New molecular medicine-based scar management strategies

Burns

Volumn 40, Issue 4, 2014, Pages 539-551

  Arno, Anna I ^a,b   Gauglitz, Gerd G ^c   Barret, Juan P ^b   Jeschke, Marc G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Endoglin; FAP alpha DPPIV; Fussels; Keloid; Rapamycin; Review; Scar; Ski; SnoN; TGF

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; ENDOGLIN; FUSSEL PROTEIN; MANNOSE 6 PHOSPHATE; PROTEIN; PROTEIN INHIBITOR; PROTEOGLYCAN; RAPAMYCIN; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA3; SCATTER FACTOR; SEPRASE; SKI PROTEIN; SMAD PROTEIN; SMAD3 PROTEIN; SMAD3 PROTEIN INHIBITOR; SMAD7 PROTEIN; SNON PROTEIN; TACROLIMUS; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CYTOKINE RELEASE; ENZYME INHIBITION; FIBROSIS; HUMAN; MOLECULAR MEDICINE; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN STRUCTURE; SCAR; SIGNAL TRANSDUCTION; UPREGULATION; CICATRIX, HYPERTROPHIC; KELOID; METABOLISM;

CICATRIX, HYPERTROPHIC; HUMANS; KELOID;

EID: 84899654209     PISSN: 03054179     EISSN: 18791409     Source Type: Journal    
DOI: 10.1016/j.burns.2013.11.010     Document Type: Review

References (136)

1. T.A. Mustoe, R.D. Cooter, M.H. Gold, F.D. Hobbs, A.A. Ramelet, and P.G. Shakespeare et al. International clinical recommendations on scar management Plast Reconstr Surg 110 2 2002 560 571
2. G.G. Gauglitz, H.C. Korting, T. Pavicic, T. Ruzicka, and M.G. Jeschke Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies Mol Med 17 1-2 2011 113 125
3. D. Leventhal, M. Furr, and D. Reiter Treatment of keloids and hypertrophic scars Arch Facial Plast Surg 8 2006 362 368
4. K.J. Rolfe, J. Richardson, C. Vigor, L.M. Irvine, A.O. Grobbelaar, and C. Linge A role for TGF-β1-induced cellular responses during wound healing of the non-scarring early human fetus? J Invest Dermatol 127 11 2007 2656 2667
5. P. Löhn, A. Moren, E. Raja, M. Dahl, and A. Moustakas Regulating the stability of TGF-β receptors and Smads Cell Res 19 2009 21 35
6. N.A. Scott, and H.P. Lorenz Cells, matrix, growth factors and the surgeon. The biology of scarless fetal wound repair Ann Surg 220 1 2004 10 18
7. R. Carter, K. Jain, V. Sykes, and D. Lanning Differential expression of procollagen genes between mid-and late-gestational fetal fibroblasts J Surg Res 156 2009 90 94
8. T. Hayakawa, Y. Hashimoto, Y. Myokei, H. Aoyama, and Y. Izawa Changes in type of collagen during the development of human post-burn hypertrophic scars Clin Chim Acta 93 1 1979 119 125
9. D.T. Robles, E. Moore, M. Draznin, and D. Berg Keloids: pathophysiology and management Dermatol Online J 13 3 2007 9
10. G. Juckett, and H. Hartman-Adams Management of keloids and hypertrophic scars Am Fam Physician 80 3 2009 253 260
11. T.A. Wynn Cellular and molecular mechanisms of fibrosis J Pathol 214 2008 199 210
12. R. Govinden, and K.D. Bhoola Genealogy, expression and cellular function of transforming growth factor β Pharmacol Ther 98 2003 257 265
13. A. Leask, and D.J. Abraham TGF-β signaling and the fibrotic response FASEB J 18 2004 816 827
14. D. Pohlers, J. Brenmoehl, I. Löffler, C.K. Müller, C. Leipner, and S. Schultze-Mosgau et al. TGF-β and fibrosis in different organs: molecular pathway imprints Biochim Biophys Acta 1792 2009 746 756
15. D. Padua, and J. Massagué Roles of TGF-β in metastasis Cell Res 19 2009 89 102
16. J. Xu, S. Lamouille, and R. Derynck TGF-β-induced epithelial to mesenchymal transition Cell Res 19 2009 156 172
