Pathophysiology and treatment of fibroproliferative disorders following thermal injury

Annals of the New York Academy of Sciences

Volumn 888, Issue , 1999, Pages 165-182

  Tredget, Edward E ^a,b  

^a UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

TRIAMCINOLONE;

CONFERENCE PAPER; HUMAN; HUMAN CELL; HYPERTROPHIC SCAR; KELOID; LASER SURGERY; PATHOGENESIS; PATHOPHYSIOLOGY; THERMAL INJURY; WOUND HEALING;

EID: 0032779130     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07955.x     Document Type: Conference Paper

References (78)

1. 1. Tredget, E. E., B. Nedelec, P. G. Scott & A. Ghahary. 1997. Hypertrophic scars, keloids, and contractures: the cellular and molecular basis for therapy. Surg. Clin. North Am. 77(3): 701-715.
2. 2. Ando, Y. & P. J. Jensen. 1993. Epidermal growth factor and insulin-like growth factor I enhance keratinocyte migration. J. Invest. Dermatol. 100: 633.
3. 3. Anscher, M. W, W P. Peters, H. Reisenbichler et al. 1993. Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer. N. Engl. J. Med. 328: 1592.
4. 4. Antoniades, H. N., T. Galanopoulos & J. Neville-Golden. 1991. Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 88: 565.
5. 5. Deitch, E. A., T. M. Wheelahan, M. P. Rose et al. 1983. Hypertrophic burn scars: analysis of variables. J. Trauma 23: 895.
6. 6. Raghow, R. 1994. The role of extracellular matrix in postinflammatory wound healing and fibrosis. FASEB J. 8: 823.
7. 7. Scott, P. G., A. Ghahary, M. M. Chambers & E. E. Tredget. 1994. Biological basis of hypertrophic scarring. Adv. Struct. Biol. 3: 157.
8. 8. Linares, H. A., C. W. Kischer, M. Dobrkovsky et al. 1972. The histiotypic organization of the hypertrophic scar in humans. J. Invest. Dermatol. 59: 323.
9. 9. Scott, P. G., C. M. Dodd, E. E. Tredget et al. 1996. Chemical characterization and quantification of proteoglycans in human post-burn hypertrophic and mature scars. Clin. Sci. 90:417.
10. 10. Kischer, C. W., H. Bunce & M. R. Shetlar. 1978. Mast cell analyses in hypertrophic scars, hypertrophic scars treated with pressure, and mature scars. J. Invest. Dermatol. 71: 355.
11. 11. Ala-Kokko, L., A. Rintala & E. R. Savolainen. 1987. Collagen gene expression in keloids: analysis of collagen metabolism and type I, III, IV, and V procollagen mRNAs in keloid fibroblast cultures. J. Invest. Dermatol. 89: 238.
12. 12. Ghahary, A., P. G. Scott, S. Malhotra et al. 1992. Differential expression of type I and type III procollagen mRNA in human hypertrophic burn fibroblasts. Biomed. Lett. 47: 169.
13. 13. Kescher, C. W., H. N. Wagner, J. Pindur et al. 1989. Increased fibronectin production by cell lines from hypertrophic scar and keloid. Connect. Tissue Res, 23: 279.
14. 18O-labelled 4-hydroxyproline for measurement of collagen synthesis and intracellular degradation. J. Chromatogr. 612: 7.
15. 15. Ghahary, A., Y. J. Shen, B. Nedelec et al. 1996. Collagenase production is lower in post-burn hypertrophic scar fibroblasts than in normal fibroblasts and is reduced by insulin-like growth factor-1. J. Invest. Dermatol. 106: 476.
16. 16. Wang, R., A. Ghahary, Y. J. Shen et al. 1996. Human dermal fibroblasts produce nitric oxide and express both constitutive and inducible nitric oxide synthase isoforms. J. Invest. Dermatol. 106:419.
