메뉴 건너뛰기




Volumn 15, Issue 6, 2014, Pages 487-503

Peripheral targets in obesity treatment: A comprehensive update

Author keywords

Adipose tissue; Anti obesity drugs; Energy absorption; Energy expenditure

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; ACYLTRANSFERASE INHIBITOR; ANGIOGENESIS INHIBITOR; ANTIOBESITY AGENT; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; CANNABINOID 1 RECEPTOR ANTAGONIST; CANNABINOID RECEPTOR 1 ANTAGONIST; DIACYLGLYCEROL ACYLTRANSFERASE INHIBITOR; DIAZOXIDE; ESTERASE INHIBITOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR AGONIST; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GROWTH HORMONE DERIVATIVE; METHIONINE; METHIONINE AMINOPETIDASE 2 INHIBITOR; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITOR; MONOACYLGLYCEROL O ACYLTRANSFERASE INHIBITOR; PANCREATIC LIPASE INHIBITOR; SIRTUIN 1; SIRTUIN 1 ACTIVATOR; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; THYROID HORMONE RECEPTOR BETA AGONIST; UNCLASSIFIED DRUG; 2-ACYLGLYCEROL O-ACYLTRANSFERASE; ACYLTRANSFERASE; CARRIER PROTEIN; DIACYLGLYCEROL ACYLTRANSFERASE; ENZYME INHIBITOR; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PNLIP PROTEIN, HUMAN; SLC5A2 PROTEIN, HUMAN; SODIUM GLUCOSE COTRANSPORTER 2; THYROID HORMONE RECEPTOR BETA; TRIACYLGLYCEROL LIPASE;

EID: 84899648843     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/obr.12163     Document Type: Article
Times cited : (33)

References (169)
  • 2
    • 4444228888 scopus 로고    scopus 로고
    • WHO. Fact sheet No. 311. [WWW document], (accessed February 2014)
    • WHO. Obesity and overweight. Fact sheet No. 311. 2013. [WWW document]. URL http://www.who.int/mediacentre/factsheets/fs311/en/index.html (accessed February 2014).
    • (2013) Obesity and overweight
  • 3
    • 55849130382 scopus 로고    scopus 로고
    • Macrophage infiltration into adipose tissue: initiation, propagation and remodeling
    • Surmi BK, Hasty AH. Macrophage infiltration into adipose tissue: initiation, propagation and remodeling. Future Lipidol 2008; 3: 545-556.
    • (2008) Future Lipidol , vol.3 , pp. 545-556
    • Surmi, B.K.1    Hasty, A.H.2
  • 6
    • 33847280286 scopus 로고    scopus 로고
    • T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity
    • Wu H, Ghosh S, Perrard XD etal. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 2007; 115: 1029-1038.
    • (2007) Circulation , vol.115 , pp. 1029-1038
    • Wu, H.1    Ghosh, S.2    Perrard, X.D.3
  • 7
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q etal. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112: 1821-1830.
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 9
    • 84885436588 scopus 로고    scopus 로고
    • The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance
    • Phieler J, Chung KJ, Chatzigeorgiou A etal. The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J Immunol 2013; 191: 4367-4374.
    • (2013) J Immunol , vol.191 , pp. 4367-4374
    • Phieler, J.1    Chung, K.J.2    Chatzigeorgiou, A.3
  • 10
    • 3242795814 scopus 로고    scopus 로고
    • Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome
    • Carr DB, Utzschneider KM, Hull RL etal. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes 2004; 53: 2087-2094.
    • (2004) Diabetes , vol.53 , pp. 2087-2094
    • Carr, D.B.1    Utzschneider, K.M.2    Hull, R.L.3
  • 11
    • 34347351228 scopus 로고    scopus 로고
    • Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    • Fox CS, Massaro JM, Hoffmann U etal. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 2007; 116: 39-48.
    • (2007) Circulation , vol.116 , pp. 39-48
    • Fox, C.S.1    Massaro, J.M.2    Hoffmann, U.3
  • 12
    • 84862582505 scopus 로고    scopus 로고
    • Anti-obesity drugs: a review about their effects and safety
    • Kang JG, Park CY. Anti-obesity drugs: a review about their effects and safety. Diabetes Metab J 2012; 36: 13-25.
    • (2012) Diabetes Metab J , vol.36 , pp. 13-25
    • Kang, J.G.1    Park, C.Y.2
  • 15
    • 0017123620 scopus 로고
    • Experimental obesity, dietary-induced thermogenesis, and their clinical implications
    • Sims EA. Experimental obesity, dietary-induced thermogenesis, and their clinical implications. Clin Endocrinol Metab 1976; 5: 377-395.
    • (1976) Clin Endocrinol Metab , vol.5 , pp. 377-395
    • Sims, E.A.1
  • 16
    • 79961165599 scopus 로고    scopus 로고
    • Current and future drug targets in weight management
    • Witkamp RF. Current and future drug targets in weight management. Pharm Res 2011; 28: 1792-1818.
    • (2011) Pharm Res , vol.28 , pp. 1792-1818
    • Witkamp, R.F.1
  • 18
    • 0026604775 scopus 로고
    • Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18-0647 (tetrahydrolipstatin)
    • Hauptman JB, Jeunet FS, Hartmann D. Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18-0647 (tetrahydrolipstatin). Am J Clin Nutr 1992; 55: 309S-313S.
    • (1992) Am J Clin Nutr , vol.55
    • Hauptman, J.B.1    Jeunet, F.S.2    Hartmann, D.3
  • 19
    • 35148885200 scopus 로고    scopus 로고
    • Pancreatic lipase inhibitors from natural sources: unexplored potential
    • Birari RB, Bhutani KK. Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discov Today 2007; 12: 879-889.
    • (2007) Drug Discov Today , vol.12 , pp. 879-889
    • Birari, R.B.1    Bhutani, K.K.2
  • 20
    • 1042303480 scopus 로고    scopus 로고
    • XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients
    • Torgerson JS, Hauptman J, Boldrin MN, Sjostrom L. XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care 2004; 27: 155-161.
    • (2004) Diabetes Care , vol.27 , pp. 155-161
    • Torgerson, J.S.1    Hauptman, J.2    Boldrin, M.N.3    Sjostrom, L.4
  • 22
    • 73949084345 scopus 로고    scopus 로고
    • Weight loss, HbA1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: comparison with orlistat (Xenical)
    • Kopelman P, Groot Gde H, Rissanen A etal. Weight loss, HbA1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: comparison with orlistat (Xenical). Obesity (Silver Spring) 2010; 18: 108-115.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 108-115
    • Kopelman, P.1    Groot Gde, H.2    Rissanen, A.3
  • 23
    • 33847261129 scopus 로고    scopus 로고
    • Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients
    • Kopelman P, Bryson A, Hickling R etal. Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients. Int J Obes (Lond) 2007; 31: 494-499.
    • (2007) Int J Obes (Lond) , vol.31 , pp. 494-499
    • Kopelman, P.1    Bryson, A.2    Hickling, R.3
  • 24
    • 84899628188 scopus 로고    scopus 로고
    • Norgine. [WWW document], (accessed February 2014)
    • Norgine. Norgine acquires cetilistat. 2009. [WWW document]. URL http://www.norgine.com/downloads/pr_archive/Norgine%20aquires%20cetilistat_2.pdf (accessed February 2014).
    • (2009) Norgine acquires cetilistat
  • 25
    • 33645782262 scopus 로고    scopus 로고
    • Obesity drugs in clinical development
    • Halford JC. Obesity drugs in clinical development. Curr Opin Investig Drugs 2006; 7: 312-318.
