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Volumn 12, Issue 1, 2012, Pages 37-51

Thymosin β4: A multi-functional regenerative peptide. Basic properties and clinical applications

Author keywords

Apoptosis; Inflammation; Migration; Regeneration; Scar formation; Stem cells; Thymosin 4; Tissue repair

Indexed keywords

DOXYCYCLINE; RGN 352; THYMOSIN BETA4; UNCLASSIFIED DRUG;

EID: 84055193007     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2012.634793     Document Type: Review
Times cited : (118)

References (97)
  • 2
    • 0019853771 scopus 로고
    • Modulation of terminal deoxynucleotidyl transferase activity by thymosin
    • Hu SK, Low TL, Goldstein AL. Modulation of terminal deoxynucleotidyl transferase activity by thymosin. Mol Cell Biochem 1981;41:49-58 (Pubitemid 12142400)
    • (1981) Molecular and Cellular Biochemistry , vol.41 , Issue.SPEC. NO. , pp. 49-58
    • Hu, S.-K.1    Low, T.L.K.2    Goldstein, A.L.3
  • 3
    • 0020575295 scopus 로고
    • 4: Chemical and biological characterization of the synthetic peptide
    • Low TL, Wang SS, Goldstein AL. Solid-phase synthesis of thymosin beta 4: chemical and biological characterization of the synthetic peptide. Biochemistry 1983;22:733-40 (Pubitemid 13134037)
    • (1983) Biochemistry , vol.22 , Issue.4 , pp. 733-740
    • Low, T.L.K.1    Wang, S.S.2    Goldstein, A.L.3
  • 4
    • 24344500165 scopus 로고    scopus 로고
    • 4: Actin-sequestering protein moonlights to repair injured tissues
    • DOI 10.1016/j.molmed.2005.07.004, PII S1471491405001668
    • Goldstein AL, Hannappel E, Kleinman HK. Thymosin beta4: Actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med 2005;11:421-9 (Pubitemid 41254045)
    • (2005) Trends in Molecular Medicine , vol.11 , Issue.9 , pp. 421-429
    • Goldstein, A.L.1    Hannappel, E.2    Kleinman, H.K.3
  • 5
    • 77951834529 scopus 로고    scopus 로고
    • Thymosin beta4 and its posttranslational modifications
    • Hannappel E. Thymosin beta4 and its posttranslational modifications. Ann NY Acad Sci 2010;1194:27-35
    • (2010) Ann. N.Y. Acad. Sci. , vol.1194 , pp. 27-35
    • Hannappel, E.1
  • 6
    • 73449125521 scopus 로고    scopus 로고
    • Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting
    • Butler GS, Overall CM. Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting. Nat Rev Drug Discov 2009;8:935-48
    • (2009) Nat. Rev. Drug. Discov. , vol.8 , pp. 935-948
    • Butler, G.S.1    Overall, C.M.2
  • 7
    • 0025856003 scopus 로고
    • 4 and Fx, an actin-sequestering peptide, are indistinguishable
    • Safer D, Elzinga M, Nachmias VT. Thymosin beta4 and Fx, an actin-sequestering peptide, are indistinguishable. J Biol Chem 1991;266:4029-32 (Pubitemid 21909312)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.7 , pp. 4029-4032
    • Safer, D.1    Elzinga, M.2    Nachmias, V.T.3
  • 9
    • 0031000223 scopus 로고    scopus 로고
    • 4 binds actin in an extended conformation and contacts both the barbed and pointed ends
    • DOI 10.1021/bi970185v
    • Safer D, Sosnick TR, Elzinga M. Thymosin beta4 binds actin in an extended conformation and contacts both the barbed and pointed ends. Biochemistry 1997;36:5806-16 (Pubitemid 27214932)
    • (1997) Biochemistry , vol.36 , Issue.19 , pp. 5806-5816
    • Safer, D.1    Sosnick, T.R.2    Elzinga, M.3
  • 10
    • 0025126869 scopus 로고
    • 4: A nuclear magnetic resonance and simulated annealing study
    • DOI 10.1021/bi00486a006
    • Zarbock J, Oschkinat H, Hannappel E, et al. Solution conformation of thymosin beta4: a nuclear magnetic resonance and simulated annealing study. Biochemistry 1990;29:7814-21 (Pubitemid 20281227)
    • (1990) Biochemistry , vol.29 , Issue.34 , pp. 7814-7821
    • Zarbock, J.1    Oschkinat, H.2    Hannappel, E.3    Kalbacher, H.4    Voelter, W.5    Holak, T.A.6
  • 11
    • 0031149237 scopus 로고    scopus 로고
    • Conformation of thymosin beta9 in water/fluoroalcohol solution determined by NMR spectroscopy
