Antifibrotic effects of hepatocyte growth factor on scleroderma fibroblasts and analysis of its mechanism

Modern Rheumatology

Volumn 16, Issue 6, 2006, Pages 364-371

  Sherriff Tadano, Ryoko ^a   Ohta, Akihide ^b   Morito, Fumitaka ^b   Mitamura, Mio ^b   Haruta, Yoshio ^b   Koarada, Shuichi ^b   Tada, Yoshifumi ^b   Nagasawa, Kohei ^b   Ozaki, Iwata ^b  

^a SAGA UNIVERSITY   (Japan)

^b SAGA UNIVERSITY   (Japan)

Author keywords

Collagen; Connective tissue growth factor; Hepatocyte growth factor; Matrix metal loproteinase 1; Scleroderma

Indexed keywords

ANTIBODY; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; CYTOKINE; GAMMA INTERFERON; INTERSTITIAL COLLAGENASE; MESSENGER RNA; PROCOLLAGEN; PROCOLLAGEN ALPHA1; SCATTER FACTOR; SCATTER FACTOR ANTIBODY; TRANSCRIPTION FACTOR ETS 1; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLLAGEN METABOLISM; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DIFFUSE SCLERODERMA; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIMITED SCLERODERMA; MALE; METABOLIC INHIBITION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; SCLERODERMA; SKIN FIBROBLAST;

ANTIBODIES, BLOCKING; CELLS, CULTURED; COLLAGEN; COLLAGEN TYPE I; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLASTS; HEPATOCYTE GROWTH FACTOR; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MATRIX METALLOPROTEINASE 1; PROTO-ONCOGENE PROTEIN C-ETS-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCLERODERMA, DIFFUSE; SCLERODERMA, LIMITED; SKIN;

EID: 33845541982     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-006-0525-z     Document Type: Article

References (37)