    • (2006) Curr Opin Investig Drugs , vol.7 , pp. 312-318
    • Halford, J.C.1
  • 26
    • 67650096808 scopus 로고    scopus 로고
    • Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism
    • Shi Y, Cheng D. Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism. Am J Physiol Endocrinol Metab 2009; 297: E10-E18.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Shi, Y.1    Cheng, D.2
  • 27
    • 14744304497 scopus 로고    scopus 로고
    • Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice
    • Chen HC, Farese RV Jr. Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice. Arterioscler Thromb Vasc Biol 2005; 25: 482-486.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 482-486
    • Chen, H.C.1    Farese Jr., R.V.2
  • 28
    • 33947104623 scopus 로고    scopus 로고
    • Catalytic properties of MGAT3, a putative triacylglycerol synthase
    • Cao J, Cheng L, Shi Y. Catalytic properties of MGAT3, a putative triacylglycerol synthase. J Lipid Res 2007; 48: 583-591.
    • (2007) J Lipid Res , vol.48 , pp. 583-591
    • Cao, J.1    Cheng, L.2    Shi, Y.3
  • 29
    • 64149083743 scopus 로고    scopus 로고
    • Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding
    • Yen CL, Cheong ML, Grueter C etal. Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nat Med 2009; 15: 442-446.
    • (2009) Nat Med , vol.15 , pp. 442-446
    • Yen, C.L.1    Cheong, M.L.2    Grueter, C.3
  • 30
    • 24344498306 scopus 로고    scopus 로고
    • Changes in GI hormones and their effect on gastric emptying and transit times after Roux-en-Y gastric bypass in rat model
    • Suzuki S, Ramos EJ, Goncalves CG, Chen C, Meguid MM. Changes in GI hormones and their effect on gastric emptying and transit times after Roux-en-Y gastric bypass in rat model. Surgery 2005; 138: 283-290.
    • (2005) Surgery , vol.138 , pp. 283-290
    • Suzuki, S.1    Ramos, E.J.2    Goncalves, C.G.3    Chen, C.4    Meguid, M.M.5
  • 31
    • 57649233035 scopus 로고    scopus 로고
    • Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption
    • Cheng D, Iqbal J, Devenny J etal. Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption. J Biol Chem 2008; 283: 29802-29811.
    • (2008) J Biol Chem , vol.283 , pp. 29802-29811
    • Cheng, D.1    Iqbal, J.2    Devenny, J.3
  • 32
    • 20444405347 scopus 로고    scopus 로고
    • Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1
    • Yamazaki T, Sasaki E, Kakinuma C, Yano T, Miura S, Ezaki O. Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1. J Biol Chem 2005; 280: 21506-21514.
    • (2005) J Biol Chem , vol.280 , pp. 21506-21514
    • Yamazaki, T.1    Sasaki, E.2    Kakinuma, C.3    Yano, T.4    Miura, S.5    Ezaki, O.6
  • 33
    • 39149122218 scopus 로고    scopus 로고
    • Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor
    • Zhao G, Souers AJ, Voorbach M etal. Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J Med Chem 2008; 51: 380-383.
    • (2008) J Med Chem , vol.51 , pp. 380-383
    • Zhao, G.1    Souers, A.J.2    Voorbach, M.3
  • 34
    • 43249096797 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism
    • Hussain MM, Rava P, Pan X etal. Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism. Curr Opin Lipidol 2008; 19: 277-284.
    • (2008) Curr Opin Lipidol , vol.19 , pp. 277-284
    • Hussain, M.M.1    Rava, P.2    Pan, X.3
  • 35
    • 56549091924 scopus 로고    scopus 로고
    • New approaches to target microsomal triglyceride transfer protein
    • Hussain MM, Bakillah A. New approaches to target microsomal triglyceride transfer protein. Curr Opin Lipidol 2008; 19: 572-578.
    • (2008) Curr Opin Lipidol , vol.19 , pp. 572-578
    • Hussain, M.M.1    Bakillah, A.2
  • 36
    • 33845922351 scopus 로고    scopus 로고
    • Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis
    • Spann NJ, Kang S, Li AC etal. Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis. J Biol Chem 2006; 281: 33066-33077.
    • (2006) J Biol Chem , vol.281 , pp. 33066-33077
    • Spann, N.J.1    Kang, S.2    Li, A.C.3
  • 37
    • 0242290829 scopus 로고    scopus 로고
    • CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans
    • Chandler CE, Wilder DE, Pettini JL etal. CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans. J Lipid Res 2003; 44: 1887-1901.
    • (2003) J Lipid Res , vol.44 , pp. 1887-1901
    • Chandler, C.E.1    Wilder, D.E.2    Pettini, J.L.3
  • 38
    • 34249829862 scopus 로고    scopus 로고
    • Efficacy and safety of dirlotapide in the management of obese dogs evaluated in two placebo-controlled, masked clinical studies in North America
    • Wren JA, Ramudo AA, Campbell SL etal. Efficacy and safety of dirlotapide in the management of obese dogs evaluated in two placebo-controlled, masked clinical studies in North America. J Vet Pharmacol Ther 2007; 30(Suppl. 1): 81-89.
    • (2007) J Vet Pharmacol Ther , vol.30 , Issue.SUPPL. 1 , pp. 81-89
    • Wren, J.A.1    Ramudo, A.A.2    Campbell, S.L.3
  • 39
    • 33646071789 scopus 로고    scopus 로고
    • Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents
    • Li J, Bertinato P, Cheng H etal. Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents. Bioorg Med Chem Lett 2006; 16: 3039-3042.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 3039-3042
    • Li, J.1    Bertinato, P.2    Cheng, H.3
  • 40
    • 84861346519 scopus 로고    scopus 로고
    • Drugs.com, [WWW document], (accessed February 2014)
    • Drugs.com . Surface Logix achieves objectives with SLx-4090 in phase 2a clinical trial. 2008. [WWW document]. URL http://www.drugs.com/clinical_trials/surface-logix-achieves-objectives-slx-4090-phase-2a-clinical-trial-3277.html (accessed February 2014).
    • (2008) Surface Logix achieves objectives with SLx-4090 in phase 2a clinical trial
  • 42
    • 79959381980 scopus 로고    scopus 로고
    • JNJ-16269110, an enterically targeted microsomal triglyceride transfer protein inhibitor, lowers body weight in overweight/obese subjects
    • Van Gaal L, Vercruysse F, Wajs E, Xie J, Ways D, van Nueten L. JNJ-16269110, an enterically targeted microsomal triglyceride transfer protein inhibitor, lowers body weight in overweight/obese subjects. Obes Rev 2010; 11(Suppl. 1): 42.
    • (2010) Obes Rev , vol.11 , Issue.SUPPL. 1 , pp. 42
    • Van Gaal, L.1    Vercruysse, F.2    Wajs, E.3    Xie, J.4    Ways, D.5    van Nueten, L.6
  • 43
    • 58149357463 scopus 로고    scopus 로고
    • Sodium-glucose co-transporter-2 inhibitors: an emerging new class of oral antidiabetic drug
    • Idris I, Donnelly R. Sodium-glucose co-transporter-2 inhibitors: an emerging new class of oral antidiabetic drug. Diabetes Obes Metab 2009; 11: 79-88.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 79-88
    • Idris, I.1    Donnelly, R.2
  • 44
    • 84885749877 scopus 로고    scopus 로고
    • Pharmaceutical approval update
    • Goldenberg MM. Pharmaceutical approval update. P T 2013; 38: 443-445.
    • (2013) P T , vol.38 , pp. 443-445
    • Goldenberg, M.M.1
  • 45
    • 84875157685 scopus 로고    scopus 로고
    • SGLT inhibitors: a novel target for diabetes
    • Kanwal A, Banerjee SK. SGLT inhibitors: a novel target for diabetes. Pharm Pat Anal 2013; 2: 77-91.