    • Stoll R, Voelter W, Holak TA. Conformation of thymosin beta9 in water/fluoroalcohol solution determined by NMR spectroscopy. Biopolymers 1997;41:623-34
    • (1997) Biopolymers , vol.41 , pp. 623-634
    • Stoll, R.1    Voelter, W.2    Holak, T.A.3
  • 13
    • 0030831042 scopus 로고    scopus 로고
    • 4 and its influence on the interaction with G-actin studied by reverse-phase HPLC and post-column derivatization with fluorescamine
    • DOI 10.1016/S0003-2670(97)00132-3, PII S0003267097001323
    • Huff T, Hannappel E. Oxidation and reduction of thymosin beta4 and its influence on the interaction with G-actin studied by reverse-phase HPLC and postcolumn derivatization with fluorescamine. Anal Chim Acta 1997;352:249-55 (Pubitemid 27522828)
    • (1997) Analytica Chimica Acta , vol.352 , Issue.1-3 , pp. 249-255
    • Huff, T.1    Hannappel, E.2
  • 14
    • 79954586824 scopus 로고    scopus 로고
    • Regenerative protein thymosin beta 4 is a novel regulator of purinergic signaling
    • Freeman KW, Bowman BR, Zetter BR. Regenerative protein thymosin beta 4 is a novel regulator of purinergic signaling. FASEB J 2011;25:907-15
    • (2011) Faseb J. , vol.25 , pp. 907-915
    • Freeman, K.W.1    Bowman, B.R.2    Zetter, B.R.3
  • 16
    • 79956222121 scopus 로고    scopus 로고
    • Fibroblast growth factors: Biology function and application for tissue engineering
    • Yun YR, Won JE, Jeon E, et al. Fibroblast growth factors: biology, function, and application for tissue engineering. J Tissue Eng 2010;2010:218142
    • (2010) J. Tissue Eng. , vol.2010 , pp. 218142
    • Yun, Y.R.1    Won, J.E.2    Jeon, E.3
  • 17
    • 79251501315 scopus 로고    scopus 로고
    • Fibroblast growth factors: From molecular evolution to roles in development metabolism and disease
    • Itoh N, Ornitz DM. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. J Biochem 2011;149:121-30
    • (2011) J. Biochem. , vol.149 , pp. 121-130
    • Itoh, N.1    Ornitz, D.M.2
  • 18
    • 0029802607 scopus 로고    scopus 로고
    • Thymosin β15: A novel regulator of tumor cell motility upregulated in metastatic prostate cancer
    • DOI 10.1038/nm1296-1322
    • Bao L, Loda M, Janmey PA, et al. Thymosin beta15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer. Nat Med 1996;2:1322-8 (Pubitemid 26401734)
    • (1996) Nature Medicine , vol.2 , Issue.12 , pp. 1322-1328
    • Bao, L.1    Loda, M.2    Janmey, P.A.3    Stewart, R.4    Anand-Apte, B.5    Zetter, B.R.6
  • 19
    • 33846243239 scopus 로고    scopus 로고
    • Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization
    • DOI 10.1038/nature05383, PII NATURE05383
    • Smart N, Riseboro CA, Melville AA, et al. Thymosin beta4 induces adult cardiac progenitor mobilization and neovascularization. Nature 2007;445:177-82 (Pubitemid 46095717)
    • (2007) Nature , vol.445 , Issue.7124 , pp. 177-182
    • Smart, N.1    Risebro, C.A.2    Melville, A.A.D.3    Moses, K.4    Schwartz, R.J.5    Chien, K.R.6    Riley, P.R.7
  • 20
    • 77954574668 scopus 로고    scopus 로고
    • Thymosin Tbeta4 improves functional neurological outcome in a rat model of embolic stroke
    • Morris DC, Chopp M, Zhang L, et al. Thymosin Tbeta4 improves functional neurological outcome in a rat model of embolic stroke. Neuroscience 2010;169:674-82
    • (2010) Neuroscience , vol.169 , pp. 674-682
    • Morris, D.C.1    Chopp, M.2    Zhang, L.3
  • 21
    • 77951776928 scopus 로고    scopus 로고
    • Thymosin beta4: A candidate for treatment of stroke
    • Morris DC, Chopp M, Zhang ZG. Thymosin beta4: a candidate for treatment of stroke. Ann NY Acad Sci 2010;1194:112-17
    • (2010) Ann. N.Y. Acad. Sci. , vol.1194 , pp. 112-117
    • Morris, D.C.1    Chopp, M.2    Zhang, Z.G.3
  • 22
    • 1442290141 scopus 로고    scopus 로고
    • Thymosin beta4 increases hair growth by activation of hair follicle stem cells
    • Philp D, Nguyen M, Scheremeta B, et al. Thymosin beta4 increases hair growth by activation of hair follicle stem cells. FASEB J 2004;18:385-7
