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Volumn 16, Issue 1, 2014, Pages 9-21

The role of glucagon-like peptide-1 impairment in obesity and potential therapeutic implications

Author keywords

GLP 1; Obesity therapy; Type 2 diabetes

Indexed keywords

EXENDIN 4; GLIMEPIRIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; INCRETIN; INSULIN GLARGINE; LIRAGLUTIDE; METFORMIN; PIOGLITAZONE; ROSIGLITAZONE; SITAGLIPTIN;

EID: 84890547453     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12119     Document Type: Review
Times cited : (107)

References (164)
  • 1
    • 84890565557 scopus 로고    scopus 로고
    • World Health Organization. Fact Sheet 311. 2012. Available from URL:. Accessed December 2012.
    • World Health Organization. Fact Sheet 311. 2012. Available from URL: http://www.who.int/mediacentre/factsheets/fs311/en/. Accessed December 2012.
  • 2
    • 84855413061 scopus 로고    scopus 로고
    • Organisation for Economic Co-operation and Development/European Union. Health at a Glance: Europe 2010. OECD Publishing, 2010; DOI: 10.1787/health_glance-2010-en.
    • Organisation for Economic Co-operation and Development/European Union. Health at a Glance: Europe 2010. OECD Publishing, 2010; DOI: 10.1787/health_glance-2010-en.
  • 3
    • 0026781014 scopus 로고
    • Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis
    • Dattilo AM, Kris-Etherton PM. Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis. Am J Clin Nutr 1992; 56: 320-328.
    • (1992) Am J Clin Nutr , vol.56 , pp. 320-328
    • Dattilo, A.M.1    Kris-Etherton, P.M.2
  • 5
    • 77950498292 scopus 로고    scopus 로고
    • Arterial destiffening with weight loss in overweight and obese middle-aged and older adults
    • Dengo AL, Dennis EA, Orr JS et al. Arterial destiffening with weight loss in overweight and obese middle-aged and older adults. Hypertension 2010; 55: 855-861.
    • (2010) Hypertension , vol.55 , pp. 855-861
    • Dengo, A.L.1    Dennis, E.A.2    Orr, J.S.3
  • 6
    • 43849111166 scopus 로고    scopus 로고
    • The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study
    • Li G, Zhang P, Wang J et al. The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet 2008; 371: 1783-1789.
    • (2008) Lancet , vol.371 , pp. 1783-1789
    • Li, G.1    Zhang, P.2    Wang, J.3
  • 7
    • 70349776890 scopus 로고    scopus 로고
    • A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the Sleep AHEAD study
    • Sleep AHEAD Research Group of Look AHEAD Research Group.
    • Foster GD, Borradaile KE, Sanders MH et al., Sleep AHEAD Research Group of Look AHEAD Research Group. A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the Sleep AHEAD study. Arch Intern Med 2009; 169: 1619-1926.
    • (2009) Arch Intern Med , vol.169 , pp. 1619-1926
    • Foster, G.D.1    Borradaile, K.E.2    Sanders, M.H.3
  • 8
    • 0035799806 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    • Finnish Diabetes Prevention Study Group.
    • Tuomilehto J, Lindström J, Eriksson JG et al., Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344: 1343-1350.
    • (2001) N Engl J Med , vol.344 , pp. 1343-1350
    • Tuomilehto, J.1    Lindström, J.2    Eriksson, J.G.3
  • 10
    • 55849109963 scopus 로고    scopus 로고
    • Bariatric surgery: risks and rewards
    • Pories WJ. Bariatric surgery: risks and rewards. J Clin Endocrinol Metab 2008; 93: S89-96.
    • (2008) J Clin Endocrinol Metab , vol.93
    • Pories, W.J.1
  • 11
    • 84860163107 scopus 로고    scopus 로고
    • Anti-obesity drugs: a review about their effects and their safety
    • Derosa G, Maffioli P. Anti-obesity drugs: a review about their effects and their safety. Expert Opin Drug Saf 2012; 11: 459-471.
    • (2012) Expert Opin Drug Saf , vol.11 , pp. 459-471
    • Derosa, G.1    Maffioli, P.2
  • 12
    • 84890568081 scopus 로고    scopus 로고
    • Arena Pharmaceuticals. Belviq (lorcaserin hydrochloride) full prescribing information. Available from URL:. Accessed December 2012.
    • Arena Pharmaceuticals. Belviq (lorcaserin hydrochloride) full prescribing information. Available from URL: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022529lbl.pdf. Accessed December 2012.
  • 13
    • 84890570358 scopus 로고    scopus 로고
    • Vivus Inc. Qsymia (phentermine and topiramate extended-release) full prescribing information. 2012. Available from URL:. Accessed December 2012.
    • Vivus Inc. Qsymia (phentermine and topiramate extended-release) full prescribing information. 2012. Available from URL: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022580s000lbl.pdf. Accessed December 2012.
  • 15
    • 42449144221 scopus 로고    scopus 로고
    • The obesity epidemic: pharmacological challenges
    • Bloom SR, Kuhajda FP, Laher I et al. The obesity epidemic: pharmacological challenges. Mol Interv 2008; 8: 82-98.
    • (2008) Mol Interv , vol.8 , pp. 82-98
    • Bloom, S.R.1    Kuhajda, F.P.2    Laher, I.3
  • 16
    • 66649134711 scopus 로고    scopus 로고
    • Minireview. Gut peptides: targets for antiobesity drug development?
    • Moran TH, Dailey MJ. Minireview. Gut peptides: targets for antiobesity drug development? Endocrinology 2009; 150: 2526-2530.
    • (2009) Endocrinology , vol.150 , pp. 2526-2530
    • Moran, T.H.1    Dailey, M.J.2
  • 17
    • 28444467762 scopus 로고    scopus 로고
    • Signals that influence food intake and body weight
    • Woods SC. Signals that influence food intake and body weight. Physiol Behav 2005; 86: 709-716.
    • (2005) Physiol Behav , vol.86 , pp. 709-716
    • Woods, S.C.1
  • 18
    • 63849248275 scopus 로고    scopus 로고
    • Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety
    • Williams DL, Baskin DG, Schwartz MW. Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety. Endocrinology 2009; 150: 1680-1687.
    • (2009) Endocrinology , vol.150 , pp. 1680-1687
    • Williams, D.L.1    Baskin, D.G.2    Schwartz, M.W.3
  • 19
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007; 132: 2131-2157.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 20
    • 0023008693 scopus 로고
    • Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing
    • Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF. Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 1986; 261: 11880-11889.
    • (1986) J Biol Chem , vol.261 , pp. 11880-11889
    • Mojsov, S.1    Heinrich, G.2    Wilson, I.B.3    Ravazzola, M.4    Orci, L.5    Habener, J.F.6
  • 21
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007; 87: 1409-1439.
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 22
    • 0031455165 scopus 로고    scopus 로고
    • Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1
    • Rouille Y, Kantengwa S, Irminger JC, Halban PA. Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1. J Biol Chem 1997; 272: 32810-32816.
    • (1997) J Biol Chem , vol.272 , pp. 32810-32816
    • Rouille, Y.1    Kantengwa, S.2    Irminger, J.C.3    Halban, P.A.4
  • 23
    • 0023787950 scopus 로고
    • Glucagon gene expression in vertebrate brain
    • Drucker DJ, Asa S. Glucagon gene expression in vertebrate brain. J Biol Chem 1988; 263: 13475-13478.
    • (1988) J Biol Chem , vol.263 , pp. 13475-13478
    • Drucker, D.J.1    Asa, S.2
  • 24
    • 0026510891 scopus 로고
    • Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man
    • Eissele R, Göke R, Willemer S et al. Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur J Clin Invest 1992; 22: 283-291.
