Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers

Cell Cycle

Volumn 13, Issue 9, 2014, Pages 1424-1439

  Chitikova, Zhanna V ^a   Gordeev, Serguei A ^a   Bykova, Tatiana V ^a   Zubova, Svetlana G ^a   Pospelov, Valery A ^a   Pospelova, Tatiana V ^a  

^a INSTITUTE OF CYTOLOGY   (Russian Federation)

Author keywords

Apoptosis resistance; Autophagy; DNA damage response; DNA repair; mTOR; Polyploidy; Senescence reversion; Stem cells markers

Indexed keywords

CELL MARKER; E1A PROTEIN; HISTONE H2AX; INITIATION FACTOR 4E; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; BIOLOGICAL MARKER; E1B PROTEIN; MTOR PROTEIN, HUMAN; NANOG PROTEIN, RAT; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL AGING; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; DNA DAMAGE RESPONSE; DNA FRAGMENTATION; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; DOWN REGULATION; G2 PHASE CELL CYCLE CHECKPOINT; GENOTOXICITY; GIANT CELL; IONIZING RADIATION; M PHASE CELL CYCLE CHECKPOINT; POLYPLOIDY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STEM CELL; TRANSFORMED CELL; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; RADIATION RESPONSE; TRANSFORMED CELL LINE;

ADENOVIRUS E1A PROTEINS; ADENOVIRUS E1B PROTEINS; APOPTOSIS; AUTOPHAGY; BIOMARKERS; CELL AGING; CELL LINE, TRANSFORMED; CELL PROLIFERATION; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DOWN-REGULATION; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; NANOG HOMEOBOX PROTEIN; OCTAMER TRANSCRIPTION FACTOR-3; STEM CELLS; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 84899714966     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.28402     Document Type: Article

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