-
1
-
-
80053367108
-
Probing the druggability of protein-protein interactions : Targeting the Notch1 receptor ankyrin domain using a fragment-based approach
-
ABDEL-RAHMAN, N., MARTINEZ-ARIAS, A. & BLUNDELL, T. L. (2011). Probing the druggability of protein-protein interactions : targeting the Notch1 receptor ankyrin domain using a fragment-based approach. Biochemical Society Transactions 39, 1327-1333.
-
(2011)
Biochemical Society Transactions
, vol.39
, pp. 1327-1333
-
-
Abdel-Rahman, N.1
Martinez-Arias, A.2
Blundell, T.L.3
-
2
-
-
77949837779
-
Fragment-based deconstruction of Bcl-XL inhibitors
-
BARELIER, S., PON, J., MARCILLAT, O., LANCELIN, J.M. & KRIMM, I. (2010). Fragment-based deconstruction of Bcl-XL inhibitors. Journal of Medical Chemistry 53, 2577-2588.
-
(2010)
Journal of Medical Chemistry
, vol.53
, pp. 2577-2588
-
-
Barelier, S.1
Pon, J.2
Marcillat, O.3
Lancelin, J.M.4
Krimm, I.5
-
3
-
-
78249268240
-
A stapled p53 helix overcomes HDMX-mediated suppression of p53
-
BERNAL, F., WADE, M., GODES, M., DAVIS, T. N., WHITEHEAD, D. G., KUNG, A. L., WAHL, G.M. & WALENSKY, L. D. (2010). A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell 18, 411-422.
-
(2010)
Cancer Cell
, vol.18
, pp. 411-422
-
-
Bernal, F.1
Wade, M.2
Godes, M.3
Davis, T.N.4
Whitehead, D.G.5
Kung, A.L.6
Wahl, G.M.7
Walensky, L.D.8
-
4
-
-
11144231977
-
Identification of smallmolecule antagonists that inhibit an activator:coactivator interaction
-
BEST, J. L., AMEZCUA, C. A., MAYR, B., FLECHNER, L., MURAWSKY, C. M., EMERSON, B., ZOR, T., GARDNER, K. H. & MONTMINY, M. (2004). Identification of smallmolecule antagonists that inhibit an activator:coactivator interaction. Proceedings of the National Academy of Sciences of the United States of America 101, 17622-17627.
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, pp. 17622-17627
-
-
Best, J.L.1
Amezcua, C.A.2
Mayr, B.3
Flechner, L.4
Murawsky, C.M.5
Emerson, B.6
Zor, T.7
Gardner, K.H.8
Montminy, M.9
-
6
-
-
79960884702
-
Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: The PICCOLO database
-
BICKERTON, G. R., HIGUERUELO, A. P. & BLUNDELL, T. L. (2011). Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database. BMC Bioinformatics 12, 313.
-
(2011)
BMC Bioinformatics
, vol.12
, pp. 313
-
-
Bickerton, G.R.1
Higueruelo, A.P.2
Blundell, T.L.3
-
7
-
-
0018382972
-
Conformation and molecular biology of polypeptide hormones II. Glucagon
-
BLUNDELL, T. (1979). Conformation and molecular biology of polypeptide hormones II. Glucagon. Trends in Biochemical Sciences 4, 80-83.
-
(1979)
Trends in Biochemical Sciences
, vol.4
, pp. 80-83
-
-
Blundell, T.1
-
8
-
-
0020016306
-
The conformation, flexibility and dynamics of polypeptide hormones
-
BLUNDELL, T. & WOOD, S. (1982). The conformation, flexibility and dynamics of polypeptide hormones. Annual Review of Biochemistry 51, 123-154.
-
(1982)
Annual Review of Biochemistry
, vol.51
, pp. 123-154
-
-
Blundell, T.1
Wood, S.2
-
9
-
-
0033783004
-
Protein-protein interactions in receptor activation and intracellular signalling
-
BLUNDELL, T. L., BURKE, D. F., CHIRGADZE, D., DHANARAJ, V., HYVONEN, M., INNIS, C. A., PARISINI, E., PELLEGRINI, L., SAYED, M. & SIBANDA, B. L. (2000). Protein-protein interactions in receptor activation and intracellular signalling. Biological Chemistry 381, 955-959.
-
(2000)
Biological Chemistry
, vol.381
, pp. 955-959
-
-
Blundell, T.L.1
Burke, D.F.2
Chirgadze, D.3
Dhanaraj, V.4
Hyvonen, M.5
Innis, C.A.6
Parisini, E.7
Pellegrini, L.8
Sayed, M.9
Sibanda, B.L.10
-
10
-
-
0036051992
-
Highthroughput crystallography for lead discovery in drug design
-
BLUNDELL, T. L., JHOTI, H. & ABELL, C. (2002). Highthroughput crystallography for lead discovery in drug design. Nature Reviews Drug Discovery 1, 45-54.
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, pp. 45-54
-
-
Blundell, T.L.1
Jhoti, H.2
Abell, C.3
-
11
-
-
33646351764
-
Structural biology and bioinformatics in drug design: Opportunities and challenges for target identification and lead discovery. Philosophical Transactions of the Royal Society of London. Series B
-
BLUNDELL, T. L., SIBANDA, B. L., MONTALVAO, R. W., BREWERTON, S., CHELLIAH, V., WORTH, C. L., HARMER, N. J., DAVIES, O. & BURKE, D. (2006). Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 361, 413-423.
-
(2006)
Biological Sciences
, vol.361
, pp. 413-423
-
-
Blundell, T.L.1
Sibanda, B.L.2
Montalvao, R.W.3
Brewerton, S.4
Chelliah, V.5
Worth, C.L.6
Harmer, N.J.7
Davies, O.8
Burke, D.9
-
12
-
-
70350340728
-
The role of dynamic conformational ensembles in biomolecular recognition
-
BOEHR, D. D., NUSSINOV, R. & WRIGHT, P. E. (2009). The role of dynamic conformational ensembles in biomolecular recognition. Nature Chemical Biology 5, 789-796.
-
(2009)
Nature Chemical Biology
, vol.5
, pp. 789-796
-
-
Boehr, D.D.1
Nussinov, R.2
Wright, P.E.3
-
14
-
-
77749270474
-
Novel therapeutics for Alzheimer's disease: An update
-
BONDA, D. J., LEE, H. P., LEE, H. G., FRIEDLICH, A. L., PERRY, G., ZHU, X. & SMITH, M. A. (2010). Novel therapeutics for Alzheimer's disease: an update. Current Opinion in Drug Discovery and Development 13, 235-246.
-
(2010)
Current Opinion in Drug Discovery and Development
, vol.13
, pp. 235-246
-
-
Bonda, D.J.1
Lee, H.P.2
Lee, H.G.3
Friedlich, A.L.4
Perry, G.5
Zhu, X.6
Smith, M.A.7
-
15
-
-
70449408309
-
Predicting protein-protein binding sites in membrane proteins
-
BORDNER, A. J. (2009). Predicting protein-protein binding sites in membrane proteins. BMC Bioinformatics 10, 312.
-
(2009)
BMC Bioinformatics
, vol.10
, pp. 312
-
-
Bordner, A.J.1
-
16
-
-
77949743743
-
Atomic analysis of protein-protein interfaces with known inhibitors: The 2P2I database
-
BOURGEAS, R., BASSE, M. J., MORELLI, X. & ROCHE, P. (2010). Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database. PLoS ONE 5, e9598.
-
(2010)
PLoS ONE
, vol.5
-
-
Bourgeas, R.1
Basse, M.J.2
Morelli, X.3
Roche, P.4
-
17
-
-
0343841187
-
The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes
-
BOYDEN, S. (1962). The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. Journal of Experimental Medicine 115, 453-466.
-
(1962)
Journal of Experimental Medicine
, vol.115
, pp. 453-466
-
-
Boyden, S.1
-
18
-
-
0025281866
-
Study of strong to ultratight protein interactions using differential scanning calorimetry
-
BRANDTS, J. F. & LIN, L. N. (1990). Study of strong to ultratight protein interactions using differential scanning calorimetry. Biochemistry 29, 6927-6940.
-
(1990)
Biochemistry
, vol.29
, pp. 6927-6940
-
-
Brandts, J.F.1
Lin, L.N.2
-
19
-
-
0021095726
-
Conformation of glucagon in a lipid-water interphase by 1H nuclear magnetic resonance
-
BRAUN, W.,WIDER, G., LEE, K. H.&WUTHRICH, K. (1983). Conformation of glucagon in a lipid-water interphase by 1H nuclear magnetic resonance. Journal of Molecular Biology 169, 921-948.
-
(1983)
Journal of Molecular Biology
, vol.169
, pp. 921-948
-
-
Braun, W.1
Wider, G.2
Lee, K.H.3
Wuthrich, K.4
-
20
-
-
33847404358
-
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-XL
-
BRUNCKO, M., OOST, T. K., BELLI, B. A., DING, H., JOSEPH, M. K., KUNZER, A., MARTINEAU, D., MCCLELLAN, W. J., MITTEN, M., NG, S. C., NIMMER, P. M., OLTERSDORF, T., PARK, C. M., PETROS, A. M., SHOEMAKER, A. R., SONG, X., WANG, X., WENDT, M. D., ZHANG, H., FESIK, S. W., ROSENBERG, S.H. & ELMORE, S. W. (2007). Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-XL. Journal of Medical Chemistry 50, 641-662.
-
(2007)
Journal of Medical Chemistry
, vol.50
, pp. 641-662
-
-
Bruncko, M.1
Oost, T.K.2
Belli, B.A.3
Ding, H.4
Joseph, M.K.5
Kunzer, A.6
Martineau, D.7
McClellan, W.J.8
Mitten, M.9
C, N.G.S.10
Nimmer, P.M.11
Oltersdorf, T.12
Park, C.M.13
Petros, A.M.14
Shoemaker, A.R.15
Song, X.16
Wang, X.17
Wendt, M.D.18
Zhang, H.19
Fesik, S.W.20
Rosenberg, S.H.21
Elmore, S.W.22
more..
-
21
-
-
0347478160
-
Bifunctional recombinant proteins in cancer therapy: Cell penetrating peptide aptamers as inhibitors of growth factor signaling
-
BUERGER, C. & GRONER, B. (2003). Bifunctional recombinant proteins in cancer therapy: cell penetrating peptide aptamers as inhibitors of growth factor signaling. Journal of Cancer Research and Clinical Oncology 129, 669-675.
-
(2003)
Journal of Cancer Research and Clinical Oncology
, vol.129
, pp. 669-675
-
-
Buerger, C.1
Groner, B.2
-
22
-
-
77950662472
-
Homodimeric enzymes as drug targets
-
CARDINALE, D., SALO-AHEN, O. M., FERRARI, S., PONTERINI, G., CRUCIANI, G., CAROSATI, E., TOCHOWICZ, A. M., MANGANI, S., WADE, R.C. & COSTI, M. P. (2010). Homodimeric enzymes as drug targets. Current Medicinal Chemistry 17, 826-846.
-
(2010)
Current Medicinal Chemistry
, vol.17
, pp. 826-846
-
-
Cardinale, D.1
Salo-Ahen, O.M.2
Ferrari, S.3
Ponterini, G.4
Cruciani, G.5
Carosati, E.6
Tochowicz, A.M.7
Mangani, S.8
Wade, R.C.9
Costi, M.P.10
-
23
-
-
0036558207
-
Structure-based screening of low-affinity compounds
-
CARR, R. & JHOTI, H. (2002). Structure-based screening of low-affinity compounds. Drug Discovery Today 7, 522-527.
-
(2002)
Drug Discovery Today
, vol.7
, pp. 522-527
-
-
Carr, R.1
Jhoti, H.2
-
24
-
-
22044441118
-
Fragment-based lead discovery: Leads by design
-
CARR, R. A., CONGREVE, M., MURRAY, C.W. & REES, D. C. (2005). Fragment-based lead discovery: leads by design. Drug Discovery Today 10, 987-992.
-
(2005)
Drug Discovery Today
, vol.10
, pp. 987-992
-
-
Carr, R.A.1
Congreve, M.2
Murray, C.W.3
Rees, D.C.4
-
25
-
-
0038309550
-
Protein stability induced by ligand binding correlates with changes in protein flexibility
-
CELEJ, M. S., MONTICH, G.G. & FIDELIO, G. D. (2003). Protein stability induced by ligand binding correlates with changes in protein flexibility. Protein Science : A Publication of the Protein Society 12, 1496-1506.
-
(2003)
Protein Science : A Publication of the Protein Society
, vol.12
, pp. 1496-1506
-
-
Celej, M.S.1
Montich, G.G.2
Fidelio, G.D.3
-
27
-
-
33846073818
-
MINT: The Molecular INTeraction database
-
CHATR-ARYAMONTRI, A., CEOL, A., PALAZZI, L. M., NARDELLI, G., SCHNEIDER, M. V., CASTAGNOLI, L. & CESARENI, G. (2007). MINT: the Molecular INTeraction database. Nucleic Acids Research 35, D572-D574.
-
(2007)
Nucleic Acids Research
, vol.35
-
-
Chatr-Aryamontri, A.1
Ceol, A.2
Palazzi, L.M.3
Nardelli, G.4
Schneider, M.V.5
Castagnoli, L.6
Cesareni, G.7
-
28
-
-
0029055145
-
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
-
CHEN, J., ZHENG, X. F., BROWN, E. J. & SCHREIBER, S. L. (1995). Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proceedings of the National Academy of Sciences of the United States of America 92, 4947-4951.
-
(1995)
Proceedings of the National Academy of Sciences of the United States of America
, vol.92
, pp. 4947-4951
-
-
Chen, J.1
Zheng, X.F.2
Brown, E.J.3
Schreiber, S.L.4
-
29
-
-
34250212118
-
DAPID: A 3D-domain annotated protein-protein interaction database
-
CHEN, Y. C., CHEN, H. C. &YANG, J. M. (2006). DAPID: a 3D-domain annotated protein-protein interaction database. Genome Informatics 17, 206-215.
-
(2006)
Genome Informatics
, vol.17
, pp. 206-215
-
-
Chen, Y.C.1
Chen, H.C.2
Yang, J.M.3
-
30
-
-
0029842109
-
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
-
CHOI, J., CHEN, J., SCHREIBER, S. L. & CLARDY, J. (1996). Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science 273, 239-242.
-
(1996)
Science
, vol.273
, pp. 239-242
-
-
Choi, J.1
Chen, J.2
Schreiber, S.L.3
Clardy, J.4
-
31
-
-
67349204387
-
The RNA aptamer disrupts protein-protein interaction between beta-catenin and nuclear factor-kappaB p50 and regulates the expression of C-reactive protein
-
CHOI, Y. S., HUR, J., LEE, H.K. & JEONG, S. (2009). The RNA aptamer disrupts protein-protein interaction between beta-catenin and nuclear factor-kappaB p50 and regulates the expression of C-reactive protein. FEBS Letters 583, 1415-1421.