17. 17. Grant, M. B., R. N. Mames, C. Fitzgerald et al. 1993. Insulin-like growth factor 1 acts as an angiogenic agent in rabbit cornea and retina: comparative studies with basic fibroblast growth factor. Diabetologia 36: 282.
18. 18. Kiritsy, C. P. & S. E. Lynch. 1993. Role of growth factors in cutaneous wound healing: a review. Crit. Rev. Oral Biol. Med. 4: 729.
19. 19. Kovacs, E. J. & L. A. Dipietro. 1994. Fibrogenic cytokines and connective tissue production. FASEB J. 8: 854.
20. 20. Roberts, A. B. & M. B. Sporn. 1996. Transforming growth factor-b. In The Molecular and Cellular Biology of Wound Repair, p. 275-298. Plenum. New York.
21. 21. Ghahary, A., Y. J. Shen, P. G. Scott et al. 1995. Immunolocalization of TGF-b1 inhuman hypertrophic scar and normal dermal tissues. Cytokine 7: 184.
22. 22. Spencer, M. E., G. Skover & T. K. Hurt. 1988. Somatomedins - do they play a pivotal role in wound healing? Prog. Clin. Biol. Res. 266: 103.
23. 23. Engrav, L. H., M. H. Covey, K. D. Dutcher et al. 1987. Impairment, time out of school, and time off from work after burns. Plast. Reconstr. Surg. 79: 927.
24. 24. Gabbiani, G., G. B. Ryan & G. Majno. 1971. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 27: 549.
25. 25. Arora, P. D. & A. G. McCulloch. 1994. Dependence of collagen remodeling on a-smooth muscle actin expression by fibroblasts. J. Cell. Physiol. 159: 161.
26. 26. Harris, A. K., P. Wild & D. Stopak. 1980. Silicone rubber substrata: a new wrinkle in the study of cell locomotion. Science 208: 177.
27. 27. Leavitt, J., P. Gunning, L. Kedes et al. 1985. Smooth muscle a-actin is a transformation-sensitive marker for mouse NIH 3T3 and Rat-2 cells. Nature 316: 840.
28. 28. Rudolph, R., J. Van de Berg & H. P. Ehrlich. 1992. Wound contraction and scar contracture. In Wound Healing: Biochemical and Clinical Aspects, p. 96. Saunders. Philadelphia.
29. 29. DiCorleto, P. E. & D. F. BOWEN-POPE. 1983. Cultured endothelial cells produce a platelet-derived growth factor-like protein. Proc. Natl. Acad. Sci. U.S.A. 80: 1919.
30. 30. Kalvakolanu, D. V & E. C. Borden. 1996. An overview of the interferon system: signal transduction and mechanisms of action. Cancer Invest. 14: 25.
31. 31. Duncan, M. R., A. Hasan & B. Berman. 1995. Pentoxifylline, pentifylline, and interferons decrease type I and III procollagen mRNA levels in dermal fibroblasts: evidence for mediation by nuclear factor 1 down-regulation. J. Invest. Dermatol. 104: 282.
32. 32. Nedelec, B., Y. J. Shen, A. Ghahary et al. 1995. The effect of interferon-a2b on the expression of cytoskeletal proteins in an in vitro model of wound contraction. J. Lab. Clin. Med. 126: 474.
33. 33. Granstein, R. D., T. J. Flotte & E. P. Amento. 1990. Interferons and collagen production. J. Invest. Dermatol. 95: 75S.
34. 34. McCauley, R., V CHOPRA, Y. Y. Li et al. 1992. Altered cytokine production in black patients with keloids. J. Clin. Tmmunol. 12: 300.
35. 35. Da Costa, J. C. 1931. Modern Surgery. Saunders. Philadelphia.
36. 36. Ford, L. C., D. F. King, L. D. LAGASSE et al. 1993. Increased binding in keloids: a preliminary communication. J. Dermatol. Surg. Oncol. 19: 545.
37. 37. Varedi, M., E. E. Tredget, P. G. Scott et al. 1995. Alteration in cell morphology triggers transforming growth factor-b1, collagenase, and tissue inhibitor of metalloproteinases-I expression in normal and hypertrophic scar fibroblasts. J. Invest. Dermatol. 104: 118.
