Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts

Archives of Dermatological Research

Volumn 303, Issue 8, 2011, Pages 563-572

  Tang, Bing ^a   Zhu, Bin ^a   Liang, Yueying ^a   Bi, Liangkuan ^a   Hu, Zhicheng ^a   Chen, Bin ^a   Zhang, Kai ^a   Zhu, Jiayuan ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Asiaticoside; Collagen; Keloid; Smad; Transforming growth factor

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ASIATICOSIDE; COLLAGEN; MESSENGER RNA; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ADOLESCENT; ADULT; ARTICLE; CELL VIABILITY; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; KELOID; MALE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; WESTERN BLOTTING; WOUND HEALING;

ADOLESCENT; ADULT; ANTI-INFECTIVE AGENTS; CASE-CONTROL STUDIES; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CICATRIX; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FIBROBLASTS; HUMANS; KELOID; MALE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TIME FACTORS; TRITERPENES; YOUNG ADULT;

EID: 80054118848     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-010-1114-8     Document Type: Article

References (33)

1. SJ Chen W Yuan S Lo M Trojanowska J Varga 2000 Interaction of smad3 with a proximal smad-binding element of the human alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-beta J Cell Physiol 183 381 392 10797313 10.1002/(SICI)1097-4652(200006)183:3<381::AID-JCP11>3.0.CO;2-O 1:CAS:528:DC%2BD3cXivFWjtrY%3D (Pubitemid 30243869)
2. SJ Chen W Yuan Y Mori A Levenson M Trojanowska J Varga 1999 Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3 J Invest Dermatol 112 49 57 9886263 10.1046/j.1523-1747. 1999.00477.x 1:CAS:528:DyaK1MXjvFWitA%3D%3D (Pubitemid 29024705)
3. CL Cheng JS Guo J Luk MWL Koo 2004 The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats Life Sci 74 2237 2249 14987949 10.1016/j.lfs.2003.09.055 1:CAS:528:DC%2BD2cXhsVOkt7w%3D
4. GS Chin W Liu Z Peled TY Lee DS Steinbrech M Hsu MT Longaker 2001 Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblasts Plast Reconstr Surg 108 423 429 11496185 10.1097/00006534-200108000-00022 1:STN:280:DC%2BD3MvkvFamuw%3D%3D (Pubitemid 32706075)
5. R Derynck YE Zhang 2003 Smad-dependent and Smad-independent pathways in TGF-beta family signalling Nature 425 577 584 14534577 10.1038/nature02006 1:CAS:528:DC%2BD3sXnvV2hs7c%3D (Pubitemid 37280136)
6. K Dienus A Bayat BF Gilmore O Seifert 2010 Increased expression of fibroblast activation protein-alpha in keloid fibroblasts: implications for development of a novel treatment option Arch Dermatol Res 302 10 725 731 20872224 10.1007/s00403-010-1084-x 1:CAS:528:DC%2BC3cXhtlOrtLrL
7. Dong MS, Jung SH, Kim HJ, Kim JR, Zhao LX, Lee ES, Lee EJ, Yi JB, Lee N, Cho YB, Kwak WJ, Park YI (2004) Structure-related cytotoxicity and anti-hepatofibric effect of asiatic acid derivatives in rat hepatic stellate cell-line, HSC-T6. Arch Pharm Res 27:512-517 (Pubitemid 43080175)
8. S Dooley J Hamzavi K Breitkopf E Wiercinska HM Said J Lorenzen P Ten Dijke AM Gressner 2003 Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats Gastroenterology 125 178 191 12851882 10.1016/S0016-5085(03)00666-8 1:CAS:528:DC%2BD3sXmtVWquro%3D (Pubitemid 36799118)
9. MJ Goumans C Mummery 2000 Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice Int J Dev Biol 44 253 265 10853822 1:CAS:528:DC%2BD3cXks1Sgtbo%3D (Pubitemid 30368069)
10. AM Gressner R Weiskirchen 2003 The tightrope of therapeutic suppression of active transforming growth factor-beta: high enough to fall deeply? J Hepatol 39 856 859 14568271 10.1016/S0168-8278(03)00432-X 1:CAS:528: DC%2BD3sXotVert7Y%3D (Pubitemid 37372198)
11. JS Guo CL Cheng MWL Koo 2004 Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats Planta Med 70 1150 1154 15643549 10.1055/s-2004-835843 1:CAS:528:DC%2BD2MXlvFWhtA%3D%3D (Pubitemid 40101095)
12. H Hayashi S Abdollah Y Qiu J Cai YY Xu BW Grinnell MA Richardson JN Topper MA Gimbrone JL Wrana, et al. 1997 The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling Cell 89 1165 1173 9215638 10.1016/S0092-8674(00)80303-7 1:CAS:528:DyaK2sXkt1Kks70%3D (Pubitemid 127678749)
13. YC Hsu MJ Chen YM Yu SY Ko CC Chang 2010 Suppression of TGF-β1/SMAD pathway and extracellular matrix production in primary keloid fibroblasts by curcuminoids: its potential therapeutic use in the chemoprevention of keloid Arch Dermatol Res 302 10 717 724 20717830 10.1007/s00403-010-1075-y 1:CAS:528:DC%2BC3cXhtlOrtLrE
