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Volumn 8, Issue 55, 2011, Pages 153-170

Growth factor delivery-based tissue engineering: General approaches and a review of recent developments

Author keywords

Biomaterials; Nanoparticles; Regenerative medicine; Stimuli responsive materials; Synthetic extracellular matrix

Indexed keywords

BIOACTIVITY; BIOMATERIALS; NANOPARTICLES; PEPTIDES; TISSUE; TISSUE ENGINEERING;

EID: 78650842405     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2010.0223     Document Type: Review
Times cited : (1160)

References (195)
  • 2
    • 0026025755 scopus 로고
    • Growth factors in development, transformation, and tumorigenesis
    • Cross, M. & Dexter, T. M. 1991 Growth factors in development, transformation, and tumorigenesis. Cell 64, 271-280. (doi:10.1016/0092-8674(91) 90638-F) (Pubitemid 121001254)
    • (1991) Cell , vol.64 , Issue.2 , pp. 271-280
    • Cross, M.1    Michael Dexter, T.2
  • 3
    • 67649867959 scopus 로고    scopus 로고
    • Promoting angiogenesis via manipulation of VEGF responsiveness with notch signaling
    • doi:10.1016/j.biomaterials.2009.04.051
    • Cao, L., Arany, P. R., Wang, Y. S. & Mooney, D. J. 2009 Promoting angiogenesis via manipulation of VEGF responsiveness with notch signaling. Biomaterials 30, 4085-4093. (doi:10.1016/j.biomaterials.2009.04.051)
    • (2009) Biomaterials , vol.30 , pp. 4085-4093
    • Cao, L.1    Arany, P.R.2    Wang, Y.S.3    Mooney, D.J.4
  • 4
    • 27944497333 scopus 로고    scopus 로고
    • Tissue cells feel and respond to the stiffness of their substrate
    • doi:10.1126/science.1116995
    • Discher, D. E., Janmey, P. & Wang, Y. L. 2005 Tissue cells feel and respond to the stiffness of their substrate. Science 310, 1139-1143. (doi:10.1126/science.1116995)
    • (2005) Science , vol.310 , pp. 1139-1143
    • Discher, D.E.1    Janmey, P.2    Wang, Y.L.3
  • 5
    • 0038362684 scopus 로고    scopus 로고
    • Cell signaling events: A view from the matrix
    • doi:10.1016/S0945-053X(03)00002-7
    • Ramirez, F. & Rifkin, D. B. 2003 Cell signaling events: a view from the matrix. Matrix Biol. 22, 101-107. (doi:10.1016/S0945-053X(03)00002-7)
    • (2003) Matrix Biol. , vol.22 , pp. 101-107
    • Ramirez, F.1    Rifkin, D.B.2
  • 6
    • 0028895654 scopus 로고
    • Modular binding domains in signal transduction proteins
    • doi:10.1016/0092-8674(95)90406-9
    • Cohen, G. B., Ren, R. & Baltimore, D. 1995 Modular binding domains in signal transduction proteins. Cell 80, 237-248. (doi:10.1016/0092-8674(95) 90406-9)
    • (1995) Cell , vol.80 , pp. 237-248
    • Cohen, G.B.1    Ren, R.2    Baltimore, D.3
  • 7
    • 34147171490 scopus 로고    scopus 로고
    • Endothelial cell migration during angiogenesis
    • doi:10.1161/01.RES.0000259593.07661.1e
    • Lamalice, L., Le Boeuf, F. & Huot, J. 2007 Endothelial cell migration during angiogenesis. Circ. Res. 100, 782-794. (doi:10.1161/01.RES.0000259593. 07661.1e)
    • (2007) Circ. Res. , vol.100 , pp. 782-794
    • Lamalice, L.1    Le Boeuf, F.2    Huot, J.3
  • 8
    • 36049046711 scopus 로고    scopus 로고
    • Spatiotemporal control over growth factor signaling for therapeutic neovascularization
    • doi:10. 1016/j.addr.2007.08.012
    • Cao, L. & Mooney, D. J. 2007 Spatiotemporal control over growth factor signaling for therapeutic neovascularization. Adv. Drug Deliv. Rev. 59, 1340-1350. (doi:10. 1016/j.addr.2007.08.012)
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , pp. 1340-1350
    • Cao, L.1    Mooney, D.J.2
  • 9
    • 5044238876 scopus 로고    scopus 로고
    • Integrin signalling during tumour progression
    • doi:10.1038/nrm1490
    • Guo, W. & Giancotti, F. G. 2004 Integrin signalling during tumour progression. Nat. Rev. Mol. Cell Biol. 5, 816-826. (doi:10.1038/nrm1490)
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , pp. 816-826
    • Guo, W.1    Giancotti, F.G.2
  • 10
    • 33645551144 scopus 로고    scopus 로고
    • Integrins: Molecular targets in cancer therapy
    • doi:10.1007/s11912-006-0043-3
    • Tucker, G. C. 2006 Integrins: molecular targets in cancer therapy. Curr. Oncol. Rep. 8, 96-103. (doi:10.1007/s11912-006-0043-3)
    • (2006) Curr. Oncol. Rep. , vol.8 , pp. 96-103
    • Tucker, G.C.1
  • 11
    • 67650477014 scopus 로고    scopus 로고
    • Tunable interplay between epidermal growth factor and cell-cell contact governs the spatial dynamics of epithelial growth
    • doi:10.1073/pnas.0812651106
    • Kim, J. H., Kushiro, K., Graham, N. A. & Asthagiri, A. R. 2009 Tunable interplay between epidermal growth factor and cell-cell contact governs the spatial dynamics of epithelial growth. Proc. Natl. Acad. Sci. USA 106, 11 149-11 153. (doi:10.1073/pnas.0812651106)
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 11149-11153
    • Kim, J.H.1    Kushiro, K.2    Graham, N.A.3    Asthagiri, A.R.4
  • 12
    • 0026709283 scopus 로고
    • Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor
    • doi:10.1126/science.1382313
    • Yanagisawa-Miwa, A. et al. 1992 Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor. Science 257, 1401-1403. (doi:10.1126/science.1382313)
    • (1992) Science , vol.257 , pp. 1401-1403
    • Yanagisawa-Miwa, A.1
  • 14
    • 0036137469 scopus 로고    scopus 로고
    • Therapeutic angiogenesis for coronary artery disease
    • Freedman, S. B. & Isner, J. M. 2002 Therapeutic angiogenesis for coronary artery disease. Ann. Intern. Med. 136, 54-71.
    • (2002) Ann. Intern. Med. , vol.136 , pp. 54-71
    • Freedman, S.B.1    Isner, J.M.2
  • 15
    • 0028116874 scopus 로고
    • Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia
    • Takeshita, S., Pu, L. Q., Stein, L. A., Sniderman, A. D., Bunting, S., Ferrara, N., Isner, J. M. & Symes, J. F. 1994 Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia. Circulation 90, II228-II234.
    • (1994) Circulation , vol.90
    • Takeshita, S.1    Pu, L.Q.2    Stein, L.A.3    Sniderman, A.D.4    Bunting, S.5    Ferrara, N.6    Isner, J.M.7    Symes, J.F.8
  • 16
    • 0028344109 scopus 로고
    • Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model
    • doi:10.1172/JCI117018
    • Takeshita, S., Zheng, L. P., Brogi, E., Kearney, M., Pu, L. Q., Bunting, S., Ferrara, N., Symes, J. F. & Isner, J. M. 1994 Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J. Clin. Invest. 93, 662-670. (doi:10.1172/JCI117018)
    • (1994) J. Clin. Invest. , vol.93 , pp. 662-670
    • Takeshita, S.1    Zheng, L.P.2    Brogi, E.3    Kearney, M.4    Pu, L.Q.5    Bunting, S.6    Ferrara, N.7    Symes, J.F.8    Isner, J.M.9
  • 17
    • 0033503798 scopus 로고    scopus 로고
    • Six-month assessment of a phase I trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA
    • (Discussion 470-472.) (doi:10.1097/00000658-199910000-00002)
    • Rosengart, T. K., Lee, L. Y., Patel, S. R., Kligfield, P. D., Okin, P. M., Hackett, N. R., Isom, O.W. & Crystal, R. G. 1999 Six-month assessment of a phase I trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA. Ann. Surg. 230, 466-470. (Discussion 470-472.) (doi:10.1097/00000658-199910000-00002)
    • (1999) Ann. Surg. , vol.230 , pp. 466-470
    • Rosengart, T.K.1    Lee, L.Y.2    Patel, S.R.3    Kligfield, P.D.4    Okin, P.M.5    Hackett, N.R.6    Isom, O.W.7    Crystal, R.G.8
  • 18
    • 0032562232 scopus 로고    scopus 로고
    • Induction of neoangiogenesis in ischemic myocardium by human growth factors: First clinical results of a new treatment of coronary heart disease
    • Schumacher, B., Pecher, P., Von Specht, B. U. & Stegmann, T. 1998 Induction of neoangiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary heart disease. Circulation 97, 645-650.
    • (1998) Circulation , vol.97 , pp. 645-650
    • Schumacher, B.1    Pecher, P.2    Von Specht, B.U.3    Stegmann, T.4
  • 20
    • 0036890693 scopus 로고    scopus 로고
    • The stability factor: Importance in formulation development
    • doi:10.2174/1389201023378229
    • Krishnamurthy, R. & Manning, M. C. 2002 The stability factor: importance in formulation development. Curr. Pharm. Biotechnol. 3, 361-371. (doi:10.2174/1389201023378229)
    • (2002) Curr. Pharm. Biotechnol. , vol.3 , pp. 361-371
    • Krishnamurthy, R.1    Manning, M.C.2
  • 21
    • 0024806396 scopus 로고
    • Stability of protein pharmaceuticals
    • doi:10.1023/A:1015929109894
    • Manning, M. C., Patel, K. & Borchardt, R. T. 1989 Stability of protein pharmaceuticals. Pharm. Res. 6, 903-918. (doi:10.1023/A:1015929109894)
    • (1989) Pharm. Res. , vol.6 , pp. 903-918
    • Manning, M.C.1    Patel, K.2    Borchardt, R.T.3
  • 22
    • 0036331674 scopus 로고    scopus 로고
    • A target-mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans
    • doi:10. 1067/mcp.2002.126179
    • Eppler, S. M., Combs, D. L., Henry, T. D., Lopez, J. J., Ellis, S. G., Yi, J. H., Annex, B. H., Mccluskey, E. R. & Zioncheck, T. F. 2002 A target-mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans. Clin. Pharmacol. Ther. 72, 20-32. (doi:10. 1067/mcp.2002.126179)
    • (2002) Clin. Pharmacol. Ther. , vol.72 , pp. 20-32
    • Eppler, S.M.1    Combs, D.L.2    Henry, T.D.3    Lopez, J.J.4    Ellis, S.G.5    Yi, J.H.6    Annex, B.H.7    Mccluskey, E.R.8    Zioncheck, T.F.9
  • 23
    • 0037453099 scopus 로고    scopus 로고
    • The VIVA trial: Vascular endothelial growth factor in ischemia for vascular angiogenesis
    • doi:10.1161/01.CIR.0000061911.47710.8A
    • Henry, T. D. et al. 2003 The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis. Circulation 107, 1359-1365. (doi:10.1161/01.CIR.0000061911.47710.8A)
    • (2003) Circulation , vol.107 , pp. 1359-1365
    • Henry, T.D.1
  • 24
    • 0242606216 scopus 로고    scopus 로고
    • Therapeutic angiogenesis in cardiovascular disease
    • doi:10.1038/nrd1226
    • Simons, M. & Ware, J. A. 2003 Therapeutic angiogenesis in cardiovascular disease. Nat. Rev. Drug Discov. 2, 863-871. (doi:10.1038/nrd1226)
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 863-871
    • Simons, M.1    Ware, J.A.2
  • 25
    • 33846678968 scopus 로고    scopus 로고
    • Polymers for proand anti-angiogenic therapy
    • doi:10.1016/j.biomaterials.2006.12.029
    • Fischbach, C. & Mooney, D. J. 2007 Polymers for proand anti-angiogenic therapy. Biomaterials 28, 2069-2076. (doi:10.1016/j. biomaterials.2006.12.029)
    • (2007) Biomaterials , vol.28 , pp. 2069-2076
    • Fischbach, C.1    Mooney, D.J.2
  • 26
    • 57849113507 scopus 로고    scopus 로고
    • Physical approaches to biomaterial design
    • doi:10.1038/nmat2344
    • Mitragotri, S. & Lahann, J. 2009 Physical approaches to biomaterial design. Nat. Mater. 8, 15-23. (doi:10.1038/nmat2344)
    • (2009) Nat. Mater. , vol.8 , pp. 15-23
    • Mitragotri, S.1    Lahann, J.2
  • 27
    • 0034760458 scopus 로고    scopus 로고
    • Polymeric system for dual growth factor delivery
    • doi:10.1038/nbt1101-1029
    • Richardson, T. P., Peters, M. C., Ennett, A. B. & Mooney, D. J. 2001 Polymeric system for dual growth factor delivery. Nat. Biotechnol. 19, 1029-1034. (doi:10.1038/nbt1101-1029)
    • (2001) Nat. Biotechnol. , vol.19 , pp. 1029-1034
    • Richardson, T.P.1    Peters, M.C.2    Ennett, A.B.3    Mooney, D.J.4
  • 28
    • 34547123337 scopus 로고    scopus 로고
    • Regulating myoblast phenotype through controlled gel stiffness and degradation
    • doi:10.1089/ten.2006.0356
    • Boontheekul, T., Hill, E. E., Kong, H. J. & Mooney, D. J. 2007 Regulating myoblast phenotype through controlled gel stiffness and degradation. Tissue Eng. 13, 1431-1442. (doi:10.1089/ten.2006.0356)
    • (2007) Tissue Eng. , vol.13 , pp. 1431-1442