    • (2004) Faseb J. , vol.18 , pp. 385-387
    • Philp, D.1    Nguyen, M.2    Scheremeta, B.3
  • 24
    • 33750989327 scopus 로고    scopus 로고
    • Therapeutic potential of thymosin-β4 and its derivative N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) in cardiac healing after infarction
    • DOI 10.2165/00129784-200606050-00003
    • Cavasin MA. Therapeutic potential of thymosin beta4 and its derivative N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) in cardiac healing after infarction. Am J Cardiovasc Drugs 2006;6:305-11 (Pubitemid 44749340)
    • (2006) American Journal of Cardiovascular Drugs , vol.6 , Issue.5 , pp. 305-311
    • Cavasin, M.A.1
  • 26
    • 33947200192 scopus 로고    scopus 로고
    • Thymosin beta 4 suppression of corneal NFκB: A potential anti-inflammatory pathway
    • DOI 10.1016/j.exer.2006.12.004, PII S001448350600460X
    • Sosne G, Qiu P, Christopherson PL, Wheater MK. Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway. Exp Eye Res 2007;84:663-9 (Pubitemid 46420439)
    • (2007) Experimental Eye Research , vol.84 , Issue.4 , pp. 663-669
    • Sosne, G.1    Qiu, P.2    Christopherson, P.L.3    Wheater, M.K.4
  • 27
    • 23244447079 scopus 로고    scopus 로고
    • Thymosin-β4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury
    • DOI 10.1167/iovs.04-1368
    • Sosne G, Christopherson PL, Barrett RP, Fridman R. Thymosin-beta4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury. Invest Ophthalmol Vis Sci 2005;46:2388-95 (Pubitemid 43119484)
    • (2005) Investigative Ophthalmology and Visual Science , vol.46 , Issue.7 , pp. 2388-2395
    • Sosne, G.1    Christopherson, P.L.2    Barrett, R.P.3    Fridman, R.4
  • 28
    • 0032735680 scopus 로고    scopus 로고
    • Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids
    • Young JD, Lawrence AJ, Mac Lean AG, et al. Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids. Nat Med 1999;5:1424-7
    • (1999) Nat. Med. , vol.5 , pp. 1424-1427
    • Young, J.D.1    Lawrence, A.J.2    Mac Lean, A.G.3
  • 29
    • 9644281738 scopus 로고    scopus 로고
    • Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
    • DOI 10.1038/nature03000
    • Bock-Marquette I, Saxena A, White MD, et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 2004;432:466-72 (Pubitemid 39576522)
    • (2004) Nature , vol.432 , Issue.7016 , pp. 466-472
    • Bock-Marquette, I.1    Saxena, A.2    White, M.D.3    DiMaio, J.M.4    Srivastava, D.5
  • 30
    • 77951788169 scopus 로고    scopus 로고
    • Thymosin beta4 enhances repair by organizing connective tissue and preventing the Thymosin b4: A multi-functional regenerative peptide. Basic properties and clinical applications 48
    • appearance of myofibroblasts. Ann NY Acad Sci 2010;1194:
    • Ehrlich HP, Sprague WH. Thymosin beta4 enhances repair by organizing connective tissue and preventing the Thymosin b4: a multi-functional regenerative peptide. Basic properties and clinical applications 48 Expert Opin. Biol. Ther. (2012) 12(1) appearance of myofibroblasts. Ann NY Acad Sci 2010;1194:118-24
    • (2012) Expert Opin. Biol. Ther. , vol.12 , Issue.1 , pp. 118-124
    • Ehrlich, H.P.1    Sprague, W.H.2
  • 31
    • 34548610979 scopus 로고    scopus 로고
    • Ocular surface expression and in vitro activity of antimicrobial peptides
    • DOI 10.1080/02713680701446653, PII 781951025
    • Huang LC, Jean D, Proske RJ, et al. Ocular surface expression and in vitro activity of antimicrobial peptides. Curr Eye Res 2007;32:595-609 (Pubitemid 47400679)
    • (2007) Current Eye Research , vol.32 , Issue.7-8 , pp. 595-609
    • Huang, L.C.1    Jean, D.2    Proske, R.J.3    Reins, R.Y.4    McDermott, A.M.5
  • 32
    • 47049124833 scopus 로고    scopus 로고
    • Thymosin beta-4 upregulates anti-oxidative enzymes and protects human cornea epithelial cells against oxidative damage
    • DOI 10.1136/bjo.2007.136747