    • (1992) Eur J Clin Invest , vol.22 , pp. 283-291
    • Eissele, R.1    Göke, R.2    Willemer, S.3
  • 25
    • 0028838030 scopus 로고
    • Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients
    • Hermann C, Goke R, Richter G, Fehmann HC, Arnold R, Goke B. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Digestion 1995; 56: 117-126.
    • (1995) Digestion , vol.56 , pp. 117-126
    • Hermann, C.1    Goke, R.2    Richter, G.3    Fehmann, H.C.4    Arnold, R.5    Goke, B.6
  • 26
    • 0032982267 scopus 로고    scopus 로고
    • Role of the vagus nerve in mediating proximal nutrient-induced glucagon- like peptide-1 secretion
    • Rocca AS, Brubaker PL. Role of the vagus nerve in mediating proximal nutrient-induced glucagon- like peptide-1 secretion. Endocrinology 1999; 140: 1687-1694.
    • (1999) Endocrinology , vol.140 , pp. 1687-1694
    • Rocca, A.S.1    Brubaker, P.L.2
  • 27
    • 0031034854 scopus 로고    scopus 로고
    • Rapid oscillations in plasma glucagon-like peptide-1 (GLP-1) in humans: cholinergic control of GLP-1 secretion via muscarinic receptors
    • Balks HJ, Holst JJ, von zur Muhlen A, Brabant G. Rapid oscillations in plasma glucagon-like peptide-1 (GLP-1) in humans: cholinergic control of GLP-1 secretion via muscarinic receptors. J Clin Endocrinol Metab 1997; 82: 786-790.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 786-790
    • Balks, H.J.1    Holst, J.J.2    Von Zur Muhlen, A.3    Brabant, G.4
  • 28
    • 0036090456 scopus 로고    scopus 로고
    • Muscarinic receptors control postprandial release of glucagon-like peptide-1: in vivo and in vitro studies in rats
    • Anini Y, Hansotia T, Brubaker PL. Muscarinic receptors control postprandial release of glucagon-like peptide-1: in vivo and in vitro studies in rats. Endocrinology 2002; 143: 2420-2426.
    • (2002) Endocrinology , vol.143 , pp. 2420-2426
    • Anini, Y.1    Hansotia, T.2    Brubaker, P.L.3
  • 29
    • 0038310124 scopus 로고    scopus 로고
    • Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells
    • Anini Y, Brubaker PL. Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells. Endocrinology 2003; 144: 3244-3250.
    • (2003) Endocrinology , vol.144 , pp. 3244-3250
    • Anini, Y.1    Brubaker, P.L.2
  • 30
    • 0025777064 scopus 로고
    • Secretion of proglucagon-derived peptides in response to intestinal luminal nutrients
    • Roberge JN, Brubaker PL. Secretion of proglucagon-derived peptides in response to intestinal luminal nutrients. Endocrinology 1991; 128: 3169-3174.
    • (1991) Endocrinology , vol.128 , pp. 3169-3174
    • Roberge, J.N.1    Brubaker, P.L.2
  • 31
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 1993; 214: 829-835.
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 32
    • 17844399596 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors
    • Holst JJ, Deacon CF. Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors. Diabetologia 2005; 48: 612-615.
    • (2005) Diabetologia , vol.48 , pp. 612-615
    • Holst, J.J.1    Deacon, C.F.2
  • 33
    • 0037373183 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXXV. The glucagon receptor family
    • Mayo KE, Miller LJ, Bataille D et al. International Union of Pharmacology. XXXV. The glucagon receptor family. Pharmacol Rev 2003; 55: 167-194.
    • (2003) Pharmacol Rev , vol.55 , pp. 167-194
    • Mayo, K.E.1    Miller, L.J.2    Bataille, D.3
  • 34
    • 45549086826 scopus 로고    scopus 로고
    • Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain
    • Runge S, Thøgersen H, Madsen K, Lau J, Rudolph R. Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J Biol Chem 2008; 283: 11340-11347.
    • (2008) J Biol Chem , vol.283 , pp. 11340-11347
    • Runge, S.1    Thøgersen, H.2    Madsen, K.3    Lau, J.4    Rudolph, R.5
  • 35
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint A, Raben A, Astrup A, Holst JJ. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 1998; 101: 515-520.
    • (1998) J Clin Invest , vol.101 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 36
    • 0034011021 scopus 로고    scopus 로고
    • The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humans
    • Flint A, Raben A, Rehfeld JF, Holst JJ, Astrup A. The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humans. Int J Obes Relat Metab Disord 2000; 24: 288-298.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 288-298
    • Flint, A.1    Raben, A.2    Rehfeld, J.F.3    Holst, J.J.4    Astrup, A.5
  • 37
    • 78649388633 scopus 로고    scopus 로고
    • Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis
    • Edholm T, Degerblad M, Grybäck P et al. Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis. Neurogastroenterol Motil 2010; 22: 1191-1200.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 1191-1200
    • Edholm, T.1    Degerblad, M.2    Grybäck, P.3
  • 38
    • 75149127635 scopus 로고    scopus 로고
    • Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia
    • Deane AM, Nguyen NQ, Stevens JE et al. Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia. J Clin Endocrinol Metab 2010; 95: 215-221.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 215-221
    • Deane, A.M.1    Nguyen, N.Q.2    Stevens, J.E.3
  • 39
    • 30944467225 scopus 로고    scopus 로고
    • Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans
    • Schirra J, Nicolaus M, Roggel R et al. Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans. Gut 2006; 55: 243-251.
    • (2006) Gut , vol.55 , pp. 243-251
    • Schirra, J.1    Nicolaus, M.2    Roggel, R.3
  • 40
    • 33244481977 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans
    • Meier JJ, Gethmann A, Götze O et al. Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans. Diabetologia 2006; 49: 452-458.
    • (2006) Diabetologia , vol.49 , pp. 452-458
    • Meier, J.J.1    Gethmann, A.2    Götze, O.3
  • 41
    • 84866004714 scopus 로고    scopus 로고
    • Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass
    • Dirksen C, Jorgensen NB, Bojsen-Moller KN et al. Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass. Diabetologia 2012; 55: 1890-1901.
    • (2012) Diabetologia , vol.55 , pp. 1890-1901
    • Dirksen, C.1    Jorgensen, N.B.2    Bojsen-Moller, K.N.3
  • 42
    • 17944365214 scopus 로고    scopus 로고
    • A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans
    • Verdich C, Flint A, Gutzwiller JP et al. A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans. J Clin Endocrinol Metab 2001; 86: 4382-4389.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4382-4389
    • Verdich, C.1    Flint, A.2    Gutzwiller, J.P.3
  • 43
    • 13644268431 scopus 로고    scopus 로고
    • The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem
    • Alvarez E, Martínez MD, Roncero I et al. The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem. J Neurochem 2005; 92: 798-806.
    • (2005) J Neurochem , vol.92 , pp. 798-806
    • Alvarez, E.1    Martínez, M.D.2    Roncero, I.3
  • 44
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • Turton MD, O'Shea D, Gunn I et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996; 379: 69-72.
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1    O'Shea, D.2    Gunn, I.3
  • 45
    • 0034085701 scopus 로고    scopus 로고
    • Peripheral versus central effects of glucagon-like peptide-1 receptor agonists on satiety and body weight loss in Zucker obese rats
    • Rodriguez de Fonseca F, Navarro M, Alverez E, et al. Peripheral versus central effects of glucagon-like peptide-1 receptor agonists on satiety and body weight loss in Zucker obese rats. Metabolism 2000; 49: 709-717.
