-
1
-
-
57449099863
-
Epigenetic regulation of mammalian stem cells
-
Li X and X Zhao. (2008). Epigenetic regulation of mammalian stem cells. Stem Cells Dev 17:1043-1052.
-
(2008)
Stem Cells Dev
, vol.17
, pp. 1043-1052
-
-
Li, X.1
Zhao, X.2
-
2
-
-
84874194072
-
DNA methylation: Roles in mammalian development
-
Smith ZD and A Meissner. (2013). DNA methylation: roles in mammalian development. Nat Rev Genet 14:204-220.
-
(2013)
Nat Rev Genet
, vol.14
, pp. 204-220
-
-
Smith, Z.D.1
Meissner, A.2
-
3
-
-
43749098985
-
DNA methylation landscapes: Provocative insights from epigenomics
-
Suzuki MM and A Bird. (2008). DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 9:465-476.
-
(2008)
Nat Rev Genet
, vol.9
, pp. 465-476
-
-
Suzuki, M.M.1
Bird, A.2
-
4
-
-
0001129080
-
The bases of the nucleic acids of some bacterial and animal viruses: The occurrence of 5-hydroxymethylcytosine
-
Wyatt GR and SS Cohen. (1953). The bases of the nucleic acids of some bacterial and animal viruses: the occurrence of 5-hydroxymethylcytosine. Biochem J 55:774-782.
-
(1953)
Biochem J
, vol.55
, pp. 774-782
-
-
Wyatt, G.R.1
Cohen, S.S.2
-
5
-
-
0015298215
-
The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid
-
Penn NW, R Suwalski, C O'Riley, K Bojanowski and R Yura. (1972). The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem J 126:781-790.
-
(1972)
Biochem J
, vol.126
, pp. 781-790
-
-
Penn, N.W.1
Suwalski, R.2
O'Riley, C.3
Bojanowski, K.4
Yura, R.5
-
6
-
-
66149146320
-
Conversion of 5-methylcytosine to 5- hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani M, KP Koh, Y Shen, WA Pastor, H Bandukwala, Y Brudno, S Agarwal, LM Iyer, DR Liu, L Aravind and A Rao. (2009). Conversion of 5-methylcytosine to 5- hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324:930-935.
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
Pastor, W.A.4
Bandukwala, H.5
Brudno, Y.6
Agarwal, S.7
Iyer, L.M.8
Liu, D.R.9
Aravind, L.10
Rao, A.11
-
7
-
-
66149123748
-
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
-
Kriaucionis S and N Heintz. (2009). The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324:929-930.
-
(2009)
Science
, vol.324
, pp. 929-930
-
-
Kriaucionis, S.1
Heintz, N.2
-
8
-
-
77956189495
-
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
-
Ito S, AC D'Alessio, OV Taranova, K Hong, LC Sowers and Y Zhang. (2010). Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466:1129-1133.
-
(2010)
Nature
, vol.466
, pp. 1129-1133
-
-
Ito, S.1
D'Alessio, A.C.2
Taranova, O.V.3
Hong, K.4
Sowers, L.C.5
Zhang, Y.6
-
9
-
-
80052495940
-
Tet-mediated formation of 5- carboxylcytosine and its excision by TDG in mammalian DNA
-
He YF, BZ Li, Z Li, P Liu, Y Wang, Q Tang, J Ding, Y Jia, Z Chen, et al. (2011). Tet-mediated formation of 5- carboxylcytosine and its excision by TDG in mammalian DNA. Science 333:1303-1307.
-
(2011)
Science
, vol.333
, pp. 1303-1307
-
-
He, Y.F.1
Li, B.Z.2
Li, Z.3
Liu, P.4
Wang, Y.5
Tang, Q.6
Ding, J.7
Jia, Y.8
Chen, Z.9
-
10
-
-
84869392308
-
Mapping recently identified nucleotide variants in the genome and transcriptome
-
Song CX, C Yi and C He. (2012). Mapping recently identified nucleotide variants in the genome and transcriptome. Nat Biotechnol 30:1107-1116.
-
(2012)
Nat Biotechnol
, vol.30
, pp. 1107-1116
-
-
Song, C.X.1
Yi, C.2
He, C.3
-
11
-
-
84860749868
-
Tet family proteins and 5- hydroxymethylcytosine in development and disease
-
Tan L and YG Shi. (2012). Tet family proteins and 5- hydroxymethylcytosine in development and disease. Development 139:1895-1902.
-
(2012)
Development
, vol.139
, pp. 1895-1902
-
-
Tan, L.1
Shi, Y.G.2
-
12
-
-
82955207588
-
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
-
Wu H and Y Zhang. (2011). Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev 25:2436-2452.