    • Boontheekul, T.1    Hill, E.E.2    Kong, H.J.3    Mooney, D.J.4
  • 29
    • 33644517215 scopus 로고    scopus 로고
    • In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation
    • doi:10.1073/pnas.0505661103
    • Datta, N., Pham, Q. P., Sharma, U., Sikavitsas, V. I., Jansen, J. A. & Mikos, A. G. 2006 In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation. Proc. Natl Acad. Sci. USA 103, 2488-2493. (doi:10.1073/pnas.0505661103)
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 2488-2493
    • Datta, N.1    Pham, Q.P.2    Sharma, U.3    Sikavitsas, V.I.4    Jansen, J.A.5    Mikos, A.G.6
  • 30
    • 34248402413 scopus 로고    scopus 로고
    • Shape effects of filaments versus spherical particles in flow and drug delivery
    • doi:10.1038/nnano.2007.70
    • Geng, Y., Dalhaimer, P., Cai, S., Tsai, R., Tewari, M., Minko, T. & Discher, D. E. 2007 Shape effects of filaments versus spherical particles in flow and drug delivery. Nat. Nanotechnol. 2, 249-255. (doi:10.1038/nnano.2007. 70)
    • (2007) Nat. Nanotechnol. , vol.2 , pp. 249-255
    • Geng, Y.1    Dalhaimer, P.2    Cai, S.3    Tsai, R.4    Tewari, M.5    Minko, T.6    Discher, D.E.7
  • 31
    • 0037965624 scopus 로고    scopus 로고
    • Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics
    • doi:10.1073/pnas.0737381100
    • Lutolf, M. P., Lauer-Fields, J. L., Schmoekel, H. G., Metters, A. T., Weber, F. E., Fields, G. B. & Hubbell, J. A. 2003 Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics. Proc. Natl Acad. Sci. USA 100, 5413-5418. (doi:10.1073/pnas.0737381100)
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 5413-5418
    • Lutolf, M.P.1    Lauer-Fields, J.L.2    Schmoekel, H.G.3    Metters, A.T.4    Weber, F.E.5    Fields, G.B.6    Hubbell, J.A.7
  • 32
    • 23244447869 scopus 로고    scopus 로고
    • Molecularly engineered PEG hydrogels: A novel model system for proteolytically mediated cell migration
    • doi:10.1529/biophysj.104.050682
    • Raeber, G. P., Lutolf, M. P. & Hubbell, J. A. 2005 Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration. Biophys. J. 89, 1374-1388. (doi:10.1529/biophysj.104.050682)
    • (2005) Biophys. J. , vol.89 , pp. 1374-1388
    • Raeber, G.P.1    Lutolf, M.P.2    Hubbell, J.A.3
  • 33
    • 33845990293 scopus 로고    scopus 로고
    • Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes. Part II. Biofunctional characteristics
    • doi:10.1021/bm060504a
    • Rizzi, S. C., Ehrbar, M., Halstenberg, S., Raeber, G. P., Schmoekel, H. G., Hagenmuller, H., Muller, R., Weber, F. E. & Hubbell, J. A. 2006 Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes. Part II. Biofunctional characteristics. Biomacromolecules 7, 3019-3029. (doi:10.1021/bm060504a)
    • (2006) Biomacromolecules , vol.7 , pp. 3019-3029
    • Rizzi, S.C.1    Ehrbar, M.2    Halstenberg, S.3    Raeber, G.P.4    Schmoekel, H.G.5    Hagenmuller, H.6    Muller, R.7    Weber, F.E.8    Hubbell, J.A.9
  • 34
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • doi:10.1038/nm0603-653
    • Carmeliet, P. 2003 Angiogenesis in health and disease. Nat. Med. 9, 653-660. (doi:10.1038/nm0603-653)
    • (2003) Nat. Med. , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 35
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • doi:10.1038/nature04478
    • Carmeliet, P. 2005 Angiogenesis in life, disease and medicine. Nature 438, 932-936. (doi:10.1038/nature04478)
    • (2005) Nature , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 36
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • doi:10.1038/386671a0
    • Risau, W. 1997 Mechanisms of angiogenesis. Nature 386, 671-674. (doi:10.1038/386671a0)
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 37
    • 77950518748 scopus 로고    scopus 로고
    • Combined and sequential delivery of bioactive VEGF(165) and HGF from poly(trimethylene carbonate) based photo-cross-linked elastomers
    • doi:10.1016/j.jconrel.2009.11.025
    • Chapanian, R. & Amsden, B. G. 2010 Combined and sequential delivery of bioactive VEGF(165) and HGF from poly(trimethylene carbonate) based photo-cross-linked elastomers. J. Control. Release 143, 53-63. (doi:10.1016/j.jconrel.2009.11.025)
    • (2010) J. Control. Release , vol.143 , pp. 53-63
    • Chapanian, R.1    Amsden, B.G.2
  • 39
    • 19944433012 scopus 로고    scopus 로고
    • Simultaneous application of basic fibroblast growth factor and hepatocyte growth factor to enhance the blood vessels formation
    • doi:10.1016/j.jvs.2004.10.029
    • Marui, A. et al. 2005 Simultaneous application of basic fibroblast growth factor and hepatocyte growth factor to enhance the blood vessels formation. J. Vasc. Surg. 41, 82-90. (doi:10.1016/j.jvs.2004.10.029)
    • (2005) J. Vasc. Surg. , vol.41 , pp. 82-90
    • Marui, A.1
  • 40
    • 3142703230 scopus 로고    scopus 로고
    • Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells
    • doi:10.1016/j.bone.2004.02.027
    • Simmons, C. A., Alsberg, E., Hsiong, S., Kim, W. J. & Mooney, D. J. 2004 Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone 35, 562-569. (doi:10.1016/j.bone.2004.02.027)
    • (2004) Bone , vol.35 , pp. 562-569
    • Simmons, C.A.1    Alsberg, E.2    Hsiong, S.3    Kim, W.J.4    Mooney, D.J.5
  • 41
    • 49349102874 scopus 로고    scopus 로고
    • Sequential growth factor delivery from complexed microspheres for bone tissue engineering
    • Basmanav, F. B., Kose, G. T. & Hasirci, V. 2008 Sequential growth factor delivery from complexed microspheres for bone tissue engineering. Biomaterials 29, 4195-4204.
    • (2008) Biomaterials , vol.29 , pp. 4195-4204
    • Basmanav, F.B.1    Kose, G.T.2    Hasirci, V.3
  • 42
    • 77950289445 scopus 로고    scopus 로고
    • Sequential BMP-2/BMP-7 delivery from polyester nanocapsules
    • Yilgor, P., Hasirci, N. & Hasirci, V. 2010 Sequential BMP-2/BMP-7 delivery from polyester nanocapsules. J. Biomed. Mater. Res. A 93, 528-536.
    • (2010) J. Biomed. Mater. Res. A , vol.93 , pp. 528-536
    • Yilgor, P.1    Hasirci, N.2    Hasirci, V.3
  • 43
    • 67349136033 scopus 로고    scopus 로고
    • Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering
    • doi:10.1016/j.biomaterials.2009.03.024
    • Yilgor, P., Tuzlakoglu, K., Reis, R. L., Hasirci, N. & Hasirci, V. 2009 Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering. Biomaterials 30, 3551-3559. (doi:10.1016/j.biomaterials.2009.03.024)
    • (2009) Biomaterials , vol.30 , pp. 3551-3559
    • Yilgor, P.1    Tuzlakoglu, K.2    Reis, R.L.3    Hasirci, N.4    Hasirci, V.5
  • 44
    • 51449094036 scopus 로고    scopus 로고
    • Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model
    • doi:10.1016/j.bone.2008.06.019
    • Patel, Z. S., Young, S., Tabata, Y., Jansen, J. A., Wong, M. E. & Mikos, A. G. 2008 Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model. Bone 43, 931-940. (doi:10.1016/j.bone.2008.06.019)
    • (2008) Bone , vol.43 , pp. 931-940
    • Patel, Z.S.1    Young, S.2    Tabata, Y.3    Jansen, J.A.4    Wong, M.E.5    Mikos, A.G.6
  • 45
    • 0242320973 scopus 로고    scopus 로고
    • In vitro effects of combined and sequential delivery of two bone growth factors
    • doi:10.1016/S0142-9612(03)00564-7
    • Raiche, A. T. & Puleo, D. A. 2004 In vitro effects of combined and sequential delivery of two bone growth factors. Biomaterials 25, 677-685. (doi:10.1016/S0142-9612(03)00564-7)
    • (2004) Biomaterials , vol.25 , pp. 677-685
    • Raiche, A.T.1    Puleo, D.A.2
  • 46
    • 59849107061 scopus 로고    scopus 로고
    • The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization
    • doi:10.1016/j.biomaterials.2008.12.057
    • Freeman, I. & Cohen, S. 2009 The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization. Biomaterials 30, 2122-2131. (doi:10.1016/j.biomaterials.2008. 12.057)
    • (2009) Biomaterials , vol.30 , pp. 2122-2131
    • Freeman, I.1    Cohen, S.2
  • 47
    • 43549093249 scopus 로고    scopus 로고
    • The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins
    • doi:10.1016/j.biomaterials.2008.04.025
    • Freeman, I., Kedem, A. & Cohen, S. 2008 The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins. Biomaterials 29, 3260-3268. (doi:10.1016/j. biomaterials.2008.04.025)
    • (2008) Biomaterials , vol.29 , pp. 3260-3268
    • Freeman, I.1    Kedem, A.2    Cohen, S.3
  • 48
    • 2342623399 scopus 로고    scopus 로고
    • Cell-demanded liberation of VEGF121 from fibrin implants induces local and controlled blood vessel growth
    • doi:10.1161/01.RES.0000126411.29641.08
    • Ehrbar, M. et al. 2004 Cell-demanded liberation of VEGF121 from fibrin implants induces local and controlled blood vessel growth. Circ. Res. 94, 1124-1132. (doi:10.1161/01.RES.0000126411.29641.08)
    • (2004) Circ. Res. , vol.94 , pp. 1124-1132
    • Ehrbar, M.1
  • 49
    • 34447290902 scopus 로고    scopus 로고
    • Enzymatic formation of modular cell-instructive fibrin analogs for tissue engineering
    • doi:10.1016/j.biomaterials.2007.03.027
    • Ehrbar, M., Rizzi, S. C., Hlushchuk, R., Djonov, V., Zisch, A. H., Hubbell, J. A., Weber, F. E. & Lutolf, M. P. 2007 Enzymatic formation of modular cell-instructive fibrin analogs for tissue engineering. Biomaterials 28, 3856-3866. (doi:10.1016/j.biomaterials.2007.03.027)
    • (2007) Biomaterials , vol.28 , pp. 3856-3866
    • Ehrbar, M.1    Rizzi, S.C.2    Hlushchuk, R.3    Djonov, V.4    Zisch, A.H.5    Hubbell, J.A.6    Weber, F.E.7    Lutolf, M.P.8
  • 50
    • 0035858291 scopus 로고    scopus 로고
    • Covalently conjugated VEGF-fibrin matrices for endothelialization
    • doi:10.1016/S0168-3659(01)00266-8
    • Zisch, A. H., Schenk, U., Schense, J. C., Sakiyama-Elbert, S. E. & Hubbell, J. A. 2001 Covalently conjugated VEGF-fibrin matrices for endothelialization. J. Control. Release 72, 101-113. (doi:10.1016/S0168-3659(01) 00266-8)
    • (2001) J. Control. Release , vol.72 , pp. 101-113
    • Zisch, A.H.1    Schenk, U.2    Schense, J.C.3    Sakiyama-Elbert, S.E.4    Hubbell, J.A.5
  • 51
    • 36849048162 scopus 로고    scopus 로고
    • Biomaterials for stem cell differentiation
    • doi:10.1016/j.addr.2007.08.037
    • Dawson, E., Mapili, G., Erickson, K., Taqvi, S. & Roy, K. 2008 Biomaterials for stem cell differentiation. Adv. Drug Deliv. Rev. 60, 215-228. (doi:10.1016/j.addr.2007.08.037)
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 215-228
    • Dawson, E.1    Mapili, G.2    Erickson, K.3    Taqvi, S.4    Roy, K.5
  • 52
    • 19644367664 scopus 로고    scopus 로고
    • Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
    • doi:10.1038/nbt1055
    • Lutolf, M. P. & Hubbell, J. A. 2005 Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat. Biotechnol. 23, 47-55. (doi:10.1038/nbt1055)
    • (2005) Nat. Biotechnol. , vol.23 , pp. 47-55
    • Lutolf, M.P.1    Hubbell, J.A.2
  • 54
    • 0042386426 scopus 로고    scopus 로고
    • Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis
    • doi:10.1083/jcb.200304105
    • Hood, J. D.,Frausto, R., Kiosses, W.B., Schwartz,M. A. & Cheresh, D. A. 2003 Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. J. Cell Biol. 162, 933-943. (doi:10.1083/jcb. 200304105)
    • (2003) J. Cell Biol. , vol.162 , pp. 933-943
    • Hood, J.D.1    Frausto, R.2    Kiosses, W.B.3    Schwartz, M.A.4    Cheresh, D.A.5
  • 55
    • 0042704757 scopus 로고    scopus 로고
    • Extracellular matrix-bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation
    • Hutchings, H., Ortega, N. & Plouet, J. 2003 Extracellular matrix-bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation. FASEB J. 17, 1520-1522.
