Topical tamoxifen therapy in hypertrophic scars or keloids in burns

Archives of Dermatological Research

Volumn 302, Issue 1, 2010, Pages 1-4

  Gragnani, Alfredo ^a   Warde, Mario ^a   Furtado, Fabianne ^a   Ferreira, Lydia Masako ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Administration, topical; Burns; Cicatrix, hypertrophic; Keloid; Tamoxifen

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; COLLAGEN; CYTOKINE; TAMOXIFEN; TAMOXIFEN CITRATE; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; VASCULOTROPIN;

ARTICLE; BURN; CELL PROLIFERATION; DESMOID TUMOR; DRUG EFFECT; FIBROBLAST; HUMAN; HYPERTROPHIC SCAR; KELOID; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCAR FORMATION; WOUND HEALING;

ADMINISTRATION, TOPICAL; BURNS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CICATRIX, HYPERTROPHIC; FIBROBLASTS; FIBROSIS; HUMANS; KELOID; SKIN; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA1; WOUND HEALING;

EID: 77749283386     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-009-0983-1     Document Type: Article

References (30)

1. A Al-Attar S Mess JM Thomassen CL Kauffman SP Davison 2006 Keloid pathogenesis and treatment Plast Reconstr Surg 117 286 300 10.1097/01.prs. 0000195073.73580.46 10.1097/01.prs.0000195073.73580.46 1:CAS:528: DC%2BD2sXkvVKjug%3D%3D 16404281 (Pubitemid 44391579)
2. TS Alster TB West 1997 Treatment of scars: a review Ann Plast Surg 39 418 432 10.1097/00000637-199710000-00014 10.1097/00000637-199710000-00014 1:STN:280:DyaK2svotVKitQ%3D%3D 9339286 (Pubitemid 27433267)
3. A Bayat O Bock U Mrowietz WE Ollier MW Ferguson 2003 Genetic susceptibility to keloid disease and hypertrophic scarring: transforming growth factor beta1 common polymorphisms and plasma levels Plast Reconstr Surg 111 535 543 10.1097/01.PRS.0000041536.02524.A3 10.1097/01.PRS.0000041536.02524.A3 12560674 (Pubitemid 36182284)
4. A Bayat JM Walter O Bock U Mrowietz WE Ollier MW Ferguson 2005 Genetic susceptibility to keloid disease: mutation screening of the TGFbeta(3) gene Br J Plast Surg 58 28 37 10.1016/j.bjps.2005.04.009 10.1016/j.bjps.2004.04.024 1:STN:280:DC%2BD2M%2Fgtl2gtw%3D%3D 15629164 (Pubitemid 41403682)
5. KL Blackwell ZA Haroon S Shan W Saito G Broadwater CS Greenberg MW Dewhirst 2000 Tamoxifen inhibits angiogenesis in estrogen receptor-negative animal models Clin Cancer Res 6 4359 4364 1:CAS:528:DC%2BD3cXovVSgu74%3D 11106254
6. O Bock G Schmid-Ott P Malewski U Mrowietz 2006 Quality of life of patients with keloid and hypertrophic scarring Arch Dermatol Res 297 433 438 10.1007/s00403-006-0651-7 10.1007/s00403-006-0651-7 16528552
7. BJ Broker R Chakrabarti T Blynman 1999 Comparison of growth factor expression in fetal and adult fibroblasts: a preliminary report Arch Otolaryngol Head Neck Surg 125 676 680 1:STN:280:DyaK1M3psVentA%3D%3D 10367926
8. AB Campaner LM Ferreira A Gragnani JM Bruder J Cusick JR Morgan 2006 Upregulation of TGF-beta1 expression may be necessary but is not sufficient for excessive scarring J Invest Dermatol 126 1168 1176 10.1038/sj.jid.5700200 10.1038/sj.jid.5700200 1:CAS:528:DC%2BD28XjsFSqs78%3D 16498396
9. L Carroll MM Hanasono AA Mikulec 2002 Triamcinolone stimulates bFGF production and inhibits TGF-β1 production by human dermal fibroblasts Dermatol Surg 28 704 709 10.1046/j.1524-4725.2002.02012.x 10.1046/j.1524-4725. 2002.02012.x 12174062 (Pubitemid 34913279)
10. D Chau JS Mancoll S Lee 1998 Tamoxifen downregulates TGF-beta production in keloid fibroblasts Ann Plast Surg 40 490 493 10.1097/00000637-199805000-00008 10.1097/00000637-199805000-00008 1:STN:280:DyaK1c3mtFSlsg%3D%3D 9600433 (Pubitemid 28215520)
11. G Dabiri A Campaner JR Morgan 2006 A TGF-beta1-dependent autocrine loop regulates the structure of focal adhesions in hypertrophic scar fibroblasts J Invest Dermatol 126 963 970 10.1038/sj.jid.5700187 10.1038/sj.jid.5700187 1:CAS:528:DC%2BD28XjsFSqsrg%3D 16498397