38. 38. Chang, P., K. N. Laubenthal., R. W. Lewis et al. 1995. Prospective, randomized study of the efficacy of pressure garments in patients with burns. J. Burn Care Rehabil. 16: 473.
39. 39. Murray, J. C. 1994. Keloids and hypertrophic scars. Clin. Dermatol. 12: 27.
40. 40. Assoian, R. K., A. Komoriya, C. A. Meyers et al. 1983. Transforming growth factor-β in human platelets: identification of a major storage site, purification, and characterization. J. Biol. Chem. 258: 7155.
41. 41. Larson, D. L., S. Abston, B. Willis et al. 1974. Contracture and scar formation in burn patient. Clin. Plast. Surg. 1: 653.
42. 42. Cheng, J. C. Y., J. H. Evans, K. S. Leung et al. 1984. Pressure therapy in the treatment of post-burn hypertrophic scar - a critical look into its usefulness and fallacies by pressure monitoring. Burns 10: 154.
43. 43. Kischer, C. W., M. R. Shetlar & C. L. Shetlar. 1975. Alteration of hypertrophic scars induced by mechanical pressure. Arch. Dermatol. 111: 60.
44. 44. Kischer, C. W. & M. R. Shetlar. 1979. Microvasculature in hypertrophic scars and the effects of pressure. J. Trauma 19: 757.
45. 45. Kischer, C. W., H. Brunce & M. R. Shetlar. 1978. Mast cell analyses in hypertrophic scars, hypertrophic scars treated with pressure, and mature scars. J. Invest. Dermatol. 71 : 355.
46. 46. Fraulin, F. O. G., S. J. Illmayer & E. E. Tredget. 1996. Assessment of cosmetic and functional results of conservative versus surgical management of facial burns. J. Burn Care Rehabil. 17: 19.
47. 47. Farquhar, K. 1992. Silicone gel and hypertrophic scar formation: a literature review. Can. J. Occup. Ther. 59: 78.
48. 48. Gold, M. H. 1994. A controlled clinical trial of topical silicone gel sheeting in the treatment of hypertrophic scars and keloids. J. Am. Acad. Dermatol. 30: 506.
49. 49. Sproat, J. E., A. Dalcin, N. Weitauer et al. 1992. Hypertrophic sternal scars: silicone gel sheet versus Kenalog injection treatment. Plast. Reconstr. Surg. 90: 988.
50. 50. Wessling, N., C. M. Ehleben, V. Chapman et al. 1985. Evidence that use of a silicone gel sheet increases range of motion over burn wound contractures. J. Burn Care Rehabil. 6: 503.
51. 51. Quinn, M. J. 1987. Silicone gel in scar treatment. Burns 13: S33.
52. 52. Lee, R. C. & H. Doong. 1993. Control of matrix production during tissue repair. In Advances in Wound Healing and Tissue Repair, p. 2. World Medical Press. Cleveland.
53. 53. Quinn, K. J., J. H. Evans, J. M. Courtney et al. 1985. Non-pressure treatment of hypertrophic scars. Burns 12: 102.
54. 54. Ahn, S. T, W. W. Monafo & T. A. Mustoe. 1989. Topical silicone gel: a new treatment for hypertrophic scars. Surgery 106: 781.
55. 55. Van den Kerckhove, E., W. BOECKX & A. Kochuyt. 1991. Silicone patches as a supplement for pressure therapy to control hypertrophic scarring. J. Burn Care Rehabil. 12: 361.
56. 56. Davey, R. B., K. A. Wallis & K. Bowering. 1991. Adhesive contact media - an update of graft fixation and burn scar management. Burns 17: 313.
57. 57. River, E., R. G. Strate & L. D. Solem. 1979. The transparent face mask. Am. J. Occup. Ther. 33: 100.
58. 58. Bennett, G. B., P. Helm, G. F. Purdue et al. 1989. Serial casting: a method for treating burn contractures. J. Burn Care Rehabil. 10: 543.