    • Ho JH, Tseng KC, Ma WH, et al. Thymosin beta-4 upregulates anti-oxidative enzymes and protects corneal epithelial cells against oxidative damage. Br J Ophthalmol 2008;92:992-7 (Pubitemid 351969686)
    • (2008) British Journal of Ophthalmology , vol.92 , Issue.7 , pp. 992-997
    • Ho, J.H.-C.1    Tseng, K.-C.2    Ma, W.-H.3    Chen, K.-H.4    Lee, K.-S.5    Su, Y.6
  • 34
    • 2142763869 scopus 로고    scopus 로고
    • Thymosin-β4 inhibits corneal epithelial cell apoptosis after ethanol exposure in vitro
    • DOI 10.1167/iovs.03-1002
    • Sosne G, Siddiqi A, Kurpakus-Wheater M. Thymosin-beta4 inhibits corneal epithelial cell apoptosis after ethanol exposure in vitro. Invest Ophthalmol Vis Sci 2004;45:1095-100 (Pubitemid 38869013)
    • (2004) Investigative Ophthalmology and Visual Science , vol.45 , Issue.4 , pp. 1095-1100
    • Sosne, G.1    Siddiqi, A.2    Kurpakus-Wheater, M.3
  • 35
    • 0030926245 scopus 로고    scopus 로고
    • 4 stimulates directional migration of human umbilical vein endothelial cells
    • Malinda KM, Goldstein AL, Kleinman HK. Thymosin beta4 stimulates directionalmigration of human umbilical vein endothelial cells. FASEB J 1997;11:474-81 (Pubitemid 27259989)
    • (1997) FASEB Journal , vol.11 , Issue.6 , pp. 474-481
    • Malinda, K.M.1    Goldstein, A.L.2    Kleinman, H.K.3
  • 36
    • 34249867441 scopus 로고    scopus 로고
    • Matrix metalloproteinase activity is necessary for thymosin beta 4 promotion of epithelial cell migration
    • DOI 10.1002/jcp.21012
    • 36, Qiu P, Kurpakus-Wheater M, Sosne G. Matrix metalloproteinase activity is necessary for thymosin beta 4 promotion of epithelial cell migration. J Cell Physiol 2007;212:165-73 (Pubitemid 46867598)
    • (2007) Journal of Cellular Physiology , vol.212 , Issue.1 , pp. 165-173
    • Qiu, P.1    Kurpakus-Wheater, M.2    Sosne, G.3
  • 37
    • 0035947763 scopus 로고    scopus 로고
    • Local photorelease of caged thymosin beta4 in locomoting keratocytes causes cell turning
    • Roy P, Raifur Z, Jones D, et al. Local photorelease of caged thymosin beta4 in locomoting keratocytes causes cell turning. J Cell Biol 2001;153:1035-48
    • (2001) J. Cell. Biol. , vol.153 , pp. 1035-1048
    • Roy, P.1    Raifur, Z.2    Jones, D.3
  • 38
    • 0036025330 scopus 로고    scopus 로고
    • Thymosin β4 promotes human conjunctival epithelial cell migration
    • DOI 10.1076/ceyr.24.4.268.8414
    • Sosne G, Hafeez S, Greenberry AL II, Kurpakus-Wheater M. Thymosin beta4 promotes human conjunctival epithelial cell migration. Curr Eye Res 2002;24:268-73 (Pubitemid 35155742)
    • (2002) Current Eye Research , vol.24 , Issue.4 , pp. 268-273
    • Sosne, G.1    Hafeez, S.2    Greenberry II, A.L.3    Kurpakus-Wheater, M.4
  • 40
    • 77954447831 scopus 로고    scopus 로고
    • Biological activities of thymosin beta4 defined by active sites in short peptide sequences
    • Sosne G, Qiu P, Goldstein AL, Wheater M. Biological activities of thymosin beta4 defined by active sites in short peptide sequences. FASEB J 2010;24:2144-51
    • (2010) Faseb J. , vol.24 , pp. 2144-2151
    • Sosne, G.1    Qiu, P.2    Goldstein, A.L.3    Wheater, M.4
  • 41
    • 44049106474 scopus 로고    scopus 로고
    • Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection
    • Hinkel R, El-Aouni C, Olson T, et al. Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection. Circulation 2008;117:2232-40
    • (2008) Circulation , vol.117 , pp. 2232-2240
    • Hinkel, R.1    El-Aouni, C.2    Olson, T.3
  • 42
    • 79958187910 scopus 로고    scopus 로고
    • Markers of progenitor cell recruitment and differentiation rise early during ischemia and continue during resuscitation in a porcine acute ischemia model
    • Shah SP, Youngquist ST, Mcclung CD, et al. Markers of progenitor cell recruitment and differentiation rise early during ischemia and continue during resuscitation in a porcine acute ischemia model. J Interferon Cytokine Res 2011;31:509-13
    • (2011) J. Interferon. Cytokine Res. , vol.31 , pp. 509-513