    • (2003) FASEB J. , vol.17 , pp. 1520-1522
    • Hutchings, H.1    Ortega, N.2    Plouet, J.3
  • 56
    • 0034793669 scopus 로고    scopus 로고
    • Integrin activation is required for VEGF and FGF receptor protein presence on human microvascular endothelial cells
    • doi:10.1023/A:1011947301849
    • Tsou, R. & Isik, F. F. 2001 Integrin activation is required for VEGF and FGF receptor protein presence on human microvascular endothelial cells. Mol. Cell. Biochem. 224, 81-89. (doi:10.1023/A:1011947301849)
    • (2001) Mol. Cell. Biochem. , vol.224 , pp. 81-89
    • Tsou, R.1    Isik, F.F.2
  • 57
    • 14244262503 scopus 로고    scopus 로고
    • Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2
    • doi:10.1016/j.mvr.2004.07.001
    • Hall, H. & Hubbell, J. A. 2004 Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2. Microvasc. Res. 68, 169-178. (doi:10.1016/j.mvr.2004.07.001)
    • (2004) Microvasc. Res. , vol.68 , pp. 169-178
    • Hall, H.1    Hubbell, J.A.2
  • 58
    • 67349250425 scopus 로고    scopus 로고
    • The effect of the local delivery of platelet-derived growth factor from reactive two-component polyurethane scaffolds on the healing in rat skin excisional wounds
    • doi:10.1016/j.biomaterials.2009.03.008
    • Li, B., Davidson, J. M. & Guelcher, S. A. 2009 The effect of the local delivery of platelet-derived growth factor from reactive two-component polyurethane scaffolds on the healing in rat skin excisional wounds. Biomaterials 30, 3486-3494. (doi:10.1016/j.biomaterials.2009.03.008)
    • (2009) Biomaterials , vol.30 , pp. 3486-3494
    • Li, B.1    Davidson, J.M.2    Guelcher, S.A.3
  • 59
    • 23244434211 scopus 로고    scopus 로고
    • Surface modification of interconnected porous scaffolds
    • doi:10.1002/jbm.a.30367
    • Liu, X., Won, Y. & Ma, P. X. 2005 Surface modification of interconnected porous scaffolds. J. Biomed. Mater. Res. A 74, 84-91. (doi:10.1002/jbm.a.30367)
    • (2005) J. Biomed. Mater. Res. A , vol.74 , pp. 84-91
    • Liu, X.1    Won, Y.2    Ma, P.X.3
  • 60
    • 23244462242 scopus 로고    scopus 로고
    • Delivery of TGF-beta1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications
    • doi:10.1016/j.biomaterials.2005.05.083
    • Park, H., Temenoff, J. S., Holland, T. A., Tabata, Y. & Mikos, A. G. 2005 Delivery of TGF-beta1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications. Biomaterials 26, 7095-7103. (doi:10.1016/j.biomaterials.2005.05.083)
    • (2005) Biomaterials , vol.26 , pp. 7095-7103
    • Park, H.1    Temenoff, J.S.2    Holland, T.A.3    Tabata, Y.4    Mikos, A.G.5
  • 61
    • 0036159505 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 promotes osteogenesis within atelopeptide type I collagen solution by combination with rat cultured marrow cells
    • doi:10.1002/jbm.1281
    • Ikeuchi, M., Dohi, Y., Horiuchi, K., Ohgushi, H., Noshi, T., Yoshikawa, T., Yamamoto, K. & Sugimura, M. 2002 Recombinant human bone morphogenetic protein-2 promotes osteogenesis within atelopeptide type I collagen solution by combination with rat cultured marrow cells. J. Biomed. Mater. Res. 60, 61-69. (doi:10.1002/jbm.1281)
    • (2002) J. Biomed. Mater. Res. , vol.60 , pp. 61-69
    • Ikeuchi, M.1    Dohi, Y.2    Horiuchi, K.3    Ohgushi, H.4    Noshi, T.5    Yoshikawa, T.6    Yamamoto, K.7    Sugimura, M.8
  • 63
    • 0032940534 scopus 로고    scopus 로고
    • Cross-linking exogenous bifunctional peptides into fibrin gels with factor XIIIa
    • doi:10.1021/bc9800769
    • Schense, J. C. & Hubbell, J. A. 1999 Cross-linking exogenous bifunctional peptides into fibrin gels with factor XIIIa. Bioconjug. Chem. 10, 75-81. (doi:10.1021/bc9800769)
    • (1999) Bioconjug. Chem. , vol.10 , pp. 75-81
    • Schense, J.C.1    Hubbell, J.A.2
  • 64
    • 0035344210 scopus 로고    scopus 로고
    • Development of growth factor fusion proteins for cell-triggered drug delivery
    • Sakiyama-Elbert, S. E., Panitch, A. & Hubbell, J. A. 2001 Development of growth factor fusion proteins for cell-triggered drug delivery. FASEB J. 15, 1300-1302.
    • (2001) FASEB J. , vol.15 , pp. 1300-1302
    • Sakiyama-Elbert, S.E.1    Panitch, A.2    Hubbell, J.A.3
  • 65
    • 14244268881 scopus 로고    scopus 로고
    • Bone repair with a form of BMP-2 engineered for incorporation into fibrin cell ingrowth matrices
    • doi:10.1002/bit.20168
    • Schmoekel, H. G., Weber, F. E., Schense, J. C., Gratz, K. W., Schawalder, P. & Hubbell, J. A. 2005 Bone repair with a form of BMP-2 engineered for incorporation into fibrin cell ingrowth matrices. Biotechnol. Bioeng. 89, 253-262. (doi:10.1002/bit.20168)
    • (2005) Biotechnol. Bioeng. , vol.89 , pp. 253-262
    • Schmoekel, H.G.1    Weber, F.E.2    Schense, J.C.3    Gratz, K.W.4    Schawalder, P.5    Hubbell, J.A.6
  • 66
    • 10044253411 scopus 로고    scopus 로고
    • Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity
    • DOI 10.1016/j.jconrel.2004.07.018, PII S016836590400330X
    • Ehrbar, M., Metters, A., Zammaretti, P., Hubbell, J. A. & Zisch, A. H. 2005 Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity. J. Control. Release 101, 93-109. (doi:10.1016/j.jconrel.2004.07.018) (Pubitemid 39600975)
    • (2005) Journal of Controlled Release , vol.101 , Issue.1-3 SPEC. ISS , pp. 93-109
    • Ehrbar, M.1    Metters, A.2    Zammaretti, P.3    Hubbell, J.A.4    Zisch, A.H.5
  • 67
    • 34247402487 scopus 로고    scopus 로고
    • Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model
    • doi:10.1016/j.jtcvs.2007.01.029
    • Walpoth, B. H. et al. 2007 Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model. J. Thorac. Cardiovasc. Surg. 133, 1163-1170. (doi:10.1016/j.jtcvs.2007.01.029)
    • (2007) J. Thorac. Cardiovasc. Surg. , vol.133 , pp. 1163-1170
    • Walpoth, B.H.1
  • 68
    • 0033997601 scopus 로고    scopus 로고
    • Development of fibrin derivatives for controlled release of heparin-binding growth factors
    • doi:10.1016/S0168-3659(99)00221-7
    • Sakiyama-Elbert, S. E. & Hubbell, J. A. 2000 Development of fibrin derivatives for controlled release of heparin-binding growth factors. J. Control. Release 65, 389-402. (doi:10.1016/S0168-3659(99)00221-7)
    • (2000) J. Control. Release , vol.65 , pp. 389-402
    • Sakiyama-Elbert, S.E.1    Hubbell, J.A.2
  • 69
    • 33751347444 scopus 로고    scopus 로고
    • Increased angiogenesis and blood vessel maturation in acellular collagen-heparin scaffolds containing both FGF2 and VEGF
    • doi:10.1016/j.biomaterials.2006.10.029
    • Nillesen, S. T., Geutjes, P. J., Wismans, R., Schalkwijk, J., Daamen, W. F. & Van Kuppevelt, T. H. 2007 Increased angiogenesis and blood vessel maturation in acellular collagen-heparin scaffolds containing both FGF2 and VEGF. Biomaterials 28, 1123-1131. (doi:10.1016/j.biomaterials.2006.10.029)
    • (2007) Biomaterials , vol.28 , pp. 1123-1131
    • Nillesen, S.T.1    Geutjes, P.J.2    Wismans, R.3    Schalkwijk, J.4    Daamen, W.F.5    Van Kuppevelt, T.H.6
  • 70
    • 0029985256 scopus 로고    scopus 로고
    • Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity
    • doi:10.1111/j.1432-1033.1996.0295n.x
    • Ruppert, R., Hoffmann, E. & Sebald, W. 1996 Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity. Eur. J. Biochem. 237, 295-302. (doi:10.1111/j.1432-1033.1996.0295n.x)
    • (1996) Eur. J. Biochem. , vol.237 , pp. 295-302
    • Ruppert, R.1    Hoffmann, E.2    Sebald, W.3
  • 71
    • 0034601868 scopus 로고    scopus 로고
    • Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix
    • doi:10.1016/S0168-3659(00)00296-0
    • Sakiyama-Elbert, S. E. & Hubbell, J. A. 2000 Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix. J. Control. Release 69, 149-158. (doi:10.1016/S0168-3659(00)00296-0)
    • (2000) J. Control. Release , vol.69 , pp. 149-158
    • Sakiyama-Elbert, S.E.1    Hubbell, J.A.2
  • 72
    • 0033582942 scopus 로고    scopus 로고
    • Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution
    • doi:10.1006/jmbi.1999.2590
    • Scheufler, C., Sebald, W. & Hulsmeyer, M. 1999 Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution. J. Mol. Biol. 287, 103-115. (doi:10.1006/jmbi.1999.2590)
    • (1999) J. Mol. Biol. , vol.287 , pp. 103-115
    • Scheufler, C.1    Sebald, W.2    Hulsmeyer, M.3
  • 73
    • 0035996325 scopus 로고    scopus 로고
    • Site-specific interaction of bone morphogenetic protein 2 with procollagen II
    • doi:10.1006/cyto.2002.1035
    • Sieron, A. L., Louneva, N. & Fertala, A. 2002 Site-specific interaction of bone morphogenetic protein 2 with procollagen II. Cytokine 18, 214-221. (doi:10.1006/cyto.2002.1035)
    • (2002) Cytokine , vol.18 , pp. 214-221
    • Sieron, A.L.1    Louneva, N.2    Fertala, A.3
  • 74
    • 0035882643 scopus 로고    scopus 로고
    • Binding and release of basic fibroblast growth factor from heparinized collagen matrices
    • doi:10.1016/S0142-9612(00)00418-X
    • Wissink, M. J., Beernink, R., Pieper, J. S., Poot, A. A., Engbers, G. H., Beugeling, T., Van Aken, W. G. & Feijen, J. 2001 Binding and release of basic fibroblast growth factor from heparinized collagen matrices. Biomaterials 22, 2291-2299. (doi:10.1016/S0142-9612(00)00418-X)
    • (2001) Biomaterials , vol.22 , pp. 2291-2299
    • Wissink, M.J.1    Beernink, R.2    Pieper, J.S.3    Poot, A.A.4    Engbers, G.H.5    Beugeling, T.6    Van Aken, W.G.7    Feijen, J.8
  • 75
    • 36048941406 scopus 로고    scopus 로고
    • Photo-crosslinkable and biodegradable Pluronic/heparin hydrogels for local and sustained delivery of angiogenic growth factor
    • doi:10.1002/jbm.a.31271
    • Yoon, J. J., Chung, H. J. & Park, T. G. 2007 Photo-crosslinkable and biodegradable Pluronic/heparin hydrogels for local and sustained delivery of angiogenic growth factor. J. Biomed. Mater. Res. A 83, 597-605. (doi:10.1002/jbm.a.31271)
    • (2007) J. Biomed. Mater. Res. A , vol.83 , pp. 597-605
    • Yoon, J.J.1    Chung, H.J.2    Park, T.G.3
  • 76
    • 67651232458 scopus 로고    scopus 로고
    • Controlling affinity binding with peptide-functionalized poly(ethylene glycol) hydrogels
    • doi:10.1002/adfm.200900107
    • Lin, C. C. & Anseth, K. S. 2009 Controlling affinity binding with peptide-functionalized poly(ethylene glycol) hydrogels. Adv. Funct. Mater. 19, 2325. (doi:10.1002/adfm.200900107)
    • (2009) Adv. Funct. Mater. , vol.19 , pp. 2325
    • Lin, C.C.1    Anseth, K.S.2
  • 77
    • 77349115935 scopus 로고    scopus 로고
    • Regulating MCP-1 diffusion in affinity hydrogels for enhancing immuno-isolation
    • doi:10.1016/j.jconrel.2009.11.022
    • Lin, C. C., Boyer, P. D., Aimetti, A. A. & Anseth, K. S. 2010 Regulating MCP-1 diffusion in affinity hydrogels for enhancing immuno-isolation. J. Control. Release 142, 384-391. (doi:10.1016/j.jconrel.2009.11.022)
    • (2010) J. Control. Release , vol.142 , pp. 384-391
    • Lin, C.C.1    Boyer, P.D.2    Aimetti, A.A.3    Anseth, K.S.4
  • 78
    • 33644804663 scopus 로고    scopus 로고
    • Discovery of a sulfated tetrapeptide that binds to vascular endothelial growth factor
    • doi:10.1016/j.actbio.2005.04.004
    • Maynard, H. D. & Hubbell, J. A. 2005 Discovery of a sulfated tetrapeptide that binds to vascular endothelial growth factor. Acta Biomater. 1, 451-459. (doi:10.1016/j.actbio.2005.04.004)
    • (2005) Acta Biomater. , vol.1 , pp. 451-459
    • Maynard, H.D.1    Hubbell, J.A.2
  • 79
    • 77949420619 scopus 로고    scopus 로고
    • Hydrogel functionalization with DNA aptamers for sustained PDGF-BB release
    • doi:10.1039/b924909e
    • Soontornworajit, B., Zhou, J., Shaw, M. T., Fan, T. H. & Wang, Y. 2010 Hydrogel functionalization with DNA aptamers for sustained PDGF-BB release. Chem. Commun. 46, 1857-1859. (doi:10.1039/b924909e)
    • (2010) Chem. Commun. , vol.46 , pp. 1857-1859
    • Soontornworajit, B.1    Zhou, J.2    Shaw, M.T.3    Fan, T.H.4    Wang, Y.5
  • 81
    • 33644540762 scopus 로고    scopus 로고
    • Regulating activation of transplanted cells controls tissue regeneration