-
(2009)
FEBS Letters
, vol.583
, pp. 1415-1421
-
-
Choi, Y.S.1
Hur, J.2
Lee, H.K.3
Jeong, S.4
-
32
-
-
67349171544
-
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
-
CHUNG, S., PARKER, J. B., BIANCHET, M., AMZEL, L.M. & STIVERS, J. T. (2009). Impact of linker strain and flexibility in the design of a fragment-based inhibitor. Nature Chemical Biology 5, 407-413.
-
(2009)
Nature Chemical Biology
, vol.5
, pp. 407-413
-
-
Chung, S.1
Parker, J.B.2
Bianchet, M.3
Amzel, L.M.4
Stivers, J.T.5
-
33
-
-
56049092342
-
A quantitative model of thermal stabilization and destabilization of proteins by ligands
-
CIMMPERMAN, P., BARANAUSKIENE, L., JACHIMOVICIUTE, S., JACHNO, J., TORRESAN, J., MICHAILOVIENE, V., MATULIENE, J., SEREIKAITE, J., BUMELIS, V. & MATULIS, D. (2008). A quantitative model of thermal stabilization and destabilization of proteins by ligands. Biophysics Journal 95, 3222-3231.
-
(2008)
Biophysics Journal
, vol.95
, pp. 3222-3231
-
-
Cimmperman, P.1
Baranauskiene, L.2
Jachimoviciute, S.3
Jachno, J.4
Torresan, J.5
Michailoviene, V.6
Matuliene, J.7
Sereikaite, J.8
Bumelis, V.9
Matulis, D.10
-
34
-
-
33746885488
-
Probing hot spots at protein-ligand binding sites : A fragment-based approach using biophysical methods
-
CIULLI, A., WILLIAMS, G., SMITH, A. G., BLUNDELL, T. L. & ABELL, C. (2006). Probing hot spots at protein-ligand binding sites : a fragment-based approach using biophysical methods. Journal of Medical Chemistry 49, 4992-5000.
-
(2006)
Journal of Medical Chemistry
, vol.49
, pp. 4992-5000
-
-
Ciulli, A.1
Williams, G.2
Smith, A.G.3
Blundell, T.L.4
Abell, C.5
-
35
-
-
0028916599
-
A hot spot of binding energy in a hormone-receptor interface
-
CLACKSON, T. & WELLS, J. A. (1995). A hot spot of binding energy in a hormone-receptor interface. Science 267, 383-386.
-
(1995)
Science
, vol.267
, pp. 383-386
-
-
Clackson, T.1
Wells, J.A.2
-
36
-
-
77955874353
-
Identification and characterization of acidic mammalian chitinase inhibitors
-
COLE, D. C., OLLAND, A. M., JACOB, J., BROOKS, J., BURSAVICH, M. G., CZERWINSKI, R., DECLERCQ, C., JOHNSON, M., JOSEPH-MCCARTHY, D., ELLINGBOE, J. W., LIN, L., NOWAK, P., PRESMAN, E., STRAND, J., TAM, A., WILLIAMS, C. M., YAO, S., TSAO, D.H. & FITZ, L. J. (2010). Identification and characterization of acidic mammalian chitinase inhibitors. Journal of Medical Chemistry 53, 6122-6128.
-
(2010)
Journal of Medical Chemistry
, vol.53
, pp. 6122-6128
-
-
Cole, D.C.1
Olland, A.M.2
Jacob, J.3
Brooks, J.4
Bursavich, M.G.5
Czerwinski, R.6
Declercq, C.7
Johnson, M.8
Joseph-Mccarthy, D.9
Ellingboe, J.W.10
Lin, L.11
Nowak, P.12
Presman, E.13
Strand, J.14
Tam, A.15
Williams, C.M.16
Yao, S.17
Tsao, D.H.18
Fitz, L.J.19
-
37
-
-
0141726877
-
A ' rule of three' for fragment-based lead discovery?
-
CONGREVE, M., CARR, R., MURRAY, C. & JHOTI, H. (2003). A ' rule of three' for fragment-based lead discovery? Drug Discovery Today 8, 876-877.
-
(2003)
Drug Discovery Today
, vol.8
, pp. 876-877
-
-
Congreve, M.1
Carr, R.2
Murray, C.3
Jhoti, H.4
-
38
-
-
46849089254
-
Recent developments in fragment-based drug discovery
-
CONGREVE, M., CHESSARI, G., TISI, D. &WOODHEAD, A. J. (2008). Recent developments in fragment-based drug discovery. Journal of Medical Chemistry 51, 3661-3680.
-
(2008)
Journal of Medical Chemistry
, vol.51
, pp. 3661-3680
-
-
Congreve, M.1
Chessari, G.2
Tisi, D.3
Woodhead, A.J.4
-
39
-
-
21544474149
-
Structural biology and drug discovery
-
CONGREVE, M., MURRAY, C.W. & BLUNDELL, T. L. (2005). Structural biology and drug discovery. Drug Discovery Today 10, 895-907.
-
(2005)
Drug Discovery Today
, vol.10
, pp. 895-907
-
-
Congreve, M.1
Murray, C.W.2
Blundell, T.L.3
-
40
-
-
79952382815
-
Fragment screening of stabilized G-protein-coupled receptors using biophysical methods
-
CONGREVE, M., RICH, R. L., MYSZKA, D. G., FIGAROA, F., SIEGAL, G. & MARSHALL, F. H. (2011). Fragment screening of stabilized G-protein-coupled receptors using biophysical methods. Methods in Enzymology 493, 115-136.
-
(2011)
Methods in Enzymology
, vol.493
, pp. 115-136
-
-
Congreve, M.1
Rich, R.L.2
Myszka, D.G.3
Figaroa, F.4
Siegal, G.5
Marshall, F.H.6
-
41
-
-
33947537616
-
An automated microseed matrix-screening method for protein crystallization
-
D'ARCY, A., VILLARD, F. & MARSH, M. (2007). An automated microseed matrix-screening method for protein crystallization. Acta Crystallographica, Section D, Biological Crystallography 63(Pt 4), 550-554.
-
(2007)
Acta Crystallographica, Section D, Biological Crystallography
, vol.63
, Issue.PART 4
, pp. 550-554
-
-
D'Arcy, A.1
Villard, F.2
Marsh, M.3
-
42
-
-
0033789206
-
Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water
-
DALVIT, C., PEVARELLO, P., TATO, M., VERONESI, M., VULPETTI, A. & SUNDSTROM, M. (2000). Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water. Journal of Biomolecular NMR 18, 65-68.
-
(2000)
Journal of Biomolecular NMR
, vol.18
, pp. 65-68
-
-
Dalvit, C.1
Pevarello, P.2
Tato, M.3
Veronesi, M.4
Vulpetti, A.5
Sundstrom, M.6
-
43
-
-
84870999598
-
Pyramid: An integrated platform for fragment-based drug discovery
-
Weinheim Wiley-VCH Verlag GmbH & Co. KGaA
-
DAVIES, T. G., VAN MONTFORT, R. L. M., WILLIAMS, G. & JHOTI, H. (2006). Pyramid: an integrated platform for fragment-based drug discovery. In Fragment-based Approaches in Drug Discovery, pp. 193-214. Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA.
-
(2006)
Fragment-based Approaches in Drug Discovery
, pp. 193-214
-
-
Davies, T.G.1
Van Montfort, R.L.M.2
Williams, G.3
Jhoti, H.4
-
44
-
-
18744382508
-
PIBASE: A comprehensive database of structurally defined protein interfaces
-
DAVIS, F. P. & SALI, A. (2005). PIBASE: a comprehensive database of structurally defined protein interfaces. Bioinformatics 21, 1901-1907.
-
(2005)
Bioinformatics
, vol.21
, pp. 1901-1907
-
-
Davis, F.P.1
Sali, A.2
-
45
-
-
77649228104
-
The overlap of small molecule and protein binding sites within families of protein structures
-
DAVIS, F. P. & SALI, A. (2010). The overlap of small molecule and protein binding sites within families of protein structures. PLoS Computational Biology 6, e1000668.
-
(2010)
PLoS Computational Biology
, vol.6
-
-
Davis, F.P.1
Sali, A.2
-
46
-
-
34250167837
-
SkelGen: A general tool for structure-based de novo ligand design
-
DEAN, P. M., FIRTH-CLARK, S., HARRIS, W., KIRTON, S. B. & TODOROV, N. P. (2006). SkelGen: a general tool for structure-based de novo ligand design. Expert Opinion on Drug Discovery 1, 179-189.
-
(2006)
Expert Opinion on Drug Discovery
, vol.1
, pp. 179-189
-
-
Dean, P.M.1
Firth-Clark, S.2
Harris, W.3
Kirton, S.B.4
Todorov, N.P.5
-
47
-
-
12944331889
-
Small-world network approach to identify key residues in protein-protein interaction
-
DEL SOL, A. & O'MEARA, P. (2005). Small-world network approach to identify key residues in protein-protein interaction. Proteins 58, 672-682.
-
(2005)
Proteins
, vol.58
, pp. 672-682
-
-
Del Sol, A.1
O'Meara, P.2
-
48
-
-
42149174453
-
Fragment-based de novo ligand design by multiobjective evolutionary optimization
-
DEY, F. & CAFLISCH, A. (2008). Fragment-based de novo ligand design by multiobjective evolutionary optimization. Journal of Chemical Information Modeling 48, 679-690.
-
(2008)
Journal of Chemical Information Modeling
, vol.48
, pp. 679-690
-
-
Dey, F.1
Caflisch, A.2
-
49
-
-
27644510382
-
Maraviroc (UK-427 857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
-
DORR, P., WESTBY, M., DOBBS, S., GRIFFIN, P., IRVINE, B., MACARTNEY, M., MORI, J., RICKETT, G., SMITHBURCHNELL, C., NAPIER, C., WEBSTER, R., ARMOUR, D., PRICE, D., STAMMEN, B., WOOD, A.&PERROS, M. (2005). Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrobial Agents and Chemotherapy 49, 4721-4732.
-
(2005)
Antimicrobial Agents and Chemotherapy
, vol.49
, pp. 4721-4732
-
-
Dorr, P.1
Westby, M.2
Dobbs, S.3
Griffin, P.4
Irvine, B.5
MacArtney, M.6
Mori, J.7
Rickett, G.8
Smithburchnell, C.9
Napier, C.10
Webster, R.11
Armour, D.12
Price, D.13
Stammen, B.14
Wood, A.15
Perros, M.16
-
50
-
-
8844277625
-
ICBS: A database of interactions between protein chains mediated by betasheet formation
-
DOU, Y., BAISNEE, P. F., POLLASTRI, G., PECOUT, Y., NOWICK, J. & BALDI, P. (2004). ICBS: a database of interactions between protein chains mediated by betasheet formation. Bioinformatics 20, 2767-2777.
-
(2004)
Bioinformatics
, vol.20
, pp. 2767-2777
-
-
Dou, Y.1
Baisnee, P.F.2
Pollastri, G.3
Pecout, Y.4
Nowick, J.5
Baldi, P.6
-
51
-
-
77954282775
-
E-LEA3D: A computational-aided drug design web server
-
Web Server issue
-
DOUGUET, D. (2010). e-LEA3D: a computational-aided drug design web server. Nucleic Acids Research 38(Web Server issue), W615-W621.
-
(2010)
Nucleic Acids Research
, vol.38
-
-
Douguet, D.1
-
52
-
-
17144419244
-
LEA3D: A computer-aided ligand design for structure-based drug design
-
DOUGUET, D., MUNIER-LEHMANN, H., LABESSE, G. & POCHET, S. (2005). LEA3D: a computer-aided ligand design for structure-based drug design. Journal of Medical Chemistry 48, 2457-2468.
-
(2005)
Journal of Medical Chemistry
, vol.48
, pp. 2457-2468
-
-
Douguet, D.1
Munier-Lehmann, H.2
Labesse, G.3
Pochet, S.4
-
53
-
-
58849145223
-
AutoGrow: A novel algorithm for protein inhibitor design
-
DURRANT, J., AMARO, R. & MCCAMMON, J. (2009). AutoGrow: a novel algorithm for protein inhibitor design. Chemical Biology & Drug Design 73, 168-178.
-
(2009)
Chemical Biology & Drug Design
, vol.73
, pp. 168-178
-
-
Durrant, J.1
Amaro, R.2
McCammon, J.3
-
55
-
-
79953703975
-
Fragment screening to predict druggability (ligandability) and lead discovery success
-
EDFELDT, F. N., FOLMER, R.H. & BREEZE, A. L. (2011). Fragment screening to predict druggability (ligandability) and lead discovery success. Drug Discovery Today 16, 284-287.
-
(2011)
Drug Discovery Today
, vol.16
, pp. 284-287
-
-
Edfeldt, F.N.1
Folmer, R.H.2
Breeze, A.L.3
-
56
-
-
79953712635
-
Fragment growing induces conformational changes in acetylcholine-binding protein: A structural and thermodynamic analysis
-
EDINK, E., RUCKTOOA, P., RETRA, K., AKDEMIR, A., NAHAR, T., ZUIDERVELD, O., VAN ELK, R., JANSSEN, E., VAN NIEROP, P., VAN MUIJLWIJK-KOEZEN, J., SMIT, A. B., SIXMA, T. K., LEURS, R. & DE ESCH, I. J. (2011). Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis. Journal of the American Chemical Society 133, 5363-5371.
-
(2011)
Journal of the American Chemical Society
, vol.133
, pp. 5363-5371
-
-
Edink, E.1
Rucktooa, P.2
Retra, K.3
Akdemir, A.4
Nahar, T.5
Zuiderveld, O.6
Van Elk, R.7
Janssen, E.8
Van Nierop, P.9
Van Muijlwijk-Koezen, J.10
Smit, A.B.11
Sixma, T.K.12
Leurs, R.13
De Esch, I.J.14
-
57
-
-
78951492035
-
Experimental validation of a fragment library for lead discovery using SPR biosensor technology
-
ELINDER, M., GEITMANN, M., GOSSAS, T., KALLBLAD, P., WINQUIST, J., NORDSTROM, H., HAMALAINEN, M. & DANIELSON, U. H. (2011). Experimental validation of a fragment library for lead discovery using SPR biosensor technology. Journal of Biomolecular Screening : The Official Journal of the Society for Biomolecular Screening 16, 15-25.