    • Shah, S.P.1    Youngquist, S.T.2    Mcclung, C.D.3
  • 43
    • 84864865622 scopus 로고    scopus 로고
    • Identification of thymosin beta4 as an effector of Hand1-mediated vascular development
    • Smart N, Dube KN, Riley PR. Identification of thymosin beta4 as an effector of Hand1-mediated vascular development. Nat Commun 2010;1:1-10
    • (2010) Nat. Commun. , vol.1 , pp. 1-10
    • Smart, N.1    Dube, K.N.2    Riley, P.R.3
  • 44
    • 79959819263 scopus 로고    scopus 로고
    • De novo cardiomyocytes from within the activated adult heart after injury
    • Smart N, Bollini S, Dube KN, et al. De novo cardiomyocytes from within the activated adult heart after injury. Nature 2011;474:640-4
    • (2011) Nature , vol.474 , pp. 640-644
    • Smart, N.1    Bollini, S.2    Dube, K.N.3
  • 45
    • 78651276633 scopus 로고    scopus 로고
    • Treatment of traumatic brain injury with thymosin beta4 in rats
    • Xiong Y, Mahmood A, Meng Y, et al. Treatment of traumatic brain injury with thymosin beta4 in rats. J Neurosurg 2011;114:102-15
    • (2011) J. Neurosurg. , vol.114 , pp. 102-115
    • Xiong, Y.1    Mahmood, A.2    Meng, Y.3
  • 47
    • 76549132349 scopus 로고    scopus 로고
    • Serum thymosin beta4 levels in patients with hepatitis B virus-related liver failure
    • Han T, Liu Y, Liu H, et al. Serum thymosin beta4 levels in patients with hepatitis B virus-related liver failure. World J Gastroenterol 2010;16:625-30
    • (2010) World J. Gastroenterol. , vol.16 , pp. 625-630
    • Han, T.1    Liu, Y.2    Liu, H.3
  • 48
    • 79956286435 scopus 로고    scopus 로고
    • Significance of thymosin beta4 and implication of pinch-1-ILK-alpha- Parvin PIP complex in human dilated cardiomyopathy
    • Sopko N, Qin Y, Finan A, et al. Significance of thymosin beta4 and implication of PINCH-1-ILK-alpha- Parvin (PIP) complex in human dilated cardiomyopathy. PLoS One 2011;6(1):e20184
    • (2011) PLoS One , vol.6 , Issue.1
    • Sopko, N.1    Qin, Y.2    Finan, A.3
  • 49
    • 80051781037 scopus 로고    scopus 로고
    • Relationship between serum thymosin beta4 levels and coronary collateral development
    • Lv S, Cheng G, Xu Y, et al. Relationship between serum thymosin beta4 levels and coronary collateral development. Coron Artery Dis 2011;22:401-4
    • (2011) Coron. Artery Dis. , vol.22 , pp. 401-404
    • Lv, S.1    Cheng, G.2    Xu, Y.3
  • 50
    • 79751537902 scopus 로고    scopus 로고
    • Beta-thymosins ad interstitial lung disease: Study of a scleroderma cohort with a one-year follow-up
    • De Santis M, Inzitari R, Bosello SL, et al. beta-thymosins ad interstitial lung disease: study of a scleroderma cohort with a one-year follow-up. Respir Res 2011;12(1):22
    • (2011) Respir. Res. , vol.12 , Issue.1 , pp. 22
    • De Santis, M.1    Inzitari, R.2    Bosello, S.L.3
  • 51
    • 0029743803 scopus 로고    scopus 로고
    • 4 mRNA following focal brain ischemia
    • Vartiainen N, Pyykonen I, Hokfelt T, Koistinaho J. Induction of thymosin beta4 mRNA following focal brain ischemia. Neuroreport 1996;7:1613-16 (Pubitemid 26332334)
    • (1996) NeuroReport , vol.7 , Issue.10 , pp. 1613-1616
    • Vartiainen, N.1    Pyykonen, I.2    Hokfelt, T.3    Koistinaho, J.4
  • 52
    • 74249094021 scopus 로고    scopus 로고
    • Overexpression of thymosin beta4 promotes abnormal tooth development and stimulations of hair growth
    • Cha HJ, Philp D, Lee SH, et al. Overexpression of thymosin beta4 promotes abnormal tooth development and stimulations of hair growth. Int J Dev Biol 2010;54:135-40
    • (2010) Int. J. Dev. Biol. , vol.54 , pp. 135-140
    • Cha, H.J.1    Philp, D.2    Lee, S.H.3
  • 53
    • 77951835066 scopus 로고    scopus 로고
    • Thymosin beta4: Structure function and biological properties suporting current and future clinical applications
    • Crockford D, Turjman N, Allan C, Angel J. Thymosin beta4:structure, function, and biological properties suporting current and future clinical applications. Ann NY Acad Sci 2010;1194:179-89