17. X. Guo, and X.F. Wang Signaling cross-talk between TGF-β/BMP and other pathways Cell Res 19 2009 71 88
18. V.A. Gabriel Transforming growth factor-β and angiotensin in fibrosis and burn injuries J Burn Care Res 30 3 2009 1 11
19. M. Ruiz-Ortega, J. Rodriguez-Vita, Sanchez, E. Lopez, G. Carvajal, and J. Egido TGF-β signaling in vascular fibrosis Cardiovasc Res 74 2007 196 206
20. A. Leask Targeting the TGF-β, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma Cell Signal 20 2008 1409 1414
21. S.R. Beanes, C. Dang, C. Soo, and K. Ting Skin repair and scar formation: the central role of TGF-β Expert Rev Mol Med 5 8 2003 1 22
22. T. Watabe, and K. Miyazono Roles of TGFB family signaling in stem cell renewal and differentiation Cell Res 19 2009 103 115
23. M. Valluru, C.A. Staton, M.W. Reed, and N.J. Brown Transforming growth factor-β and endoglin signaling orchestrate wound healing Front Physiol 2 2011 89
24. A.J. Singer, and R.A.F. Clark Cutaneous wound healing N Engl J Med 341 1999 728 746
25. G. Jenkins The role of proteases in transforming growth factor-β activation Int J Biochem Cell Biol 40 6-7 2008 1068 1078
26. F.F. Nie, Q. Wang, and Z.L. Qin The expression of fibrillin 1 in pathologic scars and its significance Zhonghua Zheng Xing Wai Ke Za Zhi 24 5 2008 339 342
27. K.H. Wrighton, X. Lin, and X.H. Feng Phospho-control of TGFB superfamily signaling Cell Res 19 2009 8 20
28. M. Böttner, K. Krieglstein, and K. Unsicker The transforming growth factor-βs: structure, signaling, and roles in nervous system development and function J Neurochem 75 2000 2227 2240
29. Y.E. Zhang Non-Smad pathways in TGF-β signaling Cell Res 19 2009 128 139
30. C. Bernabeu, J.M. Lopez-Novoa, and M. Quintanilla The emerging role of TGF-β superfamily coreceptors in cancer Biochim Biophys Acta 2009 954 973
31. E. Morris, I. Chrobak, A. Bujor, F. Hant, C. Mummery, and P. Ten Dijke et al. Endoglin promotes TGFB/Smad1 signaling in scleroderma fibroblasts J Cell Physiol 226 12 2011 3340 3348
32. K.W. Finsson, and A. Philip Endoglin in liver fibrosis J Cell Commun Signal 6 1 2012 1 4
33. P. Owens, G. Han, A.G. Li, and X.J. Wang The role of Smads in skin development J Invest Dermatol 128 2008 783 790
34. C. Hill Nucleocytoplasmic shuttling of Smad proteins Cell Res 19 2009 36 46
35. S. Bai, X. Shi, X. Yang, and X. Cao Smad6 as a transcriptional corepressor J Biol Chem 275 2000 8267 8270
36. X. Yan, Z. Liu, and Y. Chen Regulation of TGF-β signaling by Smad7 Acta Biochim Biophys Sin 41 4 2009 263 272
37. M.E. Mercado-Pimentel, and R.B. Runyan Multiple TGF-β isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart Cells Tissues Organs 185 2007 146 156
38. A.B. Roberts, A. Russo, A. Felici, and K.C. Flanders Smad3: a key player in pathogenic mechanisms dependent on TGF-β Ann N Y Acad Sci 995 2003 1 10
39. Y.G. Chen Endocytic regulation of TGF-β signaling Cell Res 19 2009 58 70
40. J. Deheuninck, and K. Luo Ski and SnoN, potent negative regulators of TGF-β signaling Cell Res 19 2009 47 57
41. P. Li, P. Liu, R.P. Xong, X.Y. Chen, Y. Zhao, and W.P. Lu et al. Ski, a modulator of wound healing and scar formation in the rat skin and rabbit ear J Pathol 223 2011 659 671
42. S. Arndt, I. Poser, M. Moser, and A.K. Bosserhoff Fussel-15, a novel ski/Sno homolog protein, antagonizes BMP signaling Mol Cell Neurosci 34 4 2007 603 611