-
(2011)
Genes Dev
, vol.25
, pp. 2436-2452
-
-
Wu, H.1
Zhang, Y.2
-
13
-
-
84878260646
-
TETonic shift: Biological roles of TET proteins in DNA demethylation and transcription
-
Pastor WA, L Aravind and A Rao. (2013). TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol 14:341-356.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 341-356
-
-
Pastor, W.A.1
Aravind, L.2
Rao, A.3
-
14
-
-
84886860116
-
TET enzymes, TDG and the dynamics of DNA demethylation
-
Kohli RM and Y Zhang. (2013). TET enzymes, TDG and the dynamics of DNA demethylation. Nature 502:472-479.
-
(2013)
Nature
, vol.502
, pp. 472-479
-
-
Kohli, R.M.1
Zhang, Y.2
-
15
-
-
80052303426
-
TET family proteins and their role in stem cell differentiation and transformation
-
Cimmino L, O Abdel-Wahab, RL Levine and I Aifantis. (2011). TET family proteins and their role in stem cell differentiation and transformation. Cell Stem Cell 9: 193-204.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 193-204
-
-
Cimmino, L.1
Abdel-Wahab, O.2
Levine, R.L.3
Aifantis, I.4
-
16
-
-
84877582944
-
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
-
Ko M, J An, HS Bandukwala, L Chavez, T Aijo, WA Pastor, MF Segal, H Li, KP Koh, et al. (2013). Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature 497:122-126.
-
(2013)
Nature
, vol.497
, pp. 122-126
-
-
Ko, M.1
An, J.2
Bandukwala, H.S.3
Chavez, L.4
Aijo, T.5
Pastor, W.A.6
Segal, M.F.7
Li, H.8
Koh, K.P.9
-
17
-
-
82255192294
-
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging
-
Szulwach KE, X Li, Y Li, CX Song, H Wu, Q Dai, H Irier, AK Upadhyay, M Gearing, et al. (2011). 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci 14:1607-1616.
-
(2011)
Nat Neurosci
, vol.14
, pp. 1607-1616
-
-
Szulwach, K.E.1
Li, X.2
Li, Y.3
Song, C.X.4
Wu, H.5
Dai, Q.6
Irier, H.7
Upadhyay, A.K.8
Gearing, M.9
-
18
-
-
84871563384
-
MeCP2 Binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
-
Mellen M, P Ayata, S Dewell, S Kriaucionis and N Heintz. (2012). MeCP2 Binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell 151:1417-1430.
-
(2012)
Cell
, vol.151
, pp. 1417-1430
-
-
Mellen, M.1
Ayata, P.2
Dewell, S.3
Kriaucionis, S.4
Heintz, N.5
-
19
-
-
84874771985
-
Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives
-
Spruijt CG, F Gnerlich, AH Smits, T Pfaffeneder, PW Jansen, C Bauer, M Munzel, M Wagner, M Muller, et al. (2013). Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell 152:1146-1159.
-
(2013)
Cell
, vol.152
, pp. 1146-1159
-
-
Spruijt, C.G.1
Gnerlich, F.2
Smits, A.H.3
Pfaffeneder, T.4
Jansen, P.W.5
Bauer, C.6
Munzel, M.7
Wagner, M.8
Muller, M.9
-
20
-
-
84455167621
-
Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells
-
Yildirim O, R Li, JH Hung, PB Chen, X Dong, LS Ee, Z Weng, OJ Rando and TG Fazzio. (2011). Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell 147:1498-1510.
-
(2011)
Cell
, vol.147
, pp. 1498-1510
-
-
Yildirim, O.1
Li, R.2
Hung, J.H.3
Chen, P.B.4
Dong, X.5
Ee, L.S.6
Weng, Z.7
Rando, O.J.8
Fazzio, T.G.9
-
21
-
-
79956292024
-
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
-
Wu H, AC D'Alessio, S Ito, K Xia, Z Wang, K Cui, K Zhao, Y Eve Sun and Y Zhang. (2011). Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature 473:389-393.
-
(2011)
Nature
, vol.473
, pp. 389-393
-
-
Wu, H.1
D'Alessio, A.C.2
Ito, S.3
Xia, K.4
Wang, Z.5
Cui, K.6
Zhao, K.7
Eve Sun, Y.8
Zhang, Y.9
-
22
-
-
78651280460
-
Selective chemical labeling reveals the genome-wide distribution of 5- hydroxymethylcytosine
-
Song CX, KE Szulwach, Y Fu, Q Dai, C Yi, X Li, Y Li, CH Chen, W Zhang, et al. (2011). Selective chemical labeling reveals the genome-wide distribution of 5- hydroxymethylcytosine. Nat Biotechnol 29:68-72.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 68-72
-
-
Song, C.X.1
Szulwach, K.E.2
Fu, Y.3
Dai, Q.4
Yi, C.5
Li, X.6
Li, Y.7
Chen, C.H.8
Zhang, W.9
-
23
-
-
79956308473
-
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
-
Pastor WA, UJ Pape, Y Huang, HR Henderson, R Lister, M Ko, EM McLoughlin, Y Brudno, S Mahapatra, et al. (2011). Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature 473:394-397.
