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Volumn 74, Issue 2, 2007, Pages 196-206

TGF-β signaling in vascular fibrosis

Author keywords

Angiotensin; Fibrosis; MAPK kinases; Signal transduction; Smooth muscle

Indexed keywords

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN II; ANTIFIBROTIC AGENT; CONNECTIVE TISSUE GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN CDC42; PROTEIN KINASE; RAC PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHO FACTOR; SERUM RESPONSE FACTOR; SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; SMAD8 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UNINDEXED DRUG;

EID: 34047156556     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2007.02.008     Document Type: Review
Times cited : (466)

References (83)
  • 1
    • 27644494876 scopus 로고    scopus 로고
    • Smad transcription factors
    • Massague J., Seoane J., and Wotton D. Smad transcription factors. Genes Dev 19 (2005) 2783-2810
    • (2005) Genes Dev , vol.19 , pp. 2783-2810
    • Massague, J.1    Seoane, J.2    Wotton, D.3
  • 2
    • 1942502823 scopus 로고    scopus 로고
    • Mammalian transforming growth factor-betas: Smad signaling and physiopathological roles
    • Javelaud D., and Mauviel A. Mammalian transforming growth factor-betas: Smad signaling and physiopathological roles. Int J Biochem Cell Biol 36 (2004) 1161-1165
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 1161-1165
    • Javelaud, D.1    Mauviel, A.2
  • 3
    • 0037013742 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling in regulation of cell growth and differentiation
    • Moustakas A., Pardali K., Gaal A., and Heldin C.H. Mechanisms of TGF-β signaling in regulation of cell growth and differentiation. Immunol Lett 82 (2002) 85-91
    • (2002) Immunol Lett , vol.82 , pp. 85-91
    • Moustakas, A.1    Pardali, K.2    Gaal, A.3    Heldin, C.H.4
  • 4
    • 0037439630 scopus 로고    scopus 로고
    • Making sense of latent TGFbeta activation
    • Annes J.P., Munger J.S., and Rifkin D.B. Making sense of latent TGFbeta activation. J Cell Sci 116 (2003) 217-224
    • (2003) J Cell Sci , vol.116 , pp. 217-224
    • Annes, J.P.1    Munger, J.S.2    Rifkin, D.B.3
  • 5
    • 2142646426 scopus 로고    scopus 로고
    • TGF-β signaling and the fibrotic response
    • Leask A., and Abraham D.J. TGF-β signaling and the fibrotic response. FASEB J 18 (2004) 816-817
    • (2004) FASEB J , vol.18 , pp. 816-817
    • Leask, A.1    Abraham, D.J.2
  • 6
    • 0026671838 scopus 로고
    • Vascular smooth muscle cell hypertrophy vs. Hyperplasia. Autocrine transforming growth factor-β1 expression determines growth responses to angiotensin
    • Gibbons G.H., Pratt R.E., and Dzau V.J. Vascular smooth muscle cell hypertrophy vs. Hyperplasia. Autocrine transforming growth factor-β1 expression determines growth responses to angiotensin. J Clin Invest 90 (1992) 456-461
    • (1992) J Clin Invest , vol.90 , pp. 456-461
    • Gibbons, G.H.1    Pratt, R.E.2    Dzau, V.J.3
  • 7
    • 0036597884 scopus 로고    scopus 로고
    • Angiotensin II induces human TGF-β1 promoter activation: similarity to hyperglycaemia
    • Weigert C., Brodbeck K., Klopfer K., Häring H.U., and Schleicher E.D. Angiotensin II induces human TGF-β1 promoter activation: similarity to hyperglycaemia. Diabetologia 45 (2002) 890-898
    • (2002) Diabetologia , vol.45 , pp. 890-898
    • Weigert, C.1    Brodbeck, K.2    Klopfer, K.3    Häring, H.U.4    Schleicher, E.D.5
  • 8
    • 0942301311 scopus 로고    scopus 로고
    • Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: a mechanism for activation of latent TGF-β1
    • Naito T., Masaki T., Nikolic-Paterson D.J., Tanji C., Yorioka, and Kohno N. Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: a mechanism for activation of latent TGF-β1. Am J Physiol Renal Physiol 286 (2004) F278-F287
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Naito, T.1    Masaki, T.2    Nikolic-Paterson, D.J.3    Tanji, C.4    Yorioka5    Kohno, N.6
  • 9
    • 33745947969 scopus 로고    scopus 로고
    • Matrix metalloproteinase 2 activation of transforming growth factor-β1 (TGF-β) and TGF-β1-type II receptor signaling within the aged arterial wall