    • (2000) Metabolism , vol.49 , pp. 709-717
    • Rodriguez de Fonseca, F.1    Navarro, M.2    Alverez, E.3
  • 46
    • 77954102250 scopus 로고    scopus 로고
    • Hepatic-portal vein infusions of glucagon-like peptide-1 reduce meal size and increase c-Fos expression in the nucleus tractussolitarii, area postrema and central nucleus of the amygdala in rats
    • Baumgartner I, Pacheco-Lopez G, Ruttimann EB et al. Hepatic-portal vein infusions of glucagon-like peptide-1 reduce meal size and increase c-Fos expression in the nucleus tractussolitarii, area postrema and central nucleus of the amygdala in rats. J Neuroendocrinol 2010; 22: 557-563.
    • (2010) J Neuroendocrinol , vol.22 , pp. 557-563
    • Baumgartner, I.1    Pacheco-Lopez, G.2    Ruttimann, E.B.3
  • 47
    • 0345726358 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites
    • Yamamoto H, Kishi T, Lee CE et al. Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci 2003; 23: 2939-2946.
    • (2003) J Neurosci , vol.23 , pp. 2939-2946
    • Yamamoto, H.1    Kishi, T.2    Lee, C.E.3
  • 48
    • 84858146844 scopus 로고    scopus 로고
    • The effect of liraglutide on gastric emptying and body weight is not mediated by vagal afferents nor the area postrema
    • Vrang N, Jelsing J, Raun K, Knudsen LB. The effect of liraglutide on gastric emptying and body weight is not mediated by vagal afferents nor the area postrema. Diabetologia 2011; 54(Suppl 1): S241.
    • (2011) Diabetologia , vol.54 , Issue.SUPPL 1
    • Vrang, N.1    Jelsing, J.2    Raun, K.3    Knudsen, L.B.4
  • 49
    • 84858146844 scopus 로고    scopus 로고
    • Liraglutide induced anorexia is not mediated by brainstem GLP-1 neurons
    • Jelsing J, Vrang N, Raun K, Knudsen LB. Liraglutide induced anorexia is not mediated by brainstem GLP-1 neurons. Diabetologia 2011; 54(Suppl 1): S241.
    • (2011) Diabetologia , vol.54 , Issue.SUPPL 1
    • Jelsing, J.1    Vrang, N.2    Raun, K.3    Knudsen, L.B.4
  • 50
    • 0030962231 scopus 로고    scopus 로고
    • The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation
    • Wettergren A, Wojdemann M, Meisner S, Stadil F, Holst JJ. The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation. Gut 1997; 40: 597-601.
    • (1997) Gut , vol.40 , pp. 597-601
    • Wettergren, A.1    Wojdemann, M.2    Meisner, S.3    Stadil, F.4    Holst, J.J.5
  • 51
    • 0031767175 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow
    • Wettergren A, Wojdemann M, Holst JJ. Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow. Am J Physiol 1998; 275: G984-G992.
    • (1998) Am J Physiol , vol.275
    • Wettergren, A.1    Wojdemann, M.2    Holst, J.J.3
  • 52
    • 18144381593 scopus 로고    scopus 로고
    • The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
    • Abbott CR, Monteiro M, Small CJ et al. The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res 2005; 1044: 127-131.
    • (2005) Brain Res , vol.1044 , pp. 127-131
    • Abbott, C.R.1    Monteiro, M.2    Small, C.J.3
  • 53
    • 79960741385 scopus 로고    scopus 로고
    • Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4
    • Kanoski SE, Fortin SM, Arnold M, Grill HJ, Hayes MR. Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology 2011; 152: 3103-3112.
    • (2011) Endocrinology , vol.152 , pp. 3103-3112
    • Kanoski, S.E.1    Fortin, S.M.2    Arnold, M.3    Grill, H.J.4    Hayes, M.R.5
  • 54
    • 0030667056 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
    • Nauck MA, Niedereichholz U, Ettler R et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 1997; 273: E981-E988.
    • (1997) Am J Physiol , vol.273
    • Nauck, M.A.1    Niedereichholz, U.2    Ettler, R.3
  • 56
    • 0031790968 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 retards gastric emptying and small bowel transit in the rat: effect mediated through central or enteric nervous mechanisms
    • Tolessa T, Gutniak M, Holst JJ, Efendic S, Hellström PM. Glucagon-like peptide-1 retards gastric emptying and small bowel transit in the rat: effect mediated through central or enteric nervous mechanisms. Dig Dis Sci 1998; 43: 2284-2290.
    • (1998) Dig Dis Sci , vol.43 , pp. 2284-2290
    • Tolessa, T.1    Gutniak, M.2    Holst, J.J.3    Efendic, S.4    Hellström, P.M.5
  • 57
    • 4344667831 scopus 로고    scopus 로고
    • A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis
    • Baggio LL, Huang Q, Brown TJ, Drucker DJ. A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis. Diabetes 2004; 53: 2492-2500.
    • (2004) Diabetes , vol.53 , pp. 2492-2500
    • Baggio, L.L.1    Huang, Q.2    Brown, T.J.3    Drucker, D.J.4
  • 58
    • 33745700396 scopus 로고    scopus 로고
    • Inhibitory effect of GLP-1 on gastric motility persists after vagal deafferentation in pigs
    • Nagell CF, Wettergren A, Orskov C, Holst JJ. Inhibitory effect of GLP-1 on gastric motility persists after vagal deafferentation in pigs. Scand J Gastroenterol 2006; 41: 667-672.
    • (2006) Scand J Gastroenterol , vol.41 , pp. 667-672
    • Nagell, C.F.1    Wettergren, A.2    Orskov, C.3    Holst, J.J.4
  • 59
    • 70350426017 scopus 로고    scopus 로고
    • Vagally mediated effects of glucagon-like peptide 1: in vitro and in vivo gastric actions
    • Holmes GM, Browning KN, Tong M, Qualls-Creekmore E, Travagli RA. Vagally mediated effects of glucagon-like peptide 1: in vitro and in vivo gastric actions. J Physiol 2009; 587: 4749-4759.
    • (2009) J Physiol , vol.587 , pp. 4749-4759
    • Holmes, G.M.1    Browning, K.N.2    Tong, M.3    Qualls-Creekmore, E.4    Travagli, R.A.5
  • 60
    • 67649636449 scopus 로고    scopus 로고
    • Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms
    • Ruttimann EB, Arnold M, Hillebrand JJ, Geary N, Langhans W. Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms. Endocrinology 2009; 150: 1174-1181.
    • (2009) Endocrinology , vol.150 , pp. 1174-1181
    • Ruttimann, E.B.1    Arnold, M.2    Hillebrand, J.J.3    Geary, N.4    Langhans, W.5
  • 62
    • 85071830683 scopus 로고    scopus 로고
    • The effect of GLP-1 on food intake is lost in trunkally vagotomised participants
    • Veedfald S, Plamboeck A, Deacon CF et al. The effect of GLP-1 on food intake is lost in trunkally vagotomised participants. Diabetologia 2012; 55(Suppl 1): S241.
    • (2012) Diabetologia , vol.55 , Issue.SUPPL 1
    • Veedfald, S.1    Plamboeck, A.2    Deacon, C.F.3
  • 63
    • 77953915094 scopus 로고    scopus 로고
    • Exenatide reduces food intake and activates the enteric nervous system of the gastrointestinal tract and the dorsal vagal complex of the hindbrain in the rat by a GLP-1 receptor
    • Washington MC, Raboin SJ, Thompson W, Larsen CJ, Sayegh AI. Exenatide reduces food intake and activates the enteric nervous system of the gastrointestinal tract and the dorsal vagal complex of the hindbrain in the rat by a GLP-1 receptor. Brain Res 2010; 1344: 124-133.
    • (2010) Brain Res , vol.1344 , pp. 124-133
    • Washington, M.C.1    Raboin, S.J.2    Thompson, W.3    Larsen, C.J.4    Sayegh, A.I.5
  • 64
    • 79959404178 scopus 로고    scopus 로고
    • Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans
    • Nauck MA, Kemmeries G, Holst JJ, Meier JJ. Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. Diabetes 2011; 60: 1561-1565.