    • doi:10.1073/pnas.0506004103
    • Hill, E., Boontheekul, T. & Mooney, D. J. 2006 Regulating activation of transplanted cells controls tissue regeneration. Proc. Natl Acad. Sci. USA 103, 2494-2499. (doi:10.1073/pnas.0506004103)
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 2494-2499
    • Hill, E.1    Boontheekul, T.2    Mooney, D.J.3
  • 82
    • 55749108538 scopus 로고    scopus 로고
    • Material-based deployment enhances efficacy of endothelial progenitor cells
    • doi:10.1073/pnas.0803873105
    • Silva, E. A., Kim, E. S., Kong, H. J. & Mooney, D. J. 2008 Material-based deployment enhances efficacy of endothelial progenitor cells. Proc. Natl Acad. Sci. USA 105, 14 347-14 352. (doi:10.1073/pnas.0803873105)
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 14347-14352
    • Silva, E.A.1    Kim, E.S.2    Kong, H.J.3    Mooney, D.J.4
  • 83
    • 67849135051 scopus 로고    scopus 로고
    • Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFalpha
    • doi:10.1016/j.biomaterials.2009.05.083
    • Lin, C. C., Metters, A. T. & Anseth, K. S. 2009 Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFalpha. Biomaterials 30, 4907-4914. (doi:10.1016/j.biomaterials.2009.05.083)
    • (2009) Biomaterials , vol.30 , pp. 4907-4914
    • Lin, C.C.1    Metters, A.T.2    Anseth, K.S.3
  • 84
    • 33744501240 scopus 로고    scopus 로고
    • Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction
    • doi:10.1073/pnas.0602877103
    • Davis, M. E., Hsieh, P. C., Takahashi, T., Song, Q., Zhang, S., Kamm, R. D., Grodzinsky, A. J., Anversa, P. & Lee, R. T. 2006 Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc. Natl Acad. Sci. USA 103, 8155-8160. (doi:10.1073/pnas.0602877103)
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 8155-8160
    • Davis, M.E.1    Hsieh, P.C.2    Takahashi, T.3    Song, Q.4    Zhang, S.5    Kamm, R.D.6    Grodzinsky, A.J.7    Anversa, P.8    Lee, R.T.9
  • 85
    • 37149053488 scopus 로고    scopus 로고
    • Covalently immobilized biosignal molecule materials for tissue engineering
    • doi:10.1039/b708359a
    • Ito, Y. 2008 Covalently immobilized biosignal molecule materials for tissue engineering. Soft Matter 4, 46-56. (doi:10.1039/b708359a)
    • (2008) Soft Matter , vol.4 , pp. 46-56
    • Ito, Y.1
  • 86
    • 0029791838 scopus 로고    scopus 로고
    • Tethered epidermal growth factor as a paradigm for growth factor-induced stimulation from the solid phase
    • doi:10.1038/nm0996-1022
    • Kuhl, P. R. & Griffithcima, L. G. 1996 Tethered epidermal growth factor as a paradigm for growth factor-induced stimulation from the solid phase. Nat. Med. 2, 1022-1027. (doi:10.1038/nm0996-1022)
    • (1996) Nat. Med. , vol.2 , pp. 1022-1027
    • Kuhl, P.R.1    Griffithcima, L.G.2
  • 87
    • 0035284541 scopus 로고    scopus 로고
    • Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells
    • doi:10.1016/S0142-9612(00)00196-4
    • Mann, B. K., Schmedlen, R. H. & West, J. L. 2001 Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells. Biomaterials 22, 439-444. (doi:10.1016/S0142-9612(00)00196-4)
    • (2001) Biomaterials , vol.22 , pp. 439-444
    • Mann, B.K.1    Schmedlen, R.H.2    West, J.L.3
  • 88
    • 0032488267 scopus 로고    scopus 로고
    • Open pore biodegradable matrices formed with gas foaming
    • doi:10.1002/(SICI)1097-4636(19981205)42:3〈396::AID-JBM7〉3.0. CO;2-E
    • Harris, L. D., Kim, B. S. & Mooney, D. J. 1998 Open pore biodegradable matrices formed with gas foaming. J. Biomed. Mater. Res. 42, 396-402. (doi:10.1002/(SICI)1097-4636(19981205)42:3〈396::AID-JBM7〉3.0. CO;2-E)
    • (1998) J. Biomed. Mater. Res. , vol.42 , pp. 396-402
    • Harris, L.D.1    Kim, B.S.2    Mooney, D.J.3
  • 89
    • 0030199526 scopus 로고    scopus 로고
    • Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents
    • doi:10.1016/0142-9612(96)87284-X
    • Mooney, D. J., Baldwin, D. F., Suh, N. P., Vacanti, J. P. & Langer, R. 1996 Novel approach to fabricate porous sponges of poly(D,L-lactic-co- glycolic acid) without the use of organic solvents. Biomaterials 17, 1417-1422. (doi:10.1016/0142-9612(96)87284-X)
    • (1996) Biomaterials , vol.17 , pp. 1417-1422
    • Mooney, D.J.1    Baldwin, D.F.2    Suh, N.P.3    Vacanti, J.P.4    Langer, R.5
  • 90
    • 0033984323 scopus 로고    scopus 로고
    • Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery
    • doi:10.1016/S0168-3659(99)00138-8
    • Sheridan, M. H., Shea, L. D., Peters, M. C. & Mooney, D. J. 2000 Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. J. Control. Release 64, 91-102. (doi:10.1016/S0168- 3659(99)00138-8)
    • (2000) J. Control. Release , vol.64 , pp. 91-102
    • Sheridan, M.H.1    Shea, L.D.2    Peters, M.C.3    Mooney, D.J.4
  • 91
    • 0042626603 scopus 로고    scopus 로고
    • Polymeric growth factor delivery strategies for tissue engineering
    • doi:10.1023/A:1025034925152
    • Chen, R. R. & Mooney, D. J. 2003 Polymeric growth factor delivery strategies for tissue engineering. Pharm. Res. 20, 1103-1112. (doi:10.1023/A:1025034925152)
    • (2003) Pharm. Res. , vol.20 , pp. 1103-1112
    • Chen, R.R.1    Mooney, D.J.2
  • 92
    • 0031469673 scopus 로고    scopus 로고
    • The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent
    • doi:10.1023/A:1012126301290
    • Desai, M. P., Labhasetwar, V., Walter, E., Levy, R. J. & Amidon, G. L. 1997 The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm. Res. 14, 1568-1573. (doi:10.1023/A:1012126301290)
    • (1997) Pharm. Res. , vol.14 , pp. 1568-1573
    • Desai, M.P.1    Labhasetwar, V.2    Walter, E.3    Levy, R.J.4    Amidon, G.L.5
  • 93
    • 0037462997 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    • doi:10.1016/S0169-409X(02)00228-4
    • Panyam, J. & Labhasetwar, V. 2003 Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 55, 329-347. (doi:10.1016/S0169-409X(02)00228-4)
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 329-347
    • Panyam, J.1    Labhasetwar, V.2
  • 94
    • 67849135050 scopus 로고    scopus 로고
    • In vitro cellular responses to scaffolds containing two microencapulated growth factors
    • doi:10.1016/j.biomaterials.2009.06.009
    • Chen, F. M., Chen, R., Wang, X. J., Sun, H. H. & Wu, Z. F. 2009 In vitro cellular responses to scaffolds containing two microencapulated growth factors. Biomaterials 30, 5215-5224. (doi:10.1016/j.biomaterials.2009.06.009)
    • (2009) Biomaterials , vol.30 , pp. 5215-5224
    • Chen, F.M.1    Chen, R.2    Wang, X.J.3    Sun, H.H.4    Wu, Z.F.5
  • 95
    • 0032994943 scopus 로고    scopus 로고
    • Bioactive biomaterials
    • doi:10.1016/S0958-1669(99)80021-4
    • Hubbell, J. A. 1999 Bioactive biomaterials. Curr. Opin. Biotechnol. 10, 123-129. (doi:10.1016/S0958-1669(99)80021-4)
    • (1999) Curr. Opin. Biotechnol. , vol.10 , pp. 123-129
    • Hubbell, J.A.1
  • 96
    • 12444321550 scopus 로고    scopus 로고
    • Localized insulin-like growth factor I delivery to enhance new bone formation
    • doi:10.1016/S8756-3282(03)00207-2
    • Meinel, L. et al. 2003 Localized insulin-like growth factor I delivery to enhance new bone formation. Bone 33, 660-672. (doi:10.1016/S8756-3282(03)00207- 2)
    • (2003) Bone , vol.33 , pp. 660-672
    • Meinel, L.1
  • 97
    • 0042562089 scopus 로고    scopus 로고
    • Biomimetic materials for tissue engineering
    • doi:10.1016/S0142-9612(03)00339-9
    • Shin, H., Jo, S. & Mikos, A. G. 2003 Biomimetic materials for tissue engineering. Biomaterials 24, 4353-4364. (doi:10.1016/S0142-9612(03)00339-9)
    • (2003) Biomaterials , vol.24 , pp. 4353-4364
    • Shin, H.1    Jo, S.2    Mikos, A.G.3
  • 98
    • 0016663097 scopus 로고
    • Considerations concerning the host-parasite relationship of Escherichia coli in poultry
    • Siccardi, F. J. 1975 Considerations concerning the host-parasite relationship of Escherichia coli in poultry. Am. J. Vet. Res. 36, 572.
    • (1975) Am. J. Vet. Res. , vol.36 , pp. 572
    • Siccardi, F.J.1
  • 99
    • 60849129103 scopus 로고    scopus 로고
    • Microporous silk fibroin scaffolds embedding PLGA microparticles for controlled growth factor delivery in tissue engineering
    • doi:10.1016/j.biomaterials.2008.12.073
    • Wenk, E., Meinel, A. J., Wildy, S., Merkle, H. P. & Meinel, L. 2009 Microporous silk fibroin scaffolds embedding PLGA microparticles for controlled growth factor delivery in tissue engineering. Biomaterials 30, 2571-2581. (doi:10.1016/j.biomaterials.2008.12.073)
    • (2009) Biomaterials , vol.30 , pp. 2571-2581
    • Wenk, E.1    Meinel, A.J.2    Wildy, S.3    Merkle, H.P.4    Meinel, L.5
  • 100
    • 0035966525 scopus 로고    scopus 로고
    • Stabilizing insulin-like growth factor-I in poly(D,L-lactide-co- glycolide) microspheres
    • doi:10.1016/S0168-3659(00)00352-7
    • Meinel, L., Illi, O. E., Zapf, J., Malfanti, M., Peter Merkle, H. & Gander, B. 2001 Stabilizing insulin-like growth factor-I in poly(D,L-lactide-co- glycolide) microspheres. J. Control. Release 70, 193-202. (doi:10.1016/S0168- 3659(00)00352-7)
    • (2001) J. Control. Release , vol.70 , pp. 193-202
    • Meinel, L.1    Illi, O.E.2    Zapf, J.3    Malfanti, M.4    Peter Merkle, H.5    Gander, B.6
  • 101
    • 42249103434 scopus 로고    scopus 로고
    • The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine
    • doi:10.1016/j.biomaterials.2008.03.026
    • Rocha, F. G., Sundback, C. A., Krebs, N. J., Leach, J. K., Mooney, D. J., Ashley, S. W., Vacanti, J. P. & Whang, E. E. 2008 The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine. Biomaterials 29, 2884-2890. (doi:10.1016/j. biomaterials.2008.03.026)
    • (2008) Biomaterials , vol.29 , pp. 2884-2890
    • Rocha, F.G.1    Sundback, C.A.2    Krebs, N.J.3    Leach, J.K.4    Mooney, D.J.5    Ashley, S.W.6    Vacanti, J.P.7    Whang, E.E.8
  • 102
    • 65549114958 scopus 로고    scopus 로고
    • In vitro characterization of hepatocyte growth factor release from PHBV/PLGA microsphere scaffold
    • doi:10.1002/jbm.a.31978
    • Zhu, X. H., Wang, C. H. & Tong, Y. W. 2009 In vitro characterization of hepatocyte growth factor release from PHBV/PLGA microsphere scaffold. J. Biomed. Mater. Res. A 89, 411-423. (doi:10.1002/jbm.a.31978)
    • (2009) J. Biomed. Mater. Res. A , vol.89 , pp. 411-423
    • Zhu, X.H.1    Wang, C.H.2    Tong, Y.W.3
  • 103
    • 0034580371 scopus 로고    scopus 로고
    • The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices
    • doi:10.1016/S0142-9612(00)00115-0
    • Jain, R. A. 2000 The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 21, 2475-2490. (doi:10.1016/S0142-9612(00)00115-0)
    • (2000) Biomaterials , vol.21 , pp. 2475-2490
    • Jain, R.A.1
  • 104
    • 56349115299 scopus 로고    scopus 로고
    • Sustained release of BMP-2 in a lipid-based microtube vehicle
    • doi:10.1016/j.actbio.2008.09.001
    • Johnson, M. R., Lee, H. J., Bellamkonda, R. V. & Guldberg, R. E. 2009 Sustained release of BMP-2 in a lipid-based microtube vehicle. Acta Biomater. 5, 23-28. (doi:10.1016/j.actbio.2008.09.001)
    • (2009) Acta Biomater. , vol.5 , pp. 23-28
    • Johnson, M.R.1    Lee, H.J.2    Bellamkonda, R.V.3    Guldberg, R.E.4
  • 105
    • 70349695703 scopus 로고    scopus 로고
    • Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac function
    • doi:10.1096/fj.08-127373
    • Scott, R. C., Rosano, J. M., Ivanov, Z.,Wang, B., Chong, P. L., Issekutz, A. C., Crabbe, D. L. & Kiani, M. F. 2009 Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac function. FASEB J. 23, 3361-3367. (doi:10.1096/fj.08-127373)
    • (2009) FASEB J. , vol.23 , pp. 3361-3367
    • Scott, R.C.1    Rosano, J.M.2    Ivanov, Z.3    Wang, B.4    Chong, P.L.5    Issekutz, A.C.6    Crabbe, D.L.7    Kiani, M.F.8
  • 106
    • 0343247711 scopus 로고    scopus 로고
    • Biodegradation and biocompatibility of PLA and PLGA microspheres
    • Shive, M. S. & Anderson, J. M. 1997 Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv. Drug Deliv. Rev. 28, 5-24.