    • Wang M., Zhao D., Spinetti G., Zhang J., Jiang L.Q., Pintus G., et al. Matrix metalloproteinase 2 activation of transforming growth factor-β1 (TGF-β) and TGF-β1-type II receptor signaling within the aged arterial wall. Arterioscler Thromb Vasc Biol 26 (2006) 1503-1509
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1503-1509
    • Wang, M.1    Zhao, D.2    Spinetti, G.3    Zhang, J.4    Jiang, L.Q.5    Pintus, G.6
  • 10
    • 17744377430 scopus 로고    scopus 로고
    • Oxidized LDL activates PAI-1 transcription through autocrine activation of TGF-β signaling in mesangial cells
    • Song C.Y., Kim B.C., Hong H.K., and Lee H.S. Oxidized LDL activates PAI-1 transcription through autocrine activation of TGF-β signaling in mesangial cells. Kidney Int 67 (2005) 1743-1752
    • (2005) Kidney Int , vol.67 , pp. 1743-1752
    • Song, C.Y.1    Kim, B.C.2    Hong, H.K.3    Lee, H.S.4
  • 11
    • 0034953381 scopus 로고    scopus 로고
    • Vascular smooth muscle growth: autocrine growth mechanisms
    • Berk B.C. Vascular smooth muscle growth: autocrine growth mechanisms. Physiol Rev 81 3 (2001) 999-1030
    • (2001) Physiol Rev , vol.81 , Issue.3 , pp. 999-1030
    • Berk, B.C.1
  • 12
    • 33644507113 scopus 로고    scopus 로고
    • Increased mRNA expression of transforming growth factor beta in the arterial wall of chronically rejected renal allografts in humans
    • Zegarska J., Paczek L., Pawlowska M., Wyczalkowska A., Michalska W., Ziolkowski J., et al. Increased mRNA expression of transforming growth factor beta in the arterial wall of chronically rejected renal allografts in humans. Transplant Proc 38 (2006) 115-118
    • (2006) Transplant Proc , vol.38 , pp. 115-118
    • Zegarska, J.1    Paczek, L.2    Pawlowska, M.3    Wyczalkowska, A.4    Michalska, W.5    Ziolkowski, J.6
  • 13
    • 0037227418 scopus 로고    scopus 로고
    • Transforming growth factor-beta-dependent events in vascular remodeling following arterial injury
    • Ryan S.T., Koteliansky V.E., Gotwals P.J., and Lindner V. Transforming growth factor-beta-dependent events in vascular remodeling following arterial injury. J Vasc Res 40 (2003) 37-46
    • (2003) J Vasc Res , vol.40 , pp. 37-46
    • Ryan, S.T.1    Koteliansky, V.E.2    Gotwals, P.J.3    Lindner, V.4
  • 14
    • 1542313954 scopus 로고    scopus 로고
    • Transforming growth factor-b and atherosclerosis: so far, so good for the protective cytokine hypothesis
    • Grainger D.J. Transforming growth factor-b and atherosclerosis: so far, so good for the protective cytokine hypothesis. Arterioscler Thromb Vasc Biol 24 (2004) 399-404
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 399-404
    • Grainger, D.J.1
  • 15
    • 34047156083 scopus 로고    scopus 로고
    • Grainger DJ. TGF-β and Atherosclerosis in Man. Cardiovasc Res in press (Accepted Manuscript, Available online 23 February 2007).
  • 16
    • 29144486106 scopus 로고    scopus 로고
    • The complex pattern of SMAD signaling in the cardiovascular system
    • Euler-Taimor G., and Heger J. The complex pattern of SMAD signaling in the cardiovascular system. Cardiovasc Res 69 (2006) 15-25
    • (2006) Cardiovasc Res , vol.69 , pp. 15-25
    • Euler-Taimor, G.1    Heger, J.2
  • 17
    • 33645806742 scopus 로고    scopus 로고
    • Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia
    • Khan R., and Sheppard R. Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia. Immunology 118 (2006) 10-14
    • (2006) Immunology , vol.118 , pp. 10-14
    • Khan, R.1    Sheppard, R.2
  • 19
    • 23844546577 scopus 로고    scopus 로고
    • Overexpression of transforming growth factor-beta1 stabilizes already-formed aortic aneurysms: a first approach to induction of functional healing by endovascular gene therapy
    • Dai J., Losy F., Guinault A.M., Pages C., Anegon I., Desgranges P., et al. Overexpression of transforming growth factor-beta1 stabilizes already-formed aortic aneurysms: a first approach to induction of functional healing by endovascular gene therapy. Circulation 112 7 (2005) 1008-1015
    • (2005) Circulation , vol.112 , Issue.7 , pp. 1008-1015
    • Dai, J.1    Losy, F.2    Guinault, A.M.3    Pages, C.4    Anegon, I.5    Desgranges, P.6
  • 21
    • 33645672459 scopus 로고    scopus 로고
    • Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    • Habashi J.P., Judge D.P., Holm T.M., Cohn R.D., Loeys B.L., Cooper T.K., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312 5770 (2006) 117-121
    • (2006) Science , vol.312 , Issue.5770 , pp. 117-121
    • Habashi, J.P.1    Judge, D.P.2    Holm, T.M.3    Cohn, R.D.4    Loeys, B.L.5    Cooper, T.K.6
  • 22
    • 0036177427 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation
    • Verrecchia F., and Mauviel A. Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J Invest Dermatol 118 (2002) 211-215
    • (2002) J Invest Dermatol , vol.118 , pp. 211-215
    • Verrecchia, F.1    Mauviel, A.2
  • 23
  • 24
    • 0037513432 scopus 로고    scopus 로고
    • Role of TGF-β signaling in extracellular matrix production under high glucose conditions
    • Li J.H., Huang X.R., Zhu H.J., Johnson R., and Lan H.Y. Role of TGF-β signaling in extracellular matrix production under high glucose conditions. Kidney Int 63 (2003) 2010-2019
    • (2003) Kidney Int , vol.63 , pp. 2010-2019
    • Li, J.H.1    Huang, X.R.2    Zhu, H.J.3    Johnson, R.4    Lan, H.Y.5
  • 25
    • 1342268353 scopus 로고    scopus 로고
    • Advanced glycation end products activate Smad signaling via TGF-β-dependent and independent mechanisms: implications for diabetic renal and vascular disease
    • Li J.H., Huang X.R., Zhu H.J., Oldfield M., Cooper M., Truong L.D., et al. Advanced glycation end products activate Smad signaling via TGF-β-dependent and independent mechanisms: implications for diabetic renal and vascular disease. FASEB J 18 (2004) 176-178
    • (2004) FASEB J , vol.18 , pp. 176-178
    • Li, J.H.1    Huang, X.R.2    Zhu, H.J.3    Oldfield, M.4    Cooper, M.5    Truong, L.D.6
  • 26
    • 0033380665 scopus 로고    scopus 로고
    • TGF-β signaling from receptors to the nucleus
    • Roberts A.B. TGF-β signaling from receptors to the nucleus. Microbes Infect 1 (1999) 1265-1273
    • (1999) Microbes Infect , vol.1 , pp. 1265-1273
    • Roberts, A.B.1
  • 27
    • 33646035242 scopus 로고    scopus 로고
    • Activin receptor-like kinases: structure, function and clinical implications
    • Graham H., and Peng C. Activin receptor-like kinases: structure, function and clinical implications. Endocr Metab Immune Disord Drug Targets 6 (2006) 45-58
    • (2006) Endocr Metab Immune Disord Drug Targets , vol.6 , pp. 45-58
    • Graham, H.1    Peng, C.2
  • 29
    • 30944436695 scopus 로고    scopus 로고
    • Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development
    • Seki T., Hong K.H., and Oh S.P. Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development. Lab Invest 86 (2006) 116-119
    • (2006) Lab Invest , vol.86 , pp. 116-119
    • Seki, T.1    Hong, K.H.2    Oh, S.P.3
  • 30
    • 33748749625 scopus 로고    scopus 로고
    • Endoglin structure and function: determinants of endoglin phosphorylation by TGFbeta receptors
    • Koleva R.I., Conley B.A., Romero D., Riley K.S., Marto J.A., Lux A., et al. Endoglin structure and function: determinants of endoglin phosphorylation by TGFbeta receptors. J Biol Chem 281 (2006) 25110-25119
    • (2006) J Biol Chem , vol.281 , pp. 25110-25119
    • Koleva, R.I.1    Conley, B.A.2    Romero, D.3    Riley, K.S.4    Marto, J.A.5    Lux, A.6
  • 31
    • 0035017536 scopus 로고    scopus 로고
    • Endoglin: an accessory component of the TGF-β-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies
    • Fonsatti E., Del Vecchio L., Altomonte M., Sigalotti L., Nicotra M.R., Coral S., et al. Endoglin: an accessory component of the TGF-β-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies. J Cell Physiol 188 (2001) 1-7
    • (2001) J Cell Physiol , vol.188 , pp. 1-7
    • Fonsatti, E.1    Del Vecchio, L.2    Altomonte, M.3    Sigalotti, L.4    Nicotra, M.R.5    Coral, S.6
  • 32
    • 85047683466 scopus 로고    scopus 로고
    • Inhibin binding protein (InhBP/p120), betaglycan, and the continuing search for the inhibin receptor
    • Bernard D.J., Chapman S.C., and Woodruff T.K. Inhibin binding protein (InhBP/p120), betaglycan, and the continuing search for the inhibin receptor. Mol Endocrinol 16 (2002) 207-212
    • (2002) Mol Endocrinol , vol.16 , pp. 207-212