    • (2010) Ann. N.Y. Acad. Sci. , vol.1194 , pp. 179-189
    • Crockford, D.1    Turjman, N.2    Allan, C.3    Angel, J.4
  • 54
    • 77951773786 scopus 로고    scopus 로고
    • A randomized placebo-controlled single and multiple dose study of intravenous thymosin beta4 in healthy volunteers
    • Ruff D, Crockford D, Girardi G, Zhang Y. A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers. Ann NY Acad Sci 2010;1194:223-9
    • (2010) Ann. N.Y. Acad. Sci. , vol.1194 , pp. 223-229
    • Ruff, D.1    Crockford, D.2    Girardi, G.3    Zhang, Y.4
  • 56
    • 0037282380 scopus 로고    scopus 로고
    • 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice
    • DOI 10.1046/j.1524-475X.2003.11105.x
    • Philp D, Badmamchiam M, Scheremeta B, et al. Thymosin beta4 and a synthetic peptde containing its actin-binding domain promote dermal wound reapri in db/db diabetic mice and in aged mice. Wound Repair Regen 2003;11:19-24 (Pubitemid 36268605)
    • (2003) Wound Repair and Regeneration , vol.11 , Issue.1 , pp. 19-24
    • Philp, D.1    Badamchian, M.2    Scheremeta, B.3    Nguyen, M.4    Goldstein, A.L.5    Kleinman, H.K.6
  • 58
    • 77951832222 scopus 로고    scopus 로고
    • The effectof thymosin treatment on venous stasis ulcers
    • Guarnera G, Derosa A, Camerini R. The effectof thymosin treatment on venous stasis ulcers. Ann NY Acad Sci 2010;1194:207-12
    • (2010) Ann. N.Y. Acad. Sci. , vol.1194 , pp. 207-212
    • Guarnera, G.1    Derosa, A.2    Camerini, R.3
  • 59
    • 0026715656 scopus 로고    scopus 로고
    • Documentation of hypertrophic scar development by laser goldstein hannappel sosne & kleinman expert opin
    • 49 doppler blood flow monitoring. Plast Reconstr Surg 1992;90:
    • Ehrlich HP, Kelley SF. Documentation of hypertrophic scar development by laser Goldstein, Hannappel, Sosne & Kleinman Expert Opin. Biol. Ther. (2012) 12(1) 49 doppler blood flow monitoring. Plast Reconstr Surg 1992;90:993-8
    • (2012) Biol. Ther. , vol.12 , Issue.1 , pp. 993-998
    • Ehrlich, H.P.1    Kelley, S.F.2
  • 60
    • 33746919929 scopus 로고    scopus 로고
    • 4 inhibits benzalkonium chloride-mediated apoptosis in corneal and conjunctival epithelial cells in vitro
    • DOI 10.1016/j.exer.2006.02.001, PII S0014483506001679
    • Sosne G, Albeiruti AR, Hollis B, et al. Thymosin beta4inhibits benzalkonium choloride-mediated apoptosis in corneal and conjunctival epithelial cells in vitro. Exp Eye Res 2006;83:502-7 (Pubitemid 44183802)
    • (2006) Experimental Eye Research , vol.83 , Issue.3 , pp. 502-507
    • Sosne, G.1    Albeiruti, A.-R.2    Hollis, B.3    Siddiqi, A.4    Ellenberg, D.5    Kurpakus-Wheater, M.6
  • 62
    • 0041326360 scopus 로고    scopus 로고
    • Corneal cells: Chatty in development, homeostasis, wound healing, and disease
    • DOI 10.1016/S0002-9394(03)00085-0
    • Wilson SE, Netto M, Ambrosio R Jr. Corneal cells: chatty in development, homeostasis, wound healing, and disease. Am J Ophthalmol 2003;136:530-6 (Pubitemid 37101252)
    • (2003) American Journal of Ophthalmology , vol.136 , Issue.3 , pp. 530-536
    • Wilson, S.E.1    Netto, M.2    Ambrosio Jr., R.3
  • 64
    • 6944233579 scopus 로고    scopus 로고
    • Uncoupling keratocyte loss of corneal crystallin from markers of fibrotic repair
    • DOI 10.1167/iovs.03-1057
    • Stramer BM, Fini ME. Uncoupling keratocyte loss of corneal crystalline from markers of fibrotic repair. Invest Ophthalmol Vis Sci 2004;45:4010-15 (Pubitemid 39411155)
    • (2004) Investigative Ophthalmology and Visual Science , vol.45 , Issue.11 , pp. 4010-4015
    • Strainer, B.M.1    Fini, M.E.2
  • 65
    • 0026493342 scopus 로고
    • The role of cytokines in the pathogenesis of inflammatory eye disease
    • Wakefield D, Lloyd A. The role of cytokines in the pathogenesis of inflammatory eye disease. Cytokine 1992;4:1-5
    • (1992) Cytokine , vol.4 , pp. 1-5
    • Wakefield, D.1    Lloyd, A.2
  • 67
    • 0028801690 scopus 로고
