOPY; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, SECONDARY ION; SURFACE PLASMON RESONANCE;

EID: 79951980363     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.33025     Document Type: Article

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