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Volumn 23, Issue 9, 2014, Pages 923-930

5-hydroxymethylcytosine-mediated DNA demethylation in stem cells and development

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; BINDING PROTEIN; DNA; 5-HYDROXYMETHYLCYTOSINE; CYTOSINE; DNA BINDING PROTEIN;

EID: 84899071179     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2013.0428     Document Type: Review
Times cited : (24)

References (76)
  • 1
    • 57449099863 scopus 로고    scopus 로고
    • Epigenetic regulation of mammalian stem cells
    • Li X and X Zhao. (2008). Epigenetic regulation of mammalian stem cells. Stem Cells Dev 17:1043-1052.
    • (2008) Stem Cells Dev , vol.17 , pp. 1043-1052
    • Li, X.1    Zhao, X.2
  • 2
    • 84874194072 scopus 로고    scopus 로고
    • DNA methylation: Roles in mammalian development
    • Smith ZD and A Meissner. (2013). DNA methylation: roles in mammalian development. Nat Rev Genet 14:204-220.
    • (2013) Nat Rev Genet , vol.14 , pp. 204-220
    • Smith, Z.D.1    Meissner, A.2
  • 3
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: Provocative insights from epigenomics
    • Suzuki MM and A Bird. (2008). DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 9:465-476.
    • (2008) Nat Rev Genet , vol.9 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 4
    • 0001129080 scopus 로고
    • The bases of the nucleic acids of some bacterial and animal viruses: The occurrence of 5-hydroxymethylcytosine
    • Wyatt GR and SS Cohen. (1953). The bases of the nucleic acids of some bacterial and animal viruses: the occurrence of 5-hydroxymethylcytosine. Biochem J 55:774-782.
    • (1953) Biochem J , vol.55 , pp. 774-782
    • Wyatt, G.R.1    Cohen, S.S.2
  • 5
    • 0015298215 scopus 로고
    • The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid
    • Penn NW, R Suwalski, C O'Riley, K Bojanowski and R Yura. (1972). The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem J 126:781-790.
    • (1972) Biochem J , vol.126 , pp. 781-790
    • Penn, N.W.1    Suwalski, R.2    O'Riley, C.3    Bojanowski, K.4    Yura, R.5
  • 7
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis S and N Heintz. (2009). The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324:929-930.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 8
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
    • Ito S, AC D'Alessio, OV Taranova, K Hong, LC Sowers and Y Zhang. (2010). Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466:1129-1133.
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 9
    • 80052495940 scopus 로고    scopus 로고
    • Tet-mediated formation of 5- carboxylcytosine and its excision by TDG in mammalian DNA
    • He YF, BZ Li, Z Li, P Liu, Y Wang, Q Tang, J Ding, Y Jia, Z Chen, et al. (2011). Tet-mediated formation of 5- carboxylcytosine and its excision by TDG in mammalian DNA. Science 333:1303-1307.
    • (2011) Science , vol.333 , pp. 1303-1307
    • He, Y.F.1    Li, B.Z.2    Li, Z.3    Liu, P.4    Wang, Y.5    Tang, Q.6    Ding, J.7    Jia, Y.8    Chen, Z.9
  • 10
    • 84869392308 scopus 로고    scopus 로고
    • Mapping recently identified nucleotide variants in the genome and transcriptome
    • Song CX, C Yi and C He. (2012). Mapping recently identified nucleotide variants in the genome and transcriptome. Nat Biotechnol 30:1107-1116.
    • (2012) Nat Biotechnol , vol.30 , pp. 1107-1116
    • Song, C.X.1    Yi, C.2    He, C.3
  • 11
    • 84860749868 scopus 로고    scopus 로고
    • Tet family proteins and 5- hydroxymethylcytosine in development and disease
    • Tan L and YG Shi. (2012). Tet family proteins and 5- hydroxymethylcytosine in development and disease. Development 139:1895-1902.
    • (2012) Development , vol.139 , pp. 1895-1902
    • Tan, L.1    Shi, Y.G.2
  • 12
    • 82955207588 scopus 로고    scopus 로고
    • Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
    • Wu H and Y Zhang. (2011). Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev 25:2436-2452.
    • (2011) Genes Dev , vol.25 , pp. 2436-2452
    • Wu, H.1    Zhang, Y.2
  • 13
    • 84878260646 scopus 로고    scopus 로고
    • TETonic shift: Biological roles of TET proteins in DNA demethylation and transcription
    • Pastor WA, L Aravind and A Rao. (2013). TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol 14:341-356.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 341-356
    • Pastor, W.A.1    Aravind, L.2    Rao, A.3
  • 14
    • 84886860116 scopus 로고    scopus 로고
    • TET enzymes, TDG and the dynamics of DNA demethylation
    • Kohli RM and Y Zhang. (2013). TET enzymes, TDG and the dynamics of DNA demethylation. Nature 502:472-479.