-
(2011)
Nature
, vol.473
, pp. 394-397
-
-
Pastor, W.A.1
Pape, U.J.2
Huang, Y.3
Henderson, H.R.4
Lister, R.5
Ko, M.6
McLoughlin, E.M.7
Brudno, Y.8
Mahapatra, S.9
-
24
-
-
77952967431
-
Direct detection of DNA methylation during single-molecule, real-time sequencing
-
Flusberg BA, DR Webster, JH Lee, KJ Travers, EC Olivares, TA Clark, J Korlach and SW Turner. (2010). Direct detection of DNA methylation during single-molecule, real-time sequencing. Nat Methods 7:461-465.
-
(2010)
Nat Methods
, vol.7
, pp. 461-465
-
-
Flusberg, B.A.1
Webster, D.R.2
Lee, J.H.3
Travers, K.J.4
Olivares, E.C.5
Clark, T.A.6
Korlach, J.7
Turner, S.W.8
-
25
-
-
79956323623
-
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
-
Ficz G, MR Branco, S Seisenberger, F Santos, F Krueger, TA Hore, CJ Marques, S Andrews and W Reik. (2011). Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature 473:398-402.
-
(2011)
Nature
, vol.473
, pp. 398-402
-
-
Ficz, G.1
Branco, M.R.2
Seisenberger, S.3
Santos, F.4
Krueger, F.5
Hore, T.A.6
Marques, C.J.7
Andrews, S.8
Reik, W.9
-
26
-
-
84897476274
-
Reactivation of capital HA, Cyrillic chromosome upon reprogramming leads to changes in the replication pattern and 5hmC accumulation
-
[Epub ahead of print]; DOI:10.1007/s00412-013-0433-x
-
Bogomazova AN, MA Lagarkova, AV Panova, ED Nekrasov and SL Kiselev. (2013). Reactivation of capital HA, Cyrillic chromosome upon reprogramming leads to changes in the replication pattern and 5hmC accumulation. Chromosoma. [Epub ahead of print]; DOI:10.1007/s00412-013-0433-x.
-
(2013)
Chromosoma
-
-
Bogomazova, A.N.1
Lagarkova, M.A.2
Panova, A.V.3
Nekrasov, E.D.4
Kiselev, S.L.5
-
27
-
-
84857891830
-
Tissue type is a major modifier of the 5- hydroxymethylcytosine content of human genes
-
Nestor CE, R Ottaviano, J Reddington, D Sproul, D Reinhardt, D Dunican, E Katz, JM Dixon, DJ Harrison and RR Meehan. (2012). Tissue type is a major modifier of the 5- hydroxymethylcytosine content of human genes. Genome Res 22:467-477.
-
(2012)
Genome Res
, vol.22
, pp. 467-477
-
-
Nestor, C.E.1
Ottaviano, R.2
Reddington, J.3
Sproul, D.4
Reinhardt, D.5
Dunican, D.6
Katz, E.7
Dixon, J.M.8
Harrison, D.J.9
Meehan, R.R.10
-
28
-
-
84874252793
-
Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis
-
Hahn MA, R Qiu, X Wu, AX Li, H Zhang, J Wang, J Jui, SG Jin, Y Jiang, GP Pfeifer and Q Lu. (2013). Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis. Cell Rep 3:291-300.
-
(2013)
Cell Rep
, vol.3
, pp. 291-300
-
-
Hahn, M.A.1
Qiu, R.2
Wu, X.3
Li, A.X.4
Zhang, H.5
Wang, J.6
Jui, J.7
Jin, S.G.8
Jiang, Y.9
Pfeifer, G.P.10
Lu, Q.11
-
29
-
-
80052285127
-
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
-
Li Z, X Cai, CL Cai, J Wang, W Zhang, BE Petersen, FC Yang and M Xu. (2011). Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood 118:4509-4518.
-
(2011)
Blood
, vol.118
, pp. 4509-4518
-
-
Li, Z.1
Cai, X.2
Cai, C.L.3
Wang, J.4
Zhang, W.5
Petersen, B.E.6
Yang, F.C.7
Xu, M.8
-
30
-
-
84892449532
-
Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage
-
Kim M, YK Park, TW Kang, SH Lee, YH Rhee, JL Park, HJ Kim, D Lee, D Lee, SY Kim and YS Kim. (2014). Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage. Hum Mol Genet 23:657-667.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 657-667
-
-
Kim, M.1
Park, Y.K.2
Kang, T.W.3
Lee, S.H.4
Rhee, Y.H.5
Park, J.L.6
Kim, H.J.7
Lee, D.8
Lee, D.9
Kim, S.Y.10
Kim, Y.S.11
-
31
-
-
80052461558
-
Tet proteins can convert 5- methylcytosine to 5-formylcytosine and 5-carboxylcytosine
-
Ito S, L Shen, Q Dai, SC Wu, LB Collins, JA Swenberg, C He and Y Zhang. (2011). Tet proteins can convert 5- methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333:1300-1303.
