The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 2, 2008, Pages 663-667

  Berkenstam, Anders ^a   Kristensen, Jens ^a   Mellström, Karin ^a   Carlsson, Bo ^a   Malm, Johan ^a   Rehnmark, Stefan ^a   Garg, Neeraj ^a   Andersson, Carl Magnus ^a   Rudling, Mats ^b   Sjöberg, Folke ^c   Angelin, Bo ^b   Baxter, John D ^d  

^a Karo Bio   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c Berzelius Science Park   (Sweden)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(3 ((3,5 DIBROMO 4 (4 HYDROXY 3 (1 METHYLETHYL) PHENOXY) PHENYL) AMINO) 3 OXOPROPANOIC ACID); HIGH DENSITY LIPOPROTEIN; KB 2115; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; THYROID HORMONE; THYROMIMETIC AGENT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BILE ACID SYNTHESIS; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG DOSE ESCALATION; DRUG EFFECT; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; HYPERLIPOPROTEINEMIA TYPE 2; LIPID METABOLISM; MALE; MUSCULOSKELETAL DISEASE; OBESITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPEATED DRUG DOSE; SIDE EFFECT;

ADOLESCENT; ADULT; ANILIDES; BILE ACIDS AND SALTS; CHOLESTEROL, LDL; DOUBLE-BLIND METHOD; FEMALE; HEART; HUMANS; LIPID METABOLISM; MALE; MIDDLE AGED; PLACEBOS; RISK FACTORS; THIAZOLIDINEDIONES; THYROID GLAND; THYROID HORMONES;

ANIMALIA;

EID: 38649135692     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0705286104     Document Type: Article

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