Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits

European Journal of Neuroscience

Volumn 39, Issue 7, 2014, Pages 1214-1224

  Miller, Eric C ^a   Teravskis, Peter J ^a   Dummer, Benjamin W ^a   Zhao, Xiaohui ^a   Huganir, Richard L ^b   Liao, Dezhi ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Abeta oligomers; Alzheimer's disease; Dendritic spines; mEPSC; Synaptic deficits; Tau phosphorylation

Indexed keywords

AMYLOID BETA PROTEIN; CALCINEURIN; GLUTAMATE RECEPTOR 1; MUTANT PROTEIN; PHOSPHATASE; TACROLIMUS; TAU PROTEIN; AMPA RECEPTOR; AMYLOID BETA-PROTEIN (1-42); CALCINEURIN INHIBITOR; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1; MAPT PROTEIN, MOUSE; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITIC SPINE; ENZYME ACTIVITY; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE TARGETING; HIPPOCAMPAL NEURONAL CULTURE; INTERNALIZATION; MOUSE; MOUSE STRAIN; NEUROPATHY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPTIC DEFICIT; SYNAPTIC DYSFUNCTION; TRANSGENIC MOUSE; ANIMAL; CELL CULTURE; DRUG EFFECTS; GENETICS; METABOLISM; MINIATURE ENDPLATE POTENTIAL; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TRANSPORT; TOXICITY;

AMYLOID BETA-PEPTIDES; ANIMALS; CALCINEURIN; CALCINEURIN INHIBITORS; CELLS, CULTURED; DENDRITIC SPINES; EXCITATORY POSTSYNAPTIC POTENTIALS; MICE; MINIATURE POSTSYNAPTIC POTENTIALS; MUTATION; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTORS, AMPA; TACROLIMUS; TAU PROTEINS;

EID: 84898719221     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/ejn.12507     Document Type: Article

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