-
(2011)
Science
, vol.333
, pp. 1300-1303
-
-
Ito, S.1
Shen, L.2
Dai, Q.3
Wu, S.C.4
Collins, L.B.5
Swenberg, J.A.6
He, C.7
Zhang, Y.8
-
32
-
-
84861990517
-
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome
-
Yu M, GC Hon, KE Szulwach, CX Song, L Zhang, A Kim, X Li, Q Dai, Y Shen, et al. (2012). Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell 149:1368-1380.
-
(2012)
Cell
, vol.149
, pp. 1368-1380
-
-
Yu, M.1
Hon, G.C.2
Szulwach, K.E.3
Song, C.X.4
Zhang, L.5
Kim, A.6
Li, X.7
Dai, Q.8
Shen, Y.9
-
33
-
-
84876907152
-
Genome-wide Profiling of 5-formylcytosine reveals its roles in epigenetic priming
-
Song CX, KE Szulwach, Q Dai, Y Fu, SQ Mao, L Lin, C Street, Y Li, M Poidevin, et al. (2013). Genome-wide Profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell 153:678-691.
-
(2013)
Cell
, vol.153
, pp. 678-691
-
-
Song, C.X.1
Szulwach, K.E.2
Dai, Q.3
Fu, Y.4
Mao, S.Q.5
Lin, L.6
Street, C.7
Li, Y.8
Poidevin, M.9
-
34
-
-
84876946045
-
Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics
-
Shen L, H Wu, D Diep, S Yamaguchi, AC D'Alessio, HL Fung, K Zhang and Y Zhang. (2013). Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell 153:692-706.
-
(2013)
Cell
, vol.153
, pp. 692-706
-
-
Shen, L.1
Wu, H.2
Diep, D.3
Yamaguchi, S.4
D'Alessio, A.C.5
Fung, H.L.6
Zhang, K.7
Zhang, Y.8
-
35
-
-
84875370281
-
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency
-
Costa Y, J Ding, TW Theunissen, F Faiola, TA Hore, PV Shliaha, M Fidalgo, A Saunders, M Lawrence, et al. (2013). NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature 495:370-374.
-
(2013)
Nature
, vol.495
, pp. 370-374
-
-
Costa, Y.1
Ding, J.2
Theunissen, T.W.3
Faiola, F.4
Hore, T.A.5
Shliaha, P.V.6
Fidalgo, M.7
Saunders, A.8
Lawrence, M.9
-
36
-
-
34249279527
-
Stability and flexibility of epigenetic gene regulation in mammalian development
-
Reik W. (2007). Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447:425-432.
-
(2007)
Nature
, vol.447
, pp. 425-432
-
-
Reik, W.1
-
37
-
-
79952763586
-
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine
-
Iqbal K, SG Jin, GP Pfeifer and PE Szabo. (2011). Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A 108:3642-3647.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 3642-3647
-
-
Iqbal, K.1
Jin, S.G.2
Pfeifer, G.P.3
Szabo, P.E.4
-
38
-
-
79952713567
-
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming
-
Wossidlo M, T Nakamura, K Lepikhov, CJ Marques, V Zakhartchenko, M Boiani, J Arand, T Nakano, W Reik and J Walter. 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat Commun 2:241.
-
Nat Commun
, vol.2
, pp. 241
-
-
Wossidlo, M.1
Nakamura, T.2
Lepikhov, K.3
Marques, C.J.4
Zakhartchenko, V.5
Boiani, M.6
Arand, J.7
Nakano, T.8
Reik, W.9
Walter, J.10
-
39
-
-
80053348585
-
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
-
Gu TP, F Guo, H Yang, HP Wu, GF Xu, W Liu, ZG Xie, L Shi, X He, et al. (2011). The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature 477:606-610.
-
(2011)
Nature
, vol.477
, pp. 606-610
-
-
Gu, T.P.1
Guo, F.2
Yang, H.3
Wu, H.P.4
Xu, G.F.5
Liu, W.6
Xie, Z.G.7
Shi, L.8
He, X.9
-
40
-
-
79551587102
-
Tet1 and tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells
-
Koh KP, A Yabuuchi, S Rao, Y Huang, K Cunniff, J Nardone, A Laiho, M Tahiliani, CA Sommer, et al. (2011). Tet1 and tet2 regulate 5- hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell 8:200-213.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 200-213
-
-
Koh, K.P.1
Yabuuchi, A.2
Rao, S.3
Huang, Y.4
Cunniff, K.5
Nardone, J.6
Laiho, A.7
Tahiliani, M.8
Sommer, C.A.9
-
41
-
-
79955948324
-
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells
-
Xu Y, F Wu, L Tan, L Kong, L Xiong, J Deng, AJ Barbera, L Zheng, H Zhang, et al. (2011). Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol cell 42:451-464.
