Global microRNA depletion suppresses tumor angiogenesis

Genes and Development

Volumn 28, Issue 10, 2014, Pages 1054-1067

  Chen, Sidi ^a,b   Xue, Yuan ^a   Wu, Xuebing ^a   Le, Cong ^b   Bhutkar, Arjun ^a   Bell, Eric L ^a   Zhang, Feng ^b   Langer, Robert ^a,c   Sharp, Phillip A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c USA   (United States)

Author keywords

Angiogenesis; CRISPR Cas9; Dicer; Gene regulation; Hypoxia; microRNA

Indexed keywords

CASPASE 9; CRISPR ASSOCIATED PROTEIN; DICER; FACTOR INHIBITING HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR; ISOLECTIN B4; KI 67 ANTIGEN; MESSENGER RNA; MICRORNA; MICRORNA 125B; MICRORNA 21A; PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

3' UNTRANSLATED REGION; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE CONTROL; GENE INACTIVATION; GENOTYPE; HYPOXIA; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA BINDING; UPREGULATION;

ANGIOGENESIS; CRISPR/CAS9; DICER; GENE REGULATION; HYPOXIA; MICRORNA;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DEAD-BOX RNA HELICASES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKOUT TECHNIQUES; GENOTYPE; MICE; MICE, NUDE; MICRORNAS; NEOVASCULARIZATION, PATHOLOGIC; RIBONUCLEASE III; TRANSCRIPTOME;

EID: 84900827112     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.239681.114     Document Type: Article

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