Neuroactive conducting scaffolds: Nerve growth factor conjugation on active ester-functionalized polypyrrole

Journal of the Royal Society Interface

Volumn 6, Issue 38, 2009, Pages 801-810

  Jae, Young Lee ^a   Lee, Joo Woon ^b   Schmidt, Christine E ^a  

^a The University of Texas at Austin   (United States)

^b Chungju National University   (South Korea)

Author keywords

Nerve growth factor; Nerve tissue engineering; PC12 cells; Polypyrrole

Indexed keywords

BIOACTIVITY; BIOSENSORS; CELL MEMBRANES; CONDUCTING POLYMERS; COPOLYMERIZATION; COPOLYMERS; ESTERIFICATION; ESTERS; INFRARED SPECTROSCOPY; MONOMERS; NITROGEN COMPOUNDS; PEPTIDES; POLYPYRROLES; SCAFFOLDS; SPECTROSCOPIC ANALYSIS; X RAY PHOTOELECTRON SPECTROSCOPY;

ACTIVE ESTERS; CELL TYPES; ELECTRICAL POTENTIAL; ELECTRICALLY CONDUCTIVE; ELECTROCONDUCTIVE; ELECTROCONDUCTIVE POLYMERS; ELECTROCONDUCTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FUNCTIONALIZED POLYPYRROLE; MONOMER COMPOSITIONS; MONOMER RATIO; NERVE GROWTH FACTOR; NERVE TISSUE ENGINEERING; NEURAL APPLICATIONS; NEURITES; NEURONAL TISSUES; NEUROTROPHIC ACTIVITIES; PC12 CELLS; PHOSPHATE-BUFFERED SALINE SOLUTIONS; PPY FILMS; SUCCINIMIDYL ESTER; TISSUE ENGINEERING SCAFFOLD; XPS;

TISSUE ENGINEERING;

COPOLYMER; MONOMER; NERVE GROWTH FACTOR; PHOSPHATE BUFFERED SALINE; POLYPYRROLE;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN; ELECTRIC CONDUCTIVITY; ELECTRIC POTENTIAL; ENZYME LINKED IMMUNOSORBENT ASSAY; INFRARED SPECTROSCOPY; NERVE CELL; NEURITE; NONHUMAN; RAT; REFLECTOMETRY; SOLUTION AND SOLUBILITY; TISSUE ENGINEERING; X RAY PHOTOELECTRON SPECTROSCOPY;

EID: 68149087557     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2008.0403     Document Type: Article

References (47)