    • (1997) Adv. Drug Deliv. Rev. , vol.28 , pp. 5-24
    • Shive, M.S.1    Anderson, J.M.2
  • 107
    • 33846050010 scopus 로고    scopus 로고
    • Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation
    • doi:10.1007/s11095-006-9173-4
    • Chen, R. R., Silva, E. A., Yuen, W. W. & Mooney, D. J. 2007 Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Pharm. Res. 24, 258-264. (doi:10.1007/s11095-006-9173-4)
    • (2007) Pharm. Res. , vol.24 , pp. 258-264
    • Chen, R.R.1    Silva, E.A.2    Yuen, W.W.3    Mooney, D.J.4
  • 108
    • 0027053487 scopus 로고
    • Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro
    • doi:10.1016/0006-291X(92)92277-5
    • Pepper, M. S., Ferrara, N., Orci, L. & Montesano, R. 1992 Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem. Biophys. Res. Commun. 189, 824-831. (doi:10.1016/0006-291X(92)92277-5)
    • (1992) Biochem. Biophys. Res. Commun. , vol.189 , pp. 824-831
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3    Montesano, R.4
  • 109
    • 26844530250 scopus 로고    scopus 로고
    • Stimulation of neurite outgrowth by neurotrophins delivered from degradable hydrogels
    • DOI 10.1016/j.biomaterials.2005.06.034, PII S0142961205006265, Biomaterials for Spinal Applications
    • Burdick, J. A., Ward, M., Liang, E., Young, M. J. & Langer, R. 2006 Stimulation of neurite outgrowth by neurotrophins delivered from degradable hydrogels. Biomaterials 27, 452-459. (doi:10.1016/j.biomaterials.2005.06.034) (Pubitemid 41457248)
    • (2006) Biomaterials , vol.27 , Issue.3 , pp. 452-459
    • Burdick, J.A.1    Ward, M.2    Liang, E.3    Young, M.J.4    Langer, R.5
  • 110
    • 67649920749 scopus 로고    scopus 로고
    • Growth factors, matrices, and forces combine and control stem cells
    • doi:10.1126/science.1171643
    • Discher, D. E., Mooney, D. J. & Zandstra, P. W. 2009 Growth factors, matrices, and forces combine and control stem cells. Science 324, 1673-1677. (doi:10.1126/science.1171643)
    • (2009) Science , vol.324 , pp. 1673-1677
    • Discher, D.E.1    Mooney, D.J.2    Zandstra, P.W.3
  • 111
    • 58949100114 scopus 로고    scopus 로고
    • Infection-mimicking materials to program dendritic cells in situ
    • doi:10.1038/nmat2357
    • Ali, O. A., Huebsch, N., Cao, L., Dranoff, G. & Mooney, D. J. 2009 Infection-mimicking materials to program dendritic cells in situ. Nat. Mater. 8, 151-158. (doi:10.1038/nmat2357)
    • (2009) Nat. Mater. , vol.8 , pp. 151-158
    • Ali, O.A.1    Huebsch, N.2    Cao, L.3    Dranoff, G.4    Mooney, D.J.5
  • 112
    • 0142122289 scopus 로고    scopus 로고
    • Protein-based signaling systems in tissue engineering
    • doi:10.1016/j.copbio.2003.08.004
    • Boontheekul, T. & Mooney, D. J. 2003 Protein-based signaling systems in tissue engineering. Curr. Opin. Biotechnol. 14, 559-565. (doi:10.1016/j. copbio.2003.08.004)
    • (2003) Curr. Opin. Biotechnol. , vol.14 , pp. 559-565
    • Boontheekul, T.1    Mooney, D.J.2
  • 113
    • 67049117927 scopus 로고    scopus 로고
    • Carrageenan-based hydrogels for the controlled delivery of PDGF-BB in bone tissue engineering applications
    • doi:10.1021/bm8014973
    • Santo, V. E., Frias, A. M., Carida, M., Cancedda, R., Gomes, M. E., Mano, J. F. & Reis, R. L. 2009 Carrageenan-based hydrogels for the controlled delivery of PDGF-BB in bone tissue engineering applications. Biomacromolecules 10, 1392-1401. (doi:10.1021/bm8014973)
    • (2009) Biomacromolecules , vol.10 , pp. 1392-1401
    • Santo, V.E.1    Frias, A.M.2    Carida, M.3    Cancedda, R.4    Gomes, M.E.5    Mano, J.F.6    Reis, R.L.7
  • 114
    • 0035385135 scopus 로고    scopus 로고
    • Hydrogels for tissue engineering
    • doi:10.1021/cr000108x
    • Lee, K. Y. & Mooney, D. J. 2001 Hydrogels for tissue engineering. Chem. Rev. 101, 1869-1879. (doi:10.1021/cr000108x)
    • (2001) Chem. Rev. , vol.101 , pp. 1869-1879
    • Lee, K.Y.1    Mooney, D.J.2
  • 115
    • 0642272484 scopus 로고    scopus 로고
    • Cell-demanded release of VEGF from synthetic, biointeractive cell ingrowth matrices for vascularized tissue growth
    • Zisch, A. H. et al. 2003 Cell-demanded release of VEGF from synthetic, biointeractive cell ingrowth matrices for vascularized tissue growth. FASEB J. 17, 2260-2262.
    • (2003) FASEB J. , vol.17 , pp. 2260-2262
    • Zisch, A.H.1
  • 116
    • 10044275514 scopus 로고    scopus 로고
    • Dual growth factor delivery from degradable oligo (poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering
    • doi:10.1016/j.jconrel.2004.07.004
    • Holland, T. A., Tabata, Y. & Mikos, A. G. 2005 Dual growth factor delivery from degradable oligo (poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering. J. Control. Release 101, 111-125. (doi:10.1016/j.jconrel.2004.07.004)
    • (2005) J. Control. Release , vol.101 , pp. 111-125
    • Holland, T.A.1    Tabata, Y.2    Mikos, A.G.3
  • 118
    • 0027976149 scopus 로고
    • Wetting of poly(L-lactic acid) and poly(DL-lacticco-glycolic acid) foams for tissue culture
    • doi:10.1016/0142-9612(94)90197-X
    • Mikos, A. G., Lyman, M. D., Freed, L. E. & Langer, R. 1994 Wetting of poly(L-lactic acid) and poly(DL-lacticco-glycolic acid) foams for tissue culture. Biomaterials 15, 55-58. (doi:10.1016/0142-9612(94)90197-X)
    • (1994) Biomaterials , vol.15 , pp. 55-58
    • Mikos, A.G.1    Lyman, M.D.2    Freed, L.E.3    Langer, R.4
  • 119
    • 0037619257 scopus 로고    scopus 로고
    • Biocompatibility of implantable synthetic polymeric drug carriers: Focus on brain biocompatibility
    • doi:10.1016/S0142-9612(03)00161-3
    • Fournier, E., Passirani, C., Montero-Menei, C. N. & Benoit, J. P. 2003 Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility. Biomaterials 24, 3311-3331. (doi:10.1016/S0142-9612(03) 00161-3)
    • (2003) Biomaterials , vol.24 , pp. 3311-3331
    • Fournier, E.1    Passirani, C.2    Montero-Menei, C.N.3    Benoit, J.P.4
  • 120
    • 0034792454 scopus 로고    scopus 로고
    • Degradation of partially oxidized alginate and its potential application for tissue engineering
    • doi:10.1021/bp010070p
    • Bouhadir, K. H., Lee, K. Y., Alsberg, E., Damm, K. L., Anderson, K. W. & Mooney, D. J. 2001 Degradation of partially oxidized alginate and its potential application for tissue engineering. Biotechnol. Prog. 17, 945-950. (doi:10.1021/bp010070p)
    • (2001) Biotechnol. Prog. , vol.17 , pp. 945-950
    • Bouhadir, K.H.1    Lee, K.Y.2    Alsberg, E.3    Damm, K.L.4    Anderson, K.W.5    Mooney, D.J.6
  • 121
    • 10044293137 scopus 로고    scopus 로고
    • Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution
    • doi:10.1016/j.biomaterials.2004.06.044
    • Boontheekul, T., Kong, H. J. & Mooney, D. J. 2005 Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution. Biomaterials 26, 2455-2465. (doi:10.1016/j.biomaterials. 2004.06.044)
    • (2005) Biomaterials , vol.26 , pp. 2455-2465
    • Boontheekul, T.1    Kong, H.J.2    Mooney, D.J.3
  • 122
    • 67349093532 scopus 로고    scopus 로고
    • Biocompatibility of injectable chitosan-phospholipid implant systems
    • doi:10.1016/j.biomaterials.2009.04.003
    • De Souza, R., Zahedi, P., Allen, C. J. & Piquette-Miller, M. 2009 Biocompatibility of injectable chitosan-phospholipid implant systems. Biomaterials 30, 3818-3824. (doi:10.1016/j.biomaterials.2009.04.003)
    • (2009) Biomaterials , vol.30 , pp. 3818-3824
    • De Souza, R.1    Zahedi, P.2    Allen, C.J.3    Piquette-Miller, M.4
  • 123
    • 29244439335 scopus 로고    scopus 로고
    • Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord
    • doi:10.1016/j.biomaterials.2005.11.015
    • Gupta, D., Tator, C. H. & Shoichet, M. S. 2006 Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord. Biomaterials 27, 2370-2379. (doi:10.1016/j.biomaterials.2005.11.015)
    • (2006) Biomaterials , vol.27 , pp. 2370-2379
    • Gupta, D.1    Tator, C.H.2    Shoichet, M.S.3
  • 124
    • 19344368945 scopus 로고    scopus 로고
    • Injectable intrathecal delivery system for localized administration of EGF and FGF-2 to the injured rat spinal cord
    • Jimenez Hamann, M. C., Tator, C. H. & Shoichet, M. S. 2005 Injectable intrathecal delivery system for localized administration of EGF and FGF-2 to the injured rat spinal cord. Exp. Neurol. 194, 106-119.
    • (2005) Exp. Neurol. , vol.194 , pp. 106-119
    • Jimenez Hamann, M.C.1    Tator, C.H.2    Shoichet, M.S.3
  • 125
    • 0042697088 scopus 로고    scopus 로고
    • Novel intrathecal delivery system for treatment of spinal cord injury
    • doi:10.1016/S0014-4886(03)00040-2
    • Jimenez Hamann, M. C., Tsai, E. C., Tator, C. H. & Shoichet, M. S. 2003 Novel intrathecal delivery system for treatment of spinal cord injury. Exp. Neurol. 182, 300-309. (doi:10.1016/S0014-4886(03)00040-2)
    • (2003) Exp. Neurol. , vol.182 , pp. 300-309
    • Jimenez Hamann, M.C.1    Tsai, E.C.2    Tator, C.H.3    Shoichet, M.S.4
  • 126
    • 64549091117 scopus 로고    scopus 로고
    • A new paradigm for local and sustained release of therapeutic molecules to the injured spinal cord for neuroprotection and tissue repair
    • doi:10.1089/ten.tea.2007.0349
    • Kang, C. E., Poon, P. C., Tator, C. H. & Shoichet, M. S. 2009 A new paradigm for local and sustained release of therapeutic molecules to the injured spinal cord for neuroprotection and tissue repair. Tissue Eng. Part A 15, 595-604. (doi:10.1089/ten.tea.2007.0349)
    • (2009) Tissue Eng. Part A , vol.15 , pp. 595-604
    • Kang, C.E.1    Poon, P.C.2    Tator, C.H.3    Shoichet, M.S.4
  • 127
    • 1942485769 scopus 로고    scopus 로고
    • Immobilized concentration gradients of nerve growth factor guide neurite outgrowth
    • Kapur, T. A. & Shoichet, M. S. 2004 Immobilized concentration gradients of nerve growth factor guide neurite outgrowth. J. Biomed. Mater. Res. A 68, 235-243.
