Unique structural features of a BCL-2 family protein CED-9 and biophysical characterization of CED-9/EGL-1 interactions

Cell Death and Differentiation

Volumn 10, Issue 12, 2003, Pages 1310-1319

  Woo, J S ^a   Jung, J S ^a   Ha, N C ^a   Shin, J ^b   Kim, K H ^a   Lee, W ^b   Oh, B H ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

Apoptosis; BCL 2 family; CED 9; EGL 1; Molecular recognition

Indexed keywords

APOPTOSIS INHIBITOR; CAENORHABDITIS ELEGANS PROTEIN; PROTEIN BCL 2; PROTEIN CED 9; PROTEIN EGL 1; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; HUMAN; HUMAN CELL; MELTING POINT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CAENORHABDITIS ELEGANS PROTEINS; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PEPTIDES; PLASMIDS; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; TEMPERATURE;

CAENORHABDITIS; CAENORHABDITIS ELEGANS;

EID: 0346121671     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401303     Document Type: Article

References (32)

1. Adams JM and Cory S (2001) Life-or-death decisions by the Bcl-2 protein family. Trends Biochem. Sci. 26: 61-66
2. Puthalakath H and Strasser A (2002) Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ. 9: 505-512
3. Bouillet P and Strasser A (2002) BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death. J. Cell. Sci. 115: 1567-1574
4. Metzstein MM, Stanfield GM and Horvitz HR (1998) Genetics of programmed cell death in C.elegans: past, present and future. Trends Genet. 14: 410-416
5. Zou H, Henzel WJ, Liu X, Lutschg A and Wang X (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90: 405-413
6. Yang X, Chang HY and Baltimore D (1998) Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281: 1355-1357
7. Chinnaiyan AM, O'Rourke K, Lane BR and Dixit VM (1997) Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science 275: 1122-1126
8. Spector MS, Desnoyers S, Hoeppner DJ and Hengartner MO (1997) Interaction between the C. elegans cell-death regulators CED-9 and CED-4. Nature 385: 653-656
9. Wu D, Wallen HD, Inohara N and Nunez G (1997) Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9. J. Biol. Chem. 272: 21449-21454
10. Wu D, Wallen HD and Nunez G (1997) Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 275: 1126-1129
11. Hengartner MO (1999) Programmed cell death in the nematode C. elegans Recent. Recent Prog. Horm. Res. 54: 213-222
12. Chen F, Hersh BM, Conradt B, Zhou Z, Riemer D, Gruenbaum Y and Horvitz HR (2000) Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science 287: 1485-1489
13. del Peso L, Gonzalez VM, Inohara N, Ellis RE and Nunez G (2000) Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans. J. Biol. Chem. 275: 27205-27211
14. Chittenden T, Flemington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, Chinnadurai G and Lutz RJ (1995) A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J. 14: 5589-5596
15. Wang K, Yin XM, Chao DT, Milliman CL and Korsmeyer SJ (1996) BID: a novel BH3 domain-only death agonist. Genes Dev. 10: 2859-2869
16. Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S and Korsmeyer SJ (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2: 183-192
17. Settler M, Liang H, Nettesheim b, Meadows RP, Harlan JE, Eberstadt M, Yoon HS, Shuker SB, Chang BS, Minn AJ, Thomson SB and Fesik SW (1997) Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science 275: 983-986
18. Xue D and Horvitz HR (1997) Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor. Nature 390: 305-308
19. Parrish J, Matters H, Chen L and Xue D (2000) Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors. Proc. Natl. Acad. Sci. USA 97: 11916-11921
20. Muchmore SW, Settler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SL and Fesik SW (1996) X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381: 335-341
21. Aritomi M, Kunishima N, Inohara N, Ishibashi Y, Ohta S and Morikawa K (1997) Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family. J. Biol. Chem. 272: 27886-27892
22. Suzuki M, Youle RJ and Tjandra N (2000) Structure of Bax: coregulation of dimer formation and intracellular localization. Cell 103: 645-654
23. Hinds MG, Lackmann M, Skea GL, Harrison PJ, Huang DC and Day CL (2003) The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity. EMBO J. 22: 1497-1507
24. Denisov AY, Madiraju MS, Chen G, Khadir A, Beauparlant P, Attardo G, Shore GC and Gehring K (2003) Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix. J. Biol. Chem. 21: 21
25. Petros AM, Medek A, Nettesheim DG, Kim DH, Yoon HS, Swift K, Matayoshi ED, Oltersdorf T and Fesik SW (2001) Solution structure of the antiapoptotic protein bcl-2. Proc. Natl. Aced. Sci. USA 98: 3012-3017
26. del Peso L, Gonzalez VM and Nunez G (1998) Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation. J. Biol. Chem. 273: 33495-33500
27. Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosova I, Kulans LA, Fu X, Weinberg JS, Heinecke JW, Roth KA and Weintraub SJ (2002) Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell 111: 51-62
28. Otwinowski Z and Minor W (1997) Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276: 307-326
29. Terwilliger TC and Berendzen J (1999) Automated MAD and MIR structure solution. Acta Crystallogr. D 55: 849-861
30. Terwilliger TC (2000) Maximum-likelihood density modification. Acta Crystallogr. D 56: 965-972
31. Jones TA, Zou JY, Cowan SW and Kjeldgaard M (1991) Improved methods for binding protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47: 110-119
32. Brunger AT, Adams PD, Clore GM, DeLano WL, Gros P, Grosse-Kunstleve RW, Jiang JS, Kuszewski J, Nilges M, Pannu NS, Read RJ, Rice LM, Simonson T and Warren GL (1998) Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Cystallogr. D 54: 905-921