43. S. Arndt, J. Schmidt, and E. Wacker et al. Fussel-15, a new player in wound healing, is deregulated in keloid and localized scleroderma Am J Pathol 178 6 2001 2622 2631
44. C. Bonnon, and S. Atanasoski C-Ski in health and disease Cell Tissue Res 347 2012 51 64
45. M. Macias-Silva, W. Li, J.I. Leu, M.A. Crissey, and R. Taub Upregulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration J Biol Chem 277 2002 28483 28490
46. C. Soeta, M. Suzuki, S. Suzuki, K. Naito, C. Tachi, and H. Tojo Possible role for the c-ski gene in the proliferation of myogenic cells in regenerating skeletal muscles of rats Dev Growth Differ 43 2001 155 164
47. H. Fukasawa, T. Yamamoto, A. Togawa, N. Ohashi, Y. Fujigaki, and T. Oda et al. Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury Kidney Int 69 2006 1733 1740
48. R.H. Cunnington, M. Nazari, and I.M.C. Dixon c-Ski, Smurf2, and Arkadia as regulators of TGF-β signaling: new targets for managing myofibroblast function and cardiac fibrosis Can J Physiol Pharmacol 87 10 2009 764 772
49. X. Zhang, K. Egawa, Y. Xie, and H. Ihn The expression of SnoN in normal human skin and cutaneous keratinous neoplasms Int J Dermatol 48 6 2009 579 583
50. G.Y. Zhang, T. Cheng, Q. Luan, T. Liao, C.L. Nie, and X. Zheng et al. Vitamin D: a novel therapeutic approach for keloid, an in vitro analysis Br J Dermatol 184 4 2011 729 737
51. R. Dahl, B. Wani, and M.J. Hayman The ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42 Oncogene 16 1998 1579 1586
52. M. Shah, D.M. Foreman, and M.W. Ferguson Control of scarring in adult wounds by neutralising antibody to transforming growth factor beta Lancet 339 1992 213 214
53. M. Gary-Bobo, P. Nirde, A. Jeanjean, A. Morère, and M. Garcia Mannose-6-phosphate receptor targeting and its applications in human diseases Curr Med Chem 14 2007 2945 2953
54. http://www.clinicaltrials.gov/ct2/show/NCT00664352?term=juvidex&rank= 3.
55. http://www.renovo.com.
56. W.C. Ngeow, S. Atkins, C.R. Morgan, A.D. Metcalfe, F.M. Boissonade, and A.R. Loescher et al. The effect of mannose-6-phosphate on recovery after sciatic nerve repair Brain Res 1394 2011 40 48
57. E.E. Tredget Pathophysiology and treatment of fibroproliferative disorders following thermal injury Ann N Y Acad Sci 888 1999 165 182
58. A. Thielitz, R.W. Vetter, B. Shultze, S. Wrenger, L. Simeoni, and S. Anorge et al. Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts J Invest Dermatol 128 2008 855 866
59. K. Dienus, A. Bayat, B.F. Gilmore, and O. Seifert Increased expression of fibroblast activation protein-alpha in keloid fibroblasts: implications for development of a novel treatment option Arch Dermatol Res 302 10 2010 725 731
60. Z. Wang, Z. Gao, Y. Shi, Y. Sun, Z. Lin, and H. Jiang et al. Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts J Plast Reconstr Aesthet Surg 60 11 2007 1193 1199
61. T.L. McGaha, R.G. Phelps, and H. Spiera Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor- β-mediated Smad3 activation in fibroblasts J Invest Dermatol 118 2002 461 470
62. T.T. Phan, I.J. Lim, S. Chan, E.K. Tan, S.T. Lee, and M.T. Longaker Suppression of transforming growth factor beta/Smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars J Trauma 57 5 2004 1032 1037
63. L.C. Huber, J.H. Distler, F. Moritz, H. Hemmatazad, T. Hauser, and B.A. Michel et al. prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis Arthritis Rheum 56 8 2007 2755 2764
