Downregulation of mitochondrial lon protease impairs mitochondrial function and causes hepatic insulin resistance in human liver SK-HEP-1 cells

Diabetologia

Volumn 54, Issue 6, 2011, Pages 1437-1446

  Lee, H J ^a   Chung, K ^b   Lee, H ^a   Lee, K ^b   Lim, J H ^a   Song, J ^a  

^a Korea National Institute of Health   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

Insulin resistance; Insulin signalling; Mitochondrial dysfunction; Mitochondrial quality control

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; CCAAT ENHANCER BINDING PROTEIN ALPHA; CHOLESTEROL; ENDOPEPTIDASE LA; GLUCOSE 6 PHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; EXPRESSION VECTOR; GENETIC TRANSFECTION; GLUCONEOGENESIS; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INSULIN RESISTANCE; MALE; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; C57BL MOUSE; CELL LINE; DIABETES MELLITUS; DISEASE MODEL; DOWN REGULATION; ENZYMOLOGY; LIVER CELL; LIVER MITOCHONDRION; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CELL LINE; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GLUCONEOGENESIS; HEPATOCYTES; HUMANS; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MITOCHONDRIA, LIVER; PROTEASE LA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 80052525717     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2074-z     Document Type: Article

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