    • Bernard, D.J.1    Chapman, S.C.2    Woodruff, T.K.3
  • 33
    • 0036313090 scopus 로고    scopus 로고
    • Smad7: a new key player in TGF-β-associated disease
    • Nakao A., Okumura K., and Ogawa H. Smad7: a new key player in TGF-β-associated disease. Trends Mol Med 8 (2002) 361-363
    • (2002) Trends Mol Med , vol.8 , pp. 361-363
    • Nakao, A.1    Okumura, K.2    Ogawa, H.3
  • 34
    • 0642378275 scopus 로고    scopus 로고
    • Smad protein and TGF-β signaling in vascular smooth muscle cells
    • Ikedo H., Tamaki K., Ueda S., Kato S., Fujii M., Ten Dijke P., et al. Smad protein and TGF-β signaling in vascular smooth muscle cells. Int J Mol Med 11 (2003) 645-650
    • (2003) Int J Mol Med , vol.11 , pp. 645-650
    • Ikedo, H.1    Tamaki, K.2    Ueda, S.3    Kato, S.4    Fujii, M.5    Ten Dijke, P.6
  • 35
    • 18844387660 scopus 로고    scopus 로고
    • Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism
    • Rodriguez-Vita J., Sanchez-Lopez E., Esteban V., Ruperez M., Egido J., and Ruiz-Ortega M. Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation 111 (2005) 2509-2517
    • (2005) Circulation , vol.111 , pp. 2509-2517
    • Rodriguez-Vita, J.1    Sanchez-Lopez, E.2    Esteban, V.3    Ruperez, M.4    Egido, J.5    Ruiz-Ortega, M.6
  • 36
    • 33646794060 scopus 로고    scopus 로고
    • Essential role of Smad3 in angiotensin II-induced vascular fibrosis
    • Wang W., Huang X.R., Canlas E., Oka K., Truong L.D., Deng C., et al. Essential role of Smad3 in angiotensin II-induced vascular fibrosis. Circ Res 98 (2006) 1032-1039
    • (2006) Circ Res , vol.98 , pp. 1032-1039
    • Wang, W.1    Huang, X.R.2    Canlas, E.3    Oka, K.4    Truong, L.D.5    Deng, C.6
  • 37
    • 17744412856 scopus 로고    scopus 로고
    • The 26S proteasome system in the signaling pathways of TGF-β superfamily
    • Wang T. The 26S proteasome system in the signaling pathways of TGF-β superfamily. Front Biosci 8 (2003) 1109-1117
    • (2003) Front Biosci , vol.8 , pp. 1109-1117
    • Wang, T.1
  • 38
    • 17644391784 scopus 로고    scopus 로고
    • Smad6s regulates plasminogen activator inhibitor-1 through a protein kinaseC-beta-dependent up-regulation of transforming growth factor-beta
    • Berg D.T., Myers L.J., Richardson M.A., Sandusky G., and Grinnell B.W. Smad6s regulates plasminogen activator inhibitor-1 through a protein kinaseC-beta-dependent up-regulation of transforming growth factor-beta. J Biol Chem 280 (2005) 14943-14947
    • (2005) J Biol Chem , vol.280 , pp. 14943-14947
    • Berg, D.T.1    Myers, L.J.2    Richardson, M.A.3    Sandusky, G.4    Grinnell, B.W.5
  • 39
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-β family signalling
    • Derynck R., and Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425 (2003) 577-584
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 40
    • 0036387022 scopus 로고    scopus 로고
    • Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-β-induced fibronectin in mesangial cells
    • Isono M., Chen S., Hong S.W., Iglesias-de la Cruz M.C., and Ziyadeh F.N. Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-β-induced fibronectin in mesangial cells. Biochem Biophys Res Commun 296 (2002) 1356-1365
    • (2002) Biochem Biophys Res Commun , vol.296 , pp. 1356-1365
    • Isono, M.1    Chen, S.2    Hong, S.W.3    Iglesias-de la Cruz, M.C.4    Ziyadeh, F.N.5
  • 41
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • Dennler S., Itoh S., Vivien D., ten Dijke P., Huet S., and Gauthier J.M. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 17 (1998) 3091-3100
    • (1998) EMBO J , vol.17 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    ten Dijke, P.4    Huet, S.5    Gauthier, J.M.6
  • 42
    • 0034011221 scopus 로고    scopus 로고
    • Interaction of smad3 with a proximal smad-binding element of the human alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-β
    • Chen S.J., Yuan W., Lo S., Trojanowska M., and Varga J. Interaction of smad3 with a proximal smad-binding element of the human alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-β. J Cell Physiol 183 (2000) 381-382
    • (2000) J Cell Physiol , vol.183 , pp. 381-382
    • Chen, S.J.1    Yuan, W.2    Lo, S.3    Trojanowska, M.4    Varga, J.5