64. X. Liu, S. Zhu, T. Wang, L. Hummers, F.M. Wigley, and P.J. Goldschmidt-Clermont et al. Paclitaxel modulates TGFbeta signaling in scleroderma skin grafos in immunodeficient mice PLoS Med 2 12 2005 e354
65. M. Elkin, miao H!, A. Nagler, E. Aingorn, R. Reich, and I. Hemo et al. Halofuginone: a potent inhibitor of critical steps in angiogenesis progression FASEB J 14 15 2000 2477 2485
66. H.B. Koon, B. Fingleton, J.Y. Lee, J.T. Geyer, E. Cesarman, and R.A. Parie et al. AIDS malignancy consortium trial of topical halofuginone in AIDS-related Kaposi sarcoma J Acquir Immune Defic Syndr 56 1 2011 64 68
67. L.L. McCormick, Y. Zhang, E. Tootell, and A.C. Gilliam Anti-TGF-B treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma J Immunol 163 1999 5693 5699
68. A. Nakao, M. Fujii, R. Matsumura, K. Kumano, Y. Saito, and K. Miyazono et al. Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice J Clin Invest 104 1999 5 11
69. J. Terao Dietary flavonoids as antioxidants Forum Nutr 61 2009 87 94
70. K. Murota, and J. Terao Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism Arch Biochem Biophys 417 1 2003 12 17
71. D.R. Ferry, A. Smith, J. Malkhandi, D.W. Fyfe, P.G. deTakats, and D. Anderson et al. Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition Clin Cancer Res 2 4 1996 659 668
72. X. Long, X. Zeng, F.Q. Zhang, and X.J. Wang Influence of quercetin and X-ray on collagen synthesis of cultured human keloid-derived fibroblasts Chin Med Sci J 21 3 2006 179 183
73. T.T. Phan, L. Sun, B.H. Bay, S.Y. Chan, and S.T. Lee Dietary compounds inhibit proliferation and contraction of keloids and hypertrophic scar-derived fibroblasts in vitro: therapeutic implication for excessive scarring J Trauma 54 2003 1212 1224
74. L.J. Hawinkels, and P. Ten Dijke Exploring anti-TGF-β therapies in cancer and fibrosis Growth Factors 29 4 2011 140 152
75. B. Santiago, I. Gutierrez-Cañas, J. Dotor, G. Palao, J.J. Lasarte, and J. Ruiz et al. Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis J Invest Dermatol 125 3 2005 450 455
76. C.G. Elliott, and D.W. Hamilton Deconstructing fibrosis research: do pro-fibrotic signals point the way for chronic dermal wound regeneration? J Cell Commun Signal 5 4 2011 301 315
77. http://www.clinicaltrials.gov/ct2/show/NCT00656825?term=P144&rank=3.
78. A. San-Martin, J. Dotor, F. Martinez, and B. Hontanilla Effect of the inhibitor peptide of the transforming growth factor beta (p144) in a new silicone pericapsular fibrotic model in pigs Aesthetic Plast Surg 34 4 2012 430 437
79. S.H. Qi, J.L. Xie, S. Pan, Y.B. Xu, T.Z. Li, and J.M. Tang et al. Effects of asiaticoside on the expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts Exp Dermatol 2007 171 175
80. B. Tang, B. Zhu, Y. Liang, L. Bi, Z. Hu, and B. Chen et al. Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts Arch Dermatol Res 303 8 2011 563 572
81. S. Saika TGF-β pathobiology in the eye Lab Invest 86 2006 106 115
82. L. Zunwen, Z. Shizhen, L. Dewu, M. Yungui, and N. Pu Effect of tetrandrine on the TGF-β-induced smad signal transduction pathway in human hypertrophic scar fibroblasts in vitro Burns 38 3 2012 404 413
83. S. Dooley, H.M. Said, A.M. Gressner, J. Floege, A. En-Nia, and P.R. Mertens Y-box protein-1 is crucial mediator of antifibrotic interferon-γ effects J Biol Chem 281 3 2006 1784 1795