    • (2013) Pharm Pat Anal , vol.2 , pp. 77-91
    • Kanwal, A.1    Banerjee, S.K.2
  • 46
    • 84899633117 scopus 로고    scopus 로고
    • Prescribing FORXIGA®: clinical experience. [WWW document], (accessed February 2014)
    • Squibb B-M. Prescribing FORXIGA®: clinical experience. 2013. [WWW document]. URL http://www.forxiga.eu/node/65 (accessed February 2014).
    • (2013)
    • Squibb, B.-M.1
  • 47
    • 84873960885 scopus 로고    scopus 로고
    • Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial
    • Bailey CJ, Gross JL, Hennicken D, Iqbal N, Mansfield TA. Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Med 2013; 11: 43.
    • (2013) BMC Med , vol.11 , pp. 43
    • Bailey, C.J.1    Gross, J.L.2    Hennicken, D.3    Iqbal, N.4    Mansfield, T.A.5
  • 48
    • 80155124676 scopus 로고    scopus 로고
    • Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial
    • Nauck MA, Del Prato S, Meier JJ etal. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care 2011; 34: 2015-2022.
    • (2011) Diabetes Care , vol.34 , pp. 2015-2022
    • Nauck, M.A.1    Del Prato, S.2    Meier, J.J.3
  • 49
    • 84899603337 scopus 로고    scopus 로고
    • The role of kidney in glucose homeostasis - SGLT2 inhibitors, a new approach in diabetes treatment
    • Andrianesis V, Doupis J. The role of kidney in glucose homeostasis - SGLT2 inhibitors, a new approach in diabetes treatment. Expert Rev Clin Pharmacol 2013; 6: 519-539.
    • (2013) Expert Rev Clin Pharmacol , vol.6 , pp. 519-539
    • Andrianesis, V.1    Doupis, J.2
  • 50
    • 84858020943 scopus 로고    scopus 로고
    • Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
    • Bolinder J, Ljunggren O, Kullberg J etal. Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. J Clin Endocrinol Metab 2012; 97: 1020-1031.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1020-1031
    • Bolinder, J.1    Ljunggren, O.2    Kullberg, J.3
  • 51
    • 84864371186 scopus 로고    scopus 로고
    • Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats
    • Devenny JJ, Godonis HE, Harvey SJ, Rooney S, Cullen MJ, Pelleymounter MA. Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats. Obesity (Silver Spring) 2012; 20: 1645-1652.
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 1645-1652
    • Devenny, J.J.1    Godonis, H.E.2    Harvey, S.J.3    Rooney, S.4    Cullen, M.J.5    Pelleymounter, M.A.6
  • 52
    • 0035970805 scopus 로고    scopus 로고
    • Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
    • Abu-Elheiga L, Matzuk MM, Abo-Hashema KA, Wakil SJ. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 2001; 291: 2613-2616.
    • (2001) Science , vol.291 , pp. 2613-2616
    • Abu-Elheiga, L.1    Matzuk, M.M.2    Abo-Hashema, K.A.3    Wakil, S.J.4
  • 53
    • 79960130715 scopus 로고    scopus 로고
    • Targeting thermogenesis and related pathways in anti-obesity drug discovery
    • Clapham JC, Arch JR. Targeting thermogenesis and related pathways in anti-obesity drug discovery. Pharmacol Ther 2011; 131: 295-308.
    • (2011) Pharmacol Ther , vol.131 , pp. 295-308
    • Clapham, J.C.1    Arch, J.R.2
  • 54
    • 0034730532 scopus 로고    scopus 로고
    • The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
    • Miyazaki M, Kim YC, Gray-Keller MP, Attie AD, Ntambi JM. The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J Biol Chem 2000; 275: 30132-30138.
    • (2000) J Biol Chem , vol.275 , pp. 30132-30138
    • Miyazaki, M.1    Kim, Y.C.2    Gray-Keller, M.P.3    Attie, A.D.4    Ntambi, J.M.5
  • 55
    • 0037143752 scopus 로고    scopus 로고
    • Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    • Ntambi JM, Miyazaki M, Stoehr JP etal. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A 2002; 99: 11482-11486.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11482-11486
    • Ntambi, J.M.1    Miyazaki, M.2    Stoehr, J.P.3
  • 56
    • 0034847971 scopus 로고    scopus 로고
    • Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid
    • Miyazaki M, Man WC, Ntambi JM. Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. J Nutr 2001; 131: 2260-2268.
    • (2001) J Nutr , vol.131 , pp. 2260-2268
    • Miyazaki, M.1    Man, W.C.2    Ntambi, J.M.3
  • 57
    • 54049132164 scopus 로고    scopus 로고
    • Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis
    • Brown JM, Chung S, Sawyer JK etal. Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. Circulation 2008; 118: 1467-1475.
    • (2008) Circulation , vol.118 , pp. 1467-1475
    • Brown, J.M.1    Chung, S.2    Sawyer, J.K.3
  • 58
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: human gut microbes associated with obesity
    • Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature 2006; 444: 1022-1023.
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 59
    • 77949363140 scopus 로고    scopus 로고
    • Vancomycin treatment of infective endocarditis is linked with recently acquired obesity
    • Thuny F, Richet H, Casalta JP, Angelakis E, Habib G, Raoult D. Vancomycin treatment of infective endocarditis is linked with recently acquired obesity. PLoS ONE 2010; 5: e9074.
    • (2010) PLoS ONE , vol.5
    • Thuny, F.1    Richet, H.2    Casalta, J.P.3    Angelakis, E.4    Habib, G.5    Raoult, D.6
  • 61
    • 56749154840 scopus 로고    scopus 로고
    • A gut feeling for obesity: 7TM sensors on enteroendocrine cells
    • Engelstoft MS, Egerod KL, Holst B, Schwartz TW. A gut feeling for obesity: 7TM sensors on enteroendocrine cells. Cell Metab 2008; 8: 447-449.
    • (2008) Cell Metab , vol.8 , pp. 447-449
    • Engelstoft, M.S.1    Egerod, K.L.2    Holst, B.3    Schwartz, T.W.4
  • 62
    • 77953169046 scopus 로고    scopus 로고
    • Cellular bioenergetics as a target for obesity therapy
    • Tseng YH, Cypess AM, Kahn CR. Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov 2010; 9: 465-482.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 465-482
    • Tseng, Y.H.1    Cypess, A.M.2    Kahn, C.R.3
  • 64
    • 84874347069 scopus 로고    scopus 로고
    • Therapeutic prospects of metabolically active brown adipose tissue in humans
    • Betz MJ, Enerback S. Therapeutic prospects of metabolically active brown adipose tissue in humans. Front Endocrinol (Lausanne) 2011; 2: 86.
    • (2011) Front Endocrinol (Lausanne) , vol.2 , pp. 86
    • Betz, M.J.1    Enerback, S.2
  • 65
    • 64049099095 scopus 로고    scopus 로고
    • Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes
    • Baxter JD, Webb P. Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov 2009; 8: 308-320.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 308-320
    • Baxter, J.D.1    Webb, P.2
  • 66
    • 84863104137 scopus 로고    scopus 로고
    • Selective thyromimetics using receptor and tissue selectivity approaches: prospects for dyslipidemia
    • Joharapurkar AA, Dhote VV, Jain MR. Selective thyromimetics using receptor and tissue selectivity approaches: prospects for dyslipidemia. J Med Chem 2012; 55: 5649-5675.
    • (2012) J Med Chem , vol.55 , pp. 5649-5675
    • Joharapurkar, A.A.1    Dhote, V.V.2    Jain, M.R.3
  • 67
    • 78650309921 scopus 로고    scopus 로고
    • Lipid lowering with thyroid hormone and thyromimetics
    • Angelin B, Rudling M. Lipid lowering with thyroid hormone and thyromimetics. Curr Opin Lipidol 2010; 21: 499-506.