-
(2011)
Journal of Biomolecular Screening : The Official Journal of the Society for Biomolecular Screening
, vol.16
, pp. 15-25
-
-
Elinder, M.1
Geitmann, M.2
Gossas, T.3
Kallblad, P.4
Winquist, J.5
Nordstrom, H.6
Hamalainen, M.7
Danielson, U.H.8
-
58
-
-
0034662911
-
Site-directed ligand discovery
-
ERLANSON, D. A., BRAISTED, A. C., RAPHAEL, D. R., RANDAL, M., STROUD, R. M., GORDON, E.M. & WELLS, J. A. (2000). Site-directed ligand discovery. Proceedings of the National Academy of Sciences of the United States of America 97, 9367-9372.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 9367-9372
-
-
Erlanson, D.A.1
Braisted, A.C.2
Raphael, D.R.3
Randal, M.4
Stroud, R.M.5
Gordon, E.M.6
Wells, J.A.7
-
59
-
-
0037337035
-
In situ assembly of enzyme inhibitors using extended tethering
-
ERLANSON, D. A., LAM, J. W.,WIESMANN, C., LUONG, T. N., SIMMONS, R. L., DELANO, W. L., CHOONG, I. C., BURDETT, M. T., FLANAGAN, W. M., LEE, D., GORDON, E. M. & O'BRIEN, T. (2003). In situ assembly of enzyme inhibitors using extended tethering. Nature Biotechnology 21 308-314.
-
(2003)
Nature Biotechnology
, vol.21
, pp. 308-314
-
-
Erlanson, D.A.1
Lam, W.2
Wiesmann, J.C.3
Luong, T.N.4
Simmons, R.L.5
Delano, W.L.6
Choong, I.C.7
Burdett, M.T.8
Flanagan, W.M.9
Lee, D.10
Gordon, E.M.11
O'Brien, T.12
-
61
-
-
73249142243
-
Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB
-
FERRARIS, D. M., GHERARDI, E., DI, Y., HEINZ, D.W. & NIEMANN, H. H. (2009). Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB. Journal of Molecular Biology 395, 522-532.
-
(2009)
Journal of Molecular Biology
, vol.395
, pp. 522-532
-
-
Ferraris, D.M.1
Gherardi, E.2
Y, D.I.3
Heinz, D.W.4
Niemann, H.H.5
-
62
-
-
0042594456
-
The binding interface database (BID): A compilation of amino acid hot spots in protein interfaces
-
FISCHER, T. B., ARUNACHALAM, K. V., BAILEY, D., MANGUAL, V., BAKHRU, S., RUSSO, R., HUANG, D., PACZKOWSKI, M., LALCHANDANI, V., RAMACHANDRA, C., ELLISON, B., GALER, S., SHAPLEY, J., FUENTES, E. & TSAI, J. (2003). The binding interface database (BID): a compilation of amino acid hot spots in protein interfaces. Bioinformatics 19, 1453-1454.
-
(2003)
Bioinformatics
, vol.19
, pp. 1453-1454
-
-
Fischer, T.B.1
Arunachalam, K.V.2
Bailey, D.3
Mangual, V.4
Bakhru, S.5
Russo, R.6
Huang, D.7
Paczkowski, M.8
Lalchandani, V.9
Ramachandra, C.10
Ellison, B.11
Galer, S.12
Shapley, J.13
Fuentes, E.14
Tsai, J.15
-
63
-
-
0027321564
-
Enzyme crystal structure in a neat organic solvent
-
FITZPATRICK, P. A., STEINMETZ, A. C., RINGE, D. & KLIBANOV, A. M. (1993). Enzyme crystal structure in a neat organic solvent. Proceedings of the National Academy of Sciences of the United States of America 90, 8653-8657.
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, pp. 8653-8657
-
-
Fitzpatrick, P.A.1
Steinmetz, A.C.2
Ringe, D.3
Klibanov, A.M.4
-
64
-
-
27744564465
-
Protein surface recognition and proteomimetics: Mimics of protein surface structure and function
-
FLETCHER, S. & HAMILTON, A. D. (2005). Protein surface recognition and proteomimetics: mimics of protein surface structure and function. Current Opinion in Chemical Biology 9, 632-638.
-
(2005)
Current Opinion in Chemical Biology
, vol.9
, pp. 632-638
-
-
Fletcher, S.1
Hamilton, A.D.2
-
65
-
-
58849145512
-
Predicting druggable binding sites at the protein-protein interface
-
FULLER, J. C., BURGOYNE, N. J. & JACKSON, R. M. (2009). Predicting druggable binding sites at the protein-protein interface. Drug Discovery Today 14, 155-161.
-
(2009)
Drug Discovery Today
, vol.14
, pp. 155-161
-
-
Fuller, J.C.1
Burgoyne, N.J.2
Jackson, R.M.3
-
66
-
-
85055753663
-
Remote access experiments at the macromolecular crystallography beamlines of the ESRF
-
GABADINHO, J., HALL, D., LEONARD, G., GORDON, E., MONACO, S. & THIBAULT, X. (2008). Remote access experiments at the macromolecular crystallography beamlines of the ESRF. Synchrotron Radiation News 21, 24-29.
-
(2008)
Synchrotron Radiation News
, vol.21
, pp. 24-29
-
-
Gabadinho, J.1
Hall, D.2
Leonard, G.3
Gordon, E.4
Monaco, S.5
Thibault, X.6
-
67
-
-
36749060694
-
DOCKGROUND system of databases for protein recognition studies : Unbound structures for docking
-
GAO, Y., DOUGUET, D., TOVCHIGRECHKO, A. & VAKSER, I. A. (2007). DOCKGROUND system of databases for protein recognition studies : unbound structures for docking. Proteins 69, 845-851.
-
(2007)
Proteins
, vol.69
, pp. 845-851
-
-
Gao, Y.1
Douguet, D.2
Tovchigrechko, A.3
Vakser, I.A.4
-
68
-
-
0030936560
-
Identification by NMR of the binding surface for the histidine-containing phosphocarrier protein HPr on the N-terminal domain of enzyme i of the Escherichia coli phosphotransferase system
-
GARRETT, D. S., SEOK, Y. J., PETERKOFSKY, A., CLORE, G. M. & GRONENBORN, A. M. (1997). Identification by NMR of the binding surface for the histidine-containing phosphocarrier protein HPr on the N-terminal domain of enzyme I of the Escherichia coli phosphotransferase system. Biochemistry 36, 4393-4398.
-
(1997)
Biochemistry
, vol.36
, pp. 4393-4398
-
-
Garrett, D.S.1
Seok, Y.J.2
Peterkofsky, A.3
Clore, G.M.4
Gronenborn, A.M.5
-
69
-
-
79851493846
-
Identification of a novel scaffold for allosteric inhibition of wild type and drug resistant HIV-1 reverse transcriptase by fragment library screening
-
GEITMANN, M., ELINDER, M., SEEGER, C., BRANDT, P., DE ESCH, I. J. & DANIELSON, U. H. (2011). Identification of a novel scaffold for allosteric inhibition of wild type and drug resistant HIV-1 reverse transcriptase by fragment library screening. Journal of Medicinal Chemistry 53, 699-708.
-
(2011)
Journal of Medicinal Chemistry
, vol.53
, pp. 699-708
-
-
Geitmann, M.1
Elinder, M.2
Seeger, C.3
Brandt, P.4
De Esch, I.J.5
Danielson, U.H.6
-
70
-
-
37848998796
-
Discovery of a novel warhead against beta-secretase through fragment-based lead generation
-
GESCHWINDNER, S., OLSSON, L. L., ALBERT, J. S., DEINUM, J., EDWARDS, P. D., DE BEER, T. & FOLMER, R.H. (2007). Discovery of a novel warhead against beta-secretase through fragment-based lead generation. Journal of Medical Chemistry 50, 5903-5911.
-
(2007)
Journal of Medical Chemistry
, vol.50
, pp. 5903-5911
-
-
Geschwindner, S.1
Olsson, L.L.2
Albert, J.S.3
Deinum, J.4
Edwards, P.D.5
De Beer, T.6
Folmer, R.H.7
-
71
-
-
79952383501
-
From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance
-
GIANNETTI, A. M. (2011). From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance. Methods in Enzymology 493, 169-218.
-
(2011)
Methods in Enzymology
, vol.493
, pp. 169-218
-
-
Giannetti, A.M.1
-
72
-
-
21144432882
-
PSIbase: A database of protein structural interactome map (PSIMAP)
-
GONG, S., YOON, G., JANG, I., BOLSER, D., DAFAS, P., SCHROEDER, M., CHOI, H., CHO, Y., HAN, K., LEE, S., LAPPE, M., HOLM, L., KIM, S., OH, D. & BHAK, J. (2005). PSIbase: a database of protein structural interactome map (PSIMAP). Bioinformatics 21, 2541-2543.
-
(2005)
Bioinformatics
, vol.21
, pp. 2541-2543
-
-
Gong, S.1
Yoon, G.2
Jang, I.3
Bolser, D.4
Dafas, P.5
Schroeder, M.6
Choi, H.7
Cho, Y.8
Han, K.9
Lee, S.10
Lappe, M.11
Holm, L.12
Kim, S.13
D, O.H.14
Bhak, J.15
-
73
-
-
0036001094
-
From knowledge-based potentials to combinatorial lead design in silico
-
GRZYBOWSKI, B. A., ISHCHENKO, A. V., SHIMADA, J. & SHAKHNOVICH, E. I. (2002). From knowledge-based potentials to combinatorial lead design in silico. Accounts of Chemical Research 35, 261-269.
-
(2002)
Accounts of Chemical Research
, vol.35
, pp. 261-269
-
-
Grzybowski, B.A.1
Ishchenko, A.V.2
Shimada, J.3
Shakhnovich, E.I.4
-
74
-
-
33845364148
-
Fragment-based drug design how big is too big ?
-
HAJDUK, P. J. (2006). Fragment-based drug design: how big is too big ? Journal of Medical Chemistry 49, 6972-6976.
-
(2006)
Journal of Medical Chemistry
, vol.49
, pp. 6972-6976
-
-
Hajduk, P.J.1
-
75
-
-
33847381100
-
A decade of fragmentbased drug design: Strategic advances and lessons learned
-
HAJDUK, P. J. & GREER, J. (2007). A decade of fragmentbased drug design: strategic advances and lessons learned. Nature Reviews. Drug Discovery 6, 211-219.
-
(2007)
Nature Reviews. Drug Discovery
, vol.6
, pp. 211-219
-
-
Hajduk, P.J.1
Greer, J.2
-
76
-
-
17144373303
-
Druggability indices for protein targets derived from NMR-based screening data
-
HAJDUK, P. J., HUTH, J.R. & FESIK, S. W. (2005). Druggability indices for protein targets derived from NMR-based screening data. Journal of Medical Chemistry 48, 2518-2525.
-
(2005)
Journal of Medical Chemistry
, vol.48
, pp. 2518-2525
-
-
Hajduk, P.J.1
Huth, J.R.2
Fesik, S.W.3
-
77
-
-
0031576702
-
One-dimensional relaxation and diffusion-edited NMR methods for screening compounds that bind to macromolecules
-
HAJDUK, P. J., OLEJNICZAK, E.T. & FESIK, S. W. (1997). One-dimensional relaxation and diffusion-edited NMR methods for screening compounds that bind to macromolecules. Journal of the American Chemical Society 119, 12257-11226.
-
(1997)
Journal of the American Chemical Society
, vol.119
, pp. 12257-11226
-
-
Hajduk, P.J.1
Olejniczak, E.T.2
Fesik, S.W.3
-
78
-
-
40049083268
-
Label-free primary screening and affinity ranking of fragment libraries using parallel analysis of protein panels
-
HAMALAINEN, M. D., ZHUKOV, A., IVARSSON, M., FEX, T., GOTTFRIES, J., KARLSSON, R. & BJORSNE, M. (2008). Label-free primary screening and affinity ranking of fragment libraries using parallel analysis of protein panels. Journal of Biomolecular Screening : The Official Journal of the Society for Biomolecular Screening 13, 202-209.
-
(2008)
Journal of Biomolecular Screening : The Official Journal of the Society for Biomolecular Screening
, vol.13
, pp. 202-209
-
-
Hamalainen, M.D.1
Zhukov, A.2
Ivarsson, M.3
Fex, T.4
Gottfries, J.5
Karlsson, R.6
Bjorsne, M.7
-
79
-
-
0035324944
-
Molecular complexity and its impact on the probability of finding leads for drug discovery
-
HANN, M. M., LEACH, A.R. & HARPER, G. (2001). Molecular complexity and its impact on the probability of finding leads for drug discovery. Journal of Chemical Information and Computer Sciences 41, 856-864.
-
(2001)
Journal of Chemical Information and Computer Sciences
, vol.41
, pp. 856-864
-
-
Hann, M.M.1
Leach, A.R.2
Harper, G.3
-
80
-
-
12344318177
-
Fragment-based lead discovery using X-ray crystallography
-
HARTSHORN, M. J., MURRAY, C. W., CLEASBY, A., FREDERICKSON, M., TICKLE, I. J. & JHOTI, H. (2005). Fragment-based lead discovery using X-ray crystallography. Journal of Medical Chemistry 48, 403-413.
-
(2005)
Journal of Medical Chemistry
, vol.48
, pp. 403-413
-
-
Hartshorn, M.J.1
Murray, C.W.2
Cleasby, A.3
Frederickson, M.4
Tickle, I.J.5
Jhoti, H.6
-
81
-
-
0031370977
-
LIGSITE: Automatic and efficient detection of potential small molecule-binding sites in proteins
-
389
-
HENDLICH, M., RIPPMANN, F. & BARNICKEL, G. (1997). LIGSITE: automatic and efficient detection of potential small molecule-binding sites in proteins. Journal of Molecular Graphics & Modeling 15, 359-363, 389.
-
(1997)
Journal of Molecular Graphics & Modeling
, vol.15
, pp. 359-363
-
-
Hendlich, M.1
Rippmann, F.2
Barnickel, G.3
-
82
-
-
9144248312
-
IntAct: An open source molecular interaction database
-
HERMJAKOB, H., MONTECCHI-PALAZZI, L., LEWINGTON, C., MUDALI, S., KERRIEN, S., ORCHARD, S., VINGRON, M., ROECHERT, B., ROEPSTORFF, P., VALENCIA, A., MARGALIT, H., ARMSTRONG, J., BAIROCH, A., CESARENI, G., SHERMAN, D. & APWELLER, R. (2004). IntAct: an open source molecular interaction database. Nucleic Acids Research 32, D452-D455.