    • (2011) Diabetes , vol.60 , pp. 1561-1565
    • Nauck, M.A.1    Kemmeries, G.2    Holst, J.J.3    Meier, J.J.4
  • 65
    • 0035432607 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion must be maintained for 24h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment
    • Larsen J, Hylleberg B, Ng K, Damsbo P. Glucagon-like peptide-1 infusion must be maintained for 24h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment. Diabetes Care 2001; 24: 1416-1421.
    • (2001) Diabetes Care , vol.24 , pp. 1416-1421
    • Larsen, J.1    Hylleberg, B.2    Ng, K.3    Damsbo, P.4
  • 66
    • 33644664033 scopus 로고    scopus 로고
    • Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes
    • Cryer PE. Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. Diabetes 2005; 54: 3592-3601.
    • (2005) Diabetes , vol.54 , pp. 3592-3601
    • Cryer, P.E.1
  • 68
    • 0019906257 scopus 로고
    • Peripheral versus central cardiorespiratory effects of morphine
    • Willette RN, Sapru HN. Peripheral versus central cardiorespiratory effects of morphine. Neuropharmacology 1982; 21: 1019-1026.
    • (1982) Neuropharmacology , vol.21 , pp. 1019-1026
    • Willette, R.N.1    Sapru, H.N.2
  • 69
    • 0031049302 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 (7-36 amide) on whole-body protein metabolism in healthy man
    • Shalev A, Holst JJ, Keller U. Effects of glucagon-like peptide 1 (7-36 amide) on whole-body protein metabolism in healthy man. Eur J Clin Invest 1997; 27: 10-16.
    • (1997) Eur J Clin Invest , vol.27 , pp. 10-16
    • Shalev, A.1    Holst, J.J.2    Keller, U.3
  • 70
    • 33750093045 scopus 로고    scopus 로고
    • Higher fasting plasma concentrations of glucagon-like peptide 1 are associated with higher resting energy expenditure and fat oxidation rates in humans
    • Pannacciulli N, Bunt JC, Koska J, Bogardus C, Krakoff J. Higher fasting plasma concentrations of glucagon-like peptide 1 are associated with higher resting energy expenditure and fat oxidation rates in humans. Am J Clin Nutr 2006; 84: 556-560.
    • (2006) Am J Clin Nutr , vol.84 , pp. 556-560
    • Pannacciulli, N.1    Bunt, J.C.2    Koska, J.3    Bogardus, C.4    Krakoff, J.5
  • 71
    • 0034951506 scopus 로고    scopus 로고
    • The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity
    • Flint A, Raben A, Ersbøll AK, Holst JJ, Astrup A. The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity. Int J Obes Relat Metab Disord 2001; 25: 781-792.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , pp. 781-792
    • Flint, A.1    Raben, A.2    Ersbøll, A.K.3    Holst, J.J.4    Astrup, A.5
  • 73
    • 84890558649 scopus 로고    scopus 로고
    • Effects of liraglutide on appetite, ad libitum energy intake, 24-hour energy expenditure and substrate oxidation in obese non-diabetic adults: a randomized, placebo-controlled, incomplete crossover trial (Abstract 259-P). The Obesity Society Meeting, San Antonio, TX, 2012. Available from URL:. Accessed December 2012.
    • van Can J, Sloth B, Jensen CB et al. Effects of liraglutide on appetite, ad libitum energy intake, 24-hour energy expenditure and substrate oxidation in obese non-diabetic adults: a randomized, placebo-controlled, incomplete crossover trial (Abstract 259-P). The Obesity Society Meeting, San Antonio, TX, 2012. Available from URL: www.obesity.org/obesity2012. Accessed December 2012.
    • van Can, J.1    Sloth, B.2    Jensen, C.B.3
  • 74
    • 0002294149 scopus 로고
    • New interpretation of oral glucose tolerance
    • Mcintyre N, Holdsworth CD, Turner DS. New interpretation of oral glucose tolerance. Lancet 1964; 2: 20-21.
    • (1964) Lancet , vol.2 , pp. 20-21
    • Mcintyre, N.1    Holdsworth, C.D.2    Turner, D.S.3
  • 75
    • 33845344395 scopus 로고
    • Plasma insulin response to oral and intravenous glucose administration
    • Elrick H, Stimmler L, Hlad CJ Jr, Arai Y. Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab 1964; 24: 1076-1082.
    • (1964) J Clin Endocrinol Metab , vol.24 , pp. 1076-1082
    • Elrick, H.1    Stimmler, L.2    Hlad Jr, C.J.3    Arai, Y.4
  • 76
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck MA, Homberger E, Siegel EG et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. Clin Endocrinol Metab 1986; 63: 492-498.
    • (1986) Clin Endocrinol Metab , vol.63 , pp. 492-498
    • Nauck, M.A.1    Homberger, E.2    Siegel, E.G.3
  • 77
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 1993; 91: 301-307.
    • (1993) J Clin Invest , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 78
    • 0344357096 scopus 로고
    • Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line
    • Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci U S A 1987; 84: 3434-3438.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 3434-3438
    • Drucker, D.J.1    Philippe, J.2    Mojsov, S.3    Chick, W.L.4    Habener, J.F.5
  • 79
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: a physiological incretin in man
    • Kreymann B, Williams G, Ghatei MA, Bloom SR. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 1987; 2: 1300-1304.
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 80
    • 0029829821 scopus 로고    scopus 로고
    • Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1
    • Nakabayashi H, Nishizawa M, Nakagawa A, Takeda R, Niijima A. Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1. Am J Physiol 1996; 271(5 Pt 1): E808-E813.
    • (1996) Am J Physiol , vol.271 , Issue.5 PART 1
    • Nakabayashi, H.1    Nishizawa, M.2    Nakagawa, A.3    Takeda, R.4    Niijima, A.5
  • 81
    • 0033696456 scopus 로고    scopus 로고
    • Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms
    • Balkan B, Li X. Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms. Am J Physiol Regul Integr Comp Physiol 2000; 279: R1449-R1454.
    • (2000) Am J Physiol Regul Integr Comp Physiol , vol.279
    • Balkan, B.1    Li, X.2
  • 82
    • 85071829686 scopus 로고    scopus 로고
    • Reduced incretin effect in truncal vagotomized subjects
    • Plamboeck A, Veedfald S, Deacon C et al. Reduced incretin effect in truncal vagotomized subjects. Diabetologia 2012; 55(Suppl 1): S110.
    • (2012) Diabetologia , vol.55 , Issue.SUPPL 1
    • Plamboeck, A.1    Veedfald, S.2    Deacon, C.3
  • 83
    • 84860242081 scopus 로고    scopus 로고
    • Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity
    • Knop FK, Aaboe K, Vilsbøll T et al. Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity. Diabetes Obes Metab 2012; 14: 500-510.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 500-510
    • Knop, F.K.1    Aaboe, K.2    Vilsbøll, T.3
  • 84
    • 48449093468 scopus 로고    scopus 로고
    • Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients
    • Muscelli E, Mari A, Casolaro A et al. Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients. Diabetes 2008; 57: 1340-1348.