59. 59. Ridgway, C. L., M. B. Daugherty & G. D. Warden. 1991. Serial casting as a technique to correct burn scar contractures. J. Burn Care Rehabil. 12: 67.
60. 60. Leman, C. J. 1992. Splints and accessories following burn reconstruction. Clin. Plast. Surg. 19: 721.
61. 61. Kiil, J. 1977. Keloids treated with topical injections of triamcinolone acetonide (Kenalog): immediate and long-term results. Scand. J. Plast. Reconstr. Surg. 11: 169.
62. 62. Cohen, I. K., R. F. Diegelmann & C. P. Bryant. 1975. Alpha globulin collagenase inhibitors in keloid and hypertrophic scar. Surg. Forum 26: 61.
63. 63. Pittet, B., L. Rubbia-Brandt, A. Desmouliere et al. 1994. Effect of g-interferon on the clinical and biologie evolution of hypertrophic scars and Dupuytren's disease: an open pilot study. Plast. Reconstr. Surg. 93: 1224.
64. 64. Ceilly, R. I. & R. W. Babin. 1979. The combined use of cryosurgery and intralesional injections of suspensions of fluorinated adrenocorticosteroids for reducing keloids and hypertrophic scars. J. Dermatol. Surg. Oncol. 5: 54.
65. 65. Rusciani, L., G. Rossi & R. Bono. 1993. Use of cryotherapy in the treatment of keloids. J. Dermatol. Surg. Oncol. 19: 529.
66. 66. Lee, R. C., H. Doong & A. F. Jellema. 1994. The response of burn scars to intralesional verapamil: report of five cases. Arch. Surg. 129: 107.
67. 67. Darzi, M. A., N. A. Chowdri, S. K. Kaul et al. 1992. Evaluation of various methods of treating keloids and hypertrophic scars: a 10-year follow-up study. Br. J. Plast. Surg. 45: 374.
68. 68. Apfelberg, D. B., M. R. Master & H. Lash. 1976. The use of epidermis over a keloid as an autograft after resection of the keloid. J. Dermatol. Surg. Oncol. 2: 409.
69. 69. Rauscher, G. E. & W. L. Kolmer. 1968. Treatment of recurrent method for treatment of early scars. Plast. Reconstr. Surg. 42: 322.
70. 70. Horton, C. E., J. Crawford & R. S. Oakey. 1953. Malignant changes in keloids. Plast. Reconstr. Surg. 12: 86.
71. 71. Levy, D. S., M. M. Salter & R. E. Roth. 1976. Postoperative irradiation in the prevention of keloids. AJR (Am. J. Roentgenol.) 127: 509.
72. 72. Sloan, D. F., R. Brown, C. Wells et al. 1978. Tissue gases in human hypertrophic burn scars. Plast. Reconstr. Surg. 61: 431.
73. 73. Feldman, J. J. 1984. Reconstruction of the burned face in children. In Pediatric Plastic Surgery, p. 552. Mosby. St. Louis.
74. 74. Williamson, J. S., C. F. Snelling, P. Clugston et al. 1995. Cultured epithelial autograft: five years of clinical experience with twenty-eight patients. J. Trauma 39: 309.
75. 75. Tredget, E. E., H. Shankowsky, R. Pannu et al. 1998. Transforming growth factor-b in thermally injured patients with hypertrophic scars: effects of interferon α-2b. Plast. Reconstr. Surg. 102: 1317.
76. 76. Alster, T. S. & C. M. Williams. 1995. Improvement of keloid sternotomy scars with 585-nm flashlamp-pumped pulsed dye laser. Lancet 345: 1198.
77. 77. Dierickx, C., M. P. Goldman & R. E. Fitzpatrick. 1995. Laser treatment of erythematous/hypertrophic and pigmented scars in 26 patients. Plast. Reconstr. Surg. 95: 84.
78. 78. Sheridan, R. L., R. J. Choucair, M. B. Donelan et al. 1985. A significant part of macrophage-derived growth factor consists of at least two forms of PEGF. Cell 43: 277.