84. L. Ulloa, J. Doody, and J. Massague Inhibition of transforming growth factor-beta/SMAD signaling by the interferon-gamma/STAT pathway Nature 397 6721 1999 710 713
85. Y. Ishida, T. Kondo, T. Takayasu, Y. Iwakura, and N. Mukaida The essential involvement of cross-talk between IFN-gamma and TGF-beta in the skin wound-healing process J Immunol 172 3 2004 1848 1855
86. R. Granstein, A. Rook, T.J. Flotte, A. Haas, R.L. Gallo, and H.S. Jaffe et al. A controlled trial of intralesional recombinant interferon-gamma in the treatment of keloidal scarring Arch Dermatol 126 1990 1295 1301
87. W.F. Larrabee, C.A. East, H.S. Jaffe, C. Stephenson, and K.E. Peterson Intralesional interferon gamma treatment for keloids and hypertrophic scars Arch Otolaryngol Head Neck Surg 116 1990 1159 1162
88. Z. Zhang, T.M. Garron, X.J. Li, Y. Liu, X. Zhang, and Y.Y. Li et al. Recombinant human decorin inhibits TGF-beta1-induced contraction of collagen lattice by hypertrophic scar fibroblasts Burns 35 4 2009 527 537
89. D. Honardoust, M. Varkey, K. Hori, J. Ding, H.A. Shankowsky, and E.E. Tredget Small leucine-rich proteoglycans, decorin and fibromodulin, are reduced in postburn hypertrophic scar Wound Repair Regen 19 3 2011 368 378
90. J. Meenakshi, S. Vidyameenakshi, D. Anathram, K.M. Ramakrishnan, V. Jayaraman, and M. Babu Low decorin expression along with inherent activation of ERK1,2 in earlobe keloids Burns 35 4 2009 519 526
91. N.L. Occleston, S. O'Kane, N. Goldspink, and M.W. Ferguson New therapeutic for the prevention and reduction of scarring Drug Discov Today 13 21/22 2008 973 981
92. M.W.J. Ferguson, J. Duncan, J. Bond, J. Bush, P. Durani, and K. So et al. Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies Lancet 373 2009 1264 1274
93. P. Durani, N. Occleston, S. O'Kane, M.W. Ferguson, and Avotermin: A novel antiscarring agent Int J Low Extrem Wounds 7 3 2008 160 168
94. M. Shah, D.M. Foreman, and M.W. Ferguson Neutralisation of TGF-beta1 and TGF-beta2 or exogenous addition of TGF-beta3 to cutaneous rat wounds reduces scarring J Cell Sci 108 Pt 3 1995 985 1002
95. J.A. Little, R. Murdy, N. Cossar, K.M. Getliffe, J. Hanak, and M.W. Ferguson TGF-β3 immunoassay standardization: comparison of NIBSC reference preparation code 98/608 with avotermin lot 205-0505-005 Immunoassay Immunochem 33 1 2012 66 81
96. M.A. Chen, and T.M. Davidson Scar management: prevention and treatment strategies Curr Opin Otolaryngol Head Neck Surg 13 2013 242 247
97. Y. Li, X. Wen, B.C. Spataro, K. Hu, C. Dai, and Y. Liu Hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists J Am Soc Nephrol 17 1 2006 54 65
98. W.J. Lee, S.E. Park, and D.K. Rah Effects of hepatocyte growth factor on collagen synthesis and matrix metalloproteinases production in keloids J Korean Med Sci 26 8 2011 1081 1086
99. R. Sherriff-Tadano, A. Ohta, F. Morito, M. Mitamura, Y. Haruta, and S. Koarada et al. Antifibrotic effects of hepatocyte growth factor on scleroderma fibroblasts and analysis of its mechanism Mod Rheumatol 16 6 2006 364 371
100. I. Ono, T. Yamashita, T. Hida, H.Y. Jin, Y. Ito, and H. Hamada et al. Local administration of hepatocyte growth factor gene enhances the regeneration of dermis in acute incisional wounds J Surg Res 120 1 2004 47 55
101. A.A. Mikulec, M.M. Hanasono, J. Lum, J.M. Kadleck, M. Kita, and R.J. Koch Effect of tamoxifen on transforming growth factor B1 production by keloid and fetal fibroblasts Arch Facial Plast Surg 3 2001 111 114
