Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: P53/Hdm2 antagonists

Angewandte Chemie - International Edition

Volumn 49, Issue 31, 2010, Pages 5352-5356

  Czarna, Anna ^b   Beck, Barbara ^a   Srivastava, Stuti ^a   Popowicz, Grzegorz M ^b   Wolf, Siglinde ^b   Huang, Yijun ^a   Bista, Michal ^b   Holak, Tad A ^b   Dömling, Alexander ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Antagonists; Drug discovery multicomponent reactions; P53 Hdm2 interaction; Protein protein interactions

Indexed keywords

DRUG DISCOVERY; HIGH-CONTENT; MULTI-COMPONENT REACTIONS; PROTEIN-PROTEIN INTERACTIONS; ROBUST GENERATION; STRUCTURAL BIOLOGY;

COMPUTATIONAL CHEMISTRY; LEAD COMPOUNDS; PROTEINS; REACTION KINETICS;

DRUG INTERACTIONS;

MDM2 PROTEIN, HUMAN; PROTEIN MDM2; PROTEIN P53; TP53 PROTEIN, HUMAN;

ARTICLE; BIOLOGY; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG DEVELOPMENT; HUMAN; METABOLISM; METHODOLOGY; PROTEIN TRANSPORT;

COMPUTATIONAL BIOLOGY; DRUG DISCOVERY; HUMANS; MODELS, MOLECULAR; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77954850783     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201001343     Document Type: Article

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