    • (2013) Nature , vol.502 , pp. 472-479
    • Kohli, R.M.1    Zhang, Y.2
  • 15
    • 80052303426 scopus 로고    scopus 로고
    • TET family proteins and their role in stem cell differentiation and transformation
    • Cimmino L, O Abdel-Wahab, RL Levine and I Aifantis. (2011). TET family proteins and their role in stem cell differentiation and transformation. Cell Stem Cell 9: 193-204.
    • (2011) Cell Stem Cell , vol.9 , pp. 193-204
    • Cimmino, L.1    Abdel-Wahab, O.2    Levine, R.L.3    Aifantis, I.4
  • 18
    • 84871563384 scopus 로고    scopus 로고
    • MeCP2 Binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
    • Mellen M, P Ayata, S Dewell, S Kriaucionis and N Heintz. (2012). MeCP2 Binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell 151:1417-1430.
    • (2012) Cell , vol.151 , pp. 1417-1430
    • Mellen, M.1    Ayata, P.2    Dewell, S.3    Kriaucionis, S.4    Heintz, N.5
  • 20
    • 84455167621 scopus 로고    scopus 로고
    • Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells
    • Yildirim O, R Li, JH Hung, PB Chen, X Dong, LS Ee, Z Weng, OJ Rando and TG Fazzio. (2011). Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell 147:1498-1510.
    • (2011) Cell , vol.147 , pp. 1498-1510
    • Yildirim, O.1    Li, R.2    Hung, J.H.3    Chen, P.B.4    Dong, X.5    Ee, L.S.6    Weng, Z.7    Rando, O.J.8    Fazzio, T.G.9
  • 22
  • 26
    • 84897476274 scopus 로고    scopus 로고
    • Reactivation of capital HA, Cyrillic chromosome upon reprogramming leads to changes in the replication pattern and 5hmC accumulation
    • [Epub ahead of print]; DOI:10.1007/s00412-013-0433-x
    • Bogomazova AN, MA Lagarkova, AV Panova, ED Nekrasov and SL Kiselev. (2013). Reactivation of capital HA, Cyrillic chromosome upon reprogramming leads to changes in the replication pattern and 5hmC accumulation. Chromosoma. [Epub ahead of print]; DOI:10.1007/s00412-013-0433-x.
    • (2013) Chromosoma
    • Bogomazova, A.N.1    Lagarkova, M.A.2    Panova, A.V.3    Nekrasov, E.D.4    Kiselev, S.L.5
  • 29
    • 80052285127 scopus 로고    scopus 로고
    • Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
    • Li Z, X Cai, CL Cai, J Wang, W Zhang, BE Petersen, FC Yang and M Xu. (2011). Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood 118:4509-4518.
    • (2011) Blood , vol.118 , pp. 4509-4518
    • Li, Z.1    Cai, X.2    Cai, C.L.3    Wang, J.4    Zhang, W.5    Petersen, B.E.6    Yang, F.C.7    Xu, M.8
  • 31
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5- methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • Ito S, L Shen, Q Dai, SC Wu, LB Collins, JA Swenberg, C He and Y Zhang. (2011). Tet proteins can convert 5- methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333:1300-1303.
    • (2011) Science , vol.333 , pp. 1300-1303
    • Ito, S.1    Shen, L.2    Dai, Q.3    Wu, S.C.4    Collins, L.B.5    Swenberg, J.A.6    He, C.7    Zhang, Y.8
  • 32
  • 34
    • 84876946045 scopus 로고    scopus 로고
    • Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics
    • Shen L, H Wu, D Diep, S Yamaguchi, AC D'Alessio, HL Fung, K Zhang and Y Zhang. (2013). Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell 153:692-706.
    • (2013) Cell , vol.153 , pp. 692-706
    • Shen, L.1    Wu, H.2    Diep, D.3    Yamaguchi, S.4    D'Alessio, A.C.5    Fung, H.L.6    Zhang, K.7    Zhang, Y.8
  • 36
    • 34249279527 scopus 로고    scopus 로고
    • Stability and flexibility of epigenetic gene regulation in mammalian development
    • Reik W. (2007). Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447:425-432.
    • (2007) Nature , vol.447 , pp. 425-432
    • Reik, W.1
  • 37
    • 79952763586 scopus 로고    scopus 로고
    • Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine
    • Iqbal K, SG Jin, GP Pfeifer and PE Szabo. (2011). Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A 108:3642-3647.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3642-3647
    • Iqbal, K.1    Jin, S.G.2    Pfeifer, G.P.3    Szabo, P.E.4
  • 39
    • 80053348585 scopus 로고    scopus 로고
    • The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
    • Gu TP, F Guo, H Yang, HP Wu, GF Xu, W Liu, ZG Xie, L Shi, X He, et al. (2011). The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature 477:606-610.
