Antiobesity effect of diazoxide in obese Zucker rats

Metabolism: Clinical and Experimental

Volumn 45, Issue 3, 1996, Pages 334-341

  Alemzadeh, Ramin ^a   Jacobs, William ^a   Pitukcheewanont, Pisit ^a  

^a UNIVERSITY OF TENNESSEE GRADUATE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DIAZOXIDE; FATTY ACID; INSULIN; INSULIN RECEPTOR; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE TOLERANCE; HORMONE RECEPTOR INTERACTION; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN SENSITIVITY; NONHUMAN; OBESITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0029938016     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90287-5     Document Type: Article

References (49)

1. Karam JH, Grodsky GM, Forsham PH: Excessive insulin response to glucose in obese subjects as measured by immunochemical assay. Diabetes 12:196-204, 1963
2. Jeanrenaud B: Hyperinsulinemia in obesity syndromes: Its metabolic consequences and possible etiology. Metabolism 12:1881-1892, 1978
3. Bray GA, York DA: Hypothalamic and genetic obesity in experimental animals. An autonomic endocrine hypothesis. Physiol Rev 59:719-809, 1979
4. Le Marchand Y, Freychet P, Jeanrenaud B: Longitudinal study on the establishment of insulin resistance in hypothalamic obese mice. Endocrinology 102:74-85, 1985
5. Pénicaud L, Rohner-Jeanrenaud F, Jeanrenaud B: In vivo metabolic changes as studied longitudinally after ventromedial hypothalamic lesions. Am J Physiol 250:E662-E668, 1986
6. Pénicaud L, Kinebanyan MF, Ferré P, et al: Development of VMH obesity: In vivo insulin secretion and tissue insulin sensitivity. Am J Physiol 257:E255-E260, 1989
7. Assimacopoulos-Jeanet F, Jeanrenaud B: The hormonal and metabolic basis of experimental obesity. Clin Endocrinol Metab 2:337-359, 1976
8. Le Stunff C, Bougneres P: Early changes in postprandial insulin secretion, not in insulin sensitivity, characterize juvenile obesity. Diabetes 43:696-702, 1994
9. Zarjevski N, Doyle P, Jeanrenaud B: Muscle insulin resistance may not be a primary etiologic factor in the genetically obese (fa/fa) rat. Endocrinology 130:1564-1570, 1992
10. Jeanrenaud B: An overview of experimental models of obesity. Recent Adv Obes Res 2:111-122, 1978
11. Terretaz J, Jeanrenaud B: In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats. Endocrinology 112:1346-1351, 1987
12. Cusin I, Terretaz J, Rohner-Jeanrenaud F, et al: Metabolic consequences of hyperinsulinemia imposed on rats on glucose handling by white adipose tissue, muscle and liver. Biochem J 267:99-103, 1990
13. Westman S: Development of the obese-hyperglycemic syndrome in mice. Diabetologia 4:141-149, 1978
14. Kashiwagi A, Verso MA, Andrews JA, et al: In vitro insulin resistance of human adipocytes isolated from subjects with non-insulin-dependent diabetes mellitus. J Clin Invest 72:1246-1254, 1983
15. Olefsky JM, Kolterman OG, Scarlett JA: Insulin action and resistance in obesity and non-insulin-dependent type II diabetes mellitus. Am J Physiol 243:E15-E30, 1982
16. Bar RS, Gorden P, Roth J, et al: Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: Effects of starvation, refeeding, and dieting. J Clin Invest 58:1123-1135, 1976
17. Kahn CR, Neville DM, Roth J: Insulin receptor interaction in the obese hyperglycemic mouse: A model of insulin resistance. J Biol Chem 248:244-250, 1973
18. Olefsky JM: Decreased insulin binding to adipocytes and circulating monocytes from obese subjects. J Clin Invest 57:1165-1172, 1976
19. Karadash C, Jeanrenaud B: Insulin binding and removal by livers of genetically obese rats. Diabetes 32:605-609, 1983
20. Rabinowitz D, Ziereler KL: Forearm metabolism in obesity and its response to intra-arterial insulin: Characterization of insulin resistance and evidence for adaptation hyperinsulinism. J Clin Invest 41:2173-2181, 1962
21. Howard BV: The antilipolytic action of insulin in obese subjects with resistance to its glycoregulatory action. J Clin Endocrinol Metab 58:544-548, 1984
22. Schade DS, Eaton RP: Dose response to insulin in man: Differential effects on glucose and ketone body regulations. J Clin Endocrinol Metab 44:1038-1047, 1977
23. Alemzadeh R, Slonim AE, Zdanowicz MM, et al: Modification of insulin resistance by diazoxide in obese Zucker rats. Endocrinology 133:705-712, 1993