-
(2011)
Mol Cell
, vol.42
, pp. 451-464
-
-
Xu, Y.1
Wu, F.2
Tan, L.3
Kong, L.4
Xiong, L.5
Deng, J.6
Barbera, A.J.7
Zheng, L.8
Zhang, H.9
-
42
-
-
79956302047
-
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
-
Williams K, J Christensen, MT Pedersen, JV Johansen, PA Cloos, J Rappsilber and K Helin. (2011). TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature 473:343-348.
-
(2011)
Nature
, vol.473
, pp. 343-348
-
-
Williams, K.1
Christensen, J.2
Pedersen, M.T.3
Johansen, J.V.4
Cloos, P.A.5
Rappsilber, J.6
Helin, K.7
-
43
-
-
80054046273
-
Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia
-
Konstandin N, S Bultmann, A Szwagierczak, A Dufour, B Ksienzyk, F Schneider, T Herold, M Mulaw, PM Kakadia, et al. (2011). Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia. Leukemia 25:1649-1652.
-
(2011)
Leukemia
, vol.25
, pp. 1649-1652
-
-
Konstandin, N.1
Bultmann, S.2
Szwagierczak, A.3
Dufour, A.4
Ksienzyk, B.5
Schneider, F.6
Herold, T.7
Mulaw, M.8
Kakadia, P.M.9
-
44
-
-
79959209733
-
5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells
-
Stroud H, S Feng, S Morey Kinney, S Pradhan and SE Jacobsen. (2011). 5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells. Genome Biol 12:R54.
-
(2011)
Genome Biol
, vol.12
-
-
Stroud, H.1
Feng, S.2
Morey Kinney, S.3
Pradhan, S.4
Jacobsen, S.E.5
-
45
-
-
79959859654
-
Integrating 5- hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells
-
Szulwach KE, X Li, Y Li, CX Song, JW Han, S Kim, S Namburi, K Hermetz, JJ Kim, et al. (2011). Integrating 5- hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet 7:e1002154.
-
(2011)
PLoS Genet
, vol.7
-
-
Szulwach, K.E.1
Li, X.2
Li, Y.3
Song, C.X.4
Han, J.W.5
Kim, S.6
Namburi, S.7
Hermetz, K.8
Kim, J.J.9
-
46
-
-
84878226536
-
Origins and implications of pluripotent stem cell variability and heterogeneity
-
Cahan P and GQ Daley. (2013). Origins and implications of pluripotent stem cell variability and heterogeneity. Nat Rev Mol Cell Biol 14:357-368.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 357-368
-
-
Cahan, P.1
Daley, G.Q.2
-
47
-
-
46449094276
-
Dissecting direct reprogramming through integrative genomic analysis
-
Mikkelsen TS, J Hanna, X Zhang, M Ku, M Wernig, P Schorderet, BE Bernstein, R Jaenisch, ES Lander and A Meissner. (2008). Dissecting direct reprogramming through integrative genomic analysis. Nature 454:49-55.
-
(2008)
Nature
, vol.454
, pp. 49-55
-
-
Mikkelsen, T.S.1
Hanna, J.2
Zhang, X.3
Ku, M.4
Wernig, M.5
Schorderet, P.6
Bernstein, B.E.7
Jaenisch, R.8
Lander, E.S.9
Meissner, A.10
-
48
-
-
84875923762
-
Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming
-
Gao Y, J Chen, K Li, T Wu, B Huang, W Liu, X Kou, Y Zhang, H Huang, et al. (2013). Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell 12:453-469.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 453-469
-
-
Gao, Y.1
Chen, J.2
Li, K.3
Wu, T.4
Huang, B.5
Liu, W.6
Kou, X.7
Zhang, Y.8
Huang, H.9
-
49
-
-
84875783959
-
Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion
-
Piccolo FM, H Bagci, KE Brown, D Landeira, J Soza-Ried, A Feytout, D Mooijman, P Hajkova, HG Leitch, et al. (2013). Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion. Mol Cell 49:1023-1033.
-
(2013)
Mol Cell
, vol.49
, pp. 1023-1033
-
-
Piccolo, F.M.1
Bagci, H.2
Brown, K.E.3
Landeira, D.4
Soza-Ried, J.5
Feytout, A.6
Mooijman, D.7
Hajkova, P.8
Leitch, H.G.9
-
50
-
-
84865486793
-
Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2
-
Doege CA, K Inoue, T Yamashita, DB Rhee, S Travis, R Fujita, P Guarnieri, G Bhagat, WB Vanti, et al. (2012). Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2. Nature 488:652-655.
