Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-β-mediated Smad3 activation in fibroblasts

Journal of Investigative Dermatology

Volumn 118, Issue 3, 2002, Pages 461-470

  McGaha, Tracy L ^a   Phelps, Robert G ^a   Spiera, Harry ^a   Bona, Constantin ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Fibrosis; Scleroderma; Signal transduction; TGF ; Tight skin

Indexed keywords

COLLAGEN TYPE 1; HALOFUGINONE; ISOPROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EMBRYO; FIBROBLAST CULTURE; MALE; MOUSE; NEWBORN; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SCLERODERMA; SIGNAL TRANSDUCTION; SKIN FIBROBLAST;

EID: 0036121027     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202x.2001.01690.x     Document Type: Article

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