-
(2004)
Nucleic Acids Research
, vol.32
-
-
Hermjakob, H.1
Montecchi-Palazzi, L.2
Lewington, C.3
Mudali, S.4
Kerrien, S.5
Orchard, S.6
Vingron, M.7
Roechert, B.8
Roepstorff, P.9
Valencia, A.10
Margalit, H.11
Armstrong, J.12
Bairoch, A.13
Cesareni, G.14
Sherman, D.15
Apweller, R.16
-
83
-
-
70349756972
-
Atomic interactions and profile of small molecules disrupting protein-protein interfaces : The TIMBAL database
-
HIGUERUELO, A. P., SCHREYER, A., BICKERTON, G. R., PITT, W. R., GROOM, C. R. & BLUNDELL, T. L. (2009). Atomic interactions and profile of small molecules disrupting protein-protein interfaces : the TIMBAL database. Chemistry Biology and Drug Design 74, 457-467.
-
(2009)
Chemistry Biology and Drug Design
, vol.74
, pp. 457-467
-
-
Higueruelo, A.P.1
Schreyer, A.2
Bickerton, G.R.3
Pitt, W.R.4
Groom, C.R.5
Blundell, T.L.6
-
84
-
-
77954615408
-
MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo
-
HIRAI, H., SOOTOME, H., NAKATSURU, Y., MIYAMA, K., TAGUCHI, S., TSUJIOKA, K., UENO, Y., HATCH, H., MAJUMDER, P. K., PAN, B. S. &KOTANI, H. (2010). MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Molecular Cancer and Therapeutics 9, 1956-1967.
-
(2010)
Molecular Cancer and Therapeutics
, vol.9
, pp. 1956-1967
-
-
Hirai, H.1
Sootome, H.2
Nakatsuru, Y.3
Miyama, K.4
Taguchi, S.5
Tsujioka, K.6
Ueno, Y.7
Hatch, H.8
Majumder, P.K.9
Pan, B.S.10
Kotani, H.11
-
85
-
-
27344436962
-
Measurements of binding thermodynamics in drug discovery
-
HOLDGATE, G.A. & WARD, W. H. (2005). Measurements of binding thermodynamics in drug discovery. Drug Discovery Today 10, 1543-1550.
-
(2005)
Drug Discovery Today
, vol.10
, pp. 1543-1550
-
-
Holdgate, G.A.1
Ward, W.H.2
-
86
-
-
0347761359
-
NMR spectroscopy tools for structure-aided drug design
-
HOMANS, S. W. (2004). NMR spectroscopy tools for structure-aided drug design. Angewandte Chemie International Edition 43, 290-300.
-
(2004)
Angewandte Chemie International Edition
, vol.43
, pp. 290-300
-
-
Homans, S.W.1
-
88
-
-
1942453243
-
Ligand efficiency: A useful metric for lead selection
-
HOPKINS, A. L., GROOM, C. R. & ALEX, A. (2004). Ligand efficiency: a useful metric for lead selection. Drug Discovery Today 9, 430-431.
-
(2004)
Drug Discovery Today
, vol.9
, pp. 430-431
-
-
Hopkins, A.L.1
Groom, C.R.2
Alex, A.3
-
89
-
-
33144470698
-
Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors
-
HOWARD, N., ABELL, C., BLAKEMORE, W., CHESSARI, G., CONGREVE, M., HOWARD, S., JHOTI, H., MURRAY, C. W., SEAVERS, L.C. & VAN MONTFORT, R. L. (2006). Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. Journal of Medical Chemistry 49, 1346-1355.
-
(2006)
Journal of Medical Chemistry
, vol.49
, pp. 1346-1355
-
-
Howard, N.1
Abell, C.2
Blakemore, W.3
Chessari, G.4
Congreve, M.5
Howard, S.6
Jhoti, H.7
Murray, C.W.8
Seavers, L.C.9
Van Montfort, R.L.10
-
90
-
-
36248956723
-
The SeeDs approach: Integrating fragments into drug discovery
-
HUBBARD, R. E., DAVIS, B., CHEN, I. & DRYSDALE, M. J. (2007). The SeeDs approach: integrating fragments into drug discovery. Current Topics in Medicinal Chemistry 7, 1568-1581.
-
(2007)
Current Topics in Medicinal Chemistry
, vol.7
, pp. 1568-1581
-
-
Hubbard, R.E.1
Davis, B.2
Chen, I.3
Drysdale, M.J.4
-
91
-
-
79952429629
-
Experiences in fragment-based lead discovery
-
HUBBARD, R.E. & MURRAY, J. B. (2011). Experiences in fragment-based lead discovery. Methods in Enzymology 493, 509-531.
-
(2011)
Methods in Enzymology
, vol.493
, pp. 509-531
-
-
Hubbard, R.E.1
Murray, J.B.2
-
92
-
-
79955566051
-
Organic synthesis toward small-molecule probes and drugs special feature: Route to three-dimensional fragments using diversity-oriented synthesis
-
HUNG, A. W., RAMEK, A., WANG, Y., KAYA, T., WILSON, J. A., CLEMONS, P.A. & YOUNG, D. W. (2011). Organic synthesis toward small-molecule probes and drugs special feature: route to three-dimensional fragments using diversity-oriented synthesis. Proceedings of the National Academy of Sciences of the United States of America 108, 6799-6804.
-
(2011)
Proceedings of the National Academy of Sciences of the United States of America
, vol.108
, pp. 6799-6804
-
-
Hung, A.W.1
Ramek, A.2
Wang, Y.3
Kaya, T.4
Wilson, J.A.5
Clemons, P.A.6
Young, D.W.7
-
93
-
-
70350346470
-
Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase
-
HUNG, A. W., SILVESTRE, H. L., WEN, S., CIULLI, A., BLUNDELL, T.L. & ABELL, C. (2009). Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angewandte Chemie International Edition 48, 8452-8456.
-
(2009)
Angewandte Chemie International Edition
, vol.48
, pp. 8452-8456
-
-
Hung, A.W.1
Silvestre, H.L.2
Wen, S.3
Ciulli, A.4
Blundell, T.L.5
Abell, C.6
-
94
-
-
13844312649
-
ZINC - A free database of commercially available compounds for virtual screening
-
IRWIN, J. J. & SHOICHET, B. K. (2005). ZINC-a free database of commercially available compounds for virtual screening. Journal of Chemical Information Model 45, 177-182.
-
(2005)
Journal of Chemical Information Model
, vol.45
, pp. 177-182
-
-
Irwin, J.J.1
Shoichet, B.K.2
-
95
-
-
33846052595
-
SNAPPI-DB: A database and API of structures, iNterfaces and alignments for protein-protein interactions
-
Database issue
-
JEFFERSON, E. R., WALSH, T. P., ROBERTS, T. J. & BARTON, G. J. (2007). SNAPPI-DB: a database and API of structures, iNterfaces and alignments for protein-protein interactions. Nucleic Acids Research 35 (Database issue), D580-D589.
-
(2007)
Nucleic Acids Research
, vol.35
-
-
Jefferson, E.R.1
Walsh, T.P.2
Roberts, T.J.3
Barton, G.J.4
-
96
-
-
4444340945
-
Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction
-
JENNINGS, L. D., FOREMAN, K. W., RUSH, III, T. S., TSAO, D. H., MOSYAK, L., KINCAID, S. L., SUKHDEO, M. N., SUTHERLAND, A. G., DING, W., KENNY, C. H., SABUS, C. L., LIU, H., DUSHIN, E. G., MOGHAZEH, S. L., LABTHAVIKUL, P., PETERSEN, P. J., TUCKMAN, M., HANEY, S. A. & RUZIN, A. V. (2004a). Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction. Bioorganic and Medicinal Chemistry 12, 5115-5131.
-
(2004)
Bioorganic and Medicinal Chemistry
, vol.12
, pp. 5115-5131
-
-
Jennings, L.D.1
Foreman, K.W.2
Rush Iii, T.S.3
Tsao, D.H.4
Mosyak, L.5
Kincaid, S.L.6
Sukhdeo, M.N.7
Sutherland, A.G.8
Ding, W.9
Kenny, C.H.10
Sabus, C.L.11
Liu, H.12
Dushin, E.G.13
Moghazeh, S.L.14
Labthavikul, P.15
Petersen, P.J.16
Tuckman, M.17
Haney, S.A.18
Ruzin, A.V.19
-
97
-
-
10744230770
-
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction
-
JENNINGS, L. D., FOREMAN, K. W., RUSH, III, T. S., TSAO, D. H., MOSYAK, L., LI, Y., SUKHDEO, M. N., DING, W., DUSHIN, E. G., KENNY, C. H., MOGHAZEH, S. L., PETERSEN, P. J., RUZIN, A. V., TUCKMAN, M. & SUTHERLAND, A. G. (2004b). Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction. Bioorganic and Medicinal Chemistry Lett 14, 1427-1431.
-
(2004)
Bioorganic and Medicinal Chemistry Lett
, vol.14
, pp. 1427-1431
-
-
Jennings, L.D.1
Foreman, K.W.2
Rush Iii, T.S.3
Tsao, D.H.4
Mosyak, L.5
Y, L.I.6
Sukhdeo, M.N.7
Ding, W.8
Dushin, E.G.9
Kenny, C.H.10
Moghazeh, S.L.11
Petersen, P.J.12
Ruzin, A.V.13
Tuckman, M.14
Sutherland, A.G.15
-
98
-
-
68949119587
-
Assessment of helical interfaces in protein-protein interactions
-
JOCHIM, A. L. & ARORA, P. S. (2009). Assessment of helical interfaces in protein-protein interactions. Molecular Biosystems 5, 924-926.
-
(2009)
Molecular Biosystems
, vol.5
, pp. 924-926
-
-
Jochim, A.L.1
Arora, P.S.2
-
99
-
-
77958105231
-
Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors
-
JOCHIM, A. L. & ARORA, P. S. (2010). Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors. ACS Chemical Biology 5, 919-923.
-
(2010)
ACS Chemical Biology
, vol.5
, pp. 919-923
-
-
Jochim, A.L.1
Arora, P.S.2
-
100
-
-
0026045194
-
Real-time biospecific interaction analysis using surface plasmon resonance and a sensor chip technology
-
JONSSON, U., FAGERSTAM, L., IVARSSON, B., JOHNSSON, B., KARLSSON, R., LUNDH, K., LOFAS, S., PERSSON, B., ROOS, H., RONNBERG, I. et al. (1991). Real-time biospecific interaction analysis using surface plasmon resonance and a sensor chip technology. Biotechniques 11, 620-627.
-
(1991)
Biotechniques
, vol.11
, pp. 620-627
-
-
Jonsson, U.1
Fagerstam, L.2
Ivarsson, B.3
Johnsson, B.4
Karlsson, R.5
Lundh, K.6
Lofas, S.7
Persson, B.8
Roos, H.9
Ronnberg, I.10
-
101
-
-
84860538154
-
Structural biology and drug discovery for protein-protein interactions
-
JUBB, H., HIGUERUELO, A., WINTER, A. & BLUNDELL, T. (2012). Structural biology and drug discovery for protein-protein interactions. Trends in Pharmacological Sciences 33, 241-248.
-
(2012)
Trends in Pharmacological Sciences
, vol.33
, pp. 241-248
-
-
Jubb, H.1
Higueruelo, A.2
Winter, A.3
Blundell, T.4
-
102
-
-
37349061824
-
PocketDepth: A new depth based algorithm for identification of ligand binding sites in proteins
-
KALIDAS, Y. & CHANDRA, N. (2008). PocketDepth: a new depth based algorithm for identification of ligand binding sites in proteins. Journal of Structurall Biology 161, 31-42.
-
(2008)
Journal of Structurall Biology
, vol.161
, pp. 31-42
-
-
Kalidas, Y.1
Chandra, N.2
-
103
-
-
0344493928
-
Development of a fluorescence polarization assay to screen for inhibitors of the FtsZ/ZipA interaction
-
KENNY, C. H., DING, W., KELLEHER, K., BENARD, S., DUSHIN, E. G., SUTHERLAND, A. G., MOSYAK, L., KRIZ, R. & ELLESTAD, G. (2003). Development of a fluorescence polarization assay to screen for inhibitors of the FtsZ/ZipA interaction. Analytical Biochemistry 323, 224-233.
-
(2003)
Analytical Biochemistry
, vol.323
, pp. 224-233
-
-
Kenny, C.H.1
Ding, W.2
Kelleher, K.3
Benard, S.4
Dushin, E.G.5
Sutherland, A.G.6
Mosyak, L.7
Kriz, R.8
Ellestad, G.9
-
104
-
-
61649109015
-
The influence of lead discovery strategies on the properties of drug candidates
-
KESERU, G.M. & MAKARA, G. M. (2009). The influence of lead discovery strategies on the properties of drug candidates. Nature Reviews. Drug Discovery 8, 203-212.
-
(2009)
Nature Reviews. Drug Discovery
, vol.8
, pp. 203-212
-
-
Keseru, G.M.1
Makara, G.M.2
-
105
-
-
22244465254
-
Protein-protein interactions: Organization, cooperativity and mapping in a bottom-up systems biology approach
-
KESKIN, O., MA, B., ROGALE, K., GUNASEKARAN, K. & NUSSINOV, R. (2005). Protein-protein interactions: organization, cooperativity and mapping in a bottom-up systems biology approach. Physical Biology 2, S24-35.
-
(2005)
Physical Biology
, vol.2
-
-
Keskin, O.1
Ma, B.2
Rogale, K.3
Gunasekaran, K.4
Nussinov, R.5
-
106
-
-
0038725634
-
Pharmacological strategies for muscular dystrophy
-
KHURANA, T. S. & DAVIES, K. E. (2003). Pharmacological strategies for muscular dystrophy. Nature Reviews Drug Discovery 2, 379-390.
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, pp. 379-390
-
-
Khurana, T.S.1
Davies, K.E.2
-
107
-
-
79953777821
-
Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis
-
KIM, O., JEONG, Y., LEE, H., HONG, S. S. & HONG, S. (2011). Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis. Journal of Medical Chemistry 54, 2455-2466.
-
(2011)
Journal of Medical Chemistry
, vol.54
, pp. 2455-2466
-
-
Kim, O.1
Jeong, Y.2
Lee, H.3
Hong, S.S.4
Hong, S.5
-
108
-
-
78449307474
-
Target immobilization as a strategy for NMR-based fragment screening: Comparison of TINS, STD, and SPR for fragment hit identification
-
KOBAYASHI, M., RETRA, K., FIGAROA, F., HOLLANDER, J. G., AB, E., HEETEBRIJ, R. J., IRTH, H. & SIEGAL, G. (2010). Target immobilization as a strategy for NMR-based fragment screening: comparison of TINS, STD, and SPR for fragment hit identification. Journal of Biomolecular Screening : The Official Journal of the Society for Biomolecular Screening 15, 978-989.
