Fumagillin reduces adipose tissue formation in murine models of nutritionally induced obesity

Obesity

Volumn 18, Issue 12, 2010, Pages 2241-2246

  Lijnen, Henri R ^a   Frederix, Liesbeth ^a   Van Hoef, Berthe ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; ANGIOGENESIS INHIBITOR; ANTIOBESITY AGENT; BIOLOGICAL PRODUCT; CYCLOHEXANE DERIVATIVE; FUMAGILLIN; GLYCOPROTEIN; METAP2 PROTEIN, MOUSE; SESQUITERPENE; UNSATURATED FATTY ACID;

ADIPOSE TISSUE; ANIMAL; ARTICLE; ASPERGILLUS FUMIGATUS; BLOOD; BODY FAT DISTRIBUTION; BODY WEIGHT; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FAT INTAKE; MALE; MOUSE; OBESITY; VASCULARIZATION;

ADIPOSE TISSUE; AMINOPEPTIDASES; ANGIOGENESIS INHIBITORS; ANIMALS; ANTI-OBESITY AGENTS; ASPERGILLUS FUMIGATUS; BIOLOGICAL PRODUCTS; BODY FAT DISTRIBUTION; BODY WEIGHT; CYCLOHEXANES; DIETARY FATS; FATTY ACIDS, UNSATURATED; GLYCOPROTEINS; MALE; MICE; MICE, INBRED C57BL; OBESITY; SESQUITERPENES;

MURINAE; MUS;

EID: 78649974913     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2009.503     Document Type: Article

References (31)

1. Kopelman PG. Obesity as a medical problem. Nature 2000;404:635-643.
2. Ogden CL, Yanovski SZ, Carroll MD, Flegal KM. The epidemiology of obesity. Gastroenterology 2007;132:2087-2102.
3. Cao Y. Angiogenesis modulates adipogenesis and obesity. J Clin Invest 2007;117:2362-2368.
4. Xue Y, Petrovic N, Cao R et al. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab 2009;9: 99-109.
5. Lijnen HR. Angiogenesis and obesity. Cardiovasc Res 2008;78:286-293.
6. Rupnick MA, Panigrahy D, Zhang CY et al. Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci USA 2002;99: 10730-10735.
7. Fukumura D, Ushiyama A, Duda DG et al. Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circ Res 2003;93:e88-e97.
8. Bråkenhielm E, Cao R, Gao B et al. Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice. Circ Res 2004;94: 1579-1588.
9. Kim YM, An JJ, Jin YJ et al. Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732. J Mol Endocrinol 2007;38:455-465.
10. Liu S, Widom J, Kemp CW, Crews CM, Clardy J. Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science 1998;282:1324-1327.
11. Yeh JR, Mohan R, Crews CM. The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest. Proc Natl Acad Sci USA 2000;97:12782-12787.
12. Bernier SG, Lazarus DD, Clark E et al. A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis. Proc Natl Acad Sci USA 2004;101:10768-10773.
13. Sin N, Meng L, Wang MQ et al. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc Natl Acad Sci USA 1997;94:6099-6103.
14. Killough JH, Magill GB, Smith RC. The treatment of amebiasis with fumagillin. Science 1952;115:71-72.
15. Dipaolo JA, Tarbell DS, Moore GE. Studies on the carcinolytic activity of fumagillin and some of its derivatives. Antibiot Annu 1958;6:541-546.
16. Garvey MJ, Ambrose PG, Ulmer JL. Topical fumagillin in the treatment of microsporidial keratoconjunctivitis in AIDS. Ann Pharmacother 1995;29: 872-874.
17. Giles AR. Guidelines for the use of animals in biomedical research. Thromb Haemost 1987;58:1078-1084.
18. Demeulemeester D, Collen D, Lijnen HR. Effect of matrix metalloproteinase inhibition on adipose tissue development. Biochem Biophys Res Commun 2005;329:105-110.
19. Laitinen L. Griffonia simplicifolia lectins bind specifically to endothelial cells and some epithelial cells in mouse tissues. Histochem J 1987;19:225-234.
20. Heymans S, Lupu F, Terclavers S et al. Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. Am J Pathol 2005;166:15-25.
21. Whittaker P, Kloner RA, Boughner DR, Pickering JG. Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light. Basic Res Cardiol 1994;89:397-410.
22. Declerck PJ, Verstreken M, Collen D. Immunoassay of murine t-PA, u-PA and PAI-1 using monoclonal antibodies raised in gene-inactivated mice. Thromb Haemost 1995;74:1305-1309.
23. Montesano R, Mouron P, Orci L. Vascular outgrowths from tissue explants embedded in fibrin or collagen gels: a simple in vitro model of angiogenesis. Cell Biol Int Rep 1985;9:869-875.
24. Varzaneh FE, Shillabeer G, Wong KL, Lau DC. Extracellular matrix components secreted by microvascular endothelial cells stimulate preadipocyte differentiation in vitro. Metab Clin Exp 1994;43:906-912.
25. Planat-Benard V, Silvestre JS, Cousin B et al. Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Circulation 2004;109:656-663.
26. Traktuev DO, Prater DN, Merfeld-Clauss S et al. Robust functional vascular network formation in vivo by cooperation of adipose progenitor and endothelial cells. Circ Res 2009;104:1410-1420.
27. Kusaka M, Sudo K, Fujita T et al. Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent. Biochem Biophys Res Commun 1991;174:1070-1076.
28. Alessi MC, Bastelica D, Morange P et al. Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity. Diabetes 2000;49:1374-1380.
29. Hanusch-Enserer U, Zorn G, Wojta J et al. Non-conventional markers of atherosclerosis before and after gastric banding surgery. Eur Heart J 2009;30:1516-1524.
30. Matsuo O, Lijnen HR, Ueshima S, Kojima S, Smyth SS. A guide to murine fibrinolytic factor structure, function, assays, and genetic alterations. J Thromb Haemost 2007;5:680-689.
31. Cao R, Brakenhielm E, Wahlestedt C, Thyberg J, Cao Y. Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF. Proc Natl Acad Sci USA 2001;98:6390-6395.