1. TA Medsger Jr 2004 Systemic sclerosis (scleroderma), clinical aspects WJ Koopman Arthritis and allied conditions 15th ed Williams and Wilkins Baltimore 1433-64
2. TA Medsger Jr VD Steen 1996 Classification and prognosis PJ Clements DE Furst Systemic sclerosis Williams and Wilkins Philadelphia 51-64
3. K Takeda A Hatamochi H Ueki M Nakata Y Oishi 1994 Decreased collagenase expression in cultured systemic sclerosis fibroblasts J Invest Dermatol 103 359-63 8077701 10.1111/1523-1747.ep12394936 1:CAS:528:DyaK2cXmt1Oqsbg%3D
4. L Bazzichi A Rossi G Giannaccini L Betti G Cercignani T Giuliano G Mascia 2005 Decreased elastase activity in circulating granulocytes of systemic sclerosis patients: A possible pathogenetic role Scand J Rheumatol 34 494-5 16393778 10.1080/03009740510026670 1:CAS:528:DC%2BD28XhtFWmt7o%3D
5. EC LeRoy EA Smith MB Kahaleh M Trojanowska RM Silver 1989 A strategy for determining the pathogenesis of systemic sclerosis. Is transforming growth factor beta the answer? Arthritis Rheum 32 817-25 2665755 1:STN:280:BiaA383ktVI%3D
6. S Gupta MR Clarkson J Duggan HR Brady 2000 Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointersitial fibrosis Kidney Int 58 1389-99 11012874 10.1046/j.1523-1755.2000.00301.x 1:CAS:528:DC%2BD3cXntlyltL4%3D
7. X Shin-wen D Pennington A Holmes A Leask D Bradham JR Beauchamp 2000 Autocrine overexpression of CTGF maintains fbrosis: RDA analysis of fibrosis genes in systemic sclerosis Exp Cell Res 259 213-24 10.1006/ excr.2000.4972
8. T Mori S Kawara M Shinozaki N Hayashi T Kakinuma A Igarashi 1999 Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model J Cell Physiol 181 153-9 10457363 10.1002/ (SICI)1097-4652(199910)181:1<153::AID-JCP16>3.0.CO;2-K 1:CAS:528:DyaK1MXlslWgs7c%3D
9. T Nakamura K Nawa A Ichihara 1984 Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats Biochem Biophys Res Commun 122 1450-9 6477569 10.1016/0006-291X(84)91253-1 1:CAS:528:DyaL2cXlsVCrsr0%3D
10. P Boros CM Miller 1995 Hepatocyte growth factor: A multifunctional cytokine Lancet 345 293-5 7837864 10.1016/S0140-6736(95)90279-1 1:STN:280:ByqC3sbmvVE%3D
11. A Bardelli P Longati D Albero S Goruppi C Schneider C Ponzetto 1996 HGF receptor associates with anti-apoptotic protein BAG-1 and prevents cell death EMBO J 15 6205-12 8947043 1:CAS:528:DyaK28XnsFOju7o%3D
12. Y Matsuda K Matsumoto T Ichida T Nakamura 1995 Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats J Biochem 118 643-9 8690730 1:CAS:528:DyaK2MXos1Snurs%3D
13. T Ueki Y Kaneda H Tsutsui K Nakanishi Y Sawa R Morishita 1999 Hepatocyte growth factor gene therapy of liver cirrhosis in rats Nat Med 5 226-30 9930873 10.1038/5593 1:CAS:528:DyaK1MXntlOhsA%3D%3D
14. T Inoue H Okada T Kobayashi Y Watanabe Y Kanno JB Kopp 2003 Hepatocyte growth factor counteracts transforming growth factor-beta;1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice FASEB J 17 268-70 12475893 1:CAS:528:DC%2BD3sXhtVOjtrw%3D
15. Y Kawaguchi M Harigai M Hara C Fukasawa K Takagi M Tanaka 2002 Expression of hepatocyte growth factor and its receptor (c-met) in skin fibroblasts from patients with systemic sclerosis J Rheumatol 29 1877-83 12233882 1:CAS:528:DC%2BD38Xns1aksL4%3D
16. Y Kawaguchi M Harigai C Fukasawa M Hara 1999 Increased levels of hepatocyte growth factor in sera of patients with systemic sclerosis J Rheumatol 26 1012-3 10229444 1:STN:280:DyaK1M3ksVCmsg%3D%3D
17. M-H Wu H Yokozeki S Takagawa T Yamamoto T Satoh Y Kaneda 2004 Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma Gene Therapy 11 170-80 14712301 10.1038/sj.gt.3302165 1:CAS:528:DC%2BD2cXhtlGjsA%3D%3D
18. M Jinnin H Inn Y Mimura Y Asano K Yamane K Tamaki 2005 Effects of hepatocyte growth factor on the expression of type Icollagen and matrix metalloproteinase-1 on normal and scleroderma dermal fibroblasts J Invest Dermatol 124 324-30 15675950 10.1111/j.0022-202X.2004.23601.x 1:CAS:528:DC%2BD2MXhsVKnu78%3D
19. Subcommittee for Scleroderma 1980 Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma) Arthritis Rheum 23 581-90
