Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides

Hepatology

Volumn 59, Issue 1, 2014, Pages 143-153

  Cinar, Resat ^a   Godlewski, Grzegorz ^a   Liu, Jie ^a   Tam, Joseph ^a   Jourdan, Tony ^a   Mukhopadhyay, Bani ^a   Harvey White, Judith ^a   Kunos, George ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANANDAMIDE; CANNABINOID 1 RECEPTOR; CERAMIDE; PROTEIN KINASE B; SERINE PALMITOYLTRANSFERASE; SPHINGOSINE; THERMOZYMOCIDIN; JD5037; PYRAZOLE DERIVATIVE; SPTLC3 PROTEIN, MOUSE; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY LIVER; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SYNTHESIS; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL STRAIN HEPG2; DRUG ANTAGONISM; ENDOPLASMIC RETICULUM STRESS; LIVER CELL; METABOLISM; OBESITY; UPREGULATION; ANTAGONISTS AND INHIBITORS; HEPG2 CELL LINE;

ANIMALS; BODY WEIGHT; CERAMIDES; DIET, HIGH-FAT; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; HEP G2 CELLS; HEPATOCYTES; HUMANS; INSULIN RESISTANCE; LIVER; MICE; MICE, INBRED C57BL; OBESITY; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; SERINE C-PALMITOYLTRANSFERASE; SULFONAMIDES; UP-REGULATION;

EID: 84894042086     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26606     Document Type: Article

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