  • 43
    • 33646683786 scopus 로고    scopus 로고
    • PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells
    • Ryer E.J., Hom R.P., Sakakibara K., Nakayama K.I., Nakayama K., Faries P.L., et al. PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2006) 26780-26786
    • (2006) Arterioscler Thromb Vasc Biol , pp. 26780-26786
    • Ryer, E.J.1    Hom, R.P.2    Sakakibara, K.3    Nakayama, K.I.4    Nakayama, K.5    Faries, P.L.6
  • 44
    • 21544479714 scopus 로고    scopus 로고
    • Smad7 gene transfer attenuates adventitial cell migration and vascular remodeling after balloon injury
    • Mallawaarachchi C.M., Weissberg P.L., and Siow R.C. Smad7 gene transfer attenuates adventitial cell migration and vascular remodeling after balloon injury. Arterioscler Thromb Vasc Biol 25 (2005) 1383-1387
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1383-1387
    • Mallawaarachchi, C.M.1    Weissberg, P.L.2    Siow, R.C.3
  • 45
    • 0032565859 scopus 로고    scopus 로고
    • Smad2 role in mesoderm formation, left-right patterning and craniofacial development
    • Nomura M., and Li E. Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature (London) 393 (1998) 786-790
    • (1998) Nature (London) , vol.393 , pp. 786-790
    • Nomura, M.1    Li, E.2
  • 46
    • 0032544448 scopus 로고    scopus 로고
    • Smad3 mutant mice develop metastatic colorectal cancer
    • Zhu Y., Richardson J.A., Parada L.F., and Graff J.M. Smad3 mutant mice develop metastatic colorectal cancer. Cell 94 (1998) 703-704
    • (1998) Cell , vol.94 , pp. 703-704
    • Zhu, Y.1    Richardson, J.A.2    Parada, L.F.3    Graff, J.M.4
  • 47
    • 0041836308 scopus 로고    scopus 로고
    • Hierarchical model of gene regulation by transforming growth factor beta
    • Yang Y.C., Piek E., Zavadil J., Liang D., Xie D., Heyer J., et al. Hierarchical model of gene regulation by transforming growth factor beta. Proc Natl Acad Sci U S A 100 (2003) 10269-10274
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10269-10274
    • Yang, Y.C.1    Piek, E.2    Zavadil, J.3    Liang, D.4    Xie, D.5    Heyer, J.6
  • 48
    • 20944432235 scopus 로고    scopus 로고
    • Targeted disruption of TGF-β-Smad3 signaling leads to enhanced neointimal hyperplasia with diminished matrix deposition in response to vascular injury
    • Kobayashi K., Yokote K., Fujimoto M., Yamashita K., Sakamoto A., Kitahara M., et al. Targeted disruption of TGF-β-Smad3 signaling leads to enhanced neointimal hyperplasia with diminished matrix deposition in response to vascular injury. Circ Res 96 (2005) 904-912
    • (2005) Circ Res , vol.96 , pp. 904-912
    • Kobayashi, K.1    Yokote, K.2    Fujimoto, M.3    Yamashita, K.4    Sakamoto, A.5    Kitahara, M.6
  • 49
    • 3943049366 scopus 로고    scopus 로고
    • Smad expression in human atherosclerotic lesions: evidence for impaired TGF-β/Smad signaling in smooth muscle cells of fibrofatty lesions. 1
    • Kalinina N., Agrotis A., Antropova Y., Ilyinskaya O., Smirnov V., Tararak E., et al. Smad expression in human atherosclerotic lesions: evidence for impaired TGF-β/Smad signaling in smooth muscle cells of fibrofatty lesions. 1. Arterioscler Thromb Vasc Biol 24 (2004) 1391-1396
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1391-1396
    • Kalinina, N.1    Agrotis, A.2    Antropova, Y.3    Ilyinskaya, O.4    Smirnov, V.5    Tararak, E.6
  • 50
    • 0042704734 scopus 로고    scopus 로고
    • Cross-talk between ERK MAP kinase and Smad-signaling pathways enhances TGF-β dependent responses in human mesangial cells
    • Hayashida T., deCasestecker M., and Schnaper H.W. Cross-talk between ERK MAP kinase and Smad-signaling pathways enhances TGF-β dependent responses in human mesangial cells. FASEB J 17 (2003) 1576-1578
    • (2003) FASEB J , vol.17 , pp. 1576-1578
    • Hayashida, T.1    deCasestecker, M.2    Schnaper, H.W.3
  • 51
    • 27744494454 scopus 로고    scopus 로고
    • Transforming growth factor-beta-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent
    • Seay U., Sedding D., Krick S., Hecker M., Seeger W., and Eickelberg O. Transforming growth factor-beta-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent. J Pharmacol Exp Ther 315 (2005) 1005-1012