    • (2010) Curr Opin Lipidol , vol.21 , pp. 499-506
    • Angelin, B.1    Rudling, M.2
  • 68
    • 84871386807 scopus 로고    scopus 로고
    • Thyroid hormone analogues for the treatment of metabolic disorders: new potential for unmet clinical needs?
    • Shoemaker TJ, Kono T, Mariash CN, Evans-Molina C. Thyroid hormone analogues for the treatment of metabolic disorders: new potential for unmet clinical needs? Endocr Pract 2012; 18: 954-964.
    • (2012) Endocr Pract , vol.18 , pp. 954-964
    • Shoemaker, T.J.1    Kono, T.2    Mariash, C.N.3    Evans-Molina, C.4
  • 69
    • 49649120105 scopus 로고    scopus 로고
    • Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor beta subtype selective agonist KB-141
    • Bryzgalova G, Effendic S, Khan A etal. Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor beta subtype selective agonist KB-141. J Steroid Biochem Mol Biol 2008; 111: 262-267.
    • (2008) J Steroid Biochem Mol Biol , vol.111 , pp. 262-267
    • Bryzgalova, G.1    Effendic, S.2    Khan, A.3
  • 70
    • 0042734823 scopus 로고    scopus 로고
    • Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability
    • Grover GJ, Mellstrom K, Ye L etal. Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability. Proc Natl Acad Sci U S A 2003; 100: 10067-10072.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10067-10072
    • Grover, G.J.1    Mellstrom, K.2    Ye, L.3
  • 71
    • 34247344167 scopus 로고    scopus 로고
    • Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats
    • Villicev CM, Freitas FR, Aoki MS etal. Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol 2007; 193: 21-29.
    • (2007) J Endocrinol , vol.193 , pp. 21-29
    • Villicev, C.M.1    Freitas, F.R.2    Aoki, M.S.3
  • 72
    • 1642505721 scopus 로고    scopus 로고
    • Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine
    • Grover GJ, Egan DM, Sleph PG etal. Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3, 5, 3'-triiodo-L-thyronine. Endocrinology 2004; 145: 1656-1661.
    • (2004) Endocrinology , vol.145 , pp. 1656-1661
    • Grover, G.J.1    Egan, D.M.2    Sleph, P.G.3
  • 73
    • 79551673577 scopus 로고    scopus 로고
    • Sobetirome: a selective thyromimetic for the treatment of dyslipidemia
    • Tancevski I, Demetz E, Eller P. Sobetirome: a selective thyromimetic for the treatment of dyslipidemia. Recent Pat Cardiovasc Drug Discov 2011; 6: 16-19.
    • (2011) Recent Pat Cardiovasc Drug Discov , vol.6 , pp. 16-19
    • Tancevski, I.1    Demetz, E.2    Eller, P.3
  • 74
    • 38649135692 scopus 로고    scopus 로고
    • The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans
    • Berkenstam A, Kristensen J, Mellstrom K etal. The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc Natl Acad Sci U S A 2008; 105: 663-667.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 663-667
    • Berkenstam, A.1    Kristensen, J.2    Mellstrom, K.3
  • 75
    • 70349326314 scopus 로고    scopus 로고
    • Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion
    • Sangiao-Alvarellos S, Vazquez MJ, Varela L etal. Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion. Endocrinology 2009; 150: 4562-4574.
    • (2009) Endocrinology , vol.150 , pp. 4562-4574
    • Sangiao-Alvarellos, S.1    Vazquez, M.J.2    Varela, L.3
  • 76
    • 77952584236 scopus 로고    scopus 로고
    • Central and peripheral molecular targets for antiobesity pharmacotherapy
    • Valentino MA, Lin JE, Waldman SA. Central and peripheral molecular targets for antiobesity pharmacotherapy. Clin Pharmacol Ther 2010; 87: 652-662.
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 652-662
    • Valentino, M.A.1    Lin, J.E.2    Waldman, S.A.3
  • 77
    • 0038030838 scopus 로고    scopus 로고
    • Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity
    • Tomlinson JW, Crabtree N, Clark PM etal. Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity. J Clin Endocrinol Metab 2003; 88: 2113-2118.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2113-2118
    • Tomlinson, J.W.1    Crabtree, N.2    Clark, P.M.3
  • 78
    • 34447126377 scopus 로고    scopus 로고
    • Growth hormone reduces inflammation in postmenopausal women with abdominal obesity: a 12-month, randomized, placebo-controlled trial
    • Franco C, Andersson B, Lonn L, Bengtsson BA, Svensson J, Johannsson G. Growth hormone reduces inflammation in postmenopausal women with abdominal obesity: a 12-month, randomized, placebo-controlled trial. J Clin Endocrinol Metab 2007; 92: 2644-2647.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2644-2647
    • Franco, C.1    Andersson, B.2    Lonn, L.3    Bengtsson, B.A.4    Svensson, J.5    Johannsson, G.6
  • 79
    • 84859415664 scopus 로고    scopus 로고
    • Effects of GH in women with abdominal adiposity: a 6-month randomized, double-blind, placebo-controlled trial
    • Bredella MA, Lin E, Brick DJ etal. Effects of GH in women with abdominal adiposity: a 6-month randomized, double-blind, placebo-controlled trial. Eur J Endocrinol 2012; 166: 601-611.
    • (2012) Eur J Endocrinol , vol.166 , pp. 601-611
    • Bredella, M.A.1    Lin, E.2    Brick, D.J.3
  • 80
    • 33847178297 scopus 로고    scopus 로고
    • The effects of recombinant human growth hormone (rhGH) supplementation on adipokines and C-reactive protein in obese subjects
    • Albert SG, Haas MJ, Mooradian AD. The effects of recombinant human growth hormone (rhGH) supplementation on adipokines and C-reactive protein in obese subjects. Growth Horm IGF Res 2007; 17: 19-25.
    • (2007) Growth Horm IGF Res , vol.17 , pp. 19-25
    • Albert, S.G.1    Haas, M.J.2    Mooradian, A.D.3
  • 81
    • 34447105433 scopus 로고    scopus 로고
    • Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target
    • Wamil M, Seckl JR. Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target. Drug Discov Today 2007; 12: 504-520.
    • (2007) Drug Discov Today , vol.12 , pp. 504-520
    • Wamil, M.1    Seckl, J.R.2
  • 82
    • 0037645827 scopus 로고    scopus 로고
    • Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice
    • Liu Y, Nakagawa Y, Wang Y etal. Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice. Diabetes 2003; 52: 1409-1416.
    • (2003) Diabetes , vol.52 , pp. 1409-1416
    • Liu, Y.1    Nakagawa, Y.2    Wang, Y.3
  • 83
    • 0034463972 scopus 로고    scopus 로고
    • Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats
    • Livingstone DE, Jones GC, Smith K etal. Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology 2000; 141: 560-563.
    • (2000) Endocrinology , vol.141 , pp. 560-563
    • Livingstone, D.E.1    Jones, G.C.2    Smith, K.3
  • 84
    • 72449133267 scopus 로고    scopus 로고
    • Obesity and corticosteroids: 11beta-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease
    • Morton NM. Obesity and corticosteroids: 11beta-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease. Mol Cell Endocrinol 2010; 316: 154-164.
    • (2010) Mol Cell Endocrinol , vol.316 , pp. 154-164
    • Morton, N.M.1
  • 85
    • 12144291638 scopus 로고    scopus 로고
    • Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice
    • Morton NM, Paterson JM, Masuzaki H etal. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 2004; 53: 931-938.
    • (2004) Diabetes , vol.53 , pp. 931-938
    • Morton, N.M.1    Paterson, J.M.2    Masuzaki, H.3
  • 86
    • 33747598035 scopus 로고    scopus 로고
    • 11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: a novel constraint to hyperphagia?