    • Differences in interleukin-6 gene expression between cultured human corneal epithelial cells and keratocytes
    • Cubitt CL, Lausch RN, Oakes JE. Differences in interleukin-6 gene expression between cultured human corneal epithelial cells and keratocytes. Invest Ophthalmol Vis Sci 1995;36:330-6
    • (1995) Invest. Ophthalmol. Vis. Sci. , vol.36 , pp. 330-336
    • Cubitt, C.L.1    Lausch, R.N.2    Oakes, J.E.3
  • 69
    • 79957922304 scopus 로고    scopus 로고
    • Thymosin beta 4 inhibits TNF-alpha-induced NF-kappaB activation IL-8 expression, and the sensitizing effects by its partners pinch-1 and ILK
    • Qui P, Wheater MK, Sosne G. Thymosin beta 4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J 2011;25:1815-26
    • (2011) Faseb J. , vol.25 , pp. 1815-1826
    • Qui, P.1    Wheater, M.K.2    Sosne, G.3
  • 72
    • 77952113150 scopus 로고    scopus 로고
    • Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin beta 4
    • Dunn SP, Heideman DG, Chow CY, et al. Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin beta 4. Arch Ophthalmol 2010;128:636-8
    • (2010) Arch. Ophthalmol. , vol.128 , pp. 636-638
    • Dunn, S.P.1    Heideman, D.G.2    Chow, C.Y.3
  • 74
    • 38149003728 scopus 로고    scopus 로고
    • Thymosin beta4 and Ac-SDKP: Tools to mend a broken heart
    • Rossdeutsch A, Smart N, Riley PR. Thymosin beta4 and Ac-SDKP: tools to mend a broken heart. J Mol Med 2008;86:29-35
    • (2008) J. Mol. Med. , vol.86 , pp. 29-35
    • Rossdeutsch, A.1    Smart, N.2    Riley, P.R.3
  • 75
    • 78649446021 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction
    • Kraehenbuehl TP, Ferreira LS, Hayward AM, et al. Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction. Biomaterials 2011;32:1102-9
    • (2011) Biomaterials , vol.32 , pp. 1102-1109
    • Kraehenbuehl, T.P.1    Ferreira, L.S.2    Hayward, A.M.3
  • 76
    • 84055214880 scopus 로고    scopus 로고
    • Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes
    • published online 26 August 2011; doi:10.1016/j.yjmcc.2011.08.020
    • Zhou B, Honor LB, Ma Q, et al. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J Mol Cell Cardiol 2011;published online 26 August 2011; doi:10.1016/j.yjmcc.2011.08.020
    • (2011) J. Mol. Cell Cardiol.
    • Zhou, B.1    Honor, L.B.2    Ma, Q.3
  • 77
    • 84857083796 scopus 로고    scopus 로고
    • Amniotic fluid stem cells are cardioprotective following acute myocardial infarction
    • Bollini S, Cheung KK, Riegler J, et al. Amniotic fluid stem cells are cardioprotective following acute myocardial infarction. Stem Cells Dev 2011;20:1-10
    • (2011) Stem. Cells Dev. , vol.20 , pp. 1-10
    • Bollini, S.1    Cheung, K.K.2    Riegler, J.3
  • 78
    • 58149149847 scopus 로고    scopus 로고
    • Progenitor cell theyrapy in a porcine acute myocardial infarction model induces cardiac hypertrophy mediated by paracrine secretion of cardiotrophic factors including TGFbeta1
    • Doyle B, Sorajja P, Hynes B, et al. Progenitor cell theyrapy in a porcine acute myocardial infarction model induces cardiac hypertrophy, mediated by paracrine secretion of cardiotrophic factors including TGFbeta1. Stem Cells Dev 2008;17:941-51
    • (2008) Stem. Cells Dev. , vol.17 , pp. 941-951
    • Doyle, B.1    Sorajja, P.2    Hynes, B.3
  • 79
    • 63549141609 scopus 로고    scopus 로고
    • Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cll activation in adult mice in vivo
    • Bock-Marquette I, Srivasatava S, Pipes GC, et al. Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cll activation in adult mice in vivo. J Mol Cell Cardiol 2009;46:728-38
    • (2009) J. Mol. Cell Cardiol. , vol.46 , pp. 728-738
    • Bock-Marquette, I.1    Srivasatava, S.2    Pipes, G.C.3
  • 81
    • 54049120719 scopus 로고    scopus 로고
    • Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiogenesis II-induced hypertension
    • Lin CX, Rhaleb NE, Yang XP, et al. Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiogenesis II-induced hypertension. Am J Physiol Heart Circ Physiol 2008;295:H1253-61