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 1005-1012
    • Seay, U.1    Sedding, D.2    Krick, S.3    Hecker, M.4    Seeger, W.5    Eickelberg, O.6
  • 52
    • 20144375510 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-β1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent
    • Samarakoon R., Higgins C.E., Higgins S.P., Kutz S.M., and Higgins P.J. Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-β1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent. J Cell Physiol 204 (2005) 236-246
    • (2005) J Cell Physiol , vol.204 , pp. 236-246
    • Samarakoon, R.1    Higgins, C.E.2    Higgins, S.P.3    Kutz, S.M.4    Higgins, P.J.5
  • 53
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • Van Aelst L., and D'Souza-Schorey C. Rho GTPases and signaling networks. Genes Dev 11 (1997) 2295-2322
    • (1997) Genes Dev , vol.11 , pp. 2295-2322
    • Van Aelst, L.1    D'Souza-Schorey, C.2
  • 54
    • 24744446597 scopus 로고    scopus 로고
    • Transforming growth factor-beta1-induced expression of smooth muscle marker genes involves activation of PKN and p38 MAPK
    • Deaton R.A., Su C., Valencia T.G., and Grant S.R. Transforming growth factor-beta1-induced expression of smooth muscle marker genes involves activation of PKN and p38 MAPK. J Biol Chem 280 (2005) 31172-31181
    • (2005) J Biol Chem , vol.280 , pp. 31172-31181
    • Deaton, R.A.1    Su, C.2    Valencia, T.G.3    Grant, S.R.4
  • 55
    • 33644974307 scopus 로고    scopus 로고
    • RhoA modulates Smad signaling during transforming growth factor-beta-induced smooth muscle differentiation
    • Chen S., Crawford M., Day R.M., Briones V.R., Leader J.E., Jose P.A., et al. RhoA modulates Smad signaling during transforming growth factor-beta-induced smooth muscle differentiation. J Biol Chem 281 (2006) 1765-1770
    • (2006) J Biol Chem , vol.281 , pp. 1765-1770
    • Chen, S.1    Crawford, M.2    Day, R.M.3    Briones, V.R.4    Leader, J.E.5    Jose, P.A.6
  • 56
    • 33745505315 scopus 로고    scopus 로고
    • DeltaEF1 mediates TGF-β signaling in vascular smooth muscle cell differentiation
    • Nishimura G., Manabe I., Tsushima K., Fujiu K., Oishi Y., Imai Y., et al. DeltaEF1 mediates TGF-β signaling in vascular smooth muscle cell differentiation. Dev Cell 11 (2006) 93-94
    • (2006) Dev Cell , vol.11 , pp. 93-94
    • Nishimura, G.1    Manabe, I.2    Tsushima, K.3    Fujiu, K.4    Oishi, Y.5    Imai, Y.6
  • 58
    • 18244401416 scopus 로고    scopus 로고
    • Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats
    • Kataoka C., Egashira K., Inoue S., Takemoto M., Ni W., Koyanagi M., et al. Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension 39 (2002) 245-250
    • (2002) Hypertension , vol.39 , pp. 245-250
    • Kataoka, C.1    Egashira, K.2    Inoue, S.3    Takemoto, M.4    Ni, W.5    Koyanagi, M.6
  • 59
    • 4344704302 scopus 로고    scopus 로고
    • Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats
    • Nishikimi T., Akimoto K., Wang X., Mori Y., Tadokoro K., Ishikawa Y., et al. Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats. Hypertens 22 (2004) 1787-1796
    • (2004) Hypertens , vol.22 , pp. 1787-1796
    • Nishikimi, T.1    Akimoto, K.2    Wang, X.3    Mori, Y.4    Tadokoro, K.5    Ishikawa, Y.6
  • 60
    • 0031227867 scopus 로고    scopus 로고
    • Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulation factor by TGF-β1
    • Hong Y.H., Peng H.B., La Fata V., and Liao J.K. Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulation factor by TGF-β1. J Immunol 159 (1997) 2418-2423
    • (1997) J Immunol , vol.159 , pp. 2418-2423
    • Hong, Y.H.1    Peng, H.B.2    La Fata, V.3    Liao, J.K.4
  • 61
    • 0032773232 scopus 로고    scopus 로고
    • Roles of RhoA and phospholipase A2 in the elevation of intracellular H2O2 by transforming growth factor-b in Swiss 3T3 fibroblasts
    • Koo H.Y., Shin I., Lee Z.W., Lee S.H., Kim S.H., Lee C.H., et al. Roles of RhoA and phospholipase A2 in the elevation of intracellular H2O2 by transforming growth factor-b in Swiss 3T3 fibroblasts. Cell Signal 11 (1999) 677-683
    • (1999) Cell Signal , vol.11 , pp. 677-683
    • Koo, H.Y.1    Shin, I.2    Lee, Z.W.3    Lee, S.H.4    Kim, S.H.5    Lee, C.H.6