    • Densmore VS, Morton NM, Mullins JJ, Seckl JR. 11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: a novel constraint to hyperphagia? Endocrinology 2006; 147: 4486-4495.
    • (2006) Endocrinology , vol.147 , pp. 4486-4495
    • Densmore, V.S.1    Morton, N.M.2    Mullins, J.J.3    Seckl, J.R.4
  • 87
    • 84855169857 scopus 로고    scopus 로고
    • Inhibition of 11beta-hydroxysteroid dehydrogenase 1 by carbenoxolone affects glucose homeostasis and obesity in db/db mice
    • Dhanesha N, Joharapurkar A, Shah G etal. Inhibition of 11beta-hydroxysteroid dehydrogenase 1 by carbenoxolone affects glucose homeostasis and obesity in db/db mice. Clin Exp Pharmacol Physiol 2012; 39: 69-77.
    • (2012) Clin Exp Pharmacol Physiol , vol.39 , pp. 69-77
    • Dhanesha, N.1    Joharapurkar, A.2    Shah, G.3
  • 88
    • 0242468543 scopus 로고    scopus 로고
    • Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains
    • Alberts P, Nilsson C, Selen G etal. Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology 2003; 144: 4755-4762.
    • (2003) Endocrinology , vol.144 , pp. 4755-4762
    • Alberts, P.1    Nilsson, C.2    Selen, G.3
  • 89
    • 23944493717 scopus 로고    scopus 로고
    • 11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
    • Hermanowski-Vosatka A, Balkovec JM, Cheng K etal. 11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J Exp Med 2005; 202: 517-527.
    • (2005) J Exp Med , vol.202 , pp. 517-527
    • Hermanowski-Vosatka, A.1    Balkovec, J.M.2    Cheng, K.3
  • 90
    • 43949124158 scopus 로고    scopus 로고
    • 2-Amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice
    • Johansson L, Fotsch C, Bartberger MD etal. 2-Amino-1, 3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice. J Med Chem 2008; 51: 2933-2943.
    • (2008) J Med Chem , vol.51 , pp. 2933-2943
    • Johansson, L.1    Fotsch, C.2    Bartberger, M.D.3
  • 91
    • 84870904243 scopus 로고    scopus 로고
    • 11Beta-hydroxysteroid dehydrogenase type 1 inhibitors: novel agents for the treatment of metabolic syndrome and obesity-related disorders?
    • Anagnostis P, Katsiki N, Adamidou F etal. 11Beta-hydroxysteroid dehydrogenase type 1 inhibitors: novel agents for the treatment of metabolic syndrome and obesity-related disorders? Metabolism 2013; 62: 21-33.
    • (2013) Metabolism , vol.62 , pp. 21-33
    • Anagnostis, P.1    Katsiki, N.2    Adamidou, F.3
  • 92
    • 0029761541 scopus 로고    scopus 로고
    • Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues
    • Deng C, Paoloni-Giacobino A, Kuehne F etal. Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues. Br J Pharmacol 1996; 118: 929-934.
    • (1996) Br J Pharmacol , vol.118 , pp. 929-934
    • Deng, C.1    Paoloni-Giacobino, A.2    Kuehne, F.3
  • 93
    • 0020518690 scopus 로고
    • Characterization of the beta-adrenoceptor of the adipose cell of the rat
    • Tan S, Curtis-Prior PB. Characterization of the beta-adrenoceptor of the adipose cell of the rat. Int J Obes 1983; 7: 409-414.
    • (1983) Int J Obes , vol.7 , pp. 409-414
    • Tan, S.1    Curtis-Prior, P.B.2
  • 94
    • 0021591281 scopus 로고
    • Treatment of obesity with thermogenic beta-adrenoceptor agonists: studies on BRL 26830A in rodents
    • Arch JR, Ainsworth AT, Ellis RD etal. Treatment of obesity with thermogenic beta-adrenoceptor agonists: studies on BRL 26830A in rodents. Int J Obes 1984; 8(Suppl. 1): 1-11.
    • (1984) Int J Obes , vol.8 , Issue.SUPPL. 1 , pp. 1-11
    • Arch, J.R.1    Ainsworth, A.T.2    Ellis, R.D.3
  • 95
    • 0020557241 scopus 로고
    • Thermogenic and antiobesity activity of a novel beta-adrenoceptor agonist (BRL 26830A) in mice and rats
    • Arch JR, Ainsworth AT. Thermogenic and antiobesity activity of a novel beta-adrenoceptor agonist (BRL 26830A) in mice and rats. Am J Clin Nutr 1983; 38: 549-558.
    • (1983) Am J Clin Nutr , vol.38 , pp. 549-558
    • Arch, J.R.1    Ainsworth, A.T.2
  • 96
    • 69249217866 scopus 로고    scopus 로고
    • Drug treatment of obesity: established and emerging therapies
    • Isidro ML, Cordido F. Drug treatment of obesity: established and emerging therapies. Mini Rev Med Chem 2009; 9: 664-673.
    • (2009) Mini Rev Med Chem , vol.9 , pp. 664-673
    • Isidro, M.L.1    Cordido, F.2
  • 97
    • 4544357340 scopus 로고    scopus 로고
    • Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism
    • Collins S, Cao W, Robidoux J. Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. Mol Endocrinol 2004; 18: 2123-2131.
    • (2004) Mol Endocrinol , vol.18 , pp. 2123-2131
    • Collins, S.1    Cao, W.2    Robidoux, J.3
  • 98
    • 0036783754 scopus 로고    scopus 로고
    • Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men
    • Larsen TM, Toubro S, van Baak MA etal. Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men. Am J Clin Nutr 2002; 76: 780-788.
    • (2002) Am J Clin Nutr , vol.76 , pp. 780-788
    • Larsen, T.M.1    Toubro, S.2    van Baak, M.A.3
  • 99
    • 33846961446 scopus 로고    scopus 로고
    • Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: a double-blind, placebo-controlled randomized study
    • Redman LM, de Jonge L, Fang X etal. Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: a double-blind, placebo-controlled randomized study. J Clin Endocrinol Metab 2007; 92: 527-531.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 527-531
    • Redman, L.M.1    de Jonge, L.2    Fang, X.3
  • 100
    • 0029938016 scopus 로고    scopus 로고
    • Antiobesity effect of diazoxide in obese Zucker rats
    • Alemzadeh R, Jacobs W, Pitukcheewanont P. Antiobesity effect of diazoxide in obese Zucker rats. Metabolism 1996; 45: 334-341.
    • (1996) Metabolism , vol.45 , pp. 334-341
    • Alemzadeh, R.1    Jacobs, W.2    Pitukcheewanont, P.3
  • 101
    • 0027305388 scopus 로고
    • Modification of insulin resistance by diazoxide in obese Zucker rats
    • Alemzadeh R, Slonim AE, Zdanowicz MM, Maturo J. Modification of insulin resistance by diazoxide in obese Zucker rats. Endocrinology 1993; 133: 705-712.
    • (1993) Endocrinology , vol.133 , pp. 705-712
    • Alemzadeh, R.1    Slonim, A.E.2    Zdanowicz, M.M.3    Maturo, J.4
  • 102
    • 34347380139 scopus 로고    scopus 로고
    • No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet
    • Due A, Flint A, Eriksen G etal. No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet. Diabetes Obes Metab 2007; 9: 566-574.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 566-574
    • Due, A.1    Flint, A.2    Eriksen, G.3
  • 104
    • 77953291369 scopus 로고    scopus 로고
    • Sirtuins regulate key aspects of lipid metabolism
    • Lomb DJ, Laurent G, Haigis MC. Sirtuins regulate key aspects of lipid metabolism. Biochim Biophys Acta 2011; 1804: 1652-1657.