    • (2011) Nature , vol.477 , pp. 606-610
    • Gu, T.P.1    Guo, F.2    Yang, H.3    Wu, H.P.4    Xu, G.F.5    Liu, W.6    Xie, Z.G.7    Shi, L.8    He, X.9
  • 41
    • 79955948324 scopus 로고    scopus 로고
    • Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells
    • Xu Y, F Wu, L Tan, L Kong, L Xiong, J Deng, AJ Barbera, L Zheng, H Zhang, et al. (2011). Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol cell 42:451-464.
    • (2011) Mol Cell , vol.42 , pp. 451-464
    • Xu, Y.1    Wu, F.2    Tan, L.3    Kong, L.4    Xiong, L.5    Deng, J.6    Barbera, A.J.7    Zheng, L.8    Zhang, H.9
  • 43
    • 80054046273 scopus 로고    scopus 로고
    • Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia
    • Konstandin N, S Bultmann, A Szwagierczak, A Dufour, B Ksienzyk, F Schneider, T Herold, M Mulaw, PM Kakadia, et al. (2011). Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia. Leukemia 25:1649-1652.
    • (2011) Leukemia , vol.25 , pp. 1649-1652
    • Konstandin, N.1    Bultmann, S.2    Szwagierczak, A.3    Dufour, A.4    Ksienzyk, B.5    Schneider, F.6    Herold, T.7    Mulaw, M.8    Kakadia, P.M.9
  • 44
    • 79959209733 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells
    • Stroud H, S Feng, S Morey Kinney, S Pradhan and SE Jacobsen. (2011). 5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells. Genome Biol 12:R54.
    • (2011) Genome Biol , vol.12
    • Stroud, H.1    Feng, S.2    Morey Kinney, S.3    Pradhan, S.4    Jacobsen, S.E.5
  • 46
    • 84878226536 scopus 로고    scopus 로고
    • Origins and implications of pluripotent stem cell variability and heterogeneity
    • Cahan P and GQ Daley. (2013). Origins and implications of pluripotent stem cell variability and heterogeneity. Nat Rev Mol Cell Biol 14:357-368.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 357-368
    • Cahan, P.1    Daley, G.Q.2
  • 48
    • 84875923762 scopus 로고    scopus 로고
    • Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming
    • Gao Y, J Chen, K Li, T Wu, B Huang, W Liu, X Kou, Y Zhang, H Huang, et al. (2013). Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell 12:453-469.
    • (2013) Cell Stem Cell , vol.12 , pp. 453-469
    • Gao, Y.1    Chen, J.2    Li, K.3    Wu, T.4    Huang, B.5    Liu, W.6    Kou, X.7    Zhang, Y.8    Huang, H.9
  • 51
    • 84878591266 scopus 로고    scopus 로고
    • Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency
    • Wang T, H Wu, Y Li, KE Szulwach, L Lin, X Li, IP Chen, IS Goldlust, SJ Chamberlain, et al. (2013). Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nat Cell Biol 15:700-711.
    • (2013) Nat Cell Biol , vol.15 , pp. 700-711
    • Wang, T.1    Wu, H.2    Li, Y.3    Szulwach, K.E.4    Lin, L.5    Li, X.6    Chen, I.P.7    Goldlust, I.S.8    Chamberlain, S.J.9
  • 52
    • 0037099537 scopus 로고    scopus 로고
    • LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)
    • Ono R, T Taki, T Taketani, M Taniwaki, H Kobayashi and Y Hayashi. (2002). LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). Cancer Res 62:4075-4080.
    • (2002) Cancer Res , vol.62 , pp. 4075-4080
    • Ono, R.1    Taki, T.2    Taketani, T.3    Taniwaki, M.4    Kobayashi, H.5    Hayashi, Y.6
  • 54
    • 79960768558 scopus 로고    scopus 로고
    • Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors
    • Pronier E, C Almire, H Mokrani, A Vasanthakumar, A Simon, B da Costa Reis Monte Mor, A Masse, JP Le Couedic, F Pendino, et al. (2011). Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors. Blood 118:2551-2555.
    • (2011) Blood , vol.118 , pp. 2551-2555
    • Pronier, E.1    Almire, C.2    Mokrani, H.3    Vasanthakumar, A.4    Simon, A.5    Da Costa-Reis-Monte Mor, B.6    Masse, A.7    Le Couedic, J.P.8    Pendino, F.9
  • 56
    • 84255200412 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations
    • Jin SG, Y Jiang, R Qiu, TA Rauch, Y Wang, G Schackert, D Krex, Q Lu and GP Pfeifer. (2011). 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res 71:7360-7365.