  • 62
    • 0141453279 scopus 로고    scopus 로고
    • Reactive oxygen species mediate TGF-β1-induced plasminogen activator inhibitor-1 upregulation in mesangial cells
    • Jiang Z., Seo J.Y., Ha H., Lee E.A., Kim Y.S., Han D.C., et al. Reactive oxygen species mediate TGF-β1-induced plasminogen activator inhibitor-1 upregulation in mesangial cells. Biochem Biophys Res Commun 309 (2003) 961-966
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 961-966
    • Jiang, Z.1    Seo, J.Y.2    Ha, H.3    Lee, E.A.4    Kim, Y.S.5    Han, D.C.6
  • 63
    • 33646593852 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells
    • Sturrock A., Cahill B., Norman K., Huecksteadt T.P., Hill K., Sanders K., et al. Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 290 (2006) L661-L663
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290
    • Sturrock, A.1    Cahill, B.2    Norman, K.3    Huecksteadt, T.P.4    Hill, K.5    Sanders, K.6
  • 64
    • 0347915577 scopus 로고    scopus 로고
    • CCN proteins: multifunctional signalling regulators
    • Perbal B. CCN proteins: multifunctional signalling regulators. Lancet 363 (2004) 62-64
    • (2004) Lancet , vol.363 , pp. 62-64
    • Perbal, B.1
  • 65
    • 16944364613 scopus 로고    scopus 로고
    • Human connective tissue growth factor is expressed in advanced atherosclerotic lesions
    • Oemar B.S., Werner A., Garnier J.M., Do D.D., Godoy N., Nauck M., et al. Human connective tissue growth factor is expressed in advanced atherosclerotic lesions. Circulation 18 (1997) 831-839
    • (1997) Circulation , vol.18 , pp. 831-839
    • Oemar, B.S.1    Werner, A.2    Garnier, J.M.3    Do, D.D.4    Godoy, N.5    Nauck, M.6
  • 66
    • 0033745462 scopus 로고    scopus 로고
    • CTGF expression is induced by TGF-β in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis
    • Chen M.M., Lam A., Abraham J.A., Schreiner G.F., and Joly A.H. CTGF expression is induced by TGF-β in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis. J Mol Cell Cardiol 32 (2000) 1805-1809
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 1805-1809
    • Chen, M.M.1    Lam, A.2    Abraham, J.A.3    Schreiner, G.F.4    Joly, A.H.5
  • 67
    • 0035870786 scopus 로고    scopus 로고
    • Cyclosporine induces myocardial connective tissue growth factor in spontaneously hypertensive rats on high-sodium diet
    • Finckenberg P., Lassila M., Inkinen K., Pere A.K., Krogerus L., Lindgren L., et al. Cyclosporine induces myocardial connective tissue growth factor in spontaneously hypertensive rats on high-sodium diet. Transplantation 71 (2001) 951-958
    • (2001) Transplantation , vol.71 , pp. 951-958
    • Finckenberg, P.1    Lassila, M.2    Inkinen, K.3    Pere, A.K.4    Krogerus, L.5    Lindgren, L.6
  • 69
    • 0034535271 scopus 로고    scopus 로고
    • Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro
    • Fan W.H., Pech M., and Karnovsky M.J. Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro. Eur J Cell Biol 79 (2000) 915-923
    • (2000) Eur J Cell Biol , vol.79 , pp. 915-923
    • Fan, W.H.1    Pech, M.2    Karnovsky, M.J.3
  • 70
    • 22744459775 scopus 로고    scopus 로고
    • Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells
    • Rodriguez-Vita J., Ruiz-Ortega M., Ruperez M., Esteban V., Sanchez-Lopez E., Plaza J.J., et al. Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells. Circ Res 97 (2005) 125-134
    • (2005) Circ Res , vol.97 , pp. 125-134
    • Rodriguez-Vita, J.1    Ruiz-Ortega, M.2    Ruperez, M.3    Esteban, V.4    Sanchez-Lopez, E.5    Plaza, J.J.6
  • 71
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates Cell Signalling by BMP and TGF-β
    • Abreu J.G., Ketpura N.I., Reversade B., and De Robertis E.M. Connective-tissue growth factor (CTGF) modulates Cell Signalling by BMP and TGF-β. Nat Cell Biol 4 (2002) 599-604
    • (2002) Nat Cell Biol , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3    De Robertis, E.M.4
  • 72
    • 20444399088 scopus 로고    scopus 로고
    • Modulation of the TGF-β/Smad signaling pathway in mesangial cells by CTGF/CCN2
    • Wahab N.A., Weston B.S., and Mason R.M. Modulation of the TGF-β/Smad signaling pathway in mesangial cells by CTGF/CCN2. Exp Cell Res 307 (2005) 305-314
