Analysis of binding site hot spots on the surface of Ras GTPase

Journal of Molecular Biology

Volumn 413, Issue 4, 2011, Pages 773-789

  Buhrman, Greg ^a   O'Connor, Casey ^b   Zerbe, Brandon ^c   Kearney, Bradley M ^a   Napoleon, Raeanne ^c   Kovrigina, Elizaveta A ^b,d   Vajda, Sandor ^c   Kozakov, Dima ^c   Kovrigin, Evgenii L ^b,d   Mattos, Carla ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c Boston University   (United States)

^d MARQUETTE UNIVERSITY   (United States)

Author keywords

allosteric switch; binding site hot spots; drug target; Ras dynamics; Ras isoforms

Indexed keywords

ISOENZYME; K RAS PROTEIN; RAS PROTEIN;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME STRUCTURE; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONCOGENE H RAS; PRIORITY JOURNAL;

EID: 80054860512     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.09.011     Document Type: Article

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