    • (2008) Diabetes , vol.57 , pp. 1340-1348
    • Muscelli, E.1    Mari, A.2    Casolaro, A.3
  • 86
    • 0034906695 scopus 로고    scopus 로고
    • The role of postprandial releases of insulin and incretin hormones in meal-induced satiety -- effect of obesity and weight reduction
    • Verdich C, Toubro S, Buemann B, Lysgård Madsen J, Juul Holst J, Astrup A. The role of postprandial releases of insulin and incretin hormones in meal-induced satiety -- effect of obesity and weight reduction. Int J Obes Relat Metab Disord 2001; 25: 1206-1214.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , pp. 1206-1214
    • Verdich, C.1    Toubro, S.2    Buemann, B.3    Lysgård Madsen, J.4    Juul Holst, J.5    Astrup, A.6
  • 87
    • 24044493651 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 release and satiety after a nutrient challenge in normal-weight and obese subjects
    • Adam TC, Westerterp-Plantenga MS. Glucagon-like peptide-1 release and satiety after a nutrient challenge in normal-weight and obese subjects. Br J Nutr 2005; 93: 845-851.
    • (2005) Br J Nutr , vol.93 , pp. 845-851
    • Adam, T.C.1    Westerterp-Plantenga, M.S.2
  • 89
    • 0031899022 scopus 로고    scopus 로고
    • Distal small bowel hormones: correlation with fasting antroduodenal motility and gastric emptying
    • Näslund E, Gryback P, Backman L et al. Distal small bowel hormones: correlation with fasting antroduodenal motility and gastric emptying. Dig Dis Sci 1998; 43: 945-952.
    • (1998) Dig Dis Sci , vol.43 , pp. 945-952
    • Näslund, E.1    Gryback, P.2    Backman, L.3
  • 90
    • 0034880655 scopus 로고    scopus 로고
    • Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
    • Toft-Nielsen MB, Damholt MB, Madsbad S et al. Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab 2001; 86: 3717-3723.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3717-3723
    • Toft-Nielsen, M.B.1    Damholt, M.B.2    Madsbad, S.3
  • 91
    • 0037902984 scopus 로고    scopus 로고
    • Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus
    • Vilsbøll T, Krarup T, Sonne J et al. Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. J Clin Endocrinol Metab 2003; 88: 2706-2713.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2706-2713
    • Vilsbøll, T.1    Krarup, T.2    Sonne, J.3
  • 92
    • 0032924425 scopus 로고    scopus 로고
    • Inhibition of carbohydrate-mediated glucagon-like peptide-1 (7-36) amide secretion by circulating non-esterified fatty acids
    • Ranganath L, Norris F, Morgan L, Wright J, Marks V. Inhibition of carbohydrate-mediated glucagon-like peptide-1 (7-36) amide secretion by circulating non-esterified fatty acids. Clin Sci (Lond) 1999; 96: 335-342.
    • (1999) Clin Sci (Lond) , vol.96 , pp. 335-342
    • Ranganath, L.1    Norris, F.2    Morgan, L.3    Wright, J.4    Marks, V.5
  • 93
    • 80052049014 scopus 로고    scopus 로고
    • GLP-1 and energy balance: an integrated model of short-term and long-term control
    • Barrera JG, Sandoval DA, D'Alessio DA, Seeley RJ. GLP-1 and energy balance: an integrated model of short-term and long-term control. Nat Rev Endocrinol 2011; 7: 507-516.
    • (2011) Nat Rev Endocrinol , vol.7 , pp. 507-516
    • Barrera, J.G.1    Sandoval, D.A.2    D'Alessio, D.A.3    Seeley, R.J.4
  • 94
    • 58149480226 scopus 로고    scopus 로고
    • Molecular physiology of weight reduction in mice and humans
    • Leibel RL. Molecular physiology of weight reduction in mice and humans. Int J Obes 2008; 32: S98-108.
    • (2008) Int J Obes , vol.32
    • Leibel, R.L.1
  • 96
    • 0037315423 scopus 로고    scopus 로고
    • Role of leptin in the regulation of glucagon like peptide-1 secretion
    • Anini Y, Brubaker PL. Role of leptin in the regulation of glucagon like peptide-1 secretion. Diabetes 2003; 52: 252-259.
    • (2003) Diabetes , vol.52 , pp. 252-259
    • Anini, Y.1    Brubaker, P.L.2
  • 97
    • 79957896911 scopus 로고    scopus 로고
    • Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
    • Scott MM, Williams KW, Rossi J, Lee CE, Elmquist JK. Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice. J Clin Invest 2011; 121: 2413-2421.
    • (2011) J Clin Invest , vol.121 , pp. 2413-2421
    • Scott, M.M.1    Williams, K.W.2    Rossi, J.3    Lee, C.E.4    Elmquist, J.K.5
  • 98
    • 33845518516 scopus 로고    scopus 로고
    • Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation
    • Williams DL, Baskin DG, Schwartz MW. Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation. Diabetes 2006; 55: 3387-3393.
    • (2006) Diabetes , vol.55 , pp. 3387-3393
    • Williams, D.L.1    Baskin, D.G.2    Schwartz, M.W.3
  • 99
    • 84862580588 scopus 로고    scopus 로고
    • Effects of leptin replacement alone and with exendin-4 on food intake and weight regain in weight-reduced diet-induced obese rats
    • Reidelberger R, Haver A, Chelikani PK et al. Effects of leptin replacement alone and with exendin-4 on food intake and weight regain in weight-reduced diet-induced obese rats. Am J Physiol Endocrinol Metab 2012; 302: E1576-E1585.
    • (2012) Am J Physiol Endocrinol Metab , vol.302
    • Reidelberger, R.1    Haver, A.2    Chelikani, P.K.3
  • 100
    • 84865324947 scopus 로고    scopus 로고
    • The effect of a very low calorie diet on insulin sensitivity, β cell function, insulin clearance, incretin hormone secretion, androgen levels and body composition in obese young women
    • Svendsen PF, Jensen FK, Holst JJ, Haugaard SB, Nilas L, Madsbad S. The effect of a very low calorie diet on insulin sensitivity, β cell function, insulin clearance, incretin hormone secretion, androgen levels and body composition in obese young women. Scand J Clin Lab Invest 2012; 72: 410-419.
    • (2012) Scand J Clin Lab Invest , vol.72 , pp. 410-419
    • Svendsen, P.F.1    Jensen, F.K.2    Holst, J.J.3    Haugaard, S.B.4    Nilas, L.5    Madsbad, S.6
  • 102
    • 69949128179 scopus 로고    scopus 로고
    • Association of Body Mass and Brain Activation during Gastric Distention: Implications for Obesity
    • Tomasi D, Wang GJ, Wang R et al. Association of Body Mass and Brain Activation during Gastric Distention: Implications for Obesity. PLoS One 2009; 4: e6847.
    • (2009) PLoS One , vol.4
    • Tomasi, D.1    Wang, G.J.2    Wang, R.3
  • 103
    • 33745851096 scopus 로고    scopus 로고
    • Insulin resistance and pancreatic β cell failure
    • Kasuga M. Insulin resistance and pancreatic β cell failure. J Clin Invest 2006; 116: 1756-1760.
    • (2006) J Clin Invest , vol.116 , pp. 1756-1760
    • Kasuga, M.1
  • 104
    • 49349090916 scopus 로고    scopus 로고
    • How strong is the association between abdominal obesity and the incidence of type 2 diabetes?
    • Freemantle N, Holmes J, Hockey A, Kumar S. How strong is the association between abdominal obesity and the incidence of type 2 diabetes? Int J Clin Pract 2008; 62: 1391-1396.
    • (2008) Int J Clin Pract , vol.62 , pp. 1391-1396
    • Freemantle, N.1    Holmes, J.2    Hockey, A.3    Kumar, S.4
  • 105
    • 33745120778 scopus 로고    scopus 로고
    • Is all fat the same? The role of fat in the pathogenesis of the metabolic syndrome and type 2 diabetes mellitus
    • Hansen E, Hajri T, Abumrad NN. Is all fat the same? The role of fat in the pathogenesis of the metabolic syndrome and type 2 diabetes mellitus. Surgery 2006; 139: 711-716.