-
(2010)
Journal of Biomolecular Screening : The Official Journal of the Society for Biomolecular Screening
, vol.15
, pp. 978-989
-
-
Kobayashi, M.1
Retra, K.2
Figaroa, F.3
Hollander, J.G.4
E, A.B.5
Heetebrij, R.J.6
Irth, H.7
Siegal, G.8
-
110
-
-
34548232365
-
Inference of macromolecular assemblies from crystalline state
-
KRISSINEL, E. & HENRICK, K. (2007). Inference of macromolecular assemblies from crystalline state. Journal of Molecular Biology 372, 774-797.
-
(2007)
Journal of Molecular Biology
, vol.372
, pp. 774-797
-
-
Krissinel, E.1
Henrick, K.2
-
111
-
-
0033621044
-
The maximal affinity of ligands
-
KUNTZ, I. D., CHEN, K., SHARP, K.A. & KOLLMAN, P.A. (1999). The maximal affinity of ligands. Proceedings of the National Academy of Sciences of the United States of America 96, 9997-10002.
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, pp. 9997-10002
-
-
Kuntz, I.D.1
Chen, K.2
Sharp, K.A.3
Kollman, P.A.4
-
112
-
-
33947095027
-
A human phenome-interactome network of protein complexes implicated in genetic disorders
-
LAGE, K., KARLBERG, E. O., STORLING, Z. M., OLASON, P. I., PEDERSEN, A. G., RIGINA, O., HINSBY, A. M., TUMER, Z., POCIOT, F., TOMMERUP, N., MOREAU, Y. & BRUNAK, S. (2007). A human phenome-interactome network of protein complexes implicated in genetic disorders. Nature Biotechnology 25, 309-316.
-
(2007)
Nature Biotechnology
, vol.25
, pp. 309-316
-
-
Lage, K.1
Karlberg, E.O.2
Storling, Z.M.3
Olason, P.I.4
Pedersen, A.G.5
Rigina, O.6
Hinsby, A.M.7
Tumer, Z.8
Pociot, F.9
Tommerup, N.10
Moreau, Y.11
Brunak, S.12
-
114
-
-
18744394070
-
Q-SiteFinder: An energy-based method for the prediction of protein-ligand binding sites
-
LAURIE, A. T. & JACKSON, R. M. (2005). Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sites. Bioinformatics 21, 1908-1916.
-
(2005)
Bioinformatics
, vol.21
, pp. 1908-1916
-
-
Laurie, A.T.1
Jackson, R.M.2
-
115
-
-
44949165598
-
Shape shifting leads to small-molecule allosteric drug discovery
-
LAWRENCE, S. H., RAMIREZ, U. D., TANG, L., FAZLIYEZ, F., KUNDRAT, L., MARKHAM, G.D. & JAFFE, E. K. (2008). Shape shifting leads to small-molecule allosteric drug discovery. Chemistry & Biology 15, 586-596.
-
(2008)
Chemistry & Biology
, vol.15
, pp. 586-596
-
-
Lawrence, S.H.1
Ramirez, U.D.2
Tang, L.3
Fazliyez, F.4
Kundrat, L.5
Markham, G.D.6
Jaffe, E.K.7
-
116
-
-
67649422714
-
Fpocket: An open source platform for ligand pocket detection
-
LE GUILLOUX, V., SCHMIDTKE, P. & TUFFERY, P. (2009). Fpocket: an open source platform for ligand pocket detection. BMC Bioinformatics 10, 168.
-
(2009)
BMC Bioinformatics
, vol.10
, pp. 168
-
-
Guilloux V, L.E.1
Schmidtke, P.2
Tuffery, P.3
-
117
-
-
0035442411
-
Direct measurement of protein binding energetics by isothermal titration calorimetry
-
LEAVITT, S. & FREIRE, E. (2001). Direct measurement of protein binding energetics by isothermal titration calorimetry. Current Opinion in Structural Biology 11, 560-566.
-
(2001)
Current Opinion in Structural Biology
, vol.11
, pp. 560-566
-
-
Leavitt, S.1
Freire, E.2
-
118
-
-
64849113665
-
Trapping moving targets with small molecules
-
LEE, G.M.&CRAIK, C. S. (2009). Trapping moving targets with small molecules. Science 324, 213-215.
-
(2009)
Science
, vol.324
, pp. 213-215
-
-
Lee, G.M.1
Craik, C.S.2
-
119
-
-
72949088844
-
Structural interactomics : Informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics
-
LEE, S., BROWN, A., PITT, W., HIGUERUELO, A., GONG, S., BICKERTON, G., SCHREYER, A., TANRAMLUK, D., BAYLAY, A. & BLUNDELL, T. (2009). Structural interactomics : informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics. Molecular Biosystems. 5, 1456-1472.
-
(2009)
Molecular Biosystems
, vol.5
, pp. 1456-1472
-
-
Lee, S.1
Brown, A.2
Pitt, W.3
Higueruelo, A.4
Gong, S.5
Bickerton, G.6
Schreyer, A.7
Tanramluk, D.8
Baylay, A.9
Blundell, T.10
-
120
-
-
79952428086
-
Practical aspects of NMR-based fragment screening
-
LEPRE, C. A. (2011). Practical aspects of NMR-based fragment screening. Methods in Enzymology 493, 219-239.
-
(2011)
Methods in Enzymology
, vol.493
, pp. 219-239
-
-
Lepre, C.A.1
-
121
-
-
4344711355
-
Theory and applications of NMR-based screening in pharmacautical research
-
LEPRE, C. A., MOORE, J.M. & PENG, J. W. (2004). Theory and applications of NMR-based screening in pharmacautical research. Chemical Reviews 104, 3641-3675.
-
(2004)
Chemical Reviews
, vol.104
, pp. 3641-3675
-
-
Lepre, C.A.1
Moore, J.M.2
Peng, J.W.3
-
122
-
-
0030112603
-
Thermal activation of the bovine Hsc70 molecular chaperone at physiological temperatures : Physical evidence of a molecular thermometer
-
LEUNG, S. M., SENISTERRA, G., RITCHIE, K. P., SADIS, S. E., LEPOCK, J. R. & HIGHTOWER, L. E. (1996). Thermal activation of the bovine Hsc70 molecular chaperone at physiological temperatures : physical evidence of a molecular thermometer. Cell Stress Chaperones 1, 78-89.
-
(1996)
Cell Stress Chaperones
, vol.1
, pp. 78-89
-
-
Leung, S.M.1
Senisterra, G.2
Ritchie, K.P.3
Sadis, S.E.4
Lepock, J.R.5
Hightower, L.E.6
-
123
-
-
62549102939
-
Double water exclusion' a hypothesis refining the O-ring theory for the hot spots at protein interfaces
-
LI, J. & LIU, Q. (2009). 'Double water exclusion' : a hypothesis refining the O-ring theory for the hot spots at protein interfaces. Bioinformatics 25, 743-750.
-
(2009)
Bioinformatics
, vol.25
, pp. 743-750
-
-
J, L.I.1
Liu, Q.2
-
124
-
-
0030965629
-
Organic solvents identify specific ligand binding sites on protein surfaces
-
LIEPINSH, E. & OTTING, G. (1997). Organic solvents identify specific ligand binding sites on protein surfaces. Nature Biotechnology 15, 264-268.
-
(1997)
Nature Biotechnology
, vol.15
, pp. 264-268
-
-
Liepinsh, E.1
Otting, G.2
-
125
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
LIPINSKI, C. A., LOMBARDO, F., DOMINY, B.W. & FEENEY, P. J. (2001). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews 46, 3-26.
-
(2001)
Advanced Drug Delivery Reviews
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
126
-
-
79952205470
-
Predictions of hot spot residues at protein-protein interfaces using support vector machines
-
LISE, S., BUCHAN, D., PONTIL, M. & JONES, D. T. (2011). Predictions of hot spot residues at protein-protein interfaces using support vector machines. PLoS ONE 6, e16774.
-
(2011)
PLoS ONE
, vol.6
-
-
Lise, S.1
Buchan, D.2
Pontil, M.3
Jones, D.T.4
-
128
-
-
0035848575
-
Novel parylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties
-
LIU, G., HUTH, J. R., OLEJNICZAK, E. T., MENDOZA, R., DEVRIES, P., LEITZA, S., REILLY, E. B., OKASINSKI, G. F., FESIK, S.W. & VON GELDERN, T. W. (2001). Novel parylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties. Journal of Medical Chemistry 44, 1202-1210.
-
(2001)
Journal of Medical Chemistry
, vol.44
, pp. 1202-1210
-
-
Liu, G.1
Huth, J.R.2
Olejniczak, E.T.3
Mendoza, R.4
Devries, P.5
Leitza, S.6
Reilly, E.B.7
Okasinski, G.F.8
Fesik, S.W.9
Von Geldern, T.W.10
-
129
-
-
4143121255
-
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery
-
LO, M. C., AULABAUGH, A., JIN, G., COWLING, R., BARD, J., MALAMAS, M. & ELLESTAD, G. (2004). Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery. Analytical Biochemistry 332, 153-159.
-
(2004)
Analytical Biochemistry
, vol.332
, pp. 153-159
-
-
C, L.O.M.1
Aulabaugh, A.2
Jin, G.3
Cowling, R.4
Bard, J.5
Malamas, M.6
Ellestad, G.7
-
130
-
-
78651334820
-
DIMA 3.0 : Domain interaction map
-
Database issue
-
LUO, Q., PAGEL, P., VILNE, B. & FRISHMAN, D. (2011). DIMA 3.0 : domain interaction map. Nucleic Acids Research 39 (Database issue), D724-D729.
-
(2011)
Nucleic Acids Research
, vol.39
-
-
Luo, Q.1
Pagel, P.2
Vilne, B.3
Frishman, D.4
-
131
-
-
0029868304
-
Locating and characterizing binding sites on proteins
-
MATTOS, C. & RINGE, D. (1996). Locating and characterizing binding sites on proteins. Nature Biotechnology 14, 595-599.
-
(1996)
Nature Biotechnology
, vol.14
, pp. 595-599
-
-
Mattos, C.1
Ringe, D.2
-
133
-
-
0033553844
-
Characterization of ligand binding by saturation transfer difference NMR spectroscopy
-
MAYER, M.&MEYER, B. (1999). Characterization of ligand binding by saturation transfer difference NMR spectroscopy. Angewandte Chemie International Edition 38, 1784-1788.
-
(1999)
Angewandte Chemie International Edition
, vol.38
, pp. 1784-1788
-
-
Mayer, M.1
Meyer, B.2
-
134
-
-
77954260900
-
ANCHOR: A web server and database for analysis of protein-protein interaction binding pockets for drug discovery
-
Web Server issue
-
MEIRELES, L. M., DOMLING, A. S. & CAMACHO, C. J. (2010). ANCHOR: a web server and database for analysis of protein-protein interaction binding pockets for drug discovery. Nucleic Acids Research 38(Web Server issue), W407-W411.
-
(2010)
Nucleic Acids Research
, vol.38
-
-
Meireles, L.M.1
Domling, A.S.2
Camacho, C.J.3
-
135
-
-
0037463033
-
NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors
-
MEYER, B. & PETERS, T. (2003). NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors. Angewandte Chemie International Edition 42, 864-890.
-
(2003)
Angewandte Chemie International Edition
, vol.42
, pp. 864-890
-
-
Meyer, B.1
Peters, T.2
-
136
-
-
70449671729
-
Direct inhibition of the NOTCH transcription factor complex
-
MOELLERING, R. E., CORNEJO, M., DAVIS, T. N., DEL BIANCO, C., ASTER, J. C., BLACKLOW, S. C., KUNG, A. L., GILLILAND, D. G., VERDINE, G.L. & BRADNER, J.E. (2009). Direct inhibition of the NOTCH transcription factor complex. Nature 462, 182-188.
-
(2009)
Nature
, vol.462
, pp. 182-188
-
-
Moellering, R.E.1
Cornejo, M.2
Davis, T.N.3
Del Bianco, C.4
Aster, J.C.5
Blacklow, S.C.6
Kung, A.L.7
Gilliland, D.G.8
Verdine, G.L.9
Bradner, J.E.10
-
137
-
-
52249097805
-
Highly accurate method for ligand-binding site prediction in unbound state (apo) protein structures
-
MORITA, M., NAKAMURA, S. & SHIMIZU, K. (2008). Highly accurate method for ligand-binding site prediction in unbound state (apo) protein structures. Proteins 73, 468-479.
-
(2008)
Proteins
, vol.73
, pp. 468-479
-
-
Morita, M.1
Nakamura, S.2
Shimizu, K.3
-
138
-
-
0034476897
-
Automated crystal mounting and data collection for protein crystallography
-
MUCHMORE, S. W., OLSON, J., JONES, R., PAN, J., BLUM, M., GREER, J., MERRICK, S. M., MAGDALINOS, P. & NIENABER, V. L. (2000). Automated crystal mounting and data collection for protein crystallography. Structure 8, R243-R246.
-
(2000)
Structure
, vol.8
-
-
Muchmore, S.W.1
Olson, J.2
Jones, R.3
Pan, J.4
Blum, M.5
Greer, J.6
Merrick, S.M.7
Magdalinos, P.8
Nienaber, V.L.9
-
140
-
-
79960398015
-
Screening for GPCR ligands using surface plasmon resonance
-
NAVRATILOVA, I., BESNARD, J. & HOPKINS, A. L. (2011). Screening for GPCR ligands using surface plasmon resonance. ACS Medicinal Chemistry Letters 2, 549-554.
-
(2011)
ACS Medicinal Chemistry Letters
, vol.2
, pp. 549-554
-
-
Navratilova, I.1
Besnard, J.2
Hopkins, A.L.3
-
142
-
-
0033773899
-
Discovering novel ligands for macromolecules using Xray crystallographic screening
-
NIENABER, V. L., RICHARDSON, P. L., KLIGHOFER, V., BOUSKA, J. J., GIRANDA, V.L. & GREER, J. (2000). Discovering novel ligands for macromolecules using Xray crystallographic screening. Nature Biotechnology 18, 1105-1108.
-
(2000)
Nature Biotechnology
, vol.18
, pp. 1105-1108
-
-
Nienaber, V.L.1
Richardson, P.L.2
Klighofer, V.3
Bouska, J.J.4
Giranda, V.L.5
Greer, J.6
-
143
-
-
0037474541
-
Structural characterisation and functional significance of transient protein-protein interactions
-
NOOREN, I.M. & THORNTON, J. M. (2003). Structural characterisation and functional significance of transient protein-protein interactions. Journal of Molecular Biology 325, 991-1018.