1. Aloe, L., Bracci-Laudiero, L., Bonini, S. & Manni, L. 1997 The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases. Allergy 52, 883-894. (doi:10.1111/j.1398-9995.1997.tb01247.x)
2. Ateh, D. D., Navsaria, H. A. & Vadgama, P. 2006 Polypyrrole-based conducting polymers and interactions with biological tissues. J. R. Soc. Interface 3, 741-752. (doi:10.1098/rsif.2006.0141)
3. Azioune, A., Slimane, A. B., Hamou, L. A., Pleuvy, A., Chehimi, M. M., Perruchot, C. & Armes, S. P. 2004 Synthesis and characterization of active ester-functionalized polypyrrole-silica nanoparticles: application to the covalent attachment of proteins. Langmuir 20, 3350-3356. (doi:10.1021/la030407s)
4. Bousalem, S., Mangeney, C., Chehimi, M. M., Basinska, T., Miksa, B. & Slomkowski, S. 2004 Synthesis, characterization and potential biomedical applications of N-succinimidyl ester functionalized, polypyrrole-coated polystyrene latex particles. Colloid Polym. Sci. 282, 1301-1307. (doi:10.1007/ s00396-004-1065-1068)
5. Boyd, J. G. & Gordon, T. 2003 Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury. Mol. Neurobiol. 27, 277-324. (doi:10.1385/MN:27:3:277)
6. Chalfoun, C. T., Wirth, G. A. & Evans, G. R. 2006 Tissue engineered nerve constructs: where do we stand? J. Cell. Mol. Med. 10, 309-317. (doi:10.1111/j.1582-4934.2006. tb00401.x)
7. Chao, M. V. 2003 Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat. Rev. Neurosci. 4, 299-309. (doi:10.1038/nrn1078)
8. Collier, J. H., Camp, J. P., Hudson, T. W. & Schmidt, C. E. 2000 Synthesis and characterization of polypyrrole- hyaluronic acid composite biomaterials for tissue engineering applications. J. Biomed. Mater. Res. 50, 574-584. (doi:10.1002/(SICI)1097-4636(20000615)50:4 <574::AID-JBM13>3.0. CO;2-I)
9. Cui, X., Wiler, J., Dzaman, M., Altschuler, R. A. & Martin, D. C. 2003 In vivo studies of polypyrrole/peptide coated neural probes. Biomaterials 24, 777-787. (doi:10.1016/ S0142-9612(02)00415-5)
10. Ebadi, M. et al. 1997 Neurotrophins and their receptors in nerve injury and repair. Neurochem. Int. 30, 347-374. (doi:10.1016/S0197-0186(96)00071-X)
11. Fonner, J. M., Forciniti, L., Nguyen, H., Byrene, J., Kou, Y., Syeda-Nawaz, J. & Schmidt, C. E. 2008 Biocompatibility implications of polypyrrole synthesis techniques. Biomed. Mater. 3, 034124. (doi:10.1088/1748- 6041/3/034124)
12. George, P. M., LaVan, D. A., Burdick, J. A., Chen, C. Y., Liang, E. & Langer, R. 2006 Electrically controlled drug delivery from biotin-doped conductive polypyrrole. Adv. Mater. 18, 577-581. (doi:10.1002/adma.200501242)
13. Gomez, N. & Schmidt, C. E. 2007 Nerve growth factor-immobilized polypyrrole: bioactive electrically conducting polymer for enhanced neurite extension. J. Biomed. Mater. Res. 81, 135-149. (doi:10.1002/jbm.a.31047)
14. Gomez, N., Lee, J. Y., Nickels, J. D. & Schmidt, C. E. 2007 Micropatterned polypyrrole: combination of electrical and topographical characteristics for stimulation of cells. Adv. Funct. Mater. 17, 1645-1653. (doi:10.1002/adfm. 200600669)
15. Guimard, N. K., Gomez, N. & Schmidt, C. E. 2007 Conducting polymers in biomedical engineering. Prog. Polym. Sci. 32, 876-921. (doi:10.1016/j. progpolymsci. 2007.05.012)
16. Hermanson, G. T. (ed.) 1996 Bioconjugate techniques. New York, NY: Academic Press.
17. Hodgson, A. J., John, M. J., Campbell, T., Georgevich, A., Woodhouse, S., Aoki, T., Ogata, N. & Wallace, G. G. 1996 Integration of biocomponents with synthetic structures- use of conducting polymer polyelectrolyte composites. Proc. SPIE Int. Soc. Opt. Eng. 2716, 164-176. (doi:10. 1117/12.232137)
18. Kang, E. T., Neoh, K. G., Tan, K. L. & Loh, F. C. 1997 Surface modified and functionalized polyaniline and polypyrrole films. Synth. Met. 84, 59-60. (doi:10.1016/ S0379-6779(97)80664-9)
19. Kapur, T. A. & Shoichet, M. S. 2003 Chemically-bound nerve growth factor for neural tissue engineering applications. J. Biomater. Sci. Polym. Ed. 14, 383-394. (doi:10.1163/ 156856203321478883)
20. Khan, W., Marew, T. & Kumar, N. 2006 Immobilization of drugs and biomolecules on in situ copolymerized active ester polypyrrole coatings for biomedical applications. Biomed. Mater. 1, 235-241. (doi:10.1088/1748-6041/1/4/ 009)
21. Kim, D. H., Richardson-Burns, S. M., Hendricks, J. L., Sequera, C. & Martin, D. C. 2007 Effect of immobilized nerve growth factor on conductive polymers: electrical properties and cellular response. Adv. Funct. Mater. 17, 79-86. (doi:10.1002/adfm.200500594)