    • (2006) Surgery , vol.139 , pp. 711-716
    • Hansen, E.1    Hajri, T.2    Abumrad, N.N.3
  • 106
    • 24144441285 scopus 로고    scopus 로고
    • Point: visceral adiposity is causally related to insulin resistance
    • Lebovitz HE, Banerji MA. Point: visceral adiposity is causally related to insulin resistance. Diabetes Care 2005; 28: 2322-2325.
    • (2005) Diabetes Care , vol.28 , pp. 2322-2325
    • Lebovitz, H.E.1    Banerji, M.A.2
  • 107
    • 1942437368 scopus 로고    scopus 로고
    • Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation
    • Hu G, Lindström J, Valle TT et al. Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation. Arch Intern Med 2004; 164: 892-896.
    • (2004) Arch Intern Med , vol.164 , pp. 892-896
    • Hu, G.1    Lindström, J.2    Valle, T.T.3
  • 108
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Diabetes Prevention Program Research Group.
    • Knowler WC, Barrett-Connor E, Fowler SE et al. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403.
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3
  • 109
    • 84856784864 scopus 로고    scopus 로고
    • Defects in GLP-1 response to an oral challenge do not play a significant role in the pathogenesis of prediabetes
    • Smushkin G, Sathananthan A, Man CD et al. Defects in GLP-1 response to an oral challenge do not play a significant role in the pathogenesis of prediabetes. J Clin Endocrinol Metab 2012; 97: 589-598.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 589-598
    • Smushkin, G.1    Sathananthan, A.2    Man, C.D.3
  • 110
    • 40949090627 scopus 로고    scopus 로고
    • Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance
    • Vollmer K, Holst JJ, Baller B et al. Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance. Diabetes 2008; 57: 678-687.
    • (2008) Diabetes , vol.57 , pp. 678-687
    • Vollmer, K.1    Holst, J.J.2    Baller, B.3
  • 111
    • 33749064594 scopus 로고    scopus 로고
    • Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbA1c levels, but is not acutely affected by food intake
    • Ryskjaer J, Deacon CF, Carr RD et al. Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbA1c levels, but is not acutely affected by food intake. Eur J Endocrinol 2006; 155: 485-493.
    • (2006) Eur J Endocrinol , vol.155 , pp. 485-493
    • Ryskjaer, J.1    Deacon, C.F.2    Carr, R.D.3
  • 112
    • 79952310049 scopus 로고    scopus 로고
    • Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?
    • Nauck M, Vardarli I, Deacon CF, Holst JJ, Meier JJ. Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down? Diabetologia 2011; 54: 10-18.
    • (2011) Diabetologia , vol.54 , pp. 10-18
    • Nauck, M.1    Vardarli, I.2    Deacon, C.F.3    Holst, J.J.4    Meier, J.J.5
  • 113
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    • Vilsbøll T, Krarup T, Deacon CF, Madsbad S, Holst JJ. Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 2001; 50: 609-613.
    • (2001) Diabetes , vol.50 , pp. 609-613
    • Vilsbøll, T.1    Krarup, T.2    Deacon, C.F.3    Madsbad, S.4    Holst, J.J.5
  • 114
    • 79959781838 scopus 로고    scopus 로고
    • Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes
    • Holst JJ, Knop FK, Vilsbøll T, Krarup T, Madsbad S. Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes. Diabetes Care 2011; 34(Suppl 2): S251-257.
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL 2
    • Holst, J.J.1    Knop, F.K.2    Vilsbøll, T.3    Krarup, T.4    Madsbad, S.5
  • 115
    • 0023179206 scopus 로고
    • Effect of porcine gastric inhibitory polypeptide on β-cell function in type I and type II diabetes mellitus
    • Krarup T, Saurbrey N, Moody AJ, Kühl C, Madsbad S. Effect of porcine gastric inhibitory polypeptide on β-cell function in type I and type II diabetes mellitus. Metabolism 1987; 36: 677-682.
    • (1987) Metabolism , vol.36 , pp. 677-682
    • Krarup, T.1    Saurbrey, N.2    Moody, A.J.3    Kühl, C.4    Madsbad, S.5
  • 116
    • 58149467276 scopus 로고    scopus 로고
    • Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose dependent insulinotropic polypeptide in patients with type 2 diabetes
    • Højberg PV, Vilsbøll T, Rabøl R et al. Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose dependent insulinotropic polypeptide in patients with type 2 diabetes. Diabetologia 2009; 52: 199-207.
    • (2009) Diabetologia , vol.52 , pp. 199-207
    • Højberg, P.V.1    Vilsbøll, T.2    Rabøl, R.3
  • 117
    • 0036373430 scopus 로고    scopus 로고
    • Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients
    • Vilsbøll T, Krarup T, Madsbad S, Holst JJ. Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients. Diabetologia 2002; 45: 1111-1119.
    • (2002) Diabetologia , vol.45 , pp. 1111-1119
    • Vilsbøll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.J.4
  • 118
    • 0037312821 scopus 로고    scopus 로고
    • The influence of GLP-1 on glucose-stimulated insulin secretion: effects on β-cell sensitivity in type 2 and nondiabetic subjects
    • Kjems LL, Holst JJ, Vølund A, Madsbad S. The influence of GLP-1 on glucose-stimulated insulin secretion: effects on β-cell sensitivity in type 2 and nondiabetic subjects. Diabetes 2003; 52: 380-386.
    • (2003) Diabetes , vol.52 , pp. 380-386
    • Kjems, L.L.1    Holst, J.J.2    Vølund, A.3    Madsbad, S.4
  • 119
    • 34548612361 scopus 로고    scopus 로고
    • Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat
    • Piteau S, Olver A, Kim SJ et al. Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat. Biochem Biophys Res Commun 2007; 362: 1007-1012.
    • (2007) Biochem Biophys Res Commun , vol.362 , pp. 1007-1012
    • Piteau, S.1    Olver, A.2    Kim, S.J.3
  • 120
    • 84865601559 scopus 로고    scopus 로고
    • Impairment of GLP1-induced insulin secretion: role of genetic background, insulin resistance and hyperglycaemia
    • Herzberg-Schäfer S, Heni M, Stefan N, Häring HU, Fritsche A. Impairment of GLP1-induced insulin secretion: role of genetic background, insulin resistance and hyperglycaemia. Diabetes Obes Metab 2012; 14(Suppl. 3): 85-90.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.SUPPL. 3 , pp. 85-90
    • Herzberg-Schäfer, S.1    Heni, M.2    Stefan, N.3    Häring, H.U.4    Fritsche, A.5
  • 121
    • 0032757178 scopus 로고    scopus 로고
    • Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of type II (non-insulin-dependent) diabetic parents: evidence of several aberrations
    • Nyholm B, Walker M, Gravholt CH et al. Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of type II (non-insulin-dependent) diabetic parents: evidence of several aberrations. Diabetologia 1999; 42: 1314-1323.
    • (1999) Diabetologia , vol.42 , pp. 1314-1323
    • Nyholm, B.1    Walker, M.2    Gravholt, C.H.3
  • 122
    • 5644221730 scopus 로고    scopus 로고
    • Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes
    • Nauck MA, El-Ouaghlidi A, Gabris B et al. Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes. Regul Pept 2004; 122: 209-217.
    • (2004) Regul Pept , vol.122 , pp. 209-217
    • Nauck, M.A.1    El-Ouaghlidi, A.2    Gabris, B.3
  • 123
    • 34547586659 scopus 로고    scopus 로고
    • Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?
    • Knop FK, Visboll T, Hojberg PV et al. Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state? Diabetes 2007; 56: 1951-1959.
