Alzheimer amyloid β-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus

Neurobiology of Learning and Memory

Volumn 77, Issue 3, 2002, Pages 354-371

  Chen, Qi Sheng ^a   Wei, Wei Zheng ^a   Shimahara, Takeshi ^b   Xie, Cui Wei ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LABORATOIRE DE NEUROBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

Author keywords

Alzheimer amyloid peptide; Dentate gyrus; Hippocampus; Late phase LTP; NMDA channel currents; Protein synthesis inhibitor

Indexed keywords

AMYLOID BETA PROTEIN; CALCINEURIN; CYCLOSPORIN A; EMETINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TACROLIMUS;

ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN PERFUSION; BRAIN SLICE; CONTROLLED STUDY; DENTATE GYRUS; DRUG EFFECT; ENZYME ACTIVITY; EXCITATORY POSTSYNAPTIC POTENTIAL; GRANULE CELL; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; NONHUMAN; PROTEIN SYNTHESIS; RAT; SYNAPSE;

EID: 0036354603     PISSN: 10747427     EISSN: None     Source Type: Journal    
DOI: 10.1006/nlme.2001.4034     Document Type: Article

References (70)

1. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory
2. An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses
3. Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
4. CREB phosphorylation and dephosphorylation: A Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression
5. Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP
6. Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region
7. 2+ influx induced by beta-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation
8. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
9. Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides
10. Amyloid β-peptide inhibits the late phase of LTP through a calcineurin-dependent mechanism in rat dentate gyrus
11. Mechanisms underlying induction of long-term potentiation in rat medial and lateral perforant paths in vitro
12. Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide
13. Protein synthesis and memory: A review
14. Reduced hippocampal CA1 Ca(2+)-induced long-term potentiation is associated with age-dependent impairment of spatial learning
15. Age-associated changes in Ca(2+)-dependent processes: Relation to hippocampal synaptic plasticity
16. Calcium regulation of gene expression: Isn't that spatial?
17. + current in rat hippocampal neurons
18. Only "de novo" long-term depression (LTD) in the rat hippocampus in vitro is blocked by the same low concentration of FK506 that blocks LTD in the visual cortex
19. cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase
20. Long-lasting forms of synaptic potentiation in the mammalian hippocampus
21. Antisense DNA against calcineurin facilitates memory in contextual fear conditioning by lowering the threshold for hippocampal long-term potentiation induction
22. Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus
23. Impairments of long-term potentiation in hippocampal slices of beta-amyloid-infused rats
24. Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats
25. Distinct cellular expression of calcineurin A alpha and A beta in rat brain
26. Calcium entry through a subpopulation of AMPA receptors desensitized neighbouring NMDA receptors in rat dorsal horn neurons
27. Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
28. NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus
29. Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium
30. Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase
31. A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory
32. FK506 and cyclosporin: Molecular probes for studying intracellular signal transduction
33. Long-term potentiation: A decade of progress?
34. Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin
35. Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory
36. Cellular functions of immunophilins
37. Different mechanisms and multiple stages of LTP
38. Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
39. Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF
40. N-methyl-D-aspartic acid receptor structure and function
41. Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression
42. Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein
43. Maintenance of late-phase LTP is accompanied by PKA-dependent increase in AMPA receptor synthesis
44. Requirement of a critical period of transcription for induction of a late phase of LTP
45. A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices
46. The current excitement in long-term potentiation
47. Expression mechanisms underlying NMDA receptor-dependent long-term potentiation
48. Alterations in the balance of protein kinase/phosphatase activities parallel reduced synaptic strength during aging
49. 2+ channels
50. Differential modulation of synaptic transmission by calcium chelators in young and aged hippocampal CA1 neurons: Evidence for altered calcium homeostasis in aging
51. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide
52. Structure-activity analyses of beta-amyloid peptides: Contribution of the beta 25-35 region to aggregation and neurotoxicity
53. β-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinase
54. Direct evidence for biphasic cAMP responsive element-binding protein phosphorylation during long-term potentiation in the rat dentate gyrus in vivo
55. Intrahippocampal injections of exogenous beta-amyloid induce postdelay errors in an eight-arm radial maze
56. Increase in single L-type calcium channels in hippocampal neurons during aging
57. Activity-dependent β-adrenergic modulation of low frequency stimulation induced LTP in the hippocampal CA1 region
58. Synaptic desensitization of NMDA receptors by calcineurin
59. 2+ channels: A possible involvement of free radicals
60. The balance between postsynaptic Ca(2+)-dependent protein kinase and phosphatase activities controlling synaptic strength
61. 2+ signaling mechanisms in hippocampal CA1 neurons
62. 2+ signaling following application of amyloid beta-peptide in hippocampal neurons
63. Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin
64. Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP
65. Opioid-mediated facilitation of long term potentiation at the lateral perforant path-dentate granule cell synapse
66. Involvement of cAMP-dependent protein kinase in mu opioid modulation of NMDA-mediated synaptic currents
67. Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene
68. Calcineurin regulation of synaptic function: From ion channels to transmitter release and gene transcription
69. Orphanin FQ/nociceptin inhibits synaptic transmission and long-term potentiation in rat dentate gyrus through postsynaptic mechanisms