-
(2003)
Journal of Molecular Biology
, vol.325
, pp. 991-1018
-
-
Nooren, I.M.1
Thornton, J.M.2
-
144
-
-
17444407490
-
Kinetic studies of small molecule interactions with protein kinases using biosensor technology
-
NORDIN, H., JUNGNELIUS, M., KARLSSON, R. & KARLSSON, O. P. (2005). Kinetic studies of small molecule interactions with protein kinases using biosensor technology. Analytical Biochemistry 340, 359-368.
-
(2005)
Analytical Biochemistry
, vol.340
, pp. 359-368
-
-
Nordin, H.1
Jungnelius, M.2
Karlsson, R.3
Karlsson, O.P.4
-
145
-
-
23144463510
-
PRISM: Protein interactions by structural matching
-
Web Server issue
-
OGMEN, U., KESKIN, O., AYTUNA, A. S., NUSSINOV, R. & GURSOY, A. (2005). PRISM: protein interactions by structural matching. Nucleic Acids Research 33 (Web Server issue), W331-W336.
-
(2005)
Nucleic Acids Research
, vol.33
-
-
Ogmen, U.1
Keskin, O.2
Aytuna, A.S.3
Nussinov, R.4
Gursoy, A.5
-
146
-
-
56549131177
-
The thermodynamics of protein-ligand interaction and solvation: Insights for ligand design
-
OLSSON, T. S., WILLIAMS, M. A., PITT, W.R. & LADBURY, J. E. (2008). The thermodynamics of protein-ligand interaction and solvation: insights for ligand design. Journal of Molecular Biology 384, 1002-1017.
-
(2008)
Journal of Molecular Biology
, vol.384
, pp. 1002-1017
-
-
Olsson, T.S.1
Williams, M.A.2
Pitt, W.R.3
Ladbury, J.E.4
-
147
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
OLTERSDORF, T., ELMORE, S. W., SHOEMAKER, A. R., ARMSTRONG, R. C., AUGERI, D. J., BELLI, B. A., BRUNCKO, M., DECKWERTH, T. L., DINGES, J., HAJDUK, P. J., JOSEPH, M. K., KITADA, S., KORSMEYER, S. J., KUNZER, A. R., LETAI, A., LI, C., MITTEN, M. J., NETTESHEIM, D. G., NG, S., NIMMER, P. M., O'CONNOR, J. M., OLEKSIJEW, A., PETROS, A. M., REED, J. C., SHEN, W., TAHIR, S. K., THOMPSON, C. B., TOMASELLI, K. J., WANG, B., WENDT, M. D., ZHANG, H., FESIK, S.W. & ROSENBERG, S. H. (2005). An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435, 677-681.
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
Bruncko, M.7
Deckwerth, T.L.8
Dinges, J.9
Hajduk, P.J.10
Joseph, M.K.11
Kitada, S.12
Korsmeyer, S.J.13
Kunzer, A.R.14
Letai, A.15
C, L.I.16
Mitten, M.J.17
Nettesheim, D.G.18
S, N.G.19
Nimmer, P.M.20
O'Connor, J.M.21
Oleksijew, A.22
Petros, A.M.23
Reed, J.C.24
Shen, W.25
Tahir, S.K.26
Thompson, C.B.27
Tomaselli, K.J.28
Wang, B.29
Wendt, M.D.30
Zhang, H.31
Fesik, S.W.32
Rosenberg, S.H.33
more..
-
148
-
-
41649106470
-
Submit your interaction data the IMEx way: A step by step guide to trouble-free deposition
-
ORCHARD, S., KERRIEN, S., JONES, P., CEOL, A., CHATRARYAMONTRI, A., SALWINSKI, L., NEROTHIN, J. & HERMJAKOB, H. (2007). Submit your interaction data the IMEx way: a step by step guide to trouble-free deposition. Proteomics 7 (Suppl. 1), 28-34.
-
(2007)
Proteomics
, vol.7
, Issue.SUPPL. 1
, pp. 28-34
-
-
Orchard, S.1
Kerrien, S.2
Jones, P.3
Ceol, A.4
Chatraryamontri, A.5
Salwinski, L.6
Nerothin, J.7
Hermjakob, H.8
-
149
-
-
18244380348
-
High-density miniaturized thermal shift assays as a general strategy for drug discovery
-
PANTOLINO, M. W., PETRELLA, E. C., KWASNOSKI, J. D., LOBANOV, V. S., MYSLIK, J., GRAF, E., CARVER, T., ASEL, E., SPRINGER, B. A., LANE, P. & SALEMME, F. R. (2001). High-density miniaturized thermal shift assays as a general strategy for drug discovery. Journal of Biomolecular Screening 6, 429-440.
-
(2001)
Journal of Biomolecular Screening
, vol.6
, pp. 429-440
-
-
Pantolino, M.W.1
Petrella, E.C.2
Kwasnoski, J.D.3
Lobanov, V.S.4
Myslik, J.5
Graf, E.6
Carver, T.7
Asel, E.8
Springer, B.A.9
Lane, P.10
Salemme, F.R.11
-
150
-
-
2242443513
-
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
-
PELLEGRINI, L., YU, D. S., LO, T., ANAND, S., LEE, M., BLUNDELL, T.L. & VENKITARAMAN, A. R. (2002). Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature 420, 287-293.
-
(2002)
Nature
, vol.420
, pp. 287-293
-
-
Pellegrini, L.1
S, Y.U.D.2
T, L.O.3
Anand, S.4
Lee, M.5
Blundell, T.L.6
Venkitaraman, A.R.7
-
151
-
-
77955517509
-
Druggable pockets and binding site centric chemical space: A paradigm shift in drug discovery
-
PEROT, S., SPERANDIO, O., MITEVA, M. A., CAMPROUX, A. C. & VILLOUTREIX, B. O. (2010). Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery. Drug Discovery Today 15, 656-667.
-
(2010)
Drug Discovery Today
, vol.15
, pp. 656-667
-
-
Perot, S.1
Sperandio, O.2
Miteva, M.A.3
Camproux, A.C.4
Villoutreix, B.O.5
-
152
-
-
65449148686
-
Fragment-based screening using surface plasmon resonance technology
-
PERSPICACE, S., BANNER, D., BENZ, J., MULLER, F., SCHLATTER, D. & HUBER, W. (2009). Fragment-based screening using surface plasmon resonance technology. Journal of Biomolecular Screening : The Official Journal of the Society for Biomolecular Screening 14, 337-349.
-
(2009)
Journal of Biomolecular Screening : The Official Journal of the Society for Biomolecular Screening
, vol.14
, pp. 337-349
-
-
Perspicace, S.1
Banner, D.2
Benz, J.3
Muller, F.4
Schlatter, D.5
Huber, W.6
-
153
-
-
31544467109
-
Discovery of a potent inhibitor of the antiapoptotic protein Bcl-XL from NMR and parallel synthesis
-
PETROS, A. M., DINGES, J., AUGERI, D. J., BAUMEISTER, S. A., BETEBENNER, D. A., BURES, M. G., ELMORE, S. W., HAJDUK, P. J., JOSEPH, M. K., LANDIS, S. K., NETTESHEIM, D. G., ROSENBERG, S. H., SHEN, W., THOMAS, S., WANG, X., ZANZE, I., ZHANG, H. & FESIK, S. W. (2006). Discovery of a potent inhibitor of the antiapoptotic protein Bcl-XL from NMR and parallel synthesis. Journal of Medicinal Chemistry 49, 656-663.
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, pp. 656-663
-
-
Petros, A.M.1
Dinges, J.2
Augeri, D.J.3
Baumeister, S.A.4
Betebenner, D.A.5
Bures, M.G.6
Elmore, S.W.7
Hajduk, P.J.8
Joseph, M.K.9
Landis, S.K.10
Nettesheim, D.G.11
Rosenberg12
-
154
-
-
0032720338
-
Isothermal titration calorimetry of protein-protein interactions
-
PIERCE, M. M., RAMAN, C.S. & NALL, B. T. (1999). Isothermal titration calorimetry of protein-protein interactions. Methods 19, 213-221.
-
(1999)
Methods
, vol.19
, pp. 213-221
-
-
Pierce, M.M.1
Raman, C.S.2
Nall, B.T.3
-
155
-
-
84870768965
-
Fragment-based methods for lead discovery
-
ed. M. Miteva Paris: Bentham Science Publishers
-
PITT, W., HIGUERUELO, A. & TODOROV, N. (2010). Fragment-based methods for lead discovery. In In Silico Lead Discovery (ed. M. Miteva), pp. 83-116. Paris: Bentham Science Publishers.
-
(2010)
Silico Lead Discovery
, pp. 83-116
-
-
Pitt, W.1
Higueruelo, A.2
Todorov, N.3
-
156
-
-
3843091516
-
Anchor residues in protein-protein interactions
-
RAJAMANI, D., THIEL, S., VAJDA, S. & CAMACHO, C. J. (2004). Anchor residues in protein-protein interactions. Proceedings of the National Academy of Sciences of the United States of America 101, 11287-11292.
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, pp. 11287-11292
-
-
Rajamani, D.1
Thiel, S.2
Vajda, S.3
Camacho, C.J.4
-
157
-
-
10744228786
-
Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis, evaluation, and mechanism of action
-
RAZAVI, H., PALANINATHAN, S. K., POWERS, E. T., WISEMAN, R. L., PURKEY, H. E., MOHAMEDMOHAIDEEN, N. N., DEECHONGKIT, S., CHIANG, K. P., DENDLE, M. T., SACCHETTINI, J. C. & KELLY, J. W. (2003). Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action. Angewandte Chemie International Edition 42, 2758-2761.
-
(2003)
Angewandte Chemie International Edition
, vol.42
, pp. 2758-2761
-
-
Razavi, H.1
Palaninathan, S.K.2
Powers, E.T.3
Wiseman, R.L.4
Purkey, H.E.5
Mohamedmohaideen, N.N.6
Deechongkit, S.7
Chiang, K.P.8
Dendle, M.T.9
Sacchettini, J.C.10
Kelly, J.W.11
-
158
-
-
42449147105
-
Fragment-based synthesis and SAR of modified FKBP ligands : Influence of different linking on binding affinity
-
ROHRIG, C. H., LOCH, C., GUAN, J. Y., SIEGAL, G. & OVERHAND, M. (2007). Fragment-based synthesis and SAR of modified FKBP ligands : influence of different linking on binding affinity. Chem Med Chem 2, 1054-1070.
-
(2007)
Chem Med Chem
, vol.2
, pp. 1054-1070
-
-
Rohrig, C.H.1
Loch, C.2
Guan, J.Y.3
Siegal, G.4
Overhand, M.5
-
159
-
-
14944348527
-
A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction
-
RUSH, T. S., 3RD, GRANT, J. A., MOSYAK, L. &NICHOLLS, A. (2005). A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction. Journal of Medical Chemistry 48, 1489-1495.
-
(2005)
Journal of Medical Chemistry
, vol.48
, pp. 1489-1495
-
-
Rush Iii., T.S.1
Grant, J.A.2
Mosyak, L.3
Nicholls, A.4
-
160
-
-
0016709043
-
X-ray analysis of glucagon and its relationship to receptor binding
-
SASAKI, K., DOCKERILL, S., ADAMIAK, D. A., TICKLE, I. J. & BLUNDELL, T. (1975). X-ray analysis of glucagon and its relationship to receptor binding. Nature 257, 751-757.
-
(1975)
Nature
, vol.257
, pp. 751-757
-
-
Sasaki, K.1
Dockerill, S.2
Adamiak, D.A.3
Tickle, I.J.4
Blundell, T.5
-
161
-
-
34249050729
-
Identification of inhibitors of protein kinase B using fragment-based lead discovery
-
SAXTY, G., WOODHEAD, S. J., BERDINI, V., DAVIES, T. G., VERDONK, M. L., WYATT, P. G., BOYLE, R. G., BARFORD, D., DOWNHAM, R., GARRETT, M.D. & CARR, R.A. (2007). Identification of inhibitors of protein kinase B using fragment-based lead discovery. Journal of Medical Chemistry 50, 2293-2296.
-
(2007)
Journal of Medical Chemistry
, vol.50
, pp. 2293-2296
-
-
Saxty, G.1
Woodhead, S.J.2
Berdini, V.3
Davies, T.G.4
Verdonk, M.L.5
Wyatt, P.G.6
Boyle, R.G.7
Barford, D.8
Downham, R.9
Garrett, M.D.10
Carr, R.A.11
-
162
-
-
77955397914
-
Understanding and predicting druggability. A high-throughput method for detection of drug binding sites
-
SCHMIDTKE, P. & BARRIL, X. (2010). Understanding and predicting druggability. A high-throughput method for detection of drug binding sites. Journal of Medical Chemistry 53, 5858-5867.
-
(2010)
Journal of Medical Chemistry
, vol.53
, pp. 5858-5867
-
-
Schmidtke, P.1
Barril, X.2
-
163
-
-
78650714726
-
Large-scale comparison of four binding site detection algorithms
-
SCHMIDTKE, P., SOUAILLE, C., ESTIENNE, F., BAURIN, N. & KROEMER, R. T. (2010). Large-scale comparison of four binding site detection algorithms. Journal of Chemical Information Model 50, 2191-2200.
-
(2010)
Journal of Chemical Information Model
, vol.50
, pp. 2191-2200
-
-
Schmidtke, P.1
Souaille, C.2
Estienne, F.3
Baurin, N.4
Kroemer, R.T.5
-
164
-
-
23844449940
-
Computer-based de novo design of drug-like molecules
-
SCHNEIDER, G. & FECHNER, U. (2005). Computer-based de novo design of drug-like molecules. Nature Reviews Drug Discovery 4, 649-663.
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, pp. 649-663
-
-
Schneider, G.1
Fechner, U.2
-
165
-
-
84961490006
-
Hormonereceptor interactions : A study of the binding of hormone-substituted tobacco mosaic virus to membrane vesicles by dynamic light scattering and by transient electric bi-refringence
-
SCHWYZER, R., KRIWACZEK, V. M., BAUMANN, K., HALLER, H.-R., WIDER, G. & WILTZIUS, A. P. (1979). Hormonereceptor interactions : a study of the binding of hormone-substituted tobacco mosaic virus to membrane vesicles by dynamic light scattering and by transient electric bi-refringence. Pure and Applied Chemistry 51, 831-835.
-
(1979)
Pure and Applied Chemistry
, vol.51
, pp. 831-835
-
-
Schwyzer, R.1
Kriwaczek, V.M.2
Baumann, K.3
Haller, H.-R.4
Wider, G.5
Wiltzius, A.P.6
-
166
-
-
84870790291
-
Using a fragment-based approach to target protein-protein interactions
-
SCOTT, D. E., EHEBAUER, M. T., PUKALA, T., MARSH, M., BLUNDELL, T. L., VENKITARAMAN, A. R., ABELL, C. & HYVÖNEN, M. (2012). Using a fragment-based approach to target protein-protein interactions. Manuscript in Preparation.