14. Y-H Huang S-H Zhang R-X Zhen X-D Xu Y-S Zhen 2004 Asiaticoside inducing apoptosis of tumor cells and enhancing anti-tumor activity of vincristine Ai Zheng 23 1599 1604 15601545 1:CAS:528:DC%2BD2MXjtVKlu7k%3D
15. Y Kimura M Sumiyoshi K-I Samukawa N Satake M Sakanaka 2008 Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism Eur J Pharmacol 584 415 423 18353310 10.1016/j.ejphar.2008.02.036 1:CAS:528:DC%2BD1cXksVaqsbk%3D
16. M Kolb PJ Margetts PJ Sime J Gauldie 2001 Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung Am J Physiol Lung Cell Mol Physiol 280 L1327 L1334 11350814 1:CAS:528:DC%2BD3MXksFKmu7c%3D
17. J Kopp E Preis H Said B Hafemann L Wickert AM Gressner N Pallua S Dooley 2005 Abrogation of transforming growth factor-beta signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts J Biol Chem 280 21570 21576 15788410 10.1074/jbc.M502071200 1:CAS:528:DC%2BD2MXks1elt7g%3D (Pubitemid 40805724)
18. ZB Kryger M Sisco NK Roy L Lu D Rosenberg TA Mustoe 2007 Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring J Am Coll Surg 205 78 88 17617336 10.1016/j.jamcollsurg.2007.03.001 (Pubitemid 47016969)
19. A Leask DJ Abraham 2004 TGF-beta signaling and the fibrotic response FASEB J 18 816 827 15117886 10.1096/fj.03-1273rev 1:CAS:528:DC%2BD2cXjvVOnt70%3D (Pubitemid 38544500)
20. 2+ release and enhanced expression of p53 in HepG2 human hepatoma cells Cancer Lett 186 83 91 12183079 10.1016/S0304-3835(02)00260-4 1:CAS:528:DC%2BD38XmtlCksrw%3D (Pubitemid 35245330)
21. W Liu DR Wang YL Cao 2004 TGF-beta: a fibrotic factor in wound scarring and a potential target for anti-scarring gene therapy Curr Gene Ther 4 123 136 15032619 10.2174/1566523044578004 1:CAS:528:DC%2BD2cXhvVCis7Y%3D (Pubitemid 38854950)
22. L Lu AS Saulis WR Liu NK Roy JD Chao S Ledbetter TA Mustoe 2005 The temporal effects of anti-TGF-β1, 2, and 3 monoclonal antibody on wound healing and hypertrophic scar formation J Am Coll Surg 201 391 397 16125072 10.1016/j.jamcollsurg.2005.03.032 (Pubitemid 41206777)
23. S Luo M Benathan W Raffoul RG Panizzon DV Egloff 2001 Abnormal balance between proliferation and apoptotic cell death in fibroblasts derived from keloid lesions Plast Reconstr Surg 107 87 96 11176606 10.1097/00006534- 200101000-00014 1:STN:280:DC%2BD3M7kt1WrtQ%3D%3D (Pubitemid 32039240)
24. FX Maquart F Chastang A Simeon P Birembaut P Gillery Y Wegrowski 1999 Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds Eur J Dermatol 9 289 296 10356407 1:CAS:528:DyaK1MXlvFShsbY%3D (Pubitemid 29272069)
25. I Mook-Jung JE Shin SH Yun K Huh JY Koh HK Park SS Jew MW Jung 1999 Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity J Neurosci Res 58 417 425 10518115 10.1002/(SICI)1097- 4547(19991101)58:3<417::AID-JNR7>3.0.CO;2-G 1:CAS:528:DyaK1MXntVOjt7k%3D (Pubitemid 29508575)
26. A Mukhopadhyay A Khoo HH Cheong SY Chan O Aalami IJ Lim TT Phan 2007 Targeting of Sp1 transcription factor: a novel therapeutic approach for keloids, an in vitro analysis Exp Dermatol 16 1023 1031 18031462 10.1111/j.1600-0625. 2007.00627.x 1:CAS:528:DC%2BD1cXjs1Wnuw%3D%3D (Pubitemid 350168126)
27. O Seifert U Mrowietz 2009 Keloid scarring: bench and bedside Arch Dermatol Res 301 4 259 272 19360429 10.1007/s00403-009-0952-8
28. B Shih A Bayat 2010 Genetics of keloid scarring Arch Dermatol Res 302 5 319 339 20130896 10.1007/s00403-009-1014-y 1:CAS:528:DC%2BC3cXmsFSlt7k%3D
29. Y Terada S Hanada A Nakao M Kuwahara S Sasaki F Marumo 2002 Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney Kidney Int 61 S94 S98 11841620 10.1046/j.1523-1755.2002. 0610s1094.x
30. F Verrecchia A Mauviel 2002 Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation J Invest Dermatol 118 211 215 11841535 10.1046/j.1523-1747.2002. 01641.x 1:CAS:528:DC%2BD38Xitl2isr0%3D (Pubitemid 34158472)
31. D Wolfram A Tzankov P Pülzl H Piza-Katzer 2009 Hypertrophic scars and keloids-a review of their pathophysiology, risk factors, and therapeutic management Dermatol Surg 35 171 181 19215252 10.1111/j.1524-4725.2008.34406.x 1:CAS:528:DC%2BD1MXislWis7w%3D
32. H Yu O Bock A Bayat MWJ Ferguson U Mrowietz 2006 Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring J Plast Reconstr Aesthet Surg 59 221 229 16676428 10.1016/j.bjps.2005.06.010
33. K-J Yun J-Y Kim J-B Kim K-W Lee S-Y Jeong H-J Park H-J Jung Y-W Cho K Yun K-T Lee 2008 Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways Int Immunopharmacol 8 431 441 18279797 10.1016/j.intimp.2007.11.003 1:CAS:528:DC%2BD1cXitVGhs7o%3D (Pubitemid 351227435)