Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

Biochemical Journal

Volumn 383, Issue 3, 2004, Pages 439-446

  Leissring, Malcolm A ^a   Farris, Wesley ^a   Wu, Xining ^a   Christodoulou, Danos C ^b   Haigis, Marcia C ^b   Guarente, Leonard ^b   Selkoe, Dennis J ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Diabetes mellitus; Insulin degrading enzyme; Metallopeptidase; Mitochondrion

Indexed keywords

AMINO ACIDS; ELECTRON MICROSCOPY; INSULIN; PROTEINS; ZINC;

CYTOSOLIC PROTEINS; INSULIN-DEGRADING ENZYME (IDE); PLASMA INSULIN;

ENZYME KINETICS;

AMYLOID BETA PROTEIN; CELL PROTEIN; GREEN FLUORESCENT PROTEIN; INSULIN; INSULINASE; METALLOPROTEINASE; PEPTIDASE; TRYPSIN;

ALLELE; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CODON; CYTOSOL; ENZYME DEGRADATION; GENE LOCUS; GENETIC LINKAGE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IN VIVO STUDY; INSULIN BLOOD LEVEL; MITOCHONDRION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TRANSLATION INITIATION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHO CELLS; CODON, INITIATOR; CONSERVED SEQUENCE; CRICETINAE; CRICETULUS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULYSIN; ISOENZYMES; KIDNEY; METHIONINE; MICE; MICROSCOPY, ELECTRON; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; RATS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUBMITOCHONDRIAL PARTICLES;

ANIMALIA; LEUCISCUS IDUS;

EID: 9144260111     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041081     Document Type: Article

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