-
(2012)
Nature
, vol.488
, pp. 652-655
-
-
Doege, C.A.1
Inoue, K.2
Yamashita, T.3
Rhee, D.B.4
Travis, S.5
Fujita, R.6
Guarnieri, P.7
Bhagat, G.8
Vanti, W.B.9
-
51
-
-
84878591266
-
Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency
-
Wang T, H Wu, Y Li, KE Szulwach, L Lin, X Li, IP Chen, IS Goldlust, SJ Chamberlain, et al. (2013). Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nat Cell Biol 15:700-711.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 700-711
-
-
Wang, T.1
Wu, H.2
Li, Y.3
Szulwach, K.E.4
Lin, L.5
Li, X.6
Chen, I.P.7
Goldlust, I.S.8
Chamberlain, S.J.9
-
52
-
-
0037099537
-
LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)
-
Ono R, T Taki, T Taketani, M Taniwaki, H Kobayashi and Y Hayashi. (2002). LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). Cancer Res 62:4075-4080.
-
(2002)
Cancer Res
, vol.62
, pp. 4075-4080
-
-
Ono, R.1
Taki, T.2
Taketani, T.3
Taniwaki, M.4
Kobayashi, H.5
Hayashi, Y.6
-
53
-
-
80052284526
-
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
-
Ko M, HS Bandukwala, J An, ED Lamperti, EC Thompson, R Hastie, A Tsangaratou, K Rajewsky, SB Koralov and A Rao. (2011). Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A 108:14566-14571.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 14566-14571
-
-
Ko, M.1
Bandukwala, H.S.2
An, J.3
Lamperti, E.D.4
Thompson, E.C.5
Hastie, R.6
Tsangaratou, A.7
Rajewsky, K.8
Koralov, S.B.9
Rao, A.10
-
54
-
-
79960768558
-
Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors
-
Pronier E, C Almire, H Mokrani, A Vasanthakumar, A Simon, B da Costa Reis Monte Mor, A Masse, JP Le Couedic, F Pendino, et al. (2011). Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors. Blood 118:2551-2555.
-
(2011)
Blood
, vol.118
, pp. 2551-2555
-
-
Pronier, E.1
Almire, C.2
Mokrani, H.3
Vasanthakumar, A.4
Simon, A.5
Da Costa-Reis-Monte Mor, B.6
Masse, A.7
Le Couedic, J.P.8
Pendino, F.9
-
55
-
-
78650175023
-
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
-
Ko M, Y Huang, AM Jankowska, UJ Pape, M Tahiliani, HS Bandukwala, J An, ED Lamperti, KP Koh, et al. (2011). Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 468:839-843.
-
(2011)
Nature
, vol.468
, pp. 839-843
-
-
Ko, M.1
Huang, Y.2
Jankowska, A.M.3
Pape, U.J.4
Tahiliani, M.5
Bandukwala, H.S.6
An, J.7
Lamperti, E.D.8
Koh, K.P.9
-
56
-
-
84255200412
-
5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations
-
Jin SG, Y Jiang, R Qiu, TA Rauch, Y Wang, G Schackert, D Krex, Q Lu and GP Pfeifer. (2011). 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res 71:7360-7365.
-
(2011)
Cancer Res
, vol.71
, pp. 7360-7365
-
-
Jin, S.G.1
Jiang, Y.2
Qiu, R.3
Rauch, T.A.4
Wang, Y.5
Schackert, G.6
Krex, D.7
Lu, Q.8
Pfeifer, G.P.9
-
57
-
-
84866419591
-
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
-
Lian CG, Y Xu, C Ceol, F Wu, A Larson, K Dresser, W Xu, L Tan, Y Hu, et al. (2012). Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 150:1135-1146.
-
(2012)
Cell
, vol.150
, pp. 1135-1146
-
-
Lian, C.G.1
Xu, Y.2
Ceol, C.3
Wu, F.4
Larson, A.5
Dresser, K.6
Xu, W.7
Tan, L.8
Hu, Y.9
-
58
-
-
84864120277
-
Nuclear exclusion of TET1 is associated with loss of 5- hydroxymethylcytosine in IDH1 wild-type gliomas
-
Muller T, M Gessi, A Waha, LJ Isselstein, D Luxen, D Freihoff, J Freihoff, A Becker, M Simon, et al. (2012). Nuclear exclusion of TET1 is associated with loss of 5- hydroxymethylcytosine in IDH1 wild-type gliomas. Am J Pathol 181:675-683.
-
(2012)
Am J Pathol
, vol.181
, pp. 675-683
-
-
Muller, T.1
Gessi, M.2
Waha, A.3
Isselstein, L.J.4
Luxen, D.5
Freihoff, D.6
Freihoff, J.7
Becker, A.8
Simon, M.9
-
59
-
-
84880570961
-
Micro RNA antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling
-
Song SJ, L Poliseno, MS Song, U Ala, K Webster, C Ng, G Beringer, NJ Brikbak, X Yuan, et al. (2013). Micro RNA antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell 154:311-324.