    • (2011) Biochim Biophys Acta , vol.1804 , pp. 1652-1657
    • Lomb, D.J.1    Laurent, G.2    Haigis, M.C.3
  • 106
    • 82255164629 scopus 로고    scopus 로고
    • SirT1 regulates adipose tissue inflammation
    • Gillum MP, Kotas ME, Erion DM etal. SirT1 regulates adipose tissue inflammation. Diabetes 2011; 60: 3235-3245.
    • (2011) Diabetes , vol.60 , pp. 3235-3245
    • Gillum, M.P.1    Kotas, M.E.2    Erion, D.M.3
  • 107
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge M, Argmann C, Gerhart-Hines Z etal. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006; 127: 1109-1122.
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3
  • 108
    • 84865296096 scopus 로고    scopus 로고
    • Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice
    • Bruckbauer A, Zemel MB, Thorpe T etal. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond) 2012; 9: 77.
    • (2012) Nutr Metab (Lond) , vol.9 , pp. 77
    • Bruckbauer, A.1    Zemel, M.B.2    Thorpe, T.3
  • 109
    • 63149150180 scopus 로고    scopus 로고
    • Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators
    • Bemis JE, Vu CB, Xie R etal. Discovery of oxazolo[4, 5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators. Bioorg Med Chem Lett 2009; 19: 2350-2353.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 2350-2353
    • Bemis, J.E.1    Vu, C.B.2    Xie, R.3
  • 110
    • 54849425547 scopus 로고    scopus 로고
    • Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
    • Feige JN, Lagouge M, Canto C etal. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab 2008; 8: 347-358.
    • (2008) Cell Metab , vol.8 , pp. 347-358
    • Feige, J.N.1    Lagouge, M.2    Canto, C.3
  • 111
    • 84864062918 scopus 로고    scopus 로고
    • Sirtuin 1 and sirtuin 3: physiological modulators of metabolism
    • Nogueiras R, Habegger KM, Chaudhary N etal. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev 2012; 92: 1479-1514.
    • (2012) Physiol Rev , vol.92 , pp. 1479-1514
    • Nogueiras, R.1    Habegger, K.M.2    Chaudhary, N.3
  • 112
    • 84899639816 scopus 로고    scopus 로고
    • Effects of resveratrol in patients with type 2 diabetes mellitus on skeletal muscle SIRT1 expression and energy expenditure
    • Epub ahead of print
    • Goh KP, Lee HY, Lau DP, Supaat W, Chan YH, Koh AF. Effects of resveratrol in patients with type 2 diabetes mellitus on skeletal muscle SIRT1 expression and energy expenditure. Int J Sport Nutr Exerc Metab 2013. [Epub ahead of print].
    • (2013) Int J Sport Nutr Exerc Metab
    • Goh, K.P.1    Lee, H.Y.2    Lau, D.P.3    Supaat, W.4    Chan, Y.H.5    Koh, A.F.6
  • 113
    • 80455143206 scopus 로고    scopus 로고
    • Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    • Timmers S, Konings E, Bilet L etal. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 2011; 14: 612-622.
    • (2011) Cell Metab , vol.14 , pp. 612-622
    • Timmers, S.1    Konings, E.2    Bilet, L.3
  • 114
    • 84871431259 scopus 로고    scopus 로고
    • A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers
    • Libri V, Brown AP, Gambarota G etal. A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers. PLoS ONE 2013; 7: e51395.
    • (2013) PLoS ONE , vol.7
    • Libri, V.1    Brown, A.P.2    Gambarota, G.3
  • 115
    • 42349093844 scopus 로고    scopus 로고
    • Angiogenesis and obesity
    • Lijnen HR. Angiogenesis and obesity. Cardiovasc Res 2008; 78: 286-293.
    • (2008) Cardiovasc Res , vol.78 , pp. 286-293
    • Lijnen, H.R.1
  • 116
    • 0036678477 scopus 로고    scopus 로고
    • Adipose tissue mass can be regulated through the vasculature
    • Rupnick MA, Panigrahy D, Zhang CY etal. Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A 2002; 99: 10730-10735.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10730-10735
    • Rupnick, M.A.1    Panigrahy, D.2    Zhang, C.Y.3
  • 117
    • 3042786130 scopus 로고    scopus 로고
    • Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice
    • Brakenhielm E, Cao R, Gao B etal. Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice. Circ Res 2004; 94: 1579-1588.
    • (2004) Circ Res , vol.94 , pp. 1579-1588
    • Brakenhielm, E.1    Cao, R.2    Gao, B.3
  • 118
    • 34248143523 scopus 로고    scopus 로고
    • Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732
    • Kim YM, An JJ, Jin YJ etal. Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732. J Mol Endocrinol 2007; 38: 455-465.
    • (2007) J Mol Endocrinol , vol.38 , pp. 455-465
    • Kim, Y.M.1    An, J.J.2    Jin, Y.J.3
  • 119
    • 34249719581 scopus 로고    scopus 로고
    • Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels
    • Nishimura S, Manabe I, Nagasaki M etal. Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes 2007; 56: 1517-1526.
    • (2007) Diabetes , vol.56 , pp. 1517-1526
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3
  • 120
    • 34547892290 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor receptor tyrosine kinases impairs adipose tissue development in mouse models of obesity
    • Lijnen HR, Van Hoef B, Kemp D, Collen D. Inhibition of vascular endothelial growth factor receptor tyrosine kinases impairs adipose tissue development in mouse models of obesity. Biochim Biophys Acta 2007; 1770: 1369-1373.
    • (2007) Biochim Biophys Acta , vol.1770 , pp. 1369-1373
    • Lijnen, H.R.1    Van Hoef, B.2    Kemp, D.3    Collen, D.4
  • 121
    • 84863198909 scopus 로고    scopus 로고
    • Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance
    • Elias I, Franckhauser S, Ferre T etal. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes 2012; 61: 1801-1813.
    • (2012) Diabetes , vol.61 , pp. 1801-1813
    • Elias, I.1    Franckhauser, S.2    Ferre, T.3
  • 123
    • 67349288052 scopus 로고    scopus 로고
    • TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders
    • Tiwari A, Maiti P. TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders. Drug Discov Today 2009; 14: 523-530.
    • (2009) Drug Discov Today , vol.14 , pp. 523-530
    • Tiwari, A.1    Maiti, P.2
  • 124
    • 79959525960 scopus 로고    scopus 로고
    • The bile acid membrane receptor TGR5: a valuable metabolic target
    • Pols TW, Noriega LG, Nomura M, Auwerx J, Schoonjans K. The bile acid membrane receptor TGR5: a valuable metabolic target. Dig Dis 2011; 29: 37-44.
    • (2011) Dig Dis , vol.29 , pp. 37-44
    • Pols, T.W.1    Noriega, L.G.2    Nomura, M.3    Auwerx, J.4    Schoonjans, K.5
  • 125
    • 79956088562 scopus 로고    scopus 로고
    • The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
    • Pols TW, Noriega LG, Nomura M, Auwerx J, Schoonjans K. The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. J Hepatol 2011; 54: 1263-1272.
    • (2011) J Hepatol , vol.54 , pp. 1263-1272
    • Pols, T.W.1    Noriega, L.G.2    Nomura, M.3    Auwerx, J.4    Schoonjans, K.5
  • 126
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • Thomas C, Gioiello A, Noriega L etal. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 2009; 10: 167-177.
    • (2009) Cell Metab , vol.10 , pp. 167-177
    • Thomas, C.1    Gioiello, A.2    Noriega, L.3
  • 127
    • 31444454037 scopus 로고    scopus 로고
    • Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    • Watanabe M, Houten SM, Mataki C etal. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006; 439: 484-489.