    • (2004) J. Biomed. Mater. Res. A , vol.68 , pp. 235-243
    • Kapur, T.A.1    Shoichet, M.S.2
  • 128
    • 0027911260 scopus 로고
    • Self-aggregates of hydrophobized polysaccharides in water. Formation and characteristics of nanoparticles
    • doi:10.1021/ma00064a011
    • Akiyoshi, K., Deguchi, S., Moriguchi, N., Yamaguchi, S. & Sunamoto, J. 1993 Self-aggregates of hydrophobized polysaccharides in water. Formation and characteristics of nanoparticles. Macromolecules 26, 3062-3068. (doi:10.1021/ma00064a011)
    • (1993) Macromolecules , vol.26 , pp. 3062-3068
    • Akiyoshi, K.1    Deguchi, S.2    Moriguchi, N.3    Yamaguchi, S.4    Sunamoto, J.5
  • 129
    • 38949116978 scopus 로고    scopus 로고
    • Humoral immune responses in patients vaccinated with 1-146 HER2 protein complexed with cholesteryl pullulan nanogel
    • doi:10.1111/j.1349-7006.2007.00705.x
    • Kageyama, S. et al. 2008 Humoral immune responses in patients vaccinated with 1-146 HER2 protein complexed with cholesteryl pullulan nanogel. Cancer Sci. 99, 601-607. (doi:10.1111/j.1349-7006.2007.00705.x)
    • (2008) Cancer Sci. , vol.99 , pp. 601-607
    • Kageyama, S.1
  • 131
    • 22944470543 scopus 로고    scopus 로고
    • Design of hybrid hydrogels with self-assembled nanogels as cross-linkers: Interaction with proteins and chaperone-like activity
    • doi:10.1021/bm050156x
    • Morimoto, N., Endo, T., Iwasaki, Y. & Akiyoshi, K. 2005 Design of hybrid hydrogels with self-assembled nanogels as cross-linkers: interaction with proteins and chaperone-like activity. Biomacromolecules 6, 1829-1834. (doi:10.1021/bm050156x)
    • (2005) Biomacromolecules , vol.6 , pp. 1829-1834
    • Morimoto, N.1    Endo, T.2    Iwasaki, Y.3    Akiyoshi, K.4
  • 132
    • 14044266150 scopus 로고    scopus 로고
    • Thermoresponsive controlled association of protein with a dynamic nanogel of hydrophobized polysaccharide and cyclodextrin: Heat shock protein-like activity of artificial molecular chaperone
    • DOI 10.1021/bm049501t
    • Nomura, Y., Sasaki, Y., Takagi, M., Narita, T., Aoyama, Y. & Akiyoshi, K. 2005 Thermoresponsive controlled association of protein with a dynamic nanogel of hydrophobized polysaccharide and cyclodextrin: heat shock protein-like activity of artificial molecular chaperone. Biomacromolecules 6, 447-452. (doi:10.1021/bm049501t) (Pubitemid 40277045)
    • (2005) Biomacromolecules , vol.6 , Issue.1 , pp. 447-452
    • Nomura, Y.1    Sasaki, Y.2    Takagi, M.3    Narita, T.4    Aoyama, Y.5    Akiyoshi, K.6
  • 133
    • 16644370406 scopus 로고    scopus 로고
    • Synthetic extracellular matrices for tissue engineering and regeneration
    • doi:10.1016/S0070-2153(04)64008-7
    • Silva, E. A. & Mooney, D. J. 2004 Synthetic extracellular matrices for tissue engineering and regeneration. Curr. Top. Dev. Biol. 64, 181-205. (doi:10.1016/S0070-2153(04)64008-7)
    • (2004) Curr. Top. Dev. Biol. , vol.64 , pp. 181-205
    • Silva, E.A.1    Mooney, D.J.2
  • 135
    • 33746273793 scopus 로고    scopus 로고
    • Conducting polymer actuator mechanism based on the conformational flexibility of calix[4]arene
    • doi:10.1002/anie.200503304
    • Casanovas, J., Zanuy, D. & Aleman, C. 2006 Conducting polymer actuator mechanism based on the conformational flexibility of calix[4]arene. Angew. Chem. Int. Ed. Engl. 45, 1103-1105. (doi:10.1002/anie.200503304)
    • (2006) Angew. Chem. Int. Ed. Engl. , vol.45 , pp. 1103-1105
    • Casanovas, J.1    Zanuy, D.2    Aleman, C.3
  • 136
    • 0028244080 scopus 로고
    • Chemical interactions between drugs containing reactive amines with hydrolyzable insoluble biopolymers in aqueous solutions
    • doi:10.1023/A:1018985909777
    • Domb, A. J., Turovsky, L. & Nudelman, R. 1994 Chemical interactions between drugs containing reactive amines with hydrolyzable insoluble biopolymers in aqueous solutions. Pharm. Res. 11, 865-868. (doi:10.1023/A:1018985909777)
    • (1994) Pharm. Res. , vol.11 , pp. 865-868
    • Domb, A.J.1    Turovsky, L.2    Nudelman, R.3
  • 137
    • 0034006495 scopus 로고    scopus 로고
    • Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres
    • doi:10.1023/A:1007582911958
    • Fu, K., Pack, D. W., Klibanov, A. M. & Langer, R. 2000 Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm. Res. 17, 100-106. (doi:10.1023/A:1007582911958)
    • (2000) Pharm. Res. , vol.17 , pp. 100-106
    • Fu, K.1    Pack, D.W.2    Klibanov, A.M.3    Langer, R.4
  • 138
    • 0031889765 scopus 로고    scopus 로고
    • Analysis of plasmid DNA from a pharmaceutical perspective
    • doi:10.1021/js970367a
    • Middaugh, C. R., Evans, R. K., Montgomery, D. L. & Casimiro, D. R. 1998 Analysis of plasmid DNA from a pharmaceutical perspective. J. Pharm. Sci. 87, 130-146. (doi:10.1021/js970367a)
    • (1998) J. Pharm. Sci. , vol.87 , pp. 130-146
    • Middaugh, C.R.1    Evans, R.K.2    Montgomery, D.L.3    Casimiro, D.R.4
  • 139
    • 33745627327 scopus 로고    scopus 로고
    • Sulfonamide-based pH- and temperature-sensitive biodegradable block copolymer hydrogels
    • doi:10.1021/bm0600567
    • Shim, W. S., Kim, S. W. & Lee, D. S. 2006 Sulfonamide-based pH- and temperature-sensitive biodegradable block copolymer hydrogels. Biomacromolecules 7, 1935-1941. (doi:10.1021/bm0600567)
    • (2006) Biomacromolecules , vol.7 , pp. 1935-1941
    • Shim, W.S.1    Kim, S.W.2    Lee, D.S.3
  • 140
    • 67049162753 scopus 로고    scopus 로고
    • Injectable in situ-forming pH/thermo-sensitive hydrogel for bone tissue engineering
    • doi:10.1089/ten.tea.2007.0407
    • Kim, H. K., Shim, W. S., Kim, S. E., Lee, K. H., Kang, E., Kim, J. H., Kim, K., Kwon, I. C. & Lee, D. S. 2009 Injectable in situ-forming pH/thermo-sensitive hydrogel for bone tissue engineering. Tissue Eng. Part A 15, 923-933. (doi:10.1089/ten.tea.2007.0407)
    • (2009) Tissue Eng. Part A , vol.15 , pp. 923-933
    • Kim, H.K.1    Shim, W.S.2    Kim, S.E.3    Lee, K.H.4    Kang, E.5    Kim, J.H.6    Kim, K.7    Kwon, I.C.8    Lee, D.S.9
  • 141
    • 28844483415 scopus 로고    scopus 로고
    • Novel injectable pH and temperature sensitive block copolymer hydrogel
    • doi:10.1021/bm050521k
    • Shim, W. S., Yoo, J. S., Bae, Y. H. & Lee, D. S. 2005 Novel injectable pH and temperature sensitive block copolymer hydrogel. Biomacromolecules 6, 2930-2934. (doi:10.1021/bm050521k)
    • (2005) Biomacromolecules , vol.6 , pp. 2930-2934
    • Shim, W.S.1    Yoo, J.S.2    Bae, Y.H.3    Lee, D.S.4
  • 142
    • 70450207980 scopus 로고    scopus 로고
    • Biodegradable thermosensitive injectable PEG-PCL-PEG hydrogel for bFGF antigen delivery to improve humoral immunity
    • doi:10.3109/08977190903159938
    • Gong, C. Y. et al. 2009 Biodegradable thermosensitive injectable PEG-PCL-PEG hydrogel for bFGF antigen delivery to improve humoral immunity. Growth Factors 27, 377-383. (doi:10.3109/08977190903159938)
    • (2009) Growth Factors , vol.27 , pp. 377-383
    • Gong, C.Y.1
  • 143
    • 0036060263 scopus 로고    scopus 로고
    • Thermogelling biodegradable copolymer aqueous solutions for injectable protein delivery and tissue engineering
    • doi:10.1021/bm025536m
    • Jeong, B., Lee, K. M., Gutowska, A. & An, Y. H. 2002 Thermogelling biodegradable copolymer aqueous solutions for injectable protein delivery and tissue engineering. Biomacromolecules 3, 865-868. (doi:10.1021/bm025536m)
    • (2002) Biomacromolecules , vol.3 , pp. 865-868
    • Jeong, B.1    Lee, K.M.2    Gutowska, A.3    An, Y.H.4
  • 144
    • 0141921483 scopus 로고    scopus 로고
    • Polymeric micelle for tumor pH and folate-mediated targeting
    • doi:10.1016/S0168-3659(03)00239-6
    • Lee, E. S., Na, K. & Bae, Y. H. 2003 Polymeric micelle for tumor pH and folate-mediated targeting. J. Control. Release 91, 103-113. (doi:10.1016/S0168-3659(03)00239-6)
    • (2003) J. Control. Release , vol.91 , pp. 103-113
    • Lee, E.S.1    Na, K.2    Bae, Y.H.3
  • 145
    • 14644433029 scopus 로고    scopus 로고
    • Super pH-sensitive multifunctional polymeric micelle
    • doi:10.1021/nl0479987
    • Lee, E. S., Na, K. & Bae, Y. H. 2005 Super pH-sensitive multifunctional polymeric micelle. Nano. Lett. 5, 325-329. (doi:10.1021/ nl0479987)
    • (2005) Nano. Lett. , vol.5 , pp. 325-329
    • Lee, E.S.1    Na, K.2    Bae, Y.H.3
  • 146
    • 33744805790 scopus 로고    scopus 로고
    • Polymers for gene delivery across length scales
    • doi:10.1038/nmat1645
    • Putnam, D. 2006 Polymers for gene delivery across length scales. Nat. Mater. 5, 439-451. (doi:10.1038/nmat1645)
    • (2006) Nat. Mater. , vol.5 , pp. 439-451
    • Putnam, D.1
  • 147
    • 28844448256 scopus 로고    scopus 로고
    • Novel functional biodegradable polymer IV: PH-sensitive controlled release of fibroblast growth factor-2 from a poly (gamma-glutamic acid)-sulfonate matrix for tissue engineering
    • doi:10.1021/bm050369m
    • Matsusaki, M. & Akashi, M. 2005 Novel functional biodegradable polymer IV: pH-sensitive controlled release of fibroblast growth factor-2 from a poly (gamma-glutamic acid)-sulfonate matrix for tissue engineering. Biomacromolecules 6, 3351-3356. (doi:10.1021/bm050369m)
    • (2005) Biomacromolecules , vol.6 , pp. 3351-3356
    • Matsusaki, M.1    Akashi, M.2
  • 148
    • 40949126455 scopus 로고    scopus 로고
    • Functionalized injectable hydrogels for controlled insulin delivery
    • doi:10.1016/j.biomaterials.2008.02.016
    • Huynh, D. P., Nguyen, M. K., Pi, B. S., Kim, M. S., Chae, S. Y., Lee, K. C., Kim, B. S., Kim, S. W. & Lee, D. S. 2008 Functionalized injectable hydrogels for controlled insulin delivery. Biomaterials 29, 2527-2534. (doi:10.1016/j.biomaterials.2008.02.016)
    • (2008) Biomaterials , vol.29 , pp. 2527-2534
    • Huynh, D.P.1    Nguyen, M.K.2    Pi, B.S.3    Kim, M.S.4    Chae, S.Y.5    Lee, K.C.6    Kim, B.S.7    Kim, S.W.8    Lee, D.S.9
  • 149
    • 3042716509 scopus 로고    scopus 로고
    • Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines
    • doi:10.1073/pnas.0403549101
    • Little, S. R., Lynn, D. M., Ge, Q., Anderson, D. G., Puram, S. V., Chen, J., Eisen, H. N. & Langer, R. 2004 Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc. Natl Acad. Sci. USA 101, 9534-9539. (doi:10.1073/pnas.0403549101)
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 9534-9539
    • Little, S.R.1    Lynn, D.M.2    Ge, Q.3    Anderson, D.G.4    Puram, S.V.5    Chen, J.6    Eisen, H.N.7    Langer, R.8
  • 150
    • 0034623567 scopus 로고    scopus 로고
    • Degradable poly(beta-amino esters): Synthesis, characterization, and self-assembly with plasmid DNA
    • doi:10.1021/ja0015388