22. Krapchetov, D. A., Ma, H., Jen, A. K., Fischer, D. A. & Loo, Y. L. 2006 High-sensitivity transmission IR spectroscopy for the chemical identification and structural analysis of conjugated molecules on gallium arsenide surfaces. Langmuir 22, 9491-9494. (doi:10.1021/la0623984) (Pubitemid 44826353)
23. Lee, J.-W., Serna, F., Nickels, J. D. & Schmidt, C. E. 2006 Carboxylic acid-functionalized conductive polypyrrole as a bioactive platform for cell adhesion. Biomacromolecules 7, 1692-1695. (doi:10.1021/bm060220q) (Pubitemid 43985085)
24. Levi-Montalcini, R. 1987 The nerve growth factor 35 years later. Science 237, 1154-1162. (doi:10.1126/science. 3306916) (Pubitemid 17124912)
25. Li, G. N. & Hoffman-Kim, D. 2008 Tissue-engineered platforms of axon guidance. Tissue Eng. B 14, 33-51. (doi:10.1089/teb.2007.0181)
26. Li, Y., Neoh, K. G. & Kang, E. T. 2005 Controlled release of heparin from polypyrrole-poly(vinyl alcohol) assembly by electrical stimulation. J. Biomed. Mater. Res. 73, 171-181. (doi:10.1002/jbm.a.30286)
27. Lutolf, M. P. & Hubbell, J. A. 2005 Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat. Biotechnol. 23, 47-55. (doi:10.1038/nbt1055)
28. Maddison, D. S. & Jenden, C. K. 1992 Dopant exchange in conducting polypyrrole films. Polym. Int. 27, 231-235. (doi:10.1002/pi.4990270306)
29. McCaig, C. D., Rajnicek, A. M., Song, B. & Zhao, M. 2002 Has electrical growth cone guidance found its potential? Trends Neurosci. 7, 354-359. (doi:10.1016/S0166-2236(02) 02174-4)
30. Naka, Y., Kitazawa, A., Akaishi, Y. & Shimizu, N. 2004 Neurite outgrowths of neurons using neurotrophin-coated nanoscale magnetic beads. J. Biosci. Bioeng. 98, 348-352. (doi:10.1016/S1389-1723(04)00294-4)
31. Nalwa, H. S. (ed.) 1997 Handbook of organic conductive molecules and polymers, vol.2. London, UK: Wiley.
32. Nico, B., Mangieri, D., Benagiano, V., Crivellato, E. & Ribatti, D. 2008 Nerve growth factor as an angiogenic factor. Microvasc. Res. 75, 135-141. (doi:10.1016/j.mvr. 2007.07.004)
33. O'Neill, M. J., Murray, T. K., Clay, M. P., Lindstrom, T., Yang, C. R. & Nisenbaum, E. S. 2005 LY503430: pharmacology, pharmacokinetics, and effects in rodent models of Parkinson's disease. CNS Drug Rev. 11, 77-96. (doi:10.1111/j.1527-3458.2005.tb00037.x) (Pubitemid 40577947)
34. Ramer, M. S., Priestley, J. V. & McMahon, S. B. 2000 Functional regeneration of sensory axons into the adult spinal cord. Nature 403, 312-316. (doi:10.1038/35002084)
35. Richardson, R. T. et al. 2007 The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons. Biomaterials 28, 513-523. (doi:10.1016/j.biomaterials.2006.09.008)
36. Runyan, W. R. (ed.) 1975 Semiconductor measurements and instrumentation. New York, NY: McGraw-Hill.
37. Sanghvi, A. B., Miller, K. P., Belcher, A. M. & Schmidt, C. E. 2005 Biomaterials functionalization using a novel peptide that selectively binds to a conducting polymer. Nat. Mater. 4, 496-502. (doi:10.1038/nmat1397)
38. Schmidt, C. E., Shastri, V. R., Vacanti, J. P. & Langer, R. 1997 Stimulation of neurite outgrowth using an electrically conducting polymer. Proc. Natl Acad. Sci. USA 94, 8948-8953. (doi:10.1073/pnas.94.17.8948)
39. Scriven, E. F. V. (ed.) 1984 Azides and nitrenes: reactivity and utility. Orlando, FL: Academic Press.
40. Serini, G. & Bussolino, F. 2005 Common cues in vascular and axon guidance. Physiology 19, 348-354. (doi:10.1152/ physiol.00021.2004) (Pubitemid 39636082)
41. Shooter, E. M. 2001 Early days of the nerve growth factor proteins. Annu. Rev. Neurosci. 24, 601-629. (doi:10.1146/ annurev.neuro.24.1.601)
42. Silva, G. A. 2006 Neuroscience nanotechnology: progress, opportunities and challenges. Nat. Rev. Neurosci. 7, 65-74. (doi:10.1038/nrn1827)
43. Skotheim, T. A., Elsenaumer, R. L. & Reynolds, J. R. (eds) 1998 Handbook of conducting polymers. New York, NY: Marcel Dekker.
44. Song, H. K., Toste, B., Ahmann, K., Hoffman-Kim, D. & Palmore, G. T. 2006 Micropatterns of positive guidance cues anchored to polypyrrole doped with polyglutamic acid: a new platform for characterizing neurite extension in complex environments. Biomaterials 27, 473-484. (doi:10. 1016/j.biomaterials. 2005.06.030) (Pubitemid 41457250)
45. Stauffer, W. R. & Cui, X. T. 2006 Polypyrrole doped with 2 peptide sequences from laminin. Biomaterials 27, 2405-2413. (doi:10.1016/j.biomaterials. 2005.10.024)
46. Zhang, Y., Moheban, D. B., Conway, B. R., Bhattacharyya, A. & Segal, R. A. 2000 Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation. J. Neurosci. 20, 5671-5678. (Pubitemid 30636894)
47. Zhang, N., Yan, H. & Wen, X. 2005 Tissue-engineering approaches for axonal guidance. Brain Res. Brain Res. Rev. 49, 48-64. (doi:10.1016/j. brainresrev.2004.11.002)