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.295
    • Lin, C.X.1    Rhaleb, N.E.2    Yang, X.P.3
  • 82
    • 0346848845 scopus 로고    scopus 로고
    • Ac-SDKP Reverses Cardiac Fibrosis in Rats with Renovascular Hypertension
    • DOI 10.1161/01.HYP.0000100423.24330.96
    • Peng H, Carretero OA, Brigstock DR, et al. Ac-SDKP reverses cardiac fibrosis in rats with renal renovascular hypertension. Hypertension 2003;42:1164-70 (Pubitemid 37549072)
    • (2003) Hypertension , vol.42 , Issue.6 , pp. 1164-1170
    • Peng, H.1    Carretero, O.A.2    Brigstock, D.R.3    Oja-Tebbe, N.4    Rhaleb, N.-E.5
  • 84
    • 70449518280 scopus 로고    scopus 로고
    • Neurological functional recovery after thymosin beta 4 treatment in mice with experimental auto encephalomyelitis
    • Zhang J, Zhang ZG, Morris D, et al. Neurological functional recovery after thymosin beta 4 treatment in mice with experimental auto encephalomyelitis. Neuroscience 2009;164:1887-93
    • (2009) Neuroscience , vol.164 , pp. 1887-1893
    • Zhang, J.1    Zhang, Z.G.2    Morris, D.3
  • 85
    • 52549114744 scopus 로고    scopus 로고
    • The promotive effects of thymosin beta4 on neuronal survival and neurite outgrowth by upregulating L1 expression
    • Yang H, Cheng X, Yao Q, et al. The promotive effects of thymosin beta4 on neuronal survival and neurite outgrowth by upregulating L1 expression. Neurochem Res 2008;33:2269-80
    • (2008) Neurochem. Res. , vol.33 , pp. 2269-2280
    • Yang, H.1    Cheng, X.2    Yao, Q.3
  • 86
    • 79961217070 scopus 로고    scopus 로고
    • Quantitative iTRAQ analysis of retinal ganglion cell degeneration after optic nerve crush
    • Magharious M, D'Onofrio PM, Hollander A, et al. Quantitative iTRAQ analysis of retinal ganglion cell degeneration after optic nerve crush. J Proteome Res 2011;10:3344-62
    • (2011) J. Proteome Res. , vol.10 , pp. 3344-3362
    • Magharious, M.1    D'Onofrio, P.M.2    Hollander, A.3
  • 87
    • 84856298885 scopus 로고    scopus 로고
    • Striking neuronal thymosin beta 4 expression in the deep layers of the mouse superior colliculus after monocular deprivation
    • published online 31 May doi: 10.1007/s00429-011-0330-0
    • Paulussen M, Arckens L. Striking neuronal thymosin beta 4 expression in the deep layers of the mouse superior colliculus after monocular deprivation. Brain Struct Func published online 31 May 2011; doi: 10.1007/s00429-011-0330-0
    • (2011) Brain Struct. Func.
    • Paulussen, M.1    Arckens, L.2
  • 89
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the WWW for general users and for biologist programmers
    • Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000;132:365-86
    • (2000) Methods Mol. Biol. , vol.132 , pp. 365-386
    • Rozen, S.1    Skaletsky, H.2
  • 90
    • 80051804855 scopus 로고    scopus 로고
    • Thymosin beta4 knockdown disrupts mitochondrial functions of SW480 human colon cancer cells
    • Tang MC, Su Y. Thymosin beta4 knockdown disrupts mitochondrial functions of SW480 human colon cancer cells. Cancer Sci 2011;102:1665-72
    • (2011) Cancer Sci. , vol.102 , pp. 1665-1672
    • Tang, M.C.1    Su, Y.2
  • 96
    • 65349102898 scopus 로고    scopus 로고
    • Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1
    • Banyard J, Barrows C, Zetter BR. Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. Genes Chromosomes Cancer 2009;48:502-9
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 502-509
    • Banyard, J.1    Barrows, C.2    Zetter, B.R.3
  • 97
    • 66249148986 scopus 로고    scopus 로고
    • Lineage-specific biology revealed by a finished genome assembly of the mouse
    • Church DM, Goodstadt L, Hillier LW, et al. Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol 2009;7(5):e1000112
    • (2009) PLoS Biol. , vol.7 , Issue.5
    • Church, D.M.1    Goodstadt, L.2    Hillier, L.W.3


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