-
(2013)
Cell
, vol.154
, pp. 311-324
-
-
Song, S.J.1
Poliseno, L.2
Song, M.S.3
Ala, U.4
Webster, K.5
Ng, C.6
Beringer, G.7
Brikbak, N.J.8
Yuan, X.9
-
60
-
-
77958605856
-
Epigenetic choreographers of neurogenesis in the adult mammalian brain
-
Ma DK, MC Marchetto, JU Guo, GL Ming, FH Gage and H Song. (2010). Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci 13:1338-1344.
-
(2010)
Nat Neurosci
, vol.13
, pp. 1338-1344
-
-
Ma, D.K.1
Marchetto, M.C.2
Guo, J.U.3
Ming, G.L.4
Gage, F.H.5
Song, H.6
-
61
-
-
77952678006
-
Epigenetic control of neural precursor cell fate during development
-
Hirabayashi Y and Y Gotoh. (2010). Epigenetic control of neural precursor cell fate during development. Nat Rev Neurosci 11:377-388.
-
(2010)
Nat Rev Neurosci
, vol.11
, pp. 377-388
-
-
Hirabayashi, Y.1
Gotoh, Y.2
-
62
-
-
84867230056
-
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary
-
Khare T, S Pai, K Koncevicius, M Pal, E Kriukiene, Z Liutkeviciute, M Irimia, P Jia, C Ptak, et al. (2012). 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary. Nat Struct Mol Biol 19:1037-1043.
-
(2012)
Nat Struct Mol Biol
, vol.19
, pp. 1037-1043
-
-
Khare, T.1
Pai, S.2
Koncevicius, K.3
Pal, M.4
Kriukiene, E.5
Liutkeviciute, Z.6
Irimia, M.7
Jia, P.8
Ptak, C.9
-
63
-
-
84870883633
-
Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development
-
Xu Y, C Xu, A Kato, W Tempel, JG Abreu, C Bian, Y Hu, D Hu, B Zhao, et al. (2012). Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell 151:1200-1213.
-
(2012)
Cell
, vol.151
, pp. 1200-1213
-
-
Xu, Y.1
Xu, C.2
Kato, A.3
Tempel, W.4
Abreu, J.G.5
Bian, C.6
Hu, Y.7
Hu, D.8
Zhao, B.9
-
64
-
-
79961139741
-
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development
-
Dawlaty MM, K Ganz, BE Powell, YC Hu, S Markoulaki, AW Cheng, Q Gao, J Kim, SW Choi, DC Page and R Jaenisch. (2011). Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell 9:166-175.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 166-175
-
-
Dawlaty, M.M.1
Ganz, K.2
Powell, B.E.3
Hu, Y.C.4
Markoulaki, S.5
Cheng, A.W.6
Gao, Q.7
Kim, J.8
Choi, S.W.9
Page, D.C.10
Jaenisch, R.11
-
65
-
-
84881178902
-
Tet1 regulates adult hippocampal neurogenesis and cognition
-
Zhang RR, QY Cui, K Murai, YC Lim, ZD Smith, S Jin, P Ye, L Rosa, YK Lee, et al. (2013). Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell 13:237-245.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 237-245
-
-
Zhang, R.R.1
Cui, Q.Y.2
Murai, K.3
Lim, Y.C.4
Smith, Z.D.5
Jin, S.6
Ye, P.7
Rosa, L.8
Lee, Y.K.9
-
66
-
-
79955538247
-
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
-
Guo JU, Y Su, C Zhong, GL Ming and H Song. (2011). Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145:423-434.
-
(2011)
Cell
, vol.145
, pp. 423-434
-
-
Guo, J.U.1
Su, Y.2
Zhong, C.3
Ming, G.L.4
Song, H.5
-
67
-
-
84884241288
-
Tet1 is critical for neuronal activity-regulated gene expression and memory extinction
-
Rudenko A, MM Dawlaty, J Seo, AW Cheng, J Meng, T Le, KF Faull, R Jaenisch and LH Tsai. (2013). Tet1 is critical for neuronal activity-regulated gene expression and memory extinction. Neuron 79:1109-1122.
-
(2013)
Neuron
, vol.79
, pp. 1109-1122
-
-
Rudenko, A.1
Dawlaty, M.M.2
Seo, J.3
Cheng, A.W.4
Meng, J.5
Le, T.6
Faull, K.F.7
Jaenisch, R.8
Tsai, L.H.9
-
68
-
-
84884471932
-
TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation
-
Kaas GA, C Zhong, DE Eason, DL Ross, RV Vachhani, GL Ming, JR King, H Song and JD Sweatt. (2013). TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation. Neuron 79:1086-1093.
