Behavior of Solvent-Exposed Hydrophobic Groove in the Anti-Apoptotic Bcl-XL Protein: Clues for Its Ability to Bind Diverse BH3 Ligands from MD Simulations

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Lama, Dilraj ^a,b   Modi, Vivek ^a   Sankararamakrishnan, Ramasubbu ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

^b BIOINFORMATICS INSTITUTE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; DIMER; PROTEIN BCL XL;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HYDROPHOBICITY; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN POLYMORPHISM; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTEIN UNFOLDING; RESIDUE ANALYSIS;

APOPTOSIS; BCL-X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; SOLVENTS;

EID: 84874508143     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054397     Document Type: Article

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