12. CP Denton K Khan RK Hoyles X Shiwen P Leoni Y Chen M Eastwood DJ Abraham 2009 Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing J Invest Dermatol 129 194 204 10.1038/jid.2008.171 10.1038/jid.2008.171 1:CAS:528:DC%2BD1cXhsVymu7zF 18563179
13. MJ Hardman E Emmerson L Campbell GS Ashcroft 2008 Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice Endocrinology 149 551 557 10.1210/en.2007-1042 10.1210/en.2007-1042 1:CAS:528:DC%2BD1cXht1yqtrw%3D 17974625 (Pubitemid 351159336)
14. B Hochman FC Vilas Bôas M Mariano LM Ferreira 2005 Keloid heterograft in the hamster (mesocricetus auratus) cheek pouch Acta Cir Bras 20 200 212 16033178
15. D Hu MA Hughes GW Cherry 1998 Topical tamoxifen-a potential therapeutic regime in treating excessive dermal scarring? Br J Plast Surg 51 462 469 1:STN:280:DyaK1M%2Fms1ahuw%3D%3D 9849367
16. D Hu MA Hughes GW Cherry 2002 The inhibitory effect of tamoxifen on human dermal fibroblast-populated collagen lattices Zhonghua Zheng Xing Wai Ke Za Zhi 18 160 162 12189703
17. B Kinzbrunner S Ritter J Domingo CJ Rosenthal 1993 Remission of rapidly growing desmoids tumors after tamoxifen therapy Cancer 52 2201 2204 10.1002/1097-0142(19831215)52:12<2201::AID-CNCR2820521204>3.0.CO;2-# 10.1002/1097-0142(19831215)52:12<2201::AID-CNCR2820521204>3.0.CO;2-#
18. MA Kuhn X Wang WG Payne F Ko MC Robson 2002 Tamoxifen decrease fibroblast function and downregulates TGF-β2 in Dupuytren's affected palmar fascia J Surg Res 103 146 152 10.1006/jsre.2001.6350 10.1006/jsre.2001.6350 1:CAS:528:DC%2BD38XitlGnt70%3D 11922728 (Pubitemid 34948495)
19. D Levenyhal M Furr D Reiter 2006 Treatment of keloids and hypertrophic scars: a meta-analysis and review of the literature Arch Facial Plast Surg 8 362 368 10.1001/archfaci.8.6.362 (Pubitemid 44862494)
20. JS Mancoll RL McCauley LG Phillips 1996 The inhibitory effect of tamoxifen on keloid fibroblasts Surg Forum 47 718 720 1:CAS:528: DyaK28Xnt1ehtrc%3D
21. A Mauviel 2009 Transforming growth factor-beta signaling in skin: stromal to epithelial cross-talk J Invest Dermatol 129 7 9 10.1038/jid.2008.385 10.1038/jid.2008.385 1:CAS:528:DC%2BD1cXhsVymurfL 19078982
22. 1 production by keloid and fetal fibroblasts Arch Facial Plast Surg 3 111 114 10.1001/archfaci.3.2.111 10.1001/archfaci.3.2.111 1:STN:280:DC%2BD3M3nsFKiug%3D%3D 11368663
23. E Osti F Osti 2003 Treatment with burnshield in patients with cutaneous burns. Definitive data Ann Burns Fire Disasters 16 151 154
24. LV Owens WG Cance JF Huth 1995 Retroperitoneal fibrosis treated with tamoxifen Am Surg 61 842 844 1:STN:280:DyaK2MzptVGrsg%3D%3D 7661488
25. HJ Paek AB Campaner JL Kim 2005 In vitro characterization of TGF-beta1 release from genetically modified fibroblasts in Ca(2+)-alginate microcapsules ASAIO J 51 379 384 10.1097/01.mat.0000169116.84336.c3 10.1097/01.mat.0000169116. 84336.c3 1:CAS:528:DC%2BD2MXmvVOitLY%3D 16156303 (Pubitemid 41078810)
26. R Robert W Meyer S Bishop L Rosenberg L Murphy P Blakeney 1999 Disfiguring burn scars and adolescent self-esteem Burns 25 581 585 10.1016/S0305-4179(99)00065-0 10.1016/S0305-4179(99)00065-0 1:STN:280: DC%2BD3c%2FisFajtA%3D%3D 10563682 (Pubitemid 29440901)
27. MB Ruffy SS Kunnavatana RJ Kock 2006 Effects of tamoxifen on normal human dermal fibroblasts Arch Facial Plast Surg 8 329 332 10.1001/archfaci.8.5.329 10.1001/archfaci.8.5.329 16982990 (Pubitemid 44497420)
28. RO Ruiz MJ Warde CA Mattar 2006 Uso do tamoxifeno no tratamento de quelóides Rev Fac Cienc Med Sorocaba 8 18 24
29. P Smith G Mosiello L Deluca 1999 TGF-beta 2 activates proliferative scar fibroblasts J Surg Res 82 319 323 10.1006/jsre.1999.5580 10.1006/jsre.1999.5580 1:CAS:528:DyaK1MXhvFKrsLc%3D 10090846 (Pubitemid 29394140)
30. S Younai LS Nichter T Wellisz 1994 Modulation of collagen synthesis by transforming growth factor-beta in keloid and hypertrophic scar fibroblasts Ann Plast Surg 33 148 151 10.1097/00000637-199408000-00005 10.1097/00000637- 199408000-00005 1:STN:280:DyaK2M%2FmvFOmtQ%3D%3D 7979045