    • (2006) Nature , vol.439 , pp. 484-489
    • Watanabe, M.1    Houten, S.M.2    Mataki, C.3
  • 129
    • 77957242451 scopus 로고    scopus 로고
    • Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist
    • Rizzo G, Passeri D, De Franco F etal. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist. Mol Pharmacol 2010; 78: 617-630.
    • (2010) Mol Pharmacol , vol.78 , pp. 617-630
    • Rizzo, G.1    Passeri, D.2    De Franco, F.3
  • 130
    • 73249142867 scopus 로고    scopus 로고
    • Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity
    • Pellicciari R, Gioiello A, Macchiarulo A etal. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem 2009; 52: 7958-7961.
    • (2009) J Med Chem , vol.52 , pp. 7958-7961
    • Pellicciari, R.1    Gioiello, A.2    Macchiarulo, A.3
  • 132
    • 84884905713 scopus 로고    scopus 로고
    • Ascending dose-controlled trial of beloranib, a novel obesity treatment for safety, tolerability, and weight loss in obese women
    • Hughes TE, Kim DD, Marjason J, Proietto J, Whitehead JP, Vath JE. Ascending dose-controlled trial of beloranib, a novel obesity treatment for safety, tolerability, and weight loss in obese women. Obesity (Silver Spring) 2013; 21: 1782-1788.
    • (2013) Obesity (Silver Spring) , vol.21 , pp. 1782-1788
    • Hughes, T.E.1    Kim, D.D.2    Marjason, J.3    Proietto, J.4    Whitehead, J.P.5    Vath, J.E.6
  • 133
    • 78649974913 scopus 로고    scopus 로고
    • Fumagillin reduces adipose tissue formation in murine models of nutritionally induced obesity
    • Lijnen HR, Frederix L, Van Hoef B. Fumagillin reduces adipose tissue formation in murine models of nutritionally induced obesity. Obesity (Silver Spring) 2010; 18: 2241-2246.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 2241-2246
    • Lijnen, H.R.1    Frederix, L.2    Van Hoef, B.3
  • 134
    • 84863116720 scopus 로고    scopus 로고
    • Blockade of cannabinoid receptor 1 improves insulin resistance, lipid metabolism, and diabetic nephropathy in db/db mice
    • Nam DH, Lee MH, Kim JE etal. Blockade of cannabinoid receptor 1 improves insulin resistance, lipid metabolism, and diabetic nephropathy in db/db mice. Endocrinology 2012; 153: 1387-1396.
    • (2012) Endocrinology , vol.153 , pp. 1387-1396
    • Nam, D.H.1    Lee, M.H.2    Kim, J.E.3
  • 135
    • 84861161242 scopus 로고    scopus 로고
    • CB(1) antagonism restores hepatic insulin sensitivity without normalization of adiposity in diet-induced obese dogs
    • Kim SP, Woolcott OO, Hsu IR etal. CB(1) antagonism restores hepatic insulin sensitivity without normalization of adiposity in diet-induced obese dogs. Am J Physiol Endocrinol Metab 2012; 302: E1261-E1268.
    • (2012) Am J Physiol Endocrinol Metab , vol.302
    • Kim, S.P.1    Woolcott, O.O.2    Hsu, I.R.3
  • 136
    • 79955746716 scopus 로고    scopus 로고
    • Personalized medicine can pave the way for the safe use of CB(1) receptor antagonists
    • Lazary J, Juhasz G, Hunyady L, Bagdy G. Personalized medicine can pave the way for the safe use of CB(1) receptor antagonists. Trends Pharmacol Sci 2011; 32: 270-280.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 270-280
    • Lazary, J.1    Juhasz, G.2    Hunyady, L.3    Bagdy, G.4
  • 137
    • 84865335261 scopus 로고    scopus 로고
    • Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders
    • Silvestri C, Di Marzo V. Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders. Expert Opin Investig Drugs 2012; 21: 1309-1322.
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 1309-1322
    • Silvestri, C.1    Di Marzo, V.2
  • 138
    • 84863358433 scopus 로고    scopus 로고
    • Design and synthesis of cannabinoid receptor 1 antagonists for peripheral selectivity
    • Fulp A, Bortoff K, Seltzman H etal. Design and synthesis of cannabinoid receptor 1 antagonists for peripheral selectivity. J Med Chem 2012; 55: 2820-2834.
    • (2012) J Med Chem , vol.55 , pp. 2820-2834
    • Fulp, A.1    Bortoff, K.2    Seltzman, H.3
  • 139
    • 84881369631 scopus 로고    scopus 로고
    • Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects
    • Klumpers LE, Fridberg M, de Kam ML etal. Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects. Br J Clin Pharmacol 2013; 76: 846-857.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 846-857
    • Klumpers, L.E.1    Fridberg, M.2    de Kam, M.L.3
  • 140
    • 84894042086 scopus 로고    scopus 로고
    • Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides
    • Cinar R, Godlewski G, Liu J etal. Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides. Hepatology 2014; 59: 143-153.
    • (2014) Hepatology , vol.59 , pp. 143-153
    • Cinar, R.1    Godlewski, G.2    Liu, J.3
  • 141
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007; 132: 2131-2157.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 142
    • 79955930032 scopus 로고    scopus 로고
    • Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus
    • Koliaki C, Doupis J. Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus. Diabetes Ther 2011; 2: 101-121.
    • (2011) Diabetes Ther , vol.2 , pp. 101-121
    • Koliaki, C.1    Doupis, J.2
  • 143
    • 79953851412 scopus 로고    scopus 로고
    • Understanding the incretin effect
    • Seino Y. Understanding the incretin effect. J Clin Endocrinol Metab 2011; 96: 934-935.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 934-935
    • Seino, Y.1
  • 144
    • 75149127635 scopus 로고    scopus 로고
    • Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia
    • Deane AM, Nguyen NQ, Stevens JE etal. Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia. J Clin Endocrinol Metab 2010; 95: 215-221.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 215-221
    • Deane, A.M.1    Nguyen, N.Q.2    Stevens, J.E.3
  • 145
    • 63849248275 scopus 로고    scopus 로고
    • Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety
    • Williams DL, Baskin DG, Schwartz MW. Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety. Endocrinology 2009; 150: 1680-1687.
    • (2009) Endocrinology , vol.150 , pp. 1680-1687
    • Williams, D.L.1    Baskin, D.G.2    Schwartz, M.W.3
  • 146
    • 0021069493 scopus 로고
    • Diurnal profile of pancreatic polypeptide, pancreatic glucagon, gut glucagon and insulin in human morbid obesity
    • Holst JJ, Schwartz TW, Lovgreen NA, Pedersen O, Beck-Nielsen H. Diurnal profile of pancreatic polypeptide, pancreatic glucagon, gut glucagon and insulin in human morbid obesity. Int J Obes 1983; 7: 529-538.
    • (1983) Int J Obes , vol.7 , pp. 529-538
    • Holst, J.J.1    Schwartz, T.W.2    Lovgreen, N.A.3    Pedersen, O.4    Beck-Nielsen, H.5
  • 147
    • 84890547453 scopus 로고    scopus 로고
    • The role of glucagon-like peptide-1 impairment in obesity and potential therapeutic implications
    • Madsbad S. The role of glucagon-like peptide-1 impairment in obesity and potential therapeutic implications. Diabetes Obes Metab 2014; 16: 9-21.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 9-21
    • Madsbad, S.1
  • 148
    • 48449093468 scopus 로고    scopus 로고
    • Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients
    • Muscelli E, Mari A, Casolaro A etal. Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients. Diabetes 2008; 57: 1340-1348.