20. EC LeRoy 1974 Increased collagen synthesis by scleroderma skin fibroblasts in vitro. A possible defect in the regulation or activation of the scleroderma fibroblasts J Clin Invest 54 880-9 4430718 1:CAS:528:DyaE2cXlsV2ktr4%3D
21. M Kulozik A Hogg B Lankat-Buttgereit T Krieg 1990 Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis J Clin Invest 86 917-22 1697606 1:CAS:528:DyaK3cXmt1yrsLo%3D
22. I Ozaki G Zhao T Mizuta Y Ogawa T Hara S Kajihara 2002 Hepatocyte growth factor induces collagenase (matrix metalloproteinase-1) via the transcription factor Ets-1 in human hepatic stellate cell line J Hepatol 36 169-78 11830328 10.1016/S0168-8278(01)00245-8 1:CAS:528:DC%2BD38Xit1eisrs%3D
23. J Westermarck A Seth VM Kahari 1997 Differential regulation of interstitial collagenase (MMP-1) gene expression by ETS transcription factors Oncogene 14 2651-60 9178763 10.1038/sj.onc.1201111 1:CAS:528:DyaK2sXktVCqsbg%3D
24. I Ozaki T Mizuta G Zhao H Zhang T Yoshimura S Kawazoe 2003 Induction of multiple matrix metalloproteinase genes in human hepatocellular carcinoma by hepatocyte growth factor via a transcription factor Ets-1 Hepatol Res 27 289-301 14662117 10.1016/S1386-6346(03)00268-7
25. H Inn K Yamane M Kubo K Tamaki 2001 Blockade of endogenous transforming growth factor beta signalling prevents up-regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor beta receptors Arthritis Rheum 44 474-80 10.1002/1529-0131(200102)44:2<474::AID-ANR67>3.0.CO;2-#
26. J Iqbal J Dudhia JL Bird MT Bayliss 2000 Age-related effects of TGF-beta on proteoglycan synthesis in equine articular cartilage Biochem Biophys Res Commun 274 467-71 10913361 10.1006/bbrc.2000.3167 1:CAS:528:DC%2BD3cXltVOktrY%3D
27. EN Blaney Davidson A Scharstuhl EL Vitters PM van der Kraan WB van den Berg 2005 Reduced transforming growth factor-beta signalling in cartilage of old mice: Role in impaired repair capacity Arthritis Res Ther 7 1338-47 10.1186/ar1833
28. K Takehara 2003 Pathogenesis of systemic sclerosis J Rheumatol 30 755-9 12672195
29. S Chujo F Shirasaki S Kawara Y Inagaki T Kinbara M Inaoki 2005 Connective tissue growth factor caused persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model J Cell Physiol 203 447-56 15605379 10.1002/jcp.20251 1:CAS:528:DC%2BD2MXjtVygtbg%3D
30. JP Van Beek L Kennedy JS Rockel SM Bernier A Leask 2006 The induction of CCN2 by TGFbeta1 involves Ets-1 Arthritis Res Ther 8 R3616469114 10.1186/ ar1890
31. J Yang C Dai Y Liu 2003 Hepatocyte growth factor suppressed renal interstitial myofibroblast activation and intercepts Smad signal transduction Am J Pathol 163 621-32 12875981 1:CAS:528:DC%2BD3sXmslSnsb4%3D
32. P Gillery H Serpier M Polette G Bellon C Clavel Y Wegrowski 1992 Gamma-interferon inhibits extracellular matrix synthesis and remodeling in collagen lattice cultures of normal and scleroderma skin fibroblasts Eur J Cell Biol 57 244-53 1511700 1:CAS:528:DyaK38Xkt1Cmtr0%3D
33. MR Duncan B Berman 1991 Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6 J Invest Dermatol 97 686-92 1940439 10.1111/ 1523-1747.ep12483971 1:CAS:528:DyaK3MXmslOluro%3D
34. CA Feghali KL Bost DW Boulware LS Levy 1992 Mechanisms of pathogenesis in scleroderma. I. Overproduction of interleukin 6 by fibroblasts cultured from affected skin sites of patients with scleroderma J Rheumatol 19 1207-11 1404155 1:STN:280:ByyD38%2FotFE%3D
35. C Parr WG Jiang 2001 Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells Int J Oncol 19 857-63 11562767 1:CAS:528:DC%2BD3MXnsFSmu7c%3D
36. N Arakaki T Kajihara R Arakaki T Ohnishi JA Kazi H Nakashima 1999 Involvement of oxidative stress in tumor cytotoxic activity of hepatocyte growth factor/scatter factor J Biol Chem 274 13541-6 10224123 10.1074/jbc.274.19.13541 1:CAS:528:DyaK1MXjtFOlur8%3D
37. H Sakata H Takayama R Sharp JS Rubin G Merlino WJ LaRochelle 1996 Hepatocyte growth factor/Scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers Cell Growth Differ 7 1513-23 8930401 1:CAS:528:DyaK28XntV2ltLc%3D