24. Pedersen O, Hjollund E, Beck-Nielsen H, et al: Insulin receptor binding and receptor mediated insulin degradation in human adipocytes. Diabetologia 20:636-641, 1981
25. Lorch E, Rentsch G: A simple method for staining and counting isolated adipose tissue fat cells. Diabetologia 5:356-357, 1969
26. Hirsch E, Rentsch G: Methods for the determinations of adipose cell size and cell number in man and animals. J Lipid Res 9:110-119, 1968
27. Wieland OH: in Bergmeyer HV (ed): Methods of Enzymatic Analysis, vol 6. Weinheim, Germany, Verlag Chemie, 1984, pp 504-510
28. Scatchard G: The attraction of proteins for small molecules and ions. Ann NY Acad Sci 51:660-672, 1949
29. Munson P, Rodbard D: LIGAND: A versatile, computerized approach for characterization of ligand-binding system. Anal Biochem 107:220-239, 1980
30. Munson P, Rodbard D: User's Guide to LIGAND. Bethesda, MD, National Institutes of Health, 1990
31. Stan JS, Johnson PR: Spontaneous activity and adipose cellularity in the genetically obese Zucker rat (fa/fa). Metabolism 26:371-380, 1977
32. Buchberger P, Schmidt I: The earliest stages of excess fat deposition in fatty Zucker rat pups are not associated with a changed drive for food intake. Int J Obes 18:129, 1994 (abstr 487)
33. Tenenbaum R, Ochoa FY, Sassano ML, et al: Altered insulin secretion from the pancreas of pro-obese Zucker rat pups: Evidence for an early and persistent genetic defect. Int J Obes 18:67, 1994 (abstr 260)
34. Caro JF, Dohm LG, Walter JP, et al: Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes. Diabetes Metab Rev 5:665-689, 1989
35. Arner P, Bolinder J, Engfeldt P, et al: Influence of obesity on the antilipolytic effect of insulin in isolated fat cells obtained before and after glucose ingestion. J Clin Invest 73:673-680, 1984
36. 1-Adenosine receptor-mediated inhibition of adipocyte adenylate cyclase and lipolysis in Zucker rats. Am J Physiol 257:E871-E878, 1989
37. DeFronzo RA: Insulin secretion, insulin resistance, and obesity. Int J Obes 6:73-82, 1982 (suppl 1)
38. Gavin JR III, Roth J, Neville DM, et al: Insulin-dependent regulation of insulin receptor concentrations in cell culture. Proc Natl Acad Sci USA 71:84-88, 1974
39. Clark JB, Keen S, Clark CM Jr: Studies on the regulation of insulin binding by liver plasma membranes from Zucker fatty rats. Diabetes 31:867-873, 1982
40. Assimacopoulos-Jeannet F, Singh A, Le Marchand-Brustel Y, et al: Abnormalities in lipogenesis and triglyceride secretion by perfused livers of obese-hyperglycemic (ob/ob) mice: Relationship with hyperinsulinemia. Diabetologia 10:155-162, 1974
41. Loten EG, Rabinovitch A, Jeanenaud B: In vitro studies on lipogenesis in obese-hyperglycemic (ob/ob) mice: Possible role of hyperinsulinemia. Diabetologia 10:45-52, 1974
42. Wigand JP, Blackard WG: Downregulation of insulin receptors in obese man. Diabetes 28:287-291, 1979
43. Lopez S, Desbuquois B: Insulin-related changes in the subcellular distribution of insulin receptors in intact rat liver: Effects of acute hypoinsulinemia induced by diazoxide, somatostatin, and xylazine. Endocrinology 120:1695-1702, 1987
44. Demeyts P, Fehlman M: Physiological implications of negative cooperativity and heterogeneity in rat liver insulin receptors. Diabetes 30:52A, 1981 (suppl 1, abstr)
45. Vingeri R, Pleam NB, Cohen NC, et al: In vivo regulation of cell surface and intracellular insulin binding sites by insulin. J Biol Chem 253:8192-8197, 1978
46. Cushman S, Zarnowski MJ, Franzusoff AJ, et al: Alterations in glucose metabolism and its stimulation by insulin in isolated adipose cells during the development of genetic obesity in the Zucker fatty rat. Metabolism 27:1930-1940, 1978
47. Richardson DK, Czech MP: Primary role of decreased fatty acid synthesis in insulin resistance of large rat adipocytes. Am J Physiol 234:E182-E189, 1978
48. Salans LB, Cushman SW: Hormones and adipocytes: Factors influencing the metabolic effects of insulin and adrenaline, in Burland WL, Samuel PD, Yudkin J (eds): Obesity. London, UK, Churchill Livingston, 1974, pp 204-211
49. Salans LB, Cushman SW: The roles of adiposity and diet in the carbohydrate and lipid metabolic abnormalities of obesity, in Datzen HM, Mabler RJ (eds): Advances in Modern Nutrition, vol 2. Diabetes, Obesity and Vascular Disease: Metabolic and Molecular Interrelationships. Washington, DC, Wiley, 1978, pp 267-275