    • (2008) Diabetes , vol.57 , pp. 1340-1348
    • Muscelli, E.1    Mari, A.2    Casolaro, A.3
  • 149
    • 0032924425 scopus 로고    scopus 로고
    • Inhibition of carbohydrate-mediated glucagon-like peptide-1 (7-36)amide secretion by circulating non-esterified fatty acids
    • Ranganath L, Norris F, Morgan L, Wright J, Marks V. Inhibition of carbohydrate-mediated glucagon-like peptide-1 (7-36)amide secretion by circulating non-esterified fatty acids. Clin Sci (Lond) 1999; 96: 335-342.
    • (1999) Clin Sci (Lond) , vol.96 , pp. 335-342
    • Ranganath, L.1    Norris, F.2    Morgan, L.3    Wright, J.4    Marks, V.5
  • 150
    • 0037315423 scopus 로고    scopus 로고
    • Role of leptin in the regulation of glucagon-like peptide-1 secretion
    • Anini Y, Brubaker PL. Role of leptin in the regulation of glucagon-like peptide-1 secretion. Diabetes 2003; 52: 252-259.
    • (2003) Diabetes , vol.52 , pp. 252-259
    • Anini, Y.1    Brubaker, P.L.2
  • 153
    • 77956090389 scopus 로고    scopus 로고
    • Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes
    • Rosenstock J, Klaff LJ, Schwartz S etal. Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes. Diabetes Care 2010; 33: 1173-1175.
    • (2010) Diabetes Care , vol.33 , pp. 1173-1175
    • Rosenstock, J.1    Klaff, L.J.2    Schwartz, S.3
  • 154
    • 84859046364 scopus 로고    scopus 로고
    • Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetes
    • Dushay J, Gao C, Gopalakrishnan GS etal. Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetes. Diabetes Care 2011; 35: 4-11.
    • (2011) Diabetes Care , vol.35 , pp. 4-11
    • Dushay, J.1    Gao, C.2    Gopalakrishnan, G.S.3
  • 155
    • 84876023362 scopus 로고    scopus 로고
    • The effect of glucagon-like peptide-1 receptor agonist therapy on body mass index in adolescents with severe obesity: a randomized, placebo-controlled, clinical trial
    • Kelly AS, Rudser KD, Nathan BM etal. The effect of glucagon-like peptide-1 receptor agonist therapy on body mass index in adolescents with severe obesity: a randomized, placebo-controlled, clinical trial. JAMA Pediatr 2013; 167: 355-360.
    • (2013) JAMA Pediatr , vol.167 , pp. 355-360
    • Kelly, A.S.1    Rudser, K.D.2    Nathan, B.M.3
  • 156
    • 77953828230 scopus 로고    scopus 로고
    • DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks
    • Buse JB, Drucker DJ, Taylor KL etal. DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks. Diabetes Care 2010; 33: 1255-1261.
    • (2010) Diabetes Care , vol.33 , pp. 1255-1261
    • Buse, J.B.1    Drucker, D.J.2    Taylor, K.L.3
  • 157
    • 84862207266 scopus 로고    scopus 로고
    • Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
    • Astrup A, Carraro R, Finer N etal. Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide. Int J Obes (Lond) 2012; 36: 843-854.
    • (2012) Int J Obes (Lond) , vol.36 , pp. 843-854
    • Astrup, A.1    Carraro, R.2    Finer, N.3
  • 158
    • 84902254986 scopus 로고    scopus 로고
    • Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults
    • Epub ahead of print
    • van Can J, Sloth B, Jensen CB, Flint A, Blaak EE, Saris WH. Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults. Int J Obes (Lond) 2013. [Epub ahead of print].
    • (2013) Int J Obes (Lond)
    • van Can, J.1    Sloth, B.2    Jensen, C.B.3    Flint, A.4    Blaak, E.E.5    Saris, W.H.6
  • 159
    • 84865984023 scopus 로고    scopus 로고
    • Patient-reported outcomes in trials of incretin-based therapies in patients with type 2 diabetes mellitus
    • Davies M, Speight J. Patient-reported outcomes in trials of incretin-based therapies in patients with type 2 diabetes mellitus. Diabetes Obes Metab 2012; 14: 882-892.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 882-892
    • Davies, M.1    Speight, J.2
  • 160
    • 84899906592 scopus 로고    scopus 로고
    • Tolerability of nausea and vomiting and associations with weight loss in a randomized trial of liraglutide in obese, non-diabetic adults
    • Epub ahead of print
    • Lean ME, Carraro R, Finer N etal. Tolerability of nausea and vomiting and associations with weight loss in a randomized trial of liraglutide in obese, non-diabetic adults. Int J Obes (Lond) 2013. [Epub ahead of print].
    • (2013) Int J Obes (Lond)
    • Lean, M.E.1    Carraro, R.2    Finer, N.3
  • 161
    • 84899660089 scopus 로고    scopus 로고
    • Incretin-based therapies: focus on effects beyond glycemic control alone
    • Davidson JA. Incretin-based therapies: focus on effects beyond glycemic control alone. Diabetes Ther 2013; 4: 221-238.
    • (2013) Diabetes Ther , vol.4 , pp. 221-238
    • Davidson, J.A.1
  • 162
    • 79960582911 scopus 로고    scopus 로고
    • Obesity - an indication for GLP-1 treatment? Obesity pathophysiology and GLP-1 treatment potential
    • Torekov SS, Madsbad S, Holst JJ. Obesity - an indication for GLP-1 treatment? Obesity pathophysiology and GLP-1 treatment potential. Obes Rev 2011; 12: 593-601.
    • (2011) Obes Rev , vol.12 , pp. 593-601
    • Torekov, S.S.1    Madsbad, S.2    Holst, J.J.3
  • 163
    • 84861890043 scopus 로고    scopus 로고
    • Outstanding Scientific Achievement Award Lecture 2011: defeating diabesity: the case for personalized combinatorial therapies
    • Tschop MH, DiMarchi RD. Outstanding Scientific Achievement Award Lecture 2011: defeating diabesity: the case for personalized combinatorial therapies. Diabetes 2012; 61: 1309-1314.
    • (2012) Diabetes , vol.61 , pp. 1309-1314
    • Tschop, M.H.1    DiMarchi, R.D.2
  • 164
    • 70349308687 scopus 로고    scopus 로고
    • A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
    • Day JW, Ottaway N, Patterson JT etal. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol 2009; 5: 749-757.
    • (2009) Nat Chem Biol , vol.5 , pp. 749-757
    • Day, J.W.1    Ottaway, N.2    Patterson, J.T.3
  • 165
    • 84866108680 scopus 로고    scopus 로고
    • Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons
    • Dietrich MO, Horvath TL. Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. Nat Rev Drug Discov 2012; 11: 675-691.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 675-691
    • Dietrich, M.O.1    Horvath, T.L.2
  • 167
    • 84897500490 scopus 로고    scopus 로고
    • Reducing the risk of obesity: defining the role of weight loss drugs
    • Ling H, Lenz TL, Burns TL, Hilleman DE. Reducing the risk of obesity: defining the role of weight loss drugs. Pharmacotherapy 2013; 33: 1308-1321.
    • (2013) Pharmacotherapy , vol.33 , pp. 1308-1321
    • Ling, H.1    Lenz, T.L.2    Burns, T.L.3    Hilleman, D.E.4
  • 168
    • 84875832818 scopus 로고    scopus 로고
    • Topiramate+phentermine. An excessively dangerous appetite-suppressant combination
    • No authors listed
    • [No authors listed]. Topiramate+phentermine. An excessively dangerous appetite-suppressant combination. Prescrire Int 2013; 22: 61-64.
    • (2013) Prescrire Int , vol.22 , pp. 61-64
  • 169
    • 84878593764 scopus 로고    scopus 로고
    • First do no harm wanti-obesity and other drugs
    • Toussaint B. First do no harm wanti-obesity and other drugs. BMJ 2013; 346: f3026.
    • (2013) BMJ , vol.346
    • Toussaint, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.