    • Lynn, D. M. & Langer, R. 2000 Degradable poly(beta-amino esters): synthesis, characterization, and self-assembly with plasmid DNA. J. Am. Chem. Soc. 122, 10 761-10 768. (doi:10.1021/ja0015388)
    • (2000) J. Am. Chem. Soc. , vol.122 , pp. 10761-10768
    • Lynn, D.M.1    Langer, R.2
  • 151
    • 43149123308 scopus 로고    scopus 로고
    • Biodegradable and pH-sensitive hydrogels for cell encapsulation and controlled drug release
    • doi:10.1021/bm7010328
    • Wu, D. Q., Sun, Y. X., Xu, X. D., Cheng, S. X., Zhang, X. Z. & Zhuo, R. X. 2008 Biodegradable and pH-sensitive hydrogels for cell encapsulation and controlled drug release. Biomacromolecules 9, 1155-1162. (doi:10.1021/bm7010328)
    • (2008) Biomacromolecules , vol.9 , pp. 1155-1162
    • Wu, D.Q.1    Sun, Y.X.2    Xu, X.D.3    Cheng, S.X.4    Zhang, X.Z.5    Zhuo, R.X.6
  • 152
    • 1942534972 scopus 로고    scopus 로고
    • On the formulation of pH-sensitive liposomes with long circulation times
    • doi:10.1016/j.addr.2003.10.038
    • Simoes, S., Moreira, J. N., Fonseca, C., Duzgunes, N. & De Lima, M. C. 2004 On the formulation of pH-sensitive liposomes with long circulation times. Adv. Drug Deliv. Rev. 56, 947-965. (doi:10.1016/j.addr.2003.10.038)
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 947-965
    • Simoes, S.1    Moreira, J.N.2    Fonseca, C.3    Duzgunes, N.4    De Lima, M.C.5
  • 153
    • 0037967001 scopus 로고    scopus 로고
    • A macromolecular delivery vehicle for protein-based vaccines: Acid-degradable protein-loaded microgels
    • doi:10.1073/pnas.0930644100
    • Murthy, N., Xu,M., Schuck, S., Kunisawa, J., Shastri, N. & Frechet, J. M. 2003 A macromolecular delivery vehicle for protein-based vaccines: acid-degradable protein-loaded microgels. Proc. Natl Acad. Sci. USA 100, 4995-5000. (doi:10.1073/pnas.0930644100)
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 4995-5000
    • Murthy, N.1    Xu, M.2    Schuck, S.3    Kunisawa, J.4    Shastri, N.5    Frechet, J.M.6
  • 154
    • 38849140903 scopus 로고    scopus 로고
    • Biodegradable and pH-sensitive hydrogels for potential colon-specific drug delivery: Characterization and in vitro release studies
    • doi:10.1021/bm700716c
    • Casadei,M. A., Pitarresi, G., Calabrese, R., Paolicelli, P. & Giammona, G. 2008 Biodegradable and pH-sensitive hydrogels for potential colon-specific drug delivery: characterization and in vitro release studies. Biomacromolecules 9, 43-49. (doi:10.1021/bm700716c)
    • (2008) Biomacromolecules , vol.9 , pp. 43-49
    • Casadei, M.A.1    Pitarresi, G.2    Calabrese, R.3    Paolicelli, P.4    Giammona, G.5
  • 155
    • 36549073613 scopus 로고    scopus 로고
    • Thermoresponsive hydrogels in biomedical applications
    • doi:10.1016/j.ejpb.2007.02.025
    • Klouda, L. & Mikos, A. G. 2008 Thermoresponsive hydrogels in biomedical applications. Eur. J. Pharm. Biopharm. 68, 34-45. (doi:10.1016/j.ejpb.2007.02.025)
    • (2008) Eur. J. Pharm. Biopharm. , vol.68 , pp. 34-45
    • Klouda, L.1    Mikos, A.G.2
  • 156
    • 46849118467 scopus 로고    scopus 로고
    • Synthesis and characterization of injectable, thermally and chemically gelable, amphiphilic poly(N-isopropylacrylamide)-based macromers
    • doi:10.1021/bm8000414
    • Hacker, M. C., Klouda, L., Ma, B. B., Kretlow, J. D. & Mikos, A. G. 2008 Synthesis and characterization of injectable, thermally and chemically gelable, amphiphilic poly(N-isopropylacrylamide)-based macromers. Biomacromolecules 9, 1558-1570. (doi:10.1021/bm8000414)
    • (2008) Biomacromolecules , vol.9 , pp. 1558-1570
    • Hacker, M.C.1    Klouda, L.2    Ma, B.B.3    Kretlow, J.D.4    Mikos, A.G.5
  • 157
    • 43149107888 scopus 로고    scopus 로고
    • Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control
    • doi:10.1021/bm701390f
    • Reddy, T. T., Kano, A., Maruyama, A., Hadano, M. & Takahara, A. 2008 Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control. Biomacromolecules 9, 1313-1321. (doi:10.1021/bm701390f)
    • (2008) Biomacromolecules , vol.9 , pp. 1313-1321
    • Reddy, T.T.1    Kano, A.2    Maruyama, A.3    Hadano, M.4    Takahara, A.5
  • 158
    • 42049083157 scopus 로고    scopus 로고
    • Preparation and characterization of pH- and temperature-sensitive pullulan microspheres for controlled release of drugs
    • doi:10.1016/j.biomaterials.2008.03.025
    • Fundueanu, G., Constantin, M. & Ascenzi, P. 2008 Preparation and characterization of pH- and temperature-sensitive pullulan microspheres for controlled release of drugs. Biomaterials 29, 2767-2775. (doi:10.1016/j. biomaterials.2008.03.025)
    • (2008) Biomaterials , vol.29 , pp. 2767-2775
    • Fundueanu, G.1    Constantin, M.2    Ascenzi, P.3
  • 159
    • 36048972285 scopus 로고    scopus 로고
    • Thermoresponsive and biodegradable linear-dendritic nanoparticles for targeted and sustained release of a pro-apoptotic drug
    • doi:10.1016/j.biomaterials.2007.09.037
    • Stover, T. C., Kim, Y. S., Lowe, T. L. & Kester, M. 2008 Thermoresponsive and biodegradable linear-dendritic nanoparticles for targeted and sustained release of a pro-apoptotic drug. Biomaterials 29, 359-369. (doi:10.1016/j.biomaterials.2007.09.037)
    • (2008) Biomaterials , vol.29 , pp. 359-369
    • Stover, T.C.1    Kim, Y.S.2    Lowe, T.L.3    Kester, M.4
  • 160
    • 0033781924 scopus 로고    scopus 로고
    • Engineering autogenous cartilage in the shape of a helix using an injectable hydrogel scaffold
    • doi:10.1097/00005537-200010000-00023
    • Saim, A. B., Cao, Y., Weng, Y., Chang, C. N., Vacanti, M. A., Vacanti, C. A. & Eavey, R. D. 2000 Engineering autogenous cartilage in the shape of a helix using an injectable hydrogel scaffold. Laryngoscope 110, 1694-1697. (doi:10.1097/00005537-200010000-00023)
    • (2000) Laryngoscope , vol.110 , pp. 1694-1697
    • Saim, A.B.1    Cao, Y.2    Weng, Y.3    Chang, C.N.4    Vacanti, M.A.5    Vacanti, C.A.6    Eavey, R.D.7
  • 161
    • 5444257585 scopus 로고    scopus 로고
    • Thermoreversible hydrogel scaffolds for articular cartilage engineering
    • Fisher, J. P., Jo, S., Mikos, A. G. & Reddi, A. H. 2004 Thermoreversible hydrogel scaffolds for articular cartilage engineering. J. Biomed. Mater. Res. A 71, 268-274.
    • (2004) J. Biomed. Mater. Res. A , vol.71 , pp. 268-274
    • Fisher, J.P.1    Jo, S.2    Mikos, A.G.3    Reddi, A.H.4
  • 162
    • 19944388918 scopus 로고    scopus 로고
    • New thermogelling poly (organophosphazenes) with methoxypoly(ethylene glycol) and oligopeptide as side groups
    • doi:10.1016/j.polymer.2005.04.024
    • Seong, J. Y., Jun, Y. J., Jeong, B. & Sohn, Y. S. 2005 New thermogelling poly (organophosphazenes) with methoxypoly(ethylene glycol) and oligopeptide as side groups. Polymer 46, 5075-5081. (doi:10.1016/j.polymer.2005. 04.024)
    • (2005) Polymer , vol.46 , pp. 5075-5081
    • Seong, J.Y.1    Jun, Y.J.2    Jeong, B.3    Sohn, Y.S.4
  • 163
  • 164
    • 0034954524 scopus 로고    scopus 로고
    • In vivo molecular target assessment of matrix metalloproteinase inhibition
    • doi:10.1038/89126
    • Bremer, C., Tung, C. H. & Weissleder, R. 2001 In vivo molecular target assessment of matrix metalloproteinase inhibition. Nat. Med. 7, 743-748. (doi:10.1038/89126)
    • (2001) Nat. Med. , vol.7 , pp. 743-748
    • Bremer, C.1    Tung, C.H.2    Weissleder, R.3
  • 166
    • 29644438441 scopus 로고    scopus 로고
    • Enzyme responsive polymer hydrogel beads
    • doi:10.1039/b511005j
    • Thornton, P. D., Mcconnell, G. & Ulijn, R. V. 2005 Enzyme responsive polymer hydrogel beads. Chem. Commun. 5913-5915. (doi:10.1039/b511005j)
    • (2005) Chem. Commun. , pp. 5913-5915
    • Thornton, P.D.1    Mcconnell, G.2    Ulijn, R.V.3
  • 167
    • 33749990933 scopus 로고    scopus 로고
    • Enzyme-catalysed assembly of DNA hydrogel
    • doi:10.1038/nmat1741
    • Um, S. H., Lee, J. B., Park, N., Kwon, S. Y., Umbach, C. C. & Luo, D. 2006 Enzyme-catalysed assembly of DNA hydrogel. Nat. Mater. 5, 797-801. (doi:10.1038/nmat1741)
    • (2006) Nat. Mater. , vol.5 , pp. 797-801
    • Um, S.H.1    Lee, J.B.2    Park, N.3    Kwon, S.Y.4    Umbach, C.C.5    Luo, D.6
  • 168
    • 28844490136 scopus 로고    scopus 로고
    • DNA-responsive hydrogels that can shrink or swell
    • doi:10.1021/bm0504330
    • Murakami, Y. & Maeda, M. 2005 DNA-responsive hydrogels that can shrink or swell. Biomacromolecules 6, 2927-2929. (doi:10.1021/bm0504330)
    • (2005) Biomacromolecules , vol.6 , pp. 2927-2929
    • Murakami, Y.1    Maeda, M.2
  • 169
    • 0033600290 scopus 로고    scopus 로고
    • A reversibly antigen-responsive hydrogel
    • doi:10.1038/21619
    • Miyata, T., Asami, N. & Uragami, T. 1999 A reversibly antigen-responsive hydrogel. Nature 399, 766-769. (doi:10.1038/21619)
    • (1999) Nature , vol.399 , pp. 766-769
    • Miyata, T.1    Asami, N.2    Uragami, T.3
  • 170
    • 52549088053 scopus 로고    scopus 로고
    • Drug-sensing hydrogels for the inducible release of biopharmaceuticals
    • doi:10.1038/nmat2250
    • Ehrbar, M., Schoenmakers, R., Christen, E. H., Fussenegger, M. & Weber, W. 2008 Drug-sensing hydrogels for the inducible release of biopharmaceuticals. Nat. Mater. 7, 800-804. (doi:10.1038/nmat2250)
    • (2008) Nat. Mater. , vol.7 , pp. 800-804
    • Ehrbar, M.1    Schoenmakers, R.2    Christen, E.H.3    Fussenegger, M.4    Weber, W.5
  • 171
    • 16244366834 scopus 로고    scopus 로고
    • Genetically engineered protein in hydrogels tailors stimuli-responsive characteristics
    • doi:10.1038/nmat1352
    • Ehrick, J. D., Deo, S. K., Browning, T.W., Bachas, L. G., Madou, M. J. & Daunert, S. 2005 Genetically engineered protein in hydrogels tailors stimuli-responsive characteristics. Nat. Mater. 4, 298-302. (doi:10.1038/ nmat1352)
    • (2005) Nat. Mater. , vol.4 , pp. 298-302
    • Ehrick, J.D.1    Deo, S.K.2    Browning, T.W.3    Bachas, L.G.4    Madou, M.J.5    Daunert, S.6
  • 172
    • 34147207633 scopus 로고    scopus 로고
    • Rapid and reversible shape changes of molecular crystals on photoirradiation
    • doi:10.1038/nature05669
    • Kobatake, S., Takami, S., Muto, H., Ishikawa, T. & Irie, M. 2007 Rapid and reversible shape changes of molecular crystals on photoirradiation. Nature 446, 778-781. (doi:10.1038/nature05669)
    • (2007) Nature , vol.446 , pp. 778-781
    • Kobatake, S.1    Takami, S.2    Muto, H.3    Ishikawa, T.4    Irie, M.5
  • 173
    • 17644390992 scopus 로고    scopus 로고
    • Light-induced shape-memory polymers
    • doi:10.1038/nature03496
    • Lendlein, A., Jiang, H., Junger, O. & Langer, R. 2005 Light-induced shape-memory polymers. Nature 434, 879-882. (doi:10.1038/nature03496)
    • (2005) Nature , vol.434 , pp. 879-882
    • Lendlein, A.1    Jiang, H.2    Junger, O.3    Langer, R.4