    • (2005) Exp Cell Res , vol.307 , pp. 305-314
    • Wahab, N.A.1    Weston, B.S.2    Mason, R.M.3
  • 73
    • 0027531528 scopus 로고
    • Transforming growth factor-b1 null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni A.B., Huh C.G., Becker D., Geiser A., Lyght M., Flanders K.C., et al. Transforming growth factor-b1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A 15 (1993) 770-774
    • (1993) Proc Natl Acad Sci U S A , vol.15 , pp. 770-774
    • Kulkarni, A.B.1    Huh, C.G.2    Becker, D.3    Geiser, A.4    Lyght, M.5    Flanders, K.C.6
  • 74
    • 0038093327 scopus 로고    scopus 로고
    • Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
    • Ivkovic S., Yoon B.S., Popoff S.N., Safadi F.F., Libuda D.E., Stephenson R.C., et al. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130 (2003) 2779-2781
    • (2003) Development , vol.130 , pp. 2779-2781
    • Ivkovic, S.1    Yoon, B.S.2    Popoff, S.N.3    Safadi, F.F.4    Libuda, D.E.5    Stephenson, R.C.6
  • 75
    • 0034136007 scopus 로고    scopus 로고
    • Regulation of matrix proteins and impact on vascular structure
    • Tuñon J., Ruiz-Ortega M., and Egido J. Regulation of matrix proteins and impact on vascular structure. Curr Hypertens Rep 2 (2000) 106-113
    • (2000) Curr Hypertens Rep , vol.2 , pp. 106-113
    • Tuñon, J.1    Ruiz-Ortega, M.2    Egido, J.3
  • 76
    • 0034537229 scopus 로고    scopus 로고
    • Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro
    • Hao J., Wang B., Jones S.C., Jassal D.S., and Dixon I.M. Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro. Am J Physiol Heart Circ Physiol 279 (2000) H3020-H3030
    • (2000) Am J Physiol Heart Circ Physiol , vol.279
    • Hao, J.1    Wang, B.2    Jones, S.C.3    Jassal, D.S.4    Dixon, I.M.5
  • 77
    • 34047128039 scopus 로고    scopus 로고
    • Angiotensin II causes epithelial mesenchymal transdifferentiation via activation of Smad and MAPK signaling pathways
    • [Abstract]
    • Carvajal G., Ruperez M., Sanchez-Lopez E., Rodriguez-Vita J., Rodrigues-Diez R., Esteban V., et al. Angiotensin II causes epithelial mesenchymal transdifferentiation via activation of Smad and MAPK signaling pathways. Nephrol Dial 21 (2006) 289 [Abstract]
    • (2006) Nephrol Dial , vol.21 , pp. 289
    • Carvajal, G.1    Ruperez, M.2    Sanchez-Lopez, E.3    Rodriguez-Vita, J.4    Rodrigues-Diez, R.5    Esteban, V.6
  • 78
    • 4644290825 scopus 로고    scopus 로고
    • AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: Preservation of kidney tissue mass using Candesartan
    • Wamsley-Davis A., Padda R., Truong L.D., Tsao C.C., Zhang P., and Sheikh-Hamad D. AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: Preservation of kidney tissue mass using Candesartan. Am J Physiol Renal Physiol 287 (2004) F474-F480
    • (2004) Am J Physiol Renal Physiol , vol.287
    • Wamsley-Davis, A.1    Padda, R.2    Truong, L.D.3    Tsao, C.C.4    Zhang, P.5    Sheikh-Hamad, D.6
  • 80
    • 33745193908 scopus 로고    scopus 로고
    • Redox signaling in hypertension
    • Paravicini T.M., and Touyz R.M. Redox signaling in hypertension. Cardiovasc Res 71 (2006) 247-258
    • (2006) Cardiovasc Res , vol.71 , pp. 247-258
    • Paravicini, T.M.1    Touyz, R.M.2
  • 81
    • 0034671895 scopus 로고    scopus 로고
    • Growth inhibition by insulin-like growth factor-binding protein-3 in T47D breast cancer cells requires transforming growth factor-β (TGF-β) and the type II TGF-β receptor
    • Fanayan S., Firth S.M., Butt A.J., and Baxter R.C. Growth inhibition by insulin-like growth factor-binding protein-3 in T47D breast cancer cells requires transforming growth factor-β (TGF-β) and the type II TGF-β receptor. J Biol Chem 275 (2000) 39146-39151
    • (2000) J Biol Chem , vol.275 , pp. 39146-39151
    • Fanayan, S.1    Firth, S.M.2    Butt, A.J.3    Baxter, R.C.4
  • 83
    • 33750069029 scopus 로고    scopus 로고
    • Escaping from the TGF-β anti-proliferative control
    • Seoane J. Escaping from the TGF-β anti-proliferative control. Carcinogenesis 27 (2006) 2148-2156
    • (2006) Carcinogenesis , vol.27 , pp. 2148-2156
    • Seoane, J.1


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