-
(2013)
Neuron
, vol.79
, pp. 1086-1093
-
-
Kaas, G.A.1
Zhong, C.2
Eason, D.E.3
Ross, D.L.4
Vachhani, R.V.5
Ming, G.L.6
King, J.R.7
Song, H.8
Sweatt, J.D.9
-
69
-
-
84875218124
-
TET2 and TET3 regulate Glc NA cylation and H3K4 methylation through OGT and SET1/COMPASS
-
Deplus R, B Delatte, MK Schwinn, M Defrance, J Mendez, N Murphy, MA Dawson, M Volkmar, P Putmans, et al. (2013). TET2 and TET3 regulate Glc NA cylation and H3K4 methylation through OGT and SET1/COMPASS. EMBO J 32:645-655.
-
(2013)
EMBO J
, vol.32
, pp. 645-655
-
-
Deplus, R.1
Delatte, B.2
Schwinn, M.K.3
Defrance, M.4
Mendez, J.5
Murphy, N.6
Dawson, M.A.7
Volkmar, M.8
Putmans, P.9
-
70
-
-
84872953223
-
TET2 promotes histone O-Glc NA cylation during gene transcription
-
Chen Q, Y Chen, C Bian, R Fujiki and X Yu. (2013). TET2 promotes histone O-Glc NA cylation during gene transcription. Nature 493:561-564.
-
(2013)
Nature
, vol.493
, pp. 561-564
-
-
Chen, Q.1
Chen, Y.2
Bian, C.3
Fujiki, R.4
Yu, X.5
-
71
-
-
84874266225
-
Tet proteins connect the O-linked Nacetylglucosamine transferase Ogt to chromatin in embryonic stem cells
-
Vella P, A Scelfo, S Jammula, F Chiacchiera, K Williams, A Cuomo, A Roberto, J Christensen, T Bonaldi, K Helin and D Pasini. (2013). Tet proteins connect the O-linked Nacetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell 49:645-656.
-
(2013)
Mol Cell
, vol.49
, pp. 645-656
-
-
Vella, P.1
Scelfo, A.2
Jammula, S.3
Chiacchiera, F.4
Williams, K.5
Cuomo, A.6
Roberto, A.7
Christensen, J.8
Bonaldi, T.9
Helin, K.10
Pasini, D.11
-
72
-
-
84887046365
-
Micro RNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation
-
Fu X, L Jin, X Wang, A Luo, J Hu, X Zheng, WM Tsark, AD Riggs, HT Ku and W Huang. (2013). Micro RNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation. Proc Natl Acad Sci U S A 110:17892-17897.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 17892-17897
-
-
Fu, X.1
Jin, L.2
Wang, X.3
Luo, A.4
Hu, J.5
Zheng, X.6
Tsark, W.M.7
Riggs, A.D.8
Ku, H.T.9
Huang, W.10
-
73
-
-
84880571480
-
The oncogenic micro RNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation
-
Song SJ, K Ito, U Ala, L Kats, K Webster, SM Sun, M Jongen-Lavrencic, K Manova-Todorova, J Teruya-Feldstein, et al. (2013). The oncogenic micro RNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation. Cell Stem Cell 13:87-101.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 87-101
-
-
Song, S.J.1
Ito, K.2
Ala, U.3
Kats, L.4
Webster, K.5
Sun, S.M.6
Jongen-Lavrencic, M.7
Manova-Todorova, K.8
Teruya-Feldstein, J.9
-
74
-
-
84888372386
-
Vitamin C modulates TET1 function during somatic cell reprogramming
-
Chen J, L Guo, L Zhang, H Wu, J Yang, H Liu, X Wang, X Hu, T Gu, et al. (2013). Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet 45:1504-1509.
-
(2013)
Nat Genet
, vol.45
, pp. 1504-1509
-
-
Chen, J.1
Guo, L.2
Zhang, L.3
Wu, H.4
Yang, J.5
Liu, H.6
Wang, X.7
Hu, X.8
Gu, T.9
-
75
-
-
84881476916
-
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
-
Blaschke K, KT Ebata, MM Karimi, JA Zepeda-Martinez, P Goyal, S Mahapatra, A Tam, DJ Laird, M Hirst, et al. (2013). Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature 500:222-226.
-
(2013)
Nature
, vol.500
, pp. 222-226
-
-
Blaschke, K.1
Ebata, K.T.2
Karimi, M.M.3
Zepeda-Martinez, J.A.4
Goyal, P.5
Mahapatra, S.6
Tam, A.7
Laird, D.J.8
Hirst, M.9
-
76
-
-
84877693964
-
Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
-
Minor EA, BL Court, JI Young and G Wang. (2013). Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine. J Biol Chem 288:13669-13674.
-
(2013)
J Biol Chem
, vol.288
, pp. 13669-13674
-
-
Minor, E.A.1
Court, B.L.2
Young, J.I.3
Wang, G.4
|