  • 174
    • 7544245269 scopus 로고    scopus 로고
    • Reversible and efficient proton dissociation of spirobenzopyran- functionalized poly(N-isopropylacrylamide) in aqueous solution triggered by light irradiation and temporary temperature rise
    • doi:10.1021/ma0487249
    • Sumaru, K., Kameda, M., Kanamori, T. & Shinbo, T. 2004 Reversible and efficient proton dissociation of spirobenzopyran-functionalized poly(N-isopropylacrylamide) in aqueous solution triggered by light irradiation and temporary temperature rise. Macromolecules 37, 7854-7856. (doi:10.1021/ma0487249)
    • (2004) Macromolecules , vol.37 , pp. 7854-7856
    • Sumaru, K.1    Kameda, M.2    Kanamori, T.3    Shinbo, T.4
  • 175
    • 0034711369 scopus 로고    scopus 로고
    • Microfabricating conjugated polymer actuators
    • doi:10.1126/science.290.5496.1540
    • Jager, E. W., Smela, E. & Inganas, O. 2000 Microfabricating conjugated polymer actuators. Science 290, 1540-1545. (doi:10.1126/science.290. 5496.1540)
    • (2000) Science , vol.290 , pp. 1540-1545
    • Jager, E.W.1    Smela, E.2    Inganas, O.3
  • 176
    • 23144433807 scopus 로고    scopus 로고
    • A tunable dendritic molecular actuator
    • doi:10.1021/nl050422c
    • Welch, P. M. 2005 A tunable dendritic molecular actuator. Nano Lett. 5, 1279-1283. (doi:10.1021/nl050422c)
    • (2005) Nano Lett. , vol.5 , pp. 1279-1283
    • Welch, P.M.1
  • 178
    • 38349148298 scopus 로고    scopus 로고
    • Magnetic-sensitive silica nanospheres for controlled drug release
    • doi:10.1021/la701570z
    • Hu, S. H., Liu, T. Y., Huang, H. Y., Liu, D. M. & Chen, S. Y. 2008 Magnetic-sensitive silica nanospheres for controlled drug release. Langmuir 24, 239-244. (doi:10.1021/la701570z)
    • (2008) Langmuir , vol.24 , pp. 239-244
    • Hu, S.H.1    Liu, T.Y.2    Huang, H.Y.3    Liu, D.M.4    Chen, S.Y.5
  • 179
    • 64249113913 scopus 로고    scopus 로고
    • Photodegradable hydrogels for dynamic tuning of physical and chemical properties
    • doi:10.1126/science.1169494
    • Kloxin, A. M., Kasko, A. M., Salinas, C. N. & Anseth, K. S. 2009 Photodegradable hydrogels for dynamic tuning of physical and chemical properties. Science 324, 59-63. (doi:10.1126/science.1169494)
    • (2009) Science , vol.324 , pp. 59-63
    • Kloxin, A.M.1    Kasko, A.M.2    Salinas, C.N.3    Anseth, K.S.4
  • 180
    • 0034700503 scopus 로고    scopus 로고
    • Controlled growth factor release from synthetic extracellular matrices
    • doi:10.1038/35044106
    • Lee, K. Y., Peters, M. C., Anderson, K. W. & Mooney, D. J. 2000 Controlled growth factor release from synthetic extracellular matrices. Nature 408, 998-1000. (doi:10.1038/35044106)
    • (2000) Nature , vol.408 , pp. 998-1000
    • Lee, K.Y.1    Peters, M.C.2    Anderson, K.W.3    Mooney, D.J.4
  • 181
    • 0033517733 scopus 로고    scopus 로고
    • Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: Results of a phase I randomized, double-blind, placebo-controlled trial
    • Laham, R. J., Sellke, F.W., Edelman, E. R., Pearlman, J. D., Ware, J. A., Brown, D. L., Gold, J. P. & Simons, M. 1999 Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: results of a phase I randomized, double-blind, placebo-controlled trial. Circulation 100, 1865-1871.
    • (1999) Circulation , vol.100 , pp. 1865-1871
    • Laham, R.J.1    Sellke, F.W.2    Edelman, E.R.3    Pearlman, J.D.4    Ware, J.A.5    Brown, D.L.6    Gold, J.P.7    Simons, M.8
  • 182
    • 0036658287 scopus 로고    scopus 로고
    • Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein
    • doi:10.1067/mtc.2002.121974
    • Ruel, M., Laham, R. J., Parker, J. A., Post, M. J., Ware, J. A., Simons, M. & Sellke, F. W. 2002 Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein. J. Thorac. Cardiovasc. Surg. 124, 28-34. (doi:10.1067/mtc.2002.121974)
    • (2002) J. Thorac. Cardiovasc. Surg. , vol.124 , pp. 28-34
    • Ruel, M.1    Laham, R.J.2    Parker, J.A.3    Post, M.J.4    Ware, J.A.5    Simons, M.6    Sellke, F.W.7
  • 183
    • 0036899744 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: A prospective, controlled, randomized study of four hundred and fifty patients
    • Govender, S. et al. 2002 Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J. Bone Joint Surg. Am. 84-A, 2123-2134.
    • (2002) J. Bone Joint Surg. Am. , vol.84 A , pp. 2123-2134
    • Govender, S.1
  • 184
    • 33745713060 scopus 로고    scopus 로고
    • Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial
    • doi:10.2106/JBJS.E.00381
    • Jones, A. L., Bucholz, R. W., Bosse, M. J., Mirza, S. K., Lyon, T. R., Webb, L. X., Pollak, A. N., Golden, J. D. & Valentin-Opran, A. 2006 Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial. J. Bone Joint Surg. Am. 88, 1431-1441. (doi:10.2106/JBJS.E.00381)
    • (2006) J. Bone Joint Surg. Am. , vol.88 , pp. 1431-1441
    • Jones, A.L.1    Bucholz, R.W.2    Bosse, M.J.3    Mirza, S.K.4    Lyon, T.R.5    Webb, L.X.6    Pollak, A.N.7    Golden, J.D.8    Valentin-Opran, A.9
  • 185
    • 66449124629 scopus 로고    scopus 로고
    • The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis: A long-term (>4 years) pivotal study
    • doi:10.1097/BRS.0b013e31818a314d
    • Vaccaro, A. R., Lawrence, J. P., Patel, T., Katz, L. D., Anderson, D. G., Fischgrund, J. S., Krop, J., Fehlings, M. G. & Wong, D. 2008 The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis: a long-term (>4 years) pivotal study. Spine 33, 2850-2862. (doi:10.1097/BRS.0b013e31818a314d)
    • (2008) Spine , vol.33 , pp. 2850-2862
    • Vaccaro, A.R.1    Lawrence, J.P.2    Patel, T.3    Katz, L.D.4    Anderson, D.G.5    Fischgrund, J.S.6    Krop, J.7    Fehlings, M.G.8    Wong, D.9
  • 186
    • 42949154302 scopus 로고    scopus 로고
    • The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: Minimum 4-year follow-up of a pilot study
    • doi:10.1016/j.spinee.2007.03.012
    • Vaccaro, A. R. et al. 2008 The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study. Spine J. 8, 457-465. (doi:10.1016/j.spinee.2007.03.012)
    • (2008) Spine J. , vol.8 , pp. 457-465
    • Vaccaro, A.R.1
  • 188
    • 0031127110 scopus 로고    scopus 로고
    • Effect of polymer foam morphology and density on kinetics of in vitro controlled release of isoniazid from compressed foam matrices
    • doi:10.1002/(SICI)1097-4636(199704)35:1〈107::AID-JBM11〉3.0. CO;2-G
    • Hsu, Y. Y., Gresser, J. D., Trantolo, D. J., Lyons, C. M., Gangadharam, P. R. & Wise, D. L. 1997 Effect of polymer foam morphology and density on kinetics of in vitro controlled release of isoniazid from compressed foam matrices. J. Biomed. Mater. Res. 35, 107-116. (doi:10.1002/(SICI)1097- 4636(199704)35:1〈107::AID-JBM11〉3.0.CO;2-G)
    • (1997) J. Biomed. Mater. Res. , vol.35 , pp. 107-116
    • Hsu, Y.Y.1    Gresser, J.D.2    Trantolo, D.J.3    Lyons, C.M.4    Gangadharam, P.R.5    Wise, D.L.6
  • 189
    • 0029253379 scopus 로고
    • A novel method to fabricate bioabsorbable scaffolds
    • doi:10.1016/0032-3861(95)93115-3
    • Whang, K., Thomas, C. H., Healy, K. E. & Nuber, G. 1995 A novel method to fabricate bioabsorbable scaffolds. Polymer 36, 837-842. (doi:10.1016/0032-3861(95)93115-3)
    • (1995) Polymer , vol.36 , pp. 837-842
    • Whang, K.1    Thomas, C.H.2    Healy, K.E.3    Nuber, G.4
  • 190
    • 0003270358 scopus 로고    scopus 로고
    • Macroporous poly(L-lactide) scaffold. 1. Preparation of a macroporous scaffold by liquid-liquid phase separation of a PLLA-dioxane-water system
    • doi:10.1002/jbm.10121
    • Hua, F. J., Kim, G. E., Lee, J. D., Son, Y. K. & Lee, D. S. 2002 Macroporous poly(L-lactide) scaffold. 1. Preparation of a macroporous scaffold by liquid-liquid phase separation of a PLLA-dioxane-water system. J. Biomed. Mater. Res. 63, 161-167. (doi:10.1002/jbm.10121)
    • (2002) J. Biomed. Mater. Res. , vol.63 , pp. 161-167
    • Hua, F.J.1    Kim, G.E.2    Lee, J.D.3    Son, Y.K.4    Lee, D.S.5
  • 191
    • 85016543400 scopus 로고
    • Fabrication of controlled release biodegradable foams by phase separation
    • doi:10.1089/ten.1995.1.15
    • Lo, H., Ponticiello, M. S. & Leong, K.W. 1995 Fabrication of controlled release biodegradable foams by phase separation. Tissue Eng. 1, 15-28. (doi:10.1089/ten.1995.1.15)
    • (1995) Tissue Eng. , vol.1 , pp. 15-28
    • Lo, H.1    Ponticiello, M.S.2    Leong, K.W.3
  • 192
    • 0029176138 scopus 로고
    • Fabrication of biodegradable polymer scaffolds to engineer trabecular bone
    • doi:10.1163/156856295X00805
    • Thomson, R. C., Yaszemski, M. J., Powers, J. M. & Mikos, A. G. 1995 Fabrication of biodegradable polymer scaffolds to engineer trabecular bone. J. Biomater. Sci. Polym. Ed. 7, 23-38. (doi:10.1163/156856295X00805)
    • (1995) J. Biomater. Sci. Polym. Ed. , vol.7 , pp. 23-38
    • Thomson, R.C.1    Yaszemski, M.J.2    Powers, J.M.3    Mikos, A.G.4
  • 193
    • 0034893620 scopus 로고    scopus 로고
    • Emulsion-derived foams (PolyHIPEs) containing poly(epsilon-caprolactone) as matrixes for tissue engineering
    • doi:10.1021/bm0000889
    • Busby, W., Cameron, N. R. & Jahoda, C. A. 2001 Emulsion-derived foams (PolyHIPEs) containing poly(epsilon-caprolactone) as matrixes for tissue engineering. Biomacromolecules 2, 154-164. (doi:10.1021/bm0000889)
    • (2001) Biomacromolecules , vol.2 , pp. 154-164
    • Busby, W.1    Cameron, N.R.2    Jahoda, C.A.3
  • 194
    • 0035869825 scopus 로고    scopus 로고
    • The effects of scaffold thickness on tissue engineered cartilage in photocrosslinked poly(ethylene oxide) hydrogels
    • doi:10.1016/S0142-9612(00)00225-8
    • Bryant, S. J. & Anseth, K. S. 2001 The effects of scaffold thickness on tissue engineered cartilage in photocrosslinked poly(ethylene oxide) hydrogels. Biomaterials 22, 619-626. (doi:10.1016/S0142-9612(00)00225-8)
    • (2001) Biomaterials , vol.22 , pp. 619-626
    • Bryant, S.J.1    Anseth, K.S.2
  • 195
    • 0842345370 scopus 로고    scopus 로고
    • Thermally cross-linked oligo(poly(ethylene glycol) fumarate) hydrogels support osteogenic differentiation of encapsulated marrow stromal cells in vitro
    • doi:10.1021/bm030067p
    • Temenoff, J. S., Park, H., Jabbari, E., Conway, D. E., Sheffield, T. L., Ambrose, C. G. & Mikos, A. G. 2004 Thermally cross-linked oligo(poly(ethylene glycol) fumarate) hydrogels support osteogenic differentiation of encapsulated marrow stromal cells in vitro. Biomacromolecules 5, 5-10. (doi:10.1021/bm030067p)
    • (2004) Biomacromolecules , vol.5 , pp. 5-10
    • Temenoff, J.S.1    Park, H.2    Jabbari, E.3    Conway, D.E.4    Sheffield, T.L.5    Ambrose, C.G.6    Mikos, A.G.7


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