Carbamazepine as a novel small molecule corrector of trafficking-impaired atp-sensitive potassium channels identified in congenital hyperinsulinism

Journal of Biological Chemistry

Volumn 288, Issue 29, 2013, Pages 20942-20954

  Chen, Pei Chun ^a   Olson, Erik M ^a   Zhou, Qing ^a   Kryukova, Yelena ^a   Sampson, Heidi M ^b   Thomas, David Y ^b   Shyng, Show Ling ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; POTASSIUM CHANNELS; SMALL MOLECULES; SULFONYLUREA RECEPTORS; SURFACE EXPRESSION;

POTASSIUM;

AMIDES;

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CARBAMAZEPINE; DIAZOXIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; SULFONYLUREA RECEPTOR 1;

ANIMAL CELL; ARTICLE; AUTOPHAGY; BIOGENESIS; BIOTINYLATION; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; DRUG MECHANISM; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; INSULIN RELEASE; MEMBRANE POTENTIAL; NONHUMAN; PANCREAS ISLET BETA CELL; PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA OF INFANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

Β-CELLS; ABC TRANSPORTER; CARBAMAZEPINE; CFTR; HYPERINSULINISM; INTRACELLULAR TRAFFICKING; KATP CHANNEL; MOLECULAR CHAPERONE; POTASSIUM CHANNELS; SULFONYLUREA RECEPTOR 1;

ANIMALS; AUTOPHAGY; CARBAMAZEPINE; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; CONGENITAL HYPERINSULINISM; COS CELLS; HEK293 CELLS; HUMANS; INSULIN-SECRETING CELLS; INSULINOMA; ION CHANNEL GATING; KATP CHANNELS; MUTANT PROTEINS; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; SMALL MOLECULE LIBRARIES; SULFONYLUREA RECEPTORS; TIME FACTORS;

EID: 84880532649     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.470948     Document Type: Article

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