    • (2011) Cancer Res , vol.71 , pp. 7360-7365
    • Jin, S.G.1    Jiang, Y.2    Qiu, R.3    Rauch, T.A.4    Wang, Y.5    Schackert, G.6    Krex, D.7    Lu, Q.8    Pfeifer, G.P.9
  • 57
    • 84866419591 scopus 로고    scopus 로고
    • Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
    • Lian CG, Y Xu, C Ceol, F Wu, A Larson, K Dresser, W Xu, L Tan, Y Hu, et al. (2012). Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 150:1135-1146.
    • (2012) Cell , vol.150 , pp. 1135-1146
    • Lian, C.G.1    Xu, Y.2    Ceol, C.3    Wu, F.4    Larson, A.5    Dresser, K.6    Xu, W.7    Tan, L.8    Hu, Y.9
  • 59
    • 84880570961 scopus 로고    scopus 로고
    • Micro RNA antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling
    • Song SJ, L Poliseno, MS Song, U Ala, K Webster, C Ng, G Beringer, NJ Brikbak, X Yuan, et al. (2013). Micro RNA antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell 154:311-324.
    • (2013) Cell , vol.154 , pp. 311-324
    • Song, S.J.1    Poliseno, L.2    Song, M.S.3    Ala, U.4    Webster, K.5    Ng, C.6    Beringer, G.7    Brikbak, N.J.8    Yuan, X.9
  • 60
  • 61
    • 77952678006 scopus 로고    scopus 로고
    • Epigenetic control of neural precursor cell fate during development
    • Hirabayashi Y and Y Gotoh. (2010). Epigenetic control of neural precursor cell fate during development. Nat Rev Neurosci 11:377-388.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 377-388
    • Hirabayashi, Y.1    Gotoh, Y.2
  • 63
    • 84870883633 scopus 로고    scopus 로고
    • Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development
    • Xu Y, C Xu, A Kato, W Tempel, JG Abreu, C Bian, Y Hu, D Hu, B Zhao, et al. (2012). Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell 151:1200-1213.
    • (2012) Cell , vol.151 , pp. 1200-1213
    • Xu, Y.1    Xu, C.2    Kato, A.3    Tempel, W.4    Abreu, J.G.5    Bian, C.6    Hu, Y.7    Hu, D.8    Zhao, B.9
  • 66
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
    • Guo JU, Y Su, C Zhong, GL Ming and H Song. (2011). Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145:423-434.
    • (2011) Cell , vol.145 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.L.4    Song, H.5
  • 68
    • 84884471932 scopus 로고    scopus 로고
    • TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation
    • Kaas GA, C Zhong, DE Eason, DL Ross, RV Vachhani, GL Ming, JR King, H Song and JD Sweatt. (2013). TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation. Neuron 79:1086-1093.
    • (2013) Neuron , vol.79 , pp. 1086-1093
    • Kaas, G.A.1    Zhong, C.2    Eason, D.E.3    Ross, D.L.4    Vachhani, R.V.5    Ming, G.L.6    King, J.R.7    Song, H.8    Sweatt, J.D.9
  • 70
    • 84872953223 scopus 로고    scopus 로고
    • TET2 promotes histone O-Glc NA cylation during gene transcription
    • Chen Q, Y Chen, C Bian, R Fujiki and X Yu. (2013). TET2 promotes histone O-Glc NA cylation during gene transcription. Nature 493:561-564.
    • (2013) Nature , vol.493 , pp. 561-564
    • Chen, Q.1    Chen, Y.2    Bian, C.3    Fujiki, R.4    Yu, X.5
  • 74
    • 84888372386 scopus 로고    scopus 로고
    • Vitamin C modulates TET1 function during somatic cell reprogramming
    • Chen J, L Guo, L Zhang, H Wu, J Yang, H Liu, X Wang, X Hu, T Gu, et al. (2013). Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet 45:1504-1509.
    • (2013) Nat Genet , vol.45 , pp. 1504-1509
    • Chen, J.1    Guo, L.2    Zhang, L.3    Wu, H.4    Yang, J.5    Liu, H.6    Wang, X.7    Hu, X.8    Gu, T.9
  • 76
    • 84877693964 scopus 로고    scopus 로고
    • Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
    • Minor EA, BL Court, JI Young and G Wang. (2013). Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine. J Biol Chem 288:13669-13674.
    • (2013) J Biol Chem , vol.288 , pp. 13669-13674
    • Minor, E.A.1    Court, B.L.2    Young, J.I.3    Wang, G.4


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