Discovery of Anthelmintic Drug Targets and Drugs Using Chokepoints in Nematode Metabolic Pathways

PLoS Pathogens

Volumn 9, Issue 8, 2013, Pages

  Taylor, Christina M ^a   Wang, Qi ^a   Rosa, Bruce A ^a   Huang, Stanley Ching Cheng ^a   Powell, Kerrie ^b   Schedl, Tim ^a   Pearce, Edward J ^a   Abubucker, Sahar ^a   Mitreva, Makedonka ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCYNEXIS Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHELMINTIC AGENT; AZATHIOPRINE; AZELAIC ACID; CARBIDOPA; CARNITINE PALMITOYLTRANSFERASE I; DOPAMINE; ETOMOXIR; IVERMECTIN; MERCAPTOPURINE; METHYLDOPA; PERHEXILINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROBENECID; HELMINTH PROTEIN;

ARTICLE; BIODEGRADATION; BIOSYNTHESIS; CAENORHABDITIS ELEGANS; CHOKEPOINT ANALYSIS; COMPUTER MODEL; CONTROLLED STUDY; DRUG DATABASE; DRUG SCREENING; FATTY ACID OXIDATION; GENE EXPRESSION; HAEMONCHUS CONTORTUS; METABOLISM; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NEMATODE; NEMATODIASIS; NONHUMAN; ONCHOCERCA; OXYGEN CONSUMPTION; RNA EXTRACTION; TOXICITY; ANIMAL; DROSOPHILA MELANOGASTER; DRUG DEVELOPMENT; DRUG EFFECTS; GENETICS; HUMAN; NEMATODE INFECTIONS; PROTEIN DATABASE;

ANIMALS; ANTHELMINTICS; DATABASES, PROTEIN; DROSOPHILA MELANOGASTER; DRUG DISCOVERY; HELMINTH PROTEINS; HUMANS; NEMATODA; NEMATODE INFECTIONS; OXYGEN CONSUMPTION;

EID: 84883312193     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003505     Document Type: Article

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