102. A. Gragnani, M. Warde, F. Furtado, and L.M. Ferreira Topical tamoxifen therapy in hypertrophic scars or keloids in burns Arch Dermatol Res 302 1 2010 1 4
103. S.R. Mousavi, M. Raaiszadeh, M. Aminseresht, and S. Behjoo Evaluating tamoxifen effect in the prevention of hypertrophic scars following surgical incisions Dermatol Surg 36 5 2010 665 669
104. J.M. Rhett, G.S. Ghatnekar, J.A. Palatinus, M. O'Quinn, M.J. Yost, and R.G. Gourdie Novel therapies for scar reduction and regenerative healing of skin wounds Trends Biotechnol 26 4 2008 173 180
105. J.Y. Zhao, J.K. Chai, H.F. Song, Y.F. Han, M.H. Xu, and T.J. Sun et al. Effect of different concentration of tamoxifen ointment on the expression of TGF-beta2 of hypertrophic scar at rabbit ears Zhonghua Zheng Xing Wai Ke Za Zhi 27 3 2011 213 217
106. M. Kho, K. Cransberg, W. Weimar, and T. van Gelder Current immunosuppressive treatment after kidney transplantation Expert Opin Pharmacother 12 8 2011 1217 1231
107. H. Gisquet, H. Liu, W.C. Blondel, A. Leroux, C. Latarche, and J.L. Merlin et al. Intradermal tacrolimus prevent scar hypertrophy in a rabbit ear model: a clinical, histological and spectroscopical analysis Skin Res Technol 17 2 2011 160 166
108. C.T. Ong, Y.T. Khoo, A. Mukhopadhyay, D.V. Do, I.J. Lim, and O. Aalami et al. mTOR as a potential therapeutic target for treatment of keloids and excessive scars Exp Dermatol 16 2007 394 404
109. A.H. Maciver, M.D. McCall, R.L. Edgar, A.L. Thiesen, D.L. Bigam, and T.A. Churchill et al. Sirolimus drug-eluting, hydrogel-impregnated polypropylene mesh reduces intra-abdominal adhesion formation in a mouse model Surgery 150 5 2011 907 915
110. A. Yoshizaki, K. Yanaba, A. Yoshizaki, Y. Iwata, K. Komura, and F. Ogawa et al. Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis Arthritis Rheum 62 8 2010 2476 2487
111. L. Fried, R.S. Kirsner, S. Bhandarkar, and J.L. Arbiser Efficacy of rapamycin in scleroderma: a case study Lymphat Res Biol 6 3-4 2008 217 219
112. D.J. Abraham, X. Shiwen, C.M. Black, S. Sa, Y. Xu, and A. Leask Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts J Biol Chem 275 20 2000 15220 15225
113. M.T. Goldberg, Y.P. Han, C. Yan, M.C. Shaw, and W.L. Garner TNF-alpha suppresses alpha-smooth muscle actin expression in human dermal fibroblasts: an implication for abnormal wound healing J Invest Dermatol 127 2007 2645 2655
114. A.J. Singer, and R.A. Clark Cutaneous wound healing N Engl J Med 341 1999 738 746
115. D. Peruccio, C. Castagnoli, M. Stella, S. D'Alfonso, P.R. Momigliano, and G. Magliacani et al. Altered biosynthesis of tumour necrosis factor (TNF) alpha is involved in postburn hypertorphic scars Burns 20 1994 118 121
116. M. Varkey, J. Ding, and C.C. Tredget Differential collagen- glycosaminoglycan matrix remodeling by superficial and deep dermal fibroblasts: potential therapeutic targets for hypertrophic scar Biomaterials 32 30 2011 7581 7591
117. D. Wolfram, A. Tzankov, P. Pülzl, and H. Piza-Katzer Hypertrophic scars and keloids: a review of their pathophysiology, risk factors, and therapeutic management Dermatol Surg 35 2 2009 171 181
118. B. Berman, J.K. Patel, O.A. Perez, M.H. Viera, S. Amini, and S. Block et al. Evaluating the tolerability and efficacy of etanercept compared to triamcinolone acetonide for the intralesional treatment of keloids J Drugs Dermatol 7 8 2008 757 761