-
(2012)
Manuscript in Preparation
-
-
Scott, D.E.1
Ehebauer, M.T.2
Pukala, T.3
Marsh, M.4
Blundell, T.L.5
Venkitaraman, A.R.6
Abell, C.7
Hyvönen, M.8
-
167
-
-
78651344116
-
PCRPi-DB: A database of computationally annotated hot spots in protein interfaces
-
Database issue
-
SEGURA, J. & FERNANDEZ-FUENTES, N. (2011). PCRPi-DB: a database of computationally annotated hot spots in protein interfaces. Nucleic Acids Research 39 (Database issue), D755-D760.
-
(2011)
Nucleic Acids Research
, vol.39
-
-
Segura, J.1
Fernandez-Fuentes, N.2
-
168
-
-
0029836953
-
Discovering high-affinity ligands for proteins : SAR by NMR
-
SHUKER, S. B., HAJDUK, P. J., MEADOWS, R.P. & FESIK, S. W. (1996). Discovering high-affinity ligands for proteins : SAR by NMR. Science 274, 1531-1534.
-
(1996)
Science
, vol.274
, pp. 1531-1534
-
-
Shuker, S.B.1
Hajduk, P.J.2
Meadows, R.P.3
Fesik, S.W.4
-
170
-
-
0034650726
-
Exact analysis of competition ligand binding by displacement isothermal titration calorimetry
-
SIGURSKJOLD, B. W. (2000). Exact analysis of competition ligand binding by displacement isothermal titration calorimetry. Analytical Biochemistry 277, 260-266.
-
(2000)
Analytical Biochemistry
, vol.277
, pp. 260-266
-
-
Sigurskjold, B.W.1
-
171
-
-
77953984062
-
New surface contacts formed upon reductive lysine methylation: Improving the probability of protein crystallization
-
SLEDZ, P., ZHENG, H., MURZYN, K., CHRUSZCZ, M., ZIMMERMAN, M. D., CHORDIA, M. D., JOACHIMIAK, A. & MINOR, W. (2010). New surface contacts formed upon reductive lysine methylation: improving the probability of protein crystallization. Protein Science : A Publication of the Protein Society 19, 1395-1404.
-
(2010)
Protein Science : A Publication of the Protein Society
, vol.19
, pp. 1395-1404
-
-
Sledz, P.1
Zheng, H.2
Murzyn, K.3
Chruszcz, M.4
Zimmerman, M.D.5
Chordia, M.D.6
Joachimiak, A.7
Minor, W.8
-
172
-
-
75549083088
-
The Negatome database: A reference set of non-interacting protein pairs
-
Database issue
-
SMIALOWSKI, P., PAGEL, P., WONG, P., BRAUNER, B., DUNGER, I., FOBO, G., FRISHMAN, G., MONTRONE, C., RATTEI, T., FRISHMAN, D. & RUEPP, A. (2010). The Negatome database: a reference set of non-interacting protein pairs. Nucleic Acids Research 38 (Database issue), D540-D544.
-
(2010)
Nucleic Acids Research
, vol.38
-
-
Smialowski, P.1
Pagel, P.2
Wong, P.3
Brauner, B.4
Dunger, I.5
Fobo, G.6
Frishman, G.7
Montrone, C.8
Rattei, T.9
Frishman, D.10
Ruepp, A.11
-
173
-
-
79952392408
-
Fragment screening purely with protein crystallography
-
SPURLINO, J. C. (2011). Fragment screening purely with protein crystallography. Methods in Enzymology 493, 321-356.
-
(2011)
Methods in Enzymology
, vol.493
, pp. 321-356
-
-
Spurlino, J.C.1
-
174
-
-
78651344377
-
3did: Identification and classification of domain-based interactions of known three-dimensional structure
-
Database issue
-
STEIN, A., CEOL, A. & ALOY, P. (2011). 3did: identification and classification of domain-based interactions of known three-dimensional structure. Nucleic Acids Research 39 (Database issue), D718-D723.
-
(2011)
Nucleic Acids Research
, vol.39
-
-
Stein, A.1
Ceol, A.2
Aloy, P.3
-
175
-
-
77955891885
-
The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
-
STEWART, M. L., FIRE, E., KEATING, A.E. & WALENSKY, L. D. (2010). The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer. Nature Chemical Biology 6, 595-601.
-
(2010)
Nature Chemical Biology
, vol.6
, pp. 595-601
-
-
Stewart, M.L.1
Fire, E.2
Keating, A.E.3
Walensky, L.D.4
-
176
-
-
58849093668
-
Identification of allosteric PIF-pocket ligands for PDK1 using NMR-based fragment screening and 1H-15N TROSY experiments
-
STOCKMAN, B. J., KOTHE, M., KOHLS, D., WEIBLEY, L., CONNOLLY, B. J., SHEILS, A. L., CAO, Q., CHENG, A. C., YANG, L., KAMATH, A. V., DING, Y.H. & CHARLTON, M. E. (2009). Identification of allosteric PIF-pocket ligands for PDK1 using NMR-based fragment screening and 1H-15N TROSY experiments. Chemical Biology and Drug Design 73, 179-188.
-
(2009)
Chemical Biology and Drug Design
, vol.73
, pp. 179-188
-
-
Stockman, B.J.1
Kothe, M.2
Kohls, D.3
Weibley, L.4
Connolly, B.J.5
Sheils, A.L.6
Cao, Q.7
Cheng, A.C.8
Yang, L.9
Kamath, A.V.10
Ding, Y.H.11
Charlton, M.E.12
-
177
-
-
34250821717
-
Mechanism of coupled folding and binding of an intrinsically disordered protein
-
SUGASE, K., DYSON, H.J. & WRIGHT, P. E. (2007). Mechanism of coupled folding and binding of an intrinsically disordered protein. Nature 447, 1021-1025.
-
(2007)
Nature
, vol.447
, pp. 1021-1025
-
-
Sugase, K.1
Dyson, H.J.2
Wright, P.E.3
-
178
-
-
79651474672
-
Dr. PIAS an integrative system for assessing the druggability of protein-protein interactions
-
SUGAYA, N. & FURUYA, T. (2011). Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions. BMC Bioinformatics 12, 50.
-
(2011)
BMC Bioinformatics
, vol.12
, pp. 50
-
-
Sugaya, N.1
Furuya, T.2
-
179
-
-
70349739403
-
Assessing the druggability of protein-protein interactions by a supervised machine-learning method
-
SUGAYA, N. & IKEDA, K. (2009). Assessing the druggability of protein-protein interactions by a supervised machine-learning method. BMC Bioinformatics 10, 263.
-
(2009)
BMC Bioinformatics
, vol.10
, pp. 263
-
-
Sugaya, N.1
Ikeda, K.2
-
180
-
-
5044241040
-
Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction
-
SUTHERLAND, A. G., ALVAREZ, J., DING, W., FOREMAN, K. W., KENNY, C. H., LABTHAVIKUL, P., MOSYAK, L., PETERSEN, P. J., RUSH, T. S., 3RD, RUZIN, A., TSAO, D. H. & WHELESS, K. L. (2003). Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction. Organic and Biomolecular Chemistry 1, 4138-4140.
-
(2003)
Organic and Biomolecular Chemistry
, vol.1
, pp. 4138-4140
-
-
Sutherland, A.G.1
Alvarez, J.2
Ding, W.3
Foreman, K.W.4
Kenny, C.H.5
Labthavikul, P.6
Mosyak, L.7
Petersen, P.J.8
Rush Iii., T.S.9
Ruzin, A.10
Tsao, D.H.11
Wheless, K.L.12
-
181
-
-
78651324347
-
The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored
-
Database issue
-
SZKLARCZYK, D., FRANCESCHINI, A., KUHN, M., SIMONOVIC, M., ROTH, A., MINGUEZ, P., DOERKS, T., STARK, M., MULLER, J., BORK, P., JENSEN, L. J. & VON MERING, C. (2011). The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Research 39 (Database issue), D561-D568.
-
(2011)
Nucleic Acids Research
, vol.39
-
-
Szklarczyk, D.1
Franceschini, A.2
Kuhn, M.3
Simonovic, M.4
Roth, A.5
Minguez, P.6
Doerks, T.7
Stark, M.8
Muller, J.9
Bork, P.10
Jensen, L.J.11
Von Mering, C.12
-
182
-
-
34248581436
-
Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation
-
TAYLOR, J. D., GILBERT, P. J., WILLIAMS, M. A., PITT, W. R. & LADBURY, J. E. (2007). Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation. Proteins 67, 981-990.
-
(2007)
Proteins
, vol.67
, pp. 981-990
-
-
Taylor, J.D.1
Gilbert, P.J.2
Williams, M.A.3
Pitt, W.R.4
Ladbury, J.E.5
-
183
-
-
40049089622
-
SCOWLP classification: Structural comparison and analysis of protein binding regions
-
TEYRA, J., PASZKOWSKI-ROGACZ, M., ANDERS, G. & PISABARRO, M. T. (2008). SCOWLP classification: structural comparison and analysis of protein binding regions. BMC Bioinformatics 9, 9.
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 9
-
-
Teyra, J.1
Paszkowski-Rogacz, M.2
Anders, G.3
Pisabarro, M.T.4
-
184
-
-
33750303565
-
Hotspot mimicry of a cytokine receptor by a small molecule
-
THANOS, C. D., DELANO, W. L. & WELLS, J. A. (2006). Hotspot mimicry of a cytokine receptor by a small molecule. Proceedings of the National Academy of Sciences of the United States of America 103, 15422-15427.
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, pp. 15422-15427
-
-
Thanos, C.D.1
Delano, W.L.2
Wells, J.A.3
-
185
-
-
52249108519
-
CONFIRM: Connecting fragments found in receptor molecules
-
THOMPSON, D., DENNY, A., NILAKANTAN, R., HUMBLET, C., JOSEPH-MCCARTHY, D. & FEYFANT, E. (2008). CONFIRM: connecting fragments found in receptor molecules. Journal of Computer-Aided Molecular Design 22, 761-772.
-
(2008)
Journal of Computer-Aided Molecular Design
, vol.22
, pp. 761-772
-
-
Thompson, D.1
Denny, A.2
Nilakantan, R.3
Humblet, C.4
Joseph-Mccarthy, D.5
Feyfant, E.6
-
186
-
-
0035066602
-
ASEdb: A database of alanine mutations and their effects on the free energy of binding in protein interactions
-
THORN, K. S. & BOGAN, A. A. (2001). ASEdb: a database of alanine mutations and their effects on the free energy of binding in protein interactions. Bioinformatics 17, 284-285.
-
(2001)
Bioinformatics
, vol.17
, pp. 284-285
-
-
Thorn, K.S.1
Bogan, A.A.2
-
187
-
-
0030753124
-
Identification of a small molecule inhibitor of the IL-2/IL-2Ra receptor interaction which binds to IL-2
-
TILLEY, J. W., CHEN, L., FRY, D. C., EMERSON, S. D., POWERS, G. D., BIONDI, D., VARNELL, T., TRILLES, R., GUTHRIE, R., MENNONA, F., KAPLAN, G., LEMAHIEU, R. A., CARSON, M., HAN, R.-J., LIU, C.-M., PALERMO, R. & JU, G. (1997). Identification of a small molecule inhibitor of the IL-2/IL-2Ra receptor interaction which binds to IL-2. Journal of the American Chemical Society 119, 7589-7590.
-
(1997)
Journal of the American Chemical Society
, vol.119
, pp. 7589-7590
-
-
Tilley, J.W.1
Chen, L.2
Fry, D.C.3
Emerson, S.D.4
Powers, G.D.5
Biondi, D.6
Varnell, T.7
Trilles, R.8
Guthrie, R.9
Mennona, F.10
Kaplan, G.11
Lemahieu, R.A.12
Carson, M.13
Han, R.-J.14
Liu, C.-M.15
Palermo, R.16
G, J.U.17
-
188
-
-
68049132168
-
A phase i study of MK-2206, an oral potent allosteric Akt inhibitor, in patients with advanced solid tumor
-
TOLCHER, A., YAP, T., FEAREN, I., TAYLOR, A., CARPENTER, C. & BRUNETTO, A. (2007). A phase I study of MK-2206, an oral potent allosteric Akt inhibitor, in patients with advanced solid tumor. Journal of Clinical Oncology 27, 3503.
-
(2007)
Journal of Clinical Oncology
, vol.27
, pp. 3503
-
-
Tolcher, A.1
Yap, T.2
Fearen, I.3
Taylor, A.4
Carpenter, C.5
Brunetto, A.6
-
189
-
-
78049417719
-
Higher throughput calorimetry: Opportunities, approaches and challenges
-
TORRES, F. E., RECHT, M. I., COYLE, J. E., BRUCE, R.H. & WILLIAMS, G. (2010). Higher throughput calorimetry: opportunities, approaches and challenges. Current Opinion in Structural Biology 20, 598-605.
-
(2010)
Current Opinion in Structural Biology
, vol.20
, pp. 598-605
-
-
Torres, F.E.1
Recht, M.I.2
Coyle, J.E.3
Bruce, R.H.4
Williams, G.5
-
191
-
-
33750067690
-
Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design
-
TSAO, D. H., SUTHERLAND, A. G., JENNINGS, L. D., LI, Y., RUSH, III, T. S., ALVAREZ, J. C., DING, W., DUSHIN, E. G., DUSHIN, R. G., HANEY, S. A., KENNY, C. H., MALAKIAN, A. K., NILAKANTAN, R.&MOSYAK, L. (2006). Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design. Bioorganic and Medicinal Chemistry 14, 7953-7961.
-
(2006)
Bioorganic and Medicinal Chemistry
, vol.14
, pp. 7953-7961
-
-
Tsao, D.H.1
Sutherland, A.G.2
Jennings, L.D.3
Y, L.I.4
Rush Iii, T.S.5
Alvarez, J.C.6
Ding, W.7
Dushin, E.G.8
Dushin, R.G.9
Haney, S.A.10
Kenny, C.H.11
Malakian, A.K.12
Nilakantan, R.13
Mosyak, L.14
-
192
-
-
65549157572
-
A survey of available tools and web servers for analysis of protein-protein interactions and interfaces
-
TUNCBAG, N., KAR, G., KESKIN, O., GURSOY, A. & NUSSINOV, R. (2009). A survey of available tools and web servers for analysis of protein-protein interactions and interfaces. Briefings in Bioinformatics 10, 217-232.