    • (2007) Diabetes , vol.56 , pp. 1951-1959
    • Knop, F.K.1    Visboll, T.2    Hojberg, P.V.3
  • 124
    • 34249096991 scopus 로고    scopus 로고
    • Effect of 4weeks of near normalization of blood glucose on -cell sensitivity to glucose and GLP-1 in type 2 diabetic patients (Abstract)
    • Højberg PV, Zander M, Vilsbøll T et al. Effect of 4weeks of near normalization of blood glucose on -cell sensitivity to glucose and GLP-1 in type 2 diabetic patients (Abstract). Diabetes 2005; 54(Suppl. 1): A362.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 1
    • Højberg, P.V.1    Zander, M.2    Vilsbøll, T.3
  • 125
    • 0036182193 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1(7-36)amide on motility and sensation of the proximal stomach in humans
    • Schirra J, Wank U, Arnold R, Göke B, Katschinski M. Effects of glucagon-like peptide-1(7-36)amide on motility and sensation of the proximal stomach in humans. Gut 2002; 50: 341-348.
    • (2002) Gut , vol.50 , pp. 341-348
    • Schirra, J.1    Wank, U.2    Arnold, R.3    Göke, B.4    Katschinski, M.5
  • 126
    • 0033021677 scopus 로고    scopus 로고
    • Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men
    • Näslund E, Barkeling B, King N et al. Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men. Int J Obes Relat Metab Disord 1999; 23: 304-311.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , pp. 304-311
    • Näslund, E.1    Barkeling, B.2    King, N.3
  • 127
    • 0032966882 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2
    • Gutzwiller JP, Drewe J, Goke B et al. Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2. Am J Physiol 1999; 276(5 Pt 2): R1541-R1544.
    • (1999) Am J Physiol , vol.276 , Issue.5 PART 2
    • Gutzwiller, J.P.1    Drewe, J.2    Goke, B.3
  • 128
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel group study. Lancet 2002; 359: 824-830.
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 129
    • 79953040963 scopus 로고    scopus 로고
    • An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future
    • Madsbad S, Kielgast U, Asmar M, Deacon CF, Torekov SS, Holst JJ. An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future. Diabetes Obes Metab 2011; 13: 394-407.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 394-407
    • Madsbad, S.1    Kielgast, U.2    Asmar, M.3    Deacon, C.F.4    Torekov, S.S.5    Holst, J.J.6
  • 130
    • 84859721063 scopus 로고    scopus 로고
    • DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials
    • Scheen AJ. DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials. Diabetes Metab 2012; 38: 89-101.
    • (2012) Diabetes Metab , vol.38 , pp. 89-101
    • Scheen, A.J.1
  • 131
    • 84862152967 scopus 로고    scopus 로고
    • Efficacy of GLP-1 receptor agonists and DPP-4 inhibitors:meta-analysis and systematic review
    • Aroda VR, Henry R, Han J et al. Efficacy of GLP-1 receptor agonists and DPP-4 inhibitors:meta-analysis and systematic review. Clin Ther 2012; 34: 1247-1258.
    • (2012) Clin Ther , vol.34 , pp. 1247-1258
    • Aroda, V.R.1    Henry, R.2    Han, J.3
  • 132
    • 84859003663 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials
    • Vilsboll T, Christensen M, Junker AE et al. Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ 2012; 344: d7771.
    • (2012) BMJ , vol.344
    • Vilsboll, T.1    Christensen, M.2    Junker, A.E.3
  • 133
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomized, parallel-group, open label trial
    • Pratley RE, Nauck M, Bailey T et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomized, parallel-group, open label trial. Lancet 2010; 375: 1447-1456.
    • (2010) Lancet , vol.375 , pp. 1447-1456
    • Pratley, R.E.1    Nauck, M.2    Bailey, T.3
  • 134
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial
    • for the DURATION-2 Study Group.
    • Bergenstal RM, Wysham C, MacConell L et al., for the DURATION-2 Study Group. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet 2010; 376: 431-439.
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    MacConell, L.3
  • 135
    • 84872084453 scopus 로고    scopus 로고
    • Exenatide once-weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study
    • DOI: 10.1016/S0140-6736(12)61267-7.
    • Buse JB, Nauck M, Forst T et al. Exenatide once-weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study. Lancet 2012; DOI: 10.1016/S0140-6736(12)61267-7.
    • (2012) Lancet
    • Buse, J.B.1    Nauck, M.2    Forst, T.3
  • 136
    • 84891642041 scopus 로고    scopus 로고
    • Mechanisms and clinical efficacy of lixisenatide for the management of type 2 diabetes
    • Horowitz M, Rayner CK, Jones KL. Mechanisms and clinical efficacy of lixisenatide for the management of type 2 diabetes. Adv Ther 2013; 30: 81-101.
    • (2013) Adv Ther , vol.30 , pp. 81-101
    • Horowitz, M.1    Rayner, C.K.2    Jones, K.L.3
  • 137
    • 84890562347 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly (QW) albiglutide vs once-daily (QD) liraglutide in type 2 diabetes (T2D) inadequately controlled on oral agents: harmony 7 trial (Abstract 945-P)
    • Pratley RE, Barnett AH, Feinglos MN et al. Efficacy and safety of once-weekly (QW) albiglutide vs once-daily (QD) liraglutide in type 2 diabetes (T2D) inadequately controlled on oral agents: harmony 7 trial (Abstract 945-P). Diabetes 2012; 61(Suppl. 1): A945-P.
    • (2012) Diabetes , vol.61 , Issue.SUPPL. 1
    • Pratley, R.E.1    Barnett, A.H.2    Feinglos, M.N.3
  • 138
    • 84866435806 scopus 로고    scopus 로고
    • Monotherapy with the once-weekly GLP-1 analogue dulaglutide for 12weeks in patients with type 2 diabetes: dose-dependent effects on glycaemic control in a randomized, double-blind, placebo-controlled study
    • Grunberger G, Chang A, Garcia Soria G et al. Monotherapy with the once-weekly GLP-1 analogue dulaglutide for 12weeks in patients with type 2 diabetes: dose-dependent effects on glycaemic control in a randomized, double-blind, placebo-controlled study. Diabet Med 2012; 29: 1260-1267.
    • (2012) Diabet Med , vol.29 , pp. 1260-1267
    • Grunberger, G.1    Chang, A.2    Garcia Soria, G.3
  • 139
    • 77956090389 scopus 로고    scopus 로고
    • Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes
    • Rosenstock J, Klaff LJ, Schwartz S et al. Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes. Diabetes Care 2010; 33: 1173-1175.
    • (2010) Diabetes Care , vol.33 , pp. 1173-1175
    • Rosenstock, J.1    Klaff, L.J.2    Schwartz, S.3
  • 140
    • 84859046364 scopus 로고    scopus 로고
    • Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetes
    • Dushay J, Gao C, Gopalakrishnan GS et al. Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetes. Diabetes Care 2012; 35: 4-11.
    • (2012) Diabetes Care , vol.35 , pp. 4-11
    • Dushay, J.1    Gao, C.2    Gopalakrishnan, G.S.3
  • 141
    • 77950827693 scopus 로고    scopus 로고
    • Effects of exenatide combined with lifestyle modification in patients with type 2 diabetes
    • Apovian CM, Bergenstal RM, Cuddihy RM et al. Effects of exenatide combined with lifestyle modification in patients with type 2 diabetes. Am J Med 2010; 123: e9-e17.
    • (2010) Am J Med , vol.123
    • Apovian, C.M.1    Bergenstal, R.M.2    Cuddihy, R.M.3
  • 142
    • 84862207266 scopus 로고    scopus 로고
    • Safety, tolerability and sustained weight loss over 2years with the once-daily human GLP-1 analogue, liraglutide
    • Astrup A, Carraro R, Finer N et al. Safety, tolerability and sustained weight loss over 2years with the once-daily human GLP-1 analogue, liraglutide. Int J Obes (Lond) 2012; 36: 843-854.
