Antiapoptotic Bcl-2 homolog CED-9 in Caenorhabditis elegans: Dynamics of BH3 and CED-4 binding regions and comparison with mammalian antiapoptotic Bcl-2 proteins

Proteins: Structure, Function and Bioinformatics

Volumn 82, Issue 6, 2014, Pages 1035-1047

  Modi, Vivek ^a   Sankararamakrishnan, Ramasubbu ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

Author keywords

Accessible surface area; Comparative simulations; Flexible and rigid binding regions; Helix bundle protein; Hydrophobic binding groove; Interhelical angle; Programmed cell death; Protein protein interactions in apoptosis

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BCL2 RELATED PROTEIN A1; BH3 PROTEIN; CED 9 PROTEIN; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN BCL XL; PROTEIN MCL 1; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; CED-9 PROTEIN, C ELEGANS; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CAENORHABDITIS ELEGANS; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CROSSING ANGLE; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTON TRANSPORT; ANIMAL; BINDING SITE; CHEMICAL PHENOMENA; CHEMISTRY; COMPARATIVE STUDY; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; STRUCTURAL HOMOLOGY;

CAENORHABDITIS ELEGANS; MAMMALIA;

ANIMALS; BINDING SITES; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 84900826276     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24476     Document Type: Article

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