119. L. Rossiello, F. d'Andrea, R. Grella, G. Signoriello, C. Abbondanza, and C. De Rosa et al. Differential expression of cyclooxygenases in hypertrophic scar and keloid tissues Wound Repair Regen 17 5 2009 750 757
120. J.E. Paderi, and A. Panitch Design of a synthetic collagen-binding peptidoglycan that modulates collagen fibrillogenesis Biomacromolecules 9 2008 2562 2566
121. K. Stuart, J. Paderi, P.W. Snyder, L. Freeman, and A. Panitch Collagen-binding peptidoglycans inhibit MMP mediated collagen degradation and reduce dermal scarring PLoS One 6 7 2011 e22139 [Epub 2011 July 11]
122. G.Y. Zhang, Q. Yu, T. Cheng, T. Liao, C.L. Nie, and A.Y. Wang et al. Role of caveolin-1 in the pathogenesis of tissue fibrosis by keloid-derived fibroblasts in vitro Br J Dermatol 164 3 2011 623 627
123. R. Castello-Cros, G. Bonuccelli, A. Molchansky, F. Capozza, A.K. Witkiewicz, and R.C. Birbe et al. Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis Cell Cycle 10 12 2011 2021 2034
124. C.R. Flynn, J. Cheung-Flynn, C.C. Smoke, D. Lowry, R. Roberson, and M.R. Sheller et al. Internalization and intracellular trafficking of a PTD-conjugated anti-fibrotic peptide, AZX100, in human dermal keloid fibroblasts J Pharm Sci 99 7 2010 3100 3121
125. L.B. Lopes, E.J. Furnish, P. Komalavilas, C.R. Flynn, P. Ashby, and A. Hansen et al. Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts J Invest Dermatol 129 3 2009 590 598
126. A.L. Goldstein, E. Hannappel, G. Sosne, and H.K. Kleinman Thymosin β(4): a multi-functional regenerative peptide. Basic properties and clinical applications Expert Opin Biol Ther 12 1 2012 37 51
127. G. Sosne, P. Qiu, P.L. Christopherson, and M.K. Wheater Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway Exp Eye Res 84 2007 663 669
128. D. Philp, B. Scheremeta, K. Sibliss, Zhou m, E.L. Fine, and M. Nguyen et al. Thymosin beta4 promotes matrix metalloproteinase expression during wound repair J Cell Physiol 208 2006 195 200
129. J. Banyard, C. Barrows, and B.R. Zetter Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1 Genes Chromosomes Cancer 48 6 2009 502 509
130. D. Philp, and H.K. Kleinman Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide Ann N Y Acad Sci 1194 2010 81 86
131. I. Banerjee, J. Zhang, T.M. Moore-Morris, S. Lange, T. Shen, and N.D. Dalton et al. Thymosin beta 4 is dispensable for murine cardiac development and function Circ Res 110 3 2012 456 464
132. F.F. Nie, J.Q. Wu, and Z.L. Qin Expression of thymosin beta 4 mRNA expression in keloid tissues and fibroblasts cultured from keloid and its significance Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17 2 2005 80 83
133. A.K. Jain, S.M. Moore, K. Yamaguchi, T.E. Eling, and S.J. Baek Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter cytoskeletal organization in human colorectal cancer cells J Pharmacol Exp Ther 311 3 2004 885 891
134. D.M. Kingsley The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms Genes Dev 8 1994 133 146
135. F. Fang, A.J. Shangguan, K. Kelly, J. Wei, K. Gruner, and B. Ye et al. Early growth response 3 (Egr-3) is induced by transforming growth factor-β and regulates fibrogenic responses Am J Pathol 183 4 2013 1197 1208
136. P. Speight, H. Nakano, T.J. Kelly, B. Hinz, and A. Kapus Differential topical susceptibility to TGFβ in the intact and injured regions of the epithelium: key role in myofibroblast transition Mol Biol Cell September 2013 [Epub ahead of print]