Zwitterionic hydrogels implanted in mice resist the foreign-body reaction

Nature Biotechnology

Volumn 31, Issue 6, 2013, Pages 553-556

  Zhang, Lei ^a   Cao, Zhiqiang ^a   Bai, Tao ^a   Carr, Louisa ^a   Ella Menye, Jean Rene ^a   Irvin, Colleen ^b   Ratner, Buddy D ^a,b   Jiang, Shaoyi ^a,b  

^a University of Washington   (United States)

^b University of Washington   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; ANTI-INFLAMMATORIES; CAPSULE FORMATION; IMPLANTABLE BIOMEDICAL DEVICES; IMPLANTABLE MEDICAL DEVICES; TISSUE SCAFFOLDS;

BIOCOMPATIBILITY; BIOMEDICAL EQUIPMENT; MAMMALS; TISSUE;

HYDROGELS;

AMPHOLYTE; TISSUE SCAFFOLD;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; FOREIGN BODY REACTION; HYDROGEL; IMPLANT; MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; BIOCOMPATIBLE MATERIALS; FOREIGN-BODY REACTION; HYDROGELS; MACROPHAGES; MICE; PROSTHESES AND IMPLANTS;

EID: 84880271647     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2580     Document Type: Article

References (28)

1. Anderson, J.M., Rodriguez, A. & Chang, D.T. Foreign body reaction to biomaterials. Semin. Immunol. 20, 86-100 (2008).
2. Langer, R. Perspectives and challenges in tissue engineering and regenerative medicine. Adv. Mater. 21, 3235-3236 (2009).
3. Langer, R. & Tirrell, D.A. Designing materials for biology and medicine. Nature 428, 487-492 (2004).
4. Ratner, B.D., Hoffman, A.S., Schoen, F.J. & Lemons, J.E. Biomaterials Science (Edn. 3) (Elsevier, Amsterdam, 2012).
5. Williams, D.F. On the mechanisms of biocompatibility. Biomaterials 29, 2941-2953 (2008).
6. Williams, D.F. On the nature of biomaterials. Biomaterials 30, 5897-5909 (2009).
7. Peppas, N.A. & Langer, R. New challenges in biomaterials. Science 263, 1715-1720 (1994).
8. Ratner, B.D. Reducing capsular thickness and enhancing angiogenesis around implant drug release systems. J. Control. Release 78, 211-218 (2002).
9. Hetrick, E.M., Prichard, H.L., Klitzman, B. & Schoenfisch, M.H. Reduced foreign body response at nitric oxide-releasing subcutaneous implants. Biomaterials 28, 4571-4580 (2007).
10. Ward, W.K. A review of the foreign-body response to subcutaneously- implanted devices: the role of macrophages and cytokines in biofouling and fibrosis. J. Diabetes Sci. Technol. 2, 768-777 (2008).
11. Ostuni, E., Chapman, R.G., Holmlin, R.E., Takayama, S. & Whitesides, G.M. A survey of structure-property relationships of surfaces that resist the adsorption of protein. Langmuir 17, 5605-5620 (2001).
12. Jiang, S.Y. & Cao, Z.Q. Ultralow-fouling, functionalizable, and hydrolyzable zwitterionic materials and their derivatives for biological applications. Adv. Mater. 22, 920-932 (2010).
13. Lynn, A.D., Kyriakides, T.R. & Bryant, S.J. Characterization of the in vitro macrophage response and in vivo host response to poly(ethylene glycol)-based hydrogels. J. Biomed. Mater. Res. A 93, 941-953 (2010).
14. Campioni, E.G., Nobrega, J.N. & Sefton, M.V. HEMA/MMMA microcapsule implants in hemiparkinsonian rat brain: biocompatibility assessment using [H-3] PK11195 as a marker for gliosis. Biomaterials 19, 829-837 (1998).
15. Shen, M.C. et al. PEO-like plasma polymerized tetraglyme surface interactions with leukocytes and proteins: in vitro and in vivo studies. J. Biomater. Sci. Polym. Ed. 13, 367-390 (2002).
16. Ward, W.K., Slobodzian, E.P., Tiekotter, K.L. & Wood, M.D. The effect of microgeometry, implant thickness and polyurethane chemistry on the foreign body response to subcutaneous implants. Biomaterials 23, 4185-4192 (2002).
17. Hayward, J.A. & Chapman, D. Biomembrane surfaces as models for polymer design: the potential for haemocompatibility. Biomaterials 5, 135-142 (1984).
18. Ishihara, K., Ziats, N.P., Tierney, B.P., Nakabayashi, N. & Anderson, J.M. Protein adsorption from human plasma is reduced on phospholipid polymers. J. Biomed. Mater. Res. 25, 1397-1407 (1991).
19. Smith, R.S. et al. Vascular catheters with a nonleaching poly-sulfobetaine surface modification reduce thrombus formation and microbial attachment. Sci. Transl. Med. 4, 153ra132 (2012).
20. Ladd, J., Zhang, Z., Chen, S., Hower, J.C. & Jiang, S. Zwitterionic polymers exhibiting high resistance to nonspecific protein adsorption from human serum and plasma. Biomacromolecules 9, 1357-1361 (2008).
21. Ueland, P.M., Holm, P.I. & Hustad, S. Betaine: a key modulator of one-carbon metabolism and homocysteine status. Clin. Chem. Lab. Med. 43, 1069-1075 (2005).
22. Carr, L.R., Cheng, G., Xue, H. & Jiang, S. Engineering the polymer backbone to strengthen nonfouling sulfobetaine hydrogels. Langmuir 26, 14793-14798 (2010).
23. Carr, L.R., Xue, H. & Jiang, S.Y. Functionalizable and nonfouling zwitterionic carboxybetaine hydrogels with a carboxybetaine dimethacrylate crosslinker. Biomaterials 32, 961-968 (2011).
24. Carr, L.R., Zhou, Y.B., Krause, J.E., Xue, H. & Jiang, S.Y. Uniform zwitterionic polymer hydrogels with a nonfouling and functionalizable crosslinker using photopolymerization. Biomaterials 32, 6893-6899 (2011).
25. Madden, L.R. et al. Proangiogenic scaffolds as functional templates for cardiac tissue engineering. Proc. Natl. Acad. Sci. USA 107, 15211-15216 (2010).
26. Liu, L.Y. et al. Reduced foreign body reaction to implanted biomaterials by surface treatment with oriented osteopontin. J. Biomater. Sci. Polym. Ed. 19, 821-835 (2008).
27. Zhang, Z. et al. Zwitterionic hydrogels: an in vivo implantation study. J. Biomater. Sci. Polym. Ed. 20, 1845-1859 (2009).
28. Tsai, A.T. et al. The role of osteopontin in foreign body giant cell formation. Biomaterials 26, 5835-5843 (2005).