-
(2009)
Briefings in Bioinformatics
, vol.10
, pp. 217-232
-
-
Tuncbag, N.1
Kar, G.2
Keskin, O.3
Gursoy, A.4
Nussinov, R.5
-
193
-
-
79955770051
-
Interaction databases on the same page
-
TURINSKY, A. L., RAZICK, S., TURNER, B., DONALDSON, I.M. & WODAK, S. J. (2011). Interaction databases on the same page. Nature Biotechnology 29, 391-393.
-
(2011)
Nature Biotechnology
, vol.29
, pp. 391-393
-
-
Turinsky, A.L.1
Razick, S.2
Turner, B.3
Donaldson, I.M.4
Wodak, S.J.5
-
194
-
-
0345293146
-
On the value of c: Can low affinity systems be studied by isothermal titration calorimetry?
-
TURNBULL, W. B. & DARANAS, A. H. (2003). On the value of c: can low affinity systems be studied by isothermal titration calorimetry? Journal of the American Chemical Society 125, 14859-14866.
-
(2003)
Journal of the American Chemical Society
, vol.125
, pp. 14859-14866
-
-
Turnbull, W.B.1
Daranas, A.H.2
-
195
-
-
58149411184
-
Features of similarity
-
TVERSKY, A. (1977). Features of Similarity. Psychological Reviews 84, 327-352.
-
(1977)
Psychological Reviews
, vol.84
, pp. 327-352
-
-
Tversky, A.1
-
196
-
-
33750470057
-
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
-
VEDADI, M., NIESEN, F. H., ALLALI-HASSANI, A., FEDOROV, O. Y., FINERTY, JR., P. J., WASNEY, G. A., YEUNG, R., ARROWSMITH, C., BALL, L. J., BERGLUND, H., HUI, R. & MARSDEN, B. D. (2006). Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proceedings of the National Academy of Sciences of the United States of America 103, 15835-15840.
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, pp. 15835-15840
-
-
Vedadi, M.1
Niesen, F.H.2
Allali-Hassani, A.3
Fedorov, O.Y.4
Finerty Jr., P.J.5
Wasney, G.A.6
Yeung, R.7
Arrowsmith, C.8
Ball, L.J.9
Berglund, H.10
Hui, R.11
Marsden, B.D.12
-
197
-
-
0035876257
-
The binding energetics of first-and second-generation HIV-1 protease inhibitors: Implications for drug design
-
VELAZQUEZ-CAMPOY, A., KISO, Y.&FREIRE, E. (2001). The binding energetics of first-and second-generation HIV-1 protease inhibitors: implications for drug design. Archives of Biochemistry and Biophysics 390, 169-175.
-
(2001)
Archives of Biochemistry and Biophysics
, vol.390
, pp. 169-175
-
-
Velazquez-Campoy, A.1
Kiso, Y.2
Freire, E.3
-
198
-
-
0034093758
-
HIV-1 protease inhibitors: Enthalpic versus entropic optimization of the binding affinity
-
VELAZQUEZ-CAMPOY, A., TODD, M. J. & FREIRE, E. (2000). HIV-1 protease inhibitors: enthalpic versus entropic optimization of the binding affinity. Biochemistry 39, 2201-2207.
-
(2000)
Biochemistry
, vol.39
, pp. 2201-2207
-
-
Velazquez-Campoy, A.1
Todd, M.J.2
Freire, E.3
-
199
-
-
58149305794
-
An empirical framework for binary interactome mapping
-
VENKATESAN, K., RUAL, J. F., VAZQUEZ, A., STELZL, U., LEMMENS, I., HIROZANE-KISHIKAWA, T., HAO, T., ZENKNER, M., XIN, X., GOH, K. I., YILDIRIM, M. A., SIMONIS, N., HEINZMANN, K., GEBREAB, F., SAHALIE, J. M., CEVIK, S., SIMON, C., DE SMET, A. S., DANN, E., SMOLYAR, A., VINAYAGAM, A., YU, H., SZETO, D., BORICK, H., DRICOT, A., KLITGORD, N., MURRAY, R. R., LIN, C., LALOWSKI, M., TIMM, J., RAU, K., BOONE, C., BRAUN, P., CUSICK, M. E., ROTH, F. P., HILL, D. E., TAVERNIER, J., WANKER, E. E., BARABASI, A. L. & VIDAL, M. (2009). An empirical framework for binary interactome mapping. Nature Methods 6, 83-90.
-
(2009)
Nature Methods
, vol.6
, pp. 83-90
-
-
Venkatesan, K.1
Rual, J.F.2
Vazquez, A.3
Stelzl, U.4
Lemmens, I.5
Hirozane-Kishikawa, T.6
Hao, T.7
Zenkner, M.8
Xin, X.9
Goh, K.I.10
Yildirim, M.A.11
Simonis, N.12
Heinzmann, K.13
Gebreab, F.14
Sahalie, J.M.15
Cevik, S.16
Simon, C.17
De Smet, A.S.18
Dann, E.19
Smolyar, A.20
Vinayagam, A.21
H, Y.U.22
Szeto, D.23
Borick, H.24
Dricot, A.25
Klitgord, N.26
Murray, R.R.27
Lin, C.28
Lalowski, M.29
Timm, J.30
Rau, K.31
Boone, C.32
Braun, P.33
Cusick, M.E.34
Roth, F.P.35
Hill, D.E.36
Tavernier, J.37
Wanker, E.E.38
Barabasi, A.L.39
Vidal, M.40
more..
-
200
-
-
0001928830
-
-
New York Marcel Dekker Inc
-
VERLINDE, C. L. M. J., KIM, H. B. B., MANDE, S. C. & WGJ, H. (1997). Anti-trypanosomiasis Drug Development Based on Structures of Glycolytic Enzymes. New York: Marcel Dekker; Inc.
-
(1997)
Anti-trypanosomiasis Drug Development Based on Structures of Glycolytic Enzymes
-
-
Verlinde, C.L.M.J.1
Kim, H.B.B.2
Mande, S.C.3
Wgj, H.4
-
201
-
-
0037777697
-
SYNOPSIS: SYNthesize and OPtimize System in Silico
-
VINKERS, H. M., DE JONGE, M. R., DAEYAERT, F. F. D., HEERES, J., KOYMANS, L. M. H., VAN LENTHE, J. H., LEWI, P. J., TIMMERMAN, H., VAN AKEN, K. & JANSSEN, P. A. J. (2003). SYNOPSIS: SYNthesize and OPtimize System in Silico. Journal of Medicinal Chemistry 46, 2765-2773.
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, pp. 2765-2773
-
-
Vinkers, H.M.1
De Jonge, M.R.2
Daeyaert, F.F.D.3
Heeres, J.4
Koymans, L.M.H.5
Van Lenthe, J.H.6
Lewi, P.J.7
Timmerman, H.8
Van Aken, K.9
Janssen, P.A.J.10
-
202
-
-
0038333283
-
Stabilization of proteins by ligand binding: Application to drug screening and determination of unfolding energetics
-
WALDRON, T. T. & MURPHY, K. P. (2003). Stabilization of proteins by ligand binding: application to drug screening and determination of unfolding energetics. Biochemistry 42, 5058-5064.
-
(2003)
Biochemistry
, vol.42
, pp. 5058-5064
-
-
Waldron, T.T.1
Murphy, K.P.2
-
204
-
-
0028936571
-
An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule
-
WANG, Z. X. (1995). An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule. FEBS Letters 360, 111-114.
-
(1995)
FEBS Letters
, vol.360
, pp. 111-114
-
-
Wang, Z.X.1
-
205
-
-
37249004920
-
Reaching for highhanging fruit in drug discovery at protein-protein interfaces
-
WELLS, J. & MCCLENDON, C. (2007). Reaching for highhanging fruit in drug discovery at protein-protein interfaces. Nature 450, 1001-1009.
-
(2007)
Nature
, vol.450
, pp. 1001-1009
-
-
Wells, J.1
McClendon, C.2
-
206
-
-
34247868131
-
Discovery of a novel small molecule binding site of human survivin
-
WENDT, M. D., SUN, C., KUNZER, A., SAUER, D., SARRIS, K., HOFF, E., YU, L., NETTESHEIM, D. G., CHEN, J., JIN, S., COMESS, K. M., FAN, Y., ANDERSON, S. N., ISAAC, B., OLEJNICZAK, E. T., HAJDUK, P. J., ROSENBERG, S.H. & ELMORE, S. W. (2007). Discovery of a novel small molecule binding site of human survivin. Bioorganic and Medicinal Chemistry Lett 17, 3122-3129.
-
(2007)
Bioorganic and Medicinal Chemistry Lett
, vol.17
, pp. 3122-3129
-
-
Wendt, M.D.1
Sun, C.2
Kunzer, A.3
Sauer, D.4
Sarris, K.5
Hoff, E.6
L, Y.U.7
Nettesheim, D.G.8
Chen, J.9
Jin, S.10
Comess, K.M.11
Fan, Y.12
Anderson, S.N.13
Isaac, B.14
Olejniczak, E.T.15
Hajduk, P.J.16
Rosenberg, S.H.17
Elmore, S.W.18
-
207
-
-
70450169243
-
Inhibition of protein-protein interactions using designed molecules
-
WILSON, A. J. (2009). Inhibition of protein-protein interactions using designed molecules. Chemical Society Reviews 38, 3289-3300.
-
(2009)
Chemical Society Reviews
, vol.38
, pp. 3289-3300
-
-
Wilson, A.J.1
-
208
-
-
33644876493
-
SCOPPI: A structural classification of protein-protein interfaces
-
Database issue
-
WINTER, C., HENSCHEL, A., KIM, W.K. & SCHROEDER, M. (2006). SCOPPI: a structural classification of protein-protein interfaces. Nucleic Acids Research 34(Database issue), D310-D314.
-
(2006)
Nucleic Acids Research
, vol.34
-
-
Winter, C.1
Henschel, A.2
Kim, W.K.3
Schroeder, M.4
-
209
-
-
0024356301
-
Rapid measurement of binding constants and heats of binding using a new titration calorimeter
-
WISEMAN, T., WILLISTON, S., BRANDTS, J. F. & LIN, L.N. (1989). Rapid measurement of binding constants and heats of binding using a new titration calorimeter. Analytical Biochemistry 179, 131-137.
-
(1989)
Analytical Biochemistry
, vol.179
, pp. 131-137
-
-
Wiseman, T.1
Williston, S.2
Brandts, J.F.3
Lin, L.N.4
-
210
-
-
0032749078
-
Intrinsically unstructured proteins: Re-assessing the protein structure-function paradigm
-
WRIGHT, P.E. & DYSON, H. J. (1999). Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. Journal of Molecular Biology 293, 321-331.
-
(1999)
Journal of Molecular Biology
, vol.293
, pp. 321-331
-
-
Wright, P.E.1
Dyson, H.J.2
-
212
-
-
77958576132
-
Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition
-
WU, W. I., VOEGTLI, W. C., STURGIS, H. L., DIZON, F. P., VIGERS, G.P. & BRANDHUBER, B. J. (2010). Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition. PLoS ONE 5, e12913.
-
(2010)
PLoS ONE
, vol.5
-
-
I, W.U.W.1
Voegtli, W.C.2
Sturgis, H.L.3
Dizon, F.P.4
Vigers, G.P.5
Brandhuber, B.J.6
-
213
-
-
0033971642
-
DIP: The database of interacting proteins
-
XENARIOS, I., RICE, D. W., SALWINSKI, L., BARON, M. K., MARCOTTE, E.M. & EISENBERG, D. (2000). DIP: the database of interacting proteins. Nucleic Acids Research 28, 289-291.
-
(2000)
Nucleic Acids Research
, vol.28
, pp. 289-291
-
-
Xenarios, I.1
Rice, D.W.2
Salwinski, L.3
Baron, M.K.4
Marcotte, E.M.5
Eisenberg, D.6
-
214
-
-
79955556964
-
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
-
XIANG, Y., HIRTH, B., ASMUSSEN, G., BIEMANN, H. P., BISHOP, K. A., GOOD, A., FITZGERALD, M., GLADYSHEVA, T., JAIN, A., JANCSICS, K., LIU, J., METZ, M., PAPOULIS, A., SKERLJ, R., STEPP, J.D. & WEI, R. R. (2011). The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors. Bioorganic and Medicinal Chemistry Lett 21, 3050-3056.
-
(2011)
Bioorganic and Medicinal Chemistry Lett
, vol.21
, pp. 3050-3056
-
-
Xiang, Y.1
Hirth, B.2
Asmussen, G.3
Biemann, H.P.4
Bishop, K.A.5
Good, A.6
Fitzgerald, M.7
Gladysheva, T.8
Jain, A.9
Jancsics, K.10
Liu, J.11
Metz, M.12
Papoulis, A.13
Skerlj, R.14
Stepp, J.D.15
Wei, R.R.16
-
215
-
-
33751357065
-
ProtBuD: A database of biological unit structures of protein families and superfamilies
-
XU, Q., CANUTESCU, A., OBRADOVIC, Z. & DUNBRACK, R. L., JR. (2006). ProtBuD: a database of biological unit structures of protein families and superfamilies. Bioinformatics 22, 2876-2882.
-
(2006)
Bioinformatics
, vol.22
, pp. 2876-2882
-
-
Q, X.U.1
Canutescu, A.2
Obradovic, Z.3
Dunbrack Jr., R.L.4
-
216
-
-
78651277455
-
DOMINE: A comprehensive collection of known and predicted domain-domain interactions
-
Database issue
-
YELLABOINA, S., TASNEEM, A., ZAYKIN, D. V., RAGHAVACHARI, B. & JOTHI, R. (2011). DOMINE: a comprehensive collection of known and predicted domain-domain interactions. Nucleic Acids Research 39(Database issue), D730-D735.
-
(2011)
Nucleic Acids Research
, vol.39
-
-
Yellaboina, S.1
Tasneem, A.2
Zaykin, D.V.3
Raghavachari, B.4
Jothi, R.5
-
217
-
-
1542285103
-
Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-XL protein
-
YIN, H. & HAMILTON, A. D. (2004). Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-XL protein. Bioorganic and Medicinal Chemistry Lett 14, 1375-1379.
-
(2004)
Bioorganic and Medicinal Chemistry Lett
, vol.14
, pp. 1375-1379
-
-
Yin, H.1
Hamilton, A.D.2
-
219
-
-
77951236321
-
Beyond the canonical 20 amino acids : Expanding the genetic lexicon
-
YOUNG, T. S. & SCHULTZ, P. G. (2010). Beyond the canonical 20 amino acids : expanding the genetic lexicon. The Journal of Biological Chemistry 285, 11039-11044.
-
(2010)
The Journal of Biological Chemistry
, vol.285
, pp. 11039-11044
-
-
Young, T.S.1
Schultz, P.G.2
|