    • (2012) Int J Obes (Lond) , vol.36 , pp. 843-854
    • Astrup, A.1    Carraro, R.2    Finer, N.3
  • 143
    • 84890563594 scopus 로고    scopus 로고
    • Liraglutide provides weight maintenance and additional weight loss after low calorie diet-induced weight loss in obese subjects without diabetes: The SCALE™ Maintenance study (Abstract 1859-P)
    • Wadden TA, Hollander P, Klein S et al. Liraglutide provides weight maintenance and additional weight loss after low calorie diet-induced weight loss in obese subjects without diabetes: The SCALE™ Maintenance study (Abstract 1859-P). Diabetes 2011; 60(Suppl. 1): A502.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Wadden, T.A.1    Hollander, P.2    Klein, S.3
  • 144
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Ratner RE, Han J et al. Effects of exenatide (exendin-4) on glycemic control and weight over 30weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005; 28: 1092-1100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • DeFronzo, R.A.1    Ratner, R.E.2    Han, J.3
  • 145
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30weeks in sulfonylurea-treated patients with type 2 diabetes
    • Exenatide-113 Clinical Study Group.
    • Buse JB, Henry RR, Han J et al., Exenatide-113 Clinical Study Group. Effects of exenatide (exendin-4) on glycemic control over 30weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 2004; 27: 2628-2635.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3
  • 146
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall DM, Riddle MC, Rosenstock J et al. Effects of exenatide (exendin-4) on glycemic control over 30weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 2005; 28: 1083-1091.
    • (2005) Diabetes Care , vol.28 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3
  • 147
    • 51549095571 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy over 24weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study
    • Erratum: 2008; 30: 1937.
    • Moretto TJ, Milton DR, Ridge TD et al. Efficacy and tolerability of exenatide monotherapy over 24weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 2008; 30: 1448-1460 Erratum: 2008; 30: 1937.
    • (2008) Clin Ther , vol.30 , pp. 1448-1460
    • Moretto, T.J.1    Milton, D.R.2    Ridge, T.D.3
  • 148
    • 34247259577 scopus 로고    scopus 로고
    • The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial
    • Zinman B, Hoogwerf BJ, Duran Garcia S et al. The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med 2007; 146: 477-485.
    • (2007) Ann Intern Med , vol.146 , pp. 477-485
    • Zinman, B.1    Hoogwerf, B.J.2    Duran Garcia, S.3
  • 149
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1)
    • LEAD-1 SU Study Group.
    • Marre M, Shaw J, Brandle M et al., LEAD-1 SU Study Group. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1). Diabet Med 2009; 26: 268-278.
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brandle, M.3
  • 150
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes
    • LEAD-2 Study Group.
    • Nauck MA, Frid A, Hermansen K et al. LEAD-2 Study Group. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes. Diabetes Care 2009; 32: 84-90.
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.A.1    Frid, A.2    Hermansen, K.3
  • 151
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • LEAD-3 (Mono) Study Group.
    • Garber A, Henry R, Ratner R et al., LEAD-3 (Mono) Study Group. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009; 373: 473-481.
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 152
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4)
    • LEAD-4 Study Investigators.
    • Zinman B, Gerich J, Buse JB et al., LEAD-4 Study Investigators. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4). Diabetes Care 2009; 32: 1224-1230.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3
  • 153
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulphonylurea therapy in type 2 diabetes mellitus: a randomised controlled trial (LEAD-5)
    • on behalf of the LEAD-5 (Liraglutide Effect and Action in Diabetes 5) met+SU Study Group.
    • Russell-Jones D, Vaag A, Schmitz O et al., on behalf of the LEAD-5 (Liraglutide Effect and Action in Diabetes 5) met+SU Study Group. Liraglutide vs insulin glargine and placebo in combination with metformin and sulphonylurea therapy in type 2 diabetes mellitus: a randomised controlled trial (LEAD-5). Diabetologia 2009; 52: 2046-2055.
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 154
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • LEAD-6 Study Group.
    • Buse JB, Rosenstock J, Sesti G et al., LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009; 374: 39-47.
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 155
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once-weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study
    • Drucker DJ, Buse JB, Taylor K et al. Exenatide once-weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 2008; 372: 1240-1250.
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3
  • 156
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial
    • Berganstal RM, Wysham C, MacConell L et al. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet 2010; 376: 431-439.
    • (2010) Lancet , vol.376 , pp. 431-439
    • Berganstal, R.M.1    Wysham, C.2    MacConell, L.3
  • 157
    • 77953859640 scopus 로고    scopus 로고
    • Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial
    • Diamant M, Van Gaal L, Stranks S et al. Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial. Lancet 2010; 375: 2234-2243.
    • (2010) Lancet , vol.375 , pp. 2234-2243
    • Diamant, M.1    Van Gaal, L.2    Stranks, S.3
  • 158
    • 84859013614 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study
    • DURATION-4 Study Group.
    • Russell-Jones D, Cuddihy RM, Hanefeld M et al., DURATION-4 Study Group. Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study. Diabetes Care 2012; 35: 252-258.
    • (2012) Diabetes Care , vol.35 , pp. 252-258
    • Russell-Jones, D.1    Cuddihy, R.M.2    Hanefeld, M.3
  • 159
    • 79955661908 scopus 로고    scopus 로고
    • DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes
    • Blevins T, Pullman J, Malloy J et al. DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes. J Clin Endocrinol Metab 2011; 96: 1301-1310.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1301-1310
    • Blevins, T.1    Pullman, J.2    Malloy, J.3
  • 160
    • 84865984023 scopus 로고    scopus 로고
    • Patient-reported outcomes in trials of incretin-based therapies in patients with type 2 diabetes mellitus
    • Davies M, Speight J. Patient-reported outcomes in trials of incretin-based therapies in patients with type 2 diabetes mellitus. Diabetes Obes Metab 2012; 14: 882-892.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 882-892
    • Davies, M.1    Speight, J.2
  • 161
    • 0033227338 scopus 로고    scopus 로고
    • Pharmaceutical cost savings of treating obesity with weight loss medications
    • Greenway FL, Ryan DH, Bray GA et al. Pharmaceutical cost savings of treating obesity with weight loss medications. Obes Res 1999; 7: 523-531.
    • (1999) Obes Res , vol.7 , pp. 523-531
    • Greenway, F.L.1    Ryan, D.H.2    Bray, G.A.3
  • 162
    • 34547136445 scopus 로고    scopus 로고
    • Effects of lifestyle intervention on health care costs: improving Control with Activity and Nutrition (ICAN)
    • Wolf AM, Siadaty M, Yaeger B et al. Effects of lifestyle intervention on health care costs: improving Control with Activity and Nutrition (ICAN). J Am Diet Assoc 2007; 107: 1365-1373.
    • (2007) J Am Diet Assoc , vol.107 , pp. 1365-1373
    • Wolf, A.M.1    Siadaty, M.2    Yaeger, B.3
  • 163
    • 77954252801 scopus 로고    scopus 로고
    • PYY3-36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans
    • Field BC, Wren AM, Peters V, Baynes KC et al. PYY3-36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans. Diabetes 2010; 59: 1635-1639.
    • (2010) Diabetes , vol.59 , pp. 1635-1639
    • Field, B.C.1    Wren, A.M.2    Peters, V.3    Baynes, K.C.4
  • 164
    • 84861890043 scopus 로고    scopus 로고
    • Outstanding Scientific Achievement Award Lecture 2011: defeating diabesity: the case for personalized combinatorial therapies
    • Tschöp MH, DiMarchi RD. Outstanding Scientific Achievement Award Lecture 2011: defeating diabesity: the case for personalized combinatorial therapies. Diabetes 2012; 61: 1309-1314.
    • (2012) Diabetes , vol.61 , pp. 1309-1314
